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Chinese Journal of Integrative Medicine 2015年第1期21卷 3-9页

作者：王肖龙 cardiovascular department Shanghai Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine

The combination of herbs and drugs is one of the most important approaches in the prevention and treatment of diseases in the integrated traditional and Western medicine （ITWM）. While most medical practices have proved that the combination of herbs and drugs led to a clinical efficacy that was often superior to merely using only one of them; results from some studies have triggered adverse reactions to such an approach. Since few herb-drug interaction studies were carried out during treatments combining herbs and drugs, it really restricts the development of treatment and treatment theory of the combination of herbs and drugs. Given that herb-drug interactions may occur through the main pathway of cytochrome P450 enzymes and transporters; then to exhaustively study the role and impact of herbs in drug metabolism, as well as to establish a corresponding database, is of greatsignificance for guiding the rational combination of herbs and drugs. When the herb-drug interaction information platform is implemented, we would get at ease a reasonable herb-drug prescription to achieve a better outcome, reduce dosage of some expensive drugs preserving the same efficacy, or even reduce some side effects of particular drugs; which might also promote the dynamic combination of Chinese and Western medicine, and accelerate the theory development of ITWM.

关键词： integrated traditional and Western medicine herb-drug interaction cytochrome P450 transporter cardiovascular disease

Significance of serum fibroblast growth factor-23 and miR-208b in pathogenesis of atrial fibrillation and their relationship with prognosis

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World Journal of Clinical Cases 2020年第16期8卷 3458-3464页

作者： Jie-Min Chen Yao-Tang Zhong Chang Tu Jun Lan department of cardiovascular Medicine Dongguan Songshan Lake Central HospitalDongguan Institute of Cardiovascular DiseaseDongguan 523326Guangdong ProvinceChina

BACKGROUND The incidence and prevalence of atrial fibrillation are increasing each year,and this condition is one of the most common clinical *** To investigate the levels and significance of serum fibroblast growth factor 23(FGF-23)and miR-208 b in patients with atrial fibrillation and their relationship with *** From May 2018 to October 2019,240 patients with atrial fibrillation were selected as an observation group,including 134 with paroxysmal atrial fibrillation and 106 with persistent atrial fibrillation;150 patients with healthy sinus rhythm were selected as a control *** serum levels of FGF-23 and miR-208 b in the two groups were *** the observation group,cardiac parameters were determined by *** The serum levels of FGF-23 and miR-208 b in the observation group were 210.20±89.60 ng/mL and 5.30±1.22 ng/mL,which were significantly higher than the corresponding values in the control group(P0.05).The serum levels of FGF-23and miR-208 b were positively correlated with the LAD(r=0.411 and 0.382,Pcardiovascular event(MACE)were 243.30±72.29 ng/mL and 6.12±1.12 ng/mL,which were significantly higher than the corresponding values in patients without a MACE(P<0.05).CONCLUSION The serum levels of FGF-23 and miR-208 b are increased in patients with atrial fibrillation and are related to the type of disease,cardiac parameters,and prognosis.

关键词： Fibroblast growth factor-23 MiR-208b Atrial fibrillation Prognosis

Effects of Bivalirudin and Unfractionated Heparin on Liver and Renal Function in Chinese Patients with Coronary Artery Disease Undergoing Coronary Angiography with/without Percutaneous Coronary Intervention

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Journal of Clinical and Translational Hepatology 2021年第4期9卷 477-483页

作者： Qiaowei Jia Jia Hu Wenfeng Ji Liansheng Wang Enzhi Jia department of cardiovascular Medicine First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsuChina department of cardiovascular Medicine Liyang People’s HospitalLiyangJiangsuChina

Background and Aims:Unfractionated heparin(UFH)and bivalirudin are widely used as anticoagulants in cardiovascular medicine,including for thrombosis prevention during coronary angiography(CAG)and percutaneous coronary intervention(PCI).Little is known of the effects of UFH and bivalirudin on liver and kidney function in patients subjected to these *** study compared the effects of bivalirudin and UFH on liver/renal function in patients with coronary artery disease who underwent CAG,with or without ***:The study comprised 134 consecutive patients(40–89 years-old),who underwent CAG(or CAG and PCI);among them,66 and 68 patients were subject to,respectively,bivalirudin or *** following indicators of liver/renal function were measured before and after the procedures:plasma alanine aminotransferase(ALT),aspartate aminotransferase(AST),blood urea nitrogen,estimated glomerular filtration rate(eGFR),creatinine clearance,and serum *** were further stratified by severity of chronic kidney disease(CKD),based on original ***:Relative to baseline,in the bivalirudin group,ALT and AST were higher after CAG(p=0.005,0.025),while blood urea nitrogen and serum creatinine were lower(p=0.049,<0.001).In the UFH group,ALT,AST,eGFR,and creatinine clearance were lower after CAG(p≤0.001,all).Patients given bivalirudin with moderate or severe CKD,but not those with mild CKD,gained significant improvement in kidney ***:Relative to UFH,bivalirudin may better safeguard the renal function of patients with coronary artery disease who undergo CAG,especially patients with moderate-to-severe renal *** may cause less liver damage than bivalirudin.

关键词： Bivalirudin Unfractionated heparin Coronary artery disease Coro-nary angiography Percutaneous coronary intervention Liver function

Horseshoe thrombus in a patient with mechanical prosthetic mitral valve: A case report and review of literature

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World Journal of Clinical Cases 2015年第9期3卷 838-842页

作者： Sanjay Mehra Assad Movahed Carlos Espinoza Constantin B Marcu department of cardiovascular Sciences East Carolina University

Patients with prosthetic cardiac valves are at high risk for thromboembolic complications and need life long anticoagulation with warfarin, which can be associated with variable dose requirements and fluctuating level of systemic anticoagulation and may predispose to thromboembolic and or hemorrhagic complications. Prosthetic cardiac valve thrombosis is associated with high morbidity and mortality. A high index of suspicion is essential for prompt diagnosis. Transthoracic echocardiography, and if required transesophageal echocardiography are the main diagnostic imaging modalities. Medically stable patients can be managed with thrombolytic therapy and anticoagulation, while some patients may require surgical thrombectomy or valve replacement. We present a case report of a patient with prosthetic mitral valve and an unusually large left atrial thrombus with both thromboembolic and hemorrhagic complications.

关键词： Thrombosis Anticoagulation Thrombolytic therapy Transthoracic echocardiogram Prosthetic valves Transesophageal echocardiogram

Homozygous phytosterolemia and a literature review:A case report

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World Journal of Clinical Cases 2025年第10期13卷 46-52页

作者： Chun-Xin Jiang Guang Yang Lian-Ping Shi Peng-Yu Su department of cardiovascular North China University of Science and Technology Affiliated HospitalTangshan 063000Hebei ProvinceChina

BACKGROUND Phytosterolemia,also known as sitosterolemia,is a rare autosomal recessive disease characterized by elevated plