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Catastrophic Antiphospholipid Antibody Syndrome:Clinical Presentation,Management,and Guidance for Future Pregnancy

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Maternal-Fetal Medicine 2019年第1期1卷 53-58页

作者： Raminder Kaur Khangura Alexandra Loza DO Shontreal Cooper Guo-Yang Luo Division of Maternal Fetal Medicine Department of Obstetrics and GynecologyUniversity ofConnecticut School of MedicineFarmingtonCT 06030USA department of Obstetrics andgynecology University of Connecticut School of MedicineFarmingtonCT 06030USA department ofobstetrics and Gynecology Howard University School of MedicineWashingtonDC 20059USA

To editor:Antiphospholipid antibody syndrome(APS)is an autoimmune condition characterized by the production of antiphospholipid antibodies(aPL)with clinical features such as vascular thrombosis or obstetric morbidity.1 APS is associated with spontaneous abortions and pregnancy *** resulting in live births may be complicated by fetal growth restriction,uteroplacental insufficiency,preeclampsia,hemolysis elevated liver enzymes,and low platelets(HELLP)syndrome,and preterm birth.

关键词： Antiphospholipid antibody syndrome Pregnancy,Catastrophic antiphospholipid antibody syndrome Management

Remodeling of the plasma for sperm-egg recognition： proteins membrane in preparation roles of acrosomal

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Asian Journal of Andrology 2015年第4期17卷 574-582页

作者： Nongnuj Tanphaichitr Kessiri Kongmanas Hathairat Kruevaisayawan Arpornrad Saewu Clarissa Sugeng Jason Fernandes Puneet Souda Jonathan B Angel Kym F Faull R John Aitken Julian Whitelegge Daniel Hardy Trish Berger Mark Baker Chronic Disease Program Ottawa Hospital ResearchInstitute Ottawa Ontario Canada department ofobstetrics and Gynaecology University of OttawaOntario Canada department of Biochemistry Microbiology and Immunology University of OttawaOntario Canada department of Anatomy Faculty ofMedical Sciences Naresuan University PhitsanulokThailand Division of Infectious Diseases OttawaHospital - General Campus Ottawa Ontario Canada Pasarow Mass Spectrometry Laboratory Universityof California Los Angeles California USA TheARC Centre of Excellence in Biotechnology andDevelopment School of Environmental and LifeSciences University of Newcastle Callaghan NewSouth Wales Australia department of Cell Biologyand Biochemistry Health Sciences Center Texas TechUniversity Texas USA department of Animal ScienceUniversity of California Davis California USA

The interaction of sperm with the egg＇s extracellular matrix, the zona pellucida （ZP） is the first step of the union between male and female gametes. The molecular mechanisms of this process have been studied for the past six decades with the results obtained being both interesting and confusing. In this article, we describe our recent work, which attempts to address two lines of questions from previous studies. First, because there are numerous ZP binding proteins reported byvarious researchers, how do these proteins act together in sperm-ZP interaction？ Second, why do a number of acrosomal proteins have ZP affinity？ Are they involved mainly in the initial sperm-ZP binding or rather in anchoring acrosome reacting/reacted spermatozoa to the ZP？ Our studies reveal that a number of ZP binding proteins and chaperones, extracted from the anterior sperm head plasma membrane, coexist as high molecular weight （HMW） complexes, and that these complexes in capacitated spermatozoa have preferential ability to bind to the ZP. Zonadhesin （ZAN）, known as an acrosomal protein with ZP affinity, is one of these proteins in the HMW complexes. Immunoprecipitation indicates that ZAN interacts with other acrosomal proteins, proacrosin/acrosin and sp32 （ACRBP）, also present in the HMW complexes. Immunodetection of ZAN and proacrosin/acrosin on spermatozoa further indicates that both proteins traffic to the sperm head surface during capacitation where the sperm acrosomal matrix is still intact, and therefore they are likely involved in the initial sperm-ZP binding step.

关键词： SPERM CAPACITATION ANDSPERM-ZONA PELLUCIDAINTERACTION- BACKGROUND ANDCONFUSION IN THE FIELDS

Evidence-Based Cesarean Section for Universal Use in China:The"Stark(Misgav Ladach)Method"

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Maternal-Fetal Medicine 2019年第1期1卷 48-52页

作者： Michael Stark New European Surgical Academy Unter den Linden 21Berlin 10117Germany department ofobstetrics and Gynecology CharitéUniversity HospitalCharitépl.1Berlin 10117Germany ELSANHospital Group 58 Rue la BoétieParis 75008France

There are many ways to perform cesarean section,with many methods developing from local *** a 3-year study process,a modified,evidence-based method has bean developed,which is now in use in many *** abdomen incision is based on the Joel-Cohen incision,the peritoneum is opened by repeated stretching,and the uterus is opened transversely after pushing the bladder *** delivery the uterus is sutured with one layer using a large needle,and the abdomen is closed with only two layers,fascia and *** method was subject to scores of studies,with all upholding its superiority over traditional *** a result,the"Stark(Misgav Ladach)method"is recommended to become a standard procedure across China.

关键词： Cesarean section Stark cesarean Misgav Ladach

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新型非口服激素避孕方法

英国医学杂志中文版 2013年第4期16卷 246-251页

作者： Deborah Bateson,medical director medical director Paula Briggs,clinical lead 曾桢(译) 廖秦平(校) FamilyPlanningNSW SydneyNSW2131Australia Discipline ofobstetrics Gynaecology andNeonatologyUniversity of SydneySydney NSW 2006Australia Family PlanningVictoria Box HillVIC 3128 AustrMia Monash MedicalCentre Department ofObstetrics andGynaeeologyClayton VIC 3168Australia Community SexualHealth Service Sefton UK 北京大学第一医院妇产科

一位24岁未生育女性希望能有一种可长期使用的避孕方法以替换复方口服避孕药。她说因为有时会忘记服用口服避孕药，所以希望寻找一种不用每天服药的避孕方法。她不抽烟，没有复方口服避孕药禁忌证，服用口服避孕药时月经量大。

关键词：复方口服避孕药避孕方法激素未生育禁忌证月经量服用

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宫颈癌治疗：SIGN指南概要

英国医学杂志中文版 2008年第2期11卷 113-115页

作者： R M James M E Cruickshank N Siddiqui Scottish IntercollegiateGuidelines Network( SIGN ) 28 ThistleStreet EdinburgEH2 IEN department ofobstetrics andGynaecology Aberdeen MaternityHospital AB25 7ZD department ofGynaecologyOncology GlasgowRoyal InfirmaryG40SF

为什么阅读本概要？在英国尽管有一个组织严谨的宫颈癌前病变筛查程序，每年仍有2800例的宫颈癌新发病例和1000例的死亡病例^1。很多患者仍然会因宫颈癌相关症状就诊于全科医生。接种和免疫联合委员会宣布明年引进人乳头瘤病毒疫苗用于1... 详细信息

为什么阅读本概要？在英国尽管有一个组织严谨的宫颈癌前病变筛查程序，每年仍有2800例的宫颈癌新发病例和1000例的死亡病例^1。很多患者仍然会因宫颈癌相关症状就诊于全科医生。接种和免疫联合委员会宣布明年引进人乳头瘤病毒疫苗用于12～13岁少女接种。但可以预见，其对宫颈癌发生率的影响需要40～60年的时间才能看出。

关键词：宫颈癌前病变人乳头瘤病毒疫苗治疗联合委员会死亡病例新发病例全科医生

Risk Factors for Gestational Diabetes Mellitus(GDM)in Subsequent Pregnancy Among Women Without GDM History in China:A Multicenter Retrospective Study

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Maternal-Fetal Medicine 2023年第1期5卷 9-15页

作者： Geng Song Yumei Wei Juan Juan Rina Su Jianying Yan Mei Xiao Xianlan Zhao Meihua Zhang Yuyan Ma Haiwei Liu Jingxia Sun Kejia Hu Huixia Yang department of Obstetrics and Gynecology Peking University First HospitalBeijing 100034China Beijing Key Laboratory of Maternal Fetal Medicine of Gestational Diabetes Mellitus Beijing 100034China department of Obstetrics and Gynecology Fujian Province Maternal and Child Health HospitalFuzhou 350005China department of Obstetrics and Gynecology Maternal and Child Health Hospital of Hubei ProvinceWuhan 430064China department of Obstetrics and Gynecology Zhengzhou University First Affiliated HospitalZhengzhou 450052China department ofobstetrics and Gynecology Taiyuan Maternal and Child Health HospitalTaiyuan 030012China department of Obstetrics and Gynecology Shandong University Qilu HospitalJinan 250063China department of Obstetrics and Gynecology Hainan General HospitalHaikou 570311China department of Obstetrics and Gynecology First Affiliated Hospital of Harbin Medical UniversityHarbin 150007China department of Obstetrics and Gynecology Beijing Shunyi District HospitalBeijing 101312China

Objective:This study aimed to determine the likelihood of gestational diabetes mellitus(GDM)in subsequent pregnancy among women without GDM history and to identify risk factors for GDM in subsequent ***:This retrospective cohort study involved participants who delivered twice in same hospital of 18 research centers when delivered the second baby from January 2018 to December *** 6204 women were enrolled and 5180 women without GDM history were analyzed *** were categorized as non-GDM or GDM based on the blood glucose values of the subsequent pregnancy,and the characteristics and GDM risk of these groups were compared.A univariate analysis of potential risk factors was performed using the Chi-squared test and/ort-test for qualitative or quantitative variables,*** withP values<0.1 were chosen to be included in the multivariate binary logistic regression ***:In primary analysis of 6204 women,the incidence of GDM in subsequent pregnancy is 48.9%(490/1002)in women with GDM history and 16.1%(835/5202)in women without GDM *** a further analysis for 5180 women without GDM at index pregnancy,compared with the non-GDM group,the GDM group had a significantly higher age,prepregnancy body mass index,and blood glucose value at each oral glucose tolerance test(OGTT)timepoint(fasting,1 h and 2 h)during the index and subsequent pregnancies,as well as higher weight retention during the interval between the two pregnancies(P<0.001).Age above 35 years in subsequent pregnancy(odds ratio(OR)=1.540,95%confidence interval(CI)=1.257-1.886,P<0.001),macrosomia in index pregnancy(OR=1.749,95%CI=1.277-2.395,P=0.001),OGTT blood glucose values in index pregnancy(fasting,OR=2.487,95%CI=1.883-3.285,P<0.001;1 h,OR=1.142,95%CI=1.051-1.241,P=0.002;2 h,OR=1.290,95%CI=1.162-1.432,P<0.001)and weight retention(OR=1.052,95%CI=1.035-1.068,P<0.001)were independent risk factors for GDM in subsequent ***:For women without G

关键词： Diabetes gestational Without GDM history Risk factors Subsequent pregnancy.

宫颈上皮内瘤变患者完成治疗并随访后宫颈癌的发生风险：人群为基础的队列研究

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英国医学杂志中文版 2013年第4期16卷 238-238页

作者： Matejka Rebolj, postdctord researche Theo Hehnerhorst,professor ofgynaecology Dik Habbema, professor of medical decision sciences Caspar Loonan,statistician Jcost van Rosrten, postcoctoral researcher Marjolein van Ballegooijen, assocate professor of medical techrulxl,,y assessment 王永学(译) 潘凌亚(校) department of PublicHealth Erasmus MCRotterdam Netherlands department of PublicHealth University ofCopegen Copenhagen Denmark Deparlmenl ofobstetrics andGynaecology ErasmusMC RotterdamNetherlands 北京协和医院妇产科

目的比较组织学确认的宫颈上皮内瘤变的妇女在完成以连续细胞学涂片正常的治疗后随访并重返常规筛查与初始细胞学涂片结果正常的妇女发生宫颈癌风险。设计人群为基础的队列研究，数据来源于一个国家范围内的病理登记系统。研究背景荷兰... 详细信息

目的比较组织学确认的宫颈上皮内瘤变的妇女在完成以连续细胞学涂片正常的治疗后随访并重返常规筛查与初始细胞学涂片结果正常的妇女发生宫颈癌风险。设计人群为基础的队列研究，数据来源于一个国家范围内的病理登记系统。研究背景荷兰，1994年至2006年。研究对象38956例经组织学确诊的宫颈上皮内瘤变1～3级的妇女，完成了治疗后随访。干预宫颈上皮内瘤变常规治疗后的随诊，推荐6、12、24个月涂片检测。主要结局测量宫颈上皮内瘤变后从完成阴性试验结果的随诊到下次基本检测期间宫颈癌的发生率。经调整随诊年，与初始涂片检测结果正常后时期比较的10年危害比。结果完成治疗后随诊的宫颈上皮内瘤变妇女在56956妇女年中共有20例宫颈癌被确诊。而既往细胞学检查阴性的妇女在25020697妇女年中发生宫颈癌1613例。两组人群宫颈癌的发生率分别为35．1（95％可信区间21．4～54．2）／每100000妇女年和6．4（6．1～6．8）／每100000妇女年，其校正危害比为4．2（95％可信区间2．7～6．5）。在所有年龄段中危害比都增加。宫颈上皮内瘤变不同级别间比较，宫颈癌的发生风险无明显差别。结论以往观察到的宫颈上皮内瘤变患者治疗后发生宫颈癌的额外风险也在完成治疗后随诊且连续3次细胞涂片都正常的妇女中观察到。经过校正后，这些妇女发生宫颈癌的风险（35例／每100000妇女年）是既往细胞学正常妇女（6例／每100 000妇女年）的4倍。

关键词：宫颈上皮内瘤变治疗后随访发生风险宫颈癌队列研究人群患者细胞学涂片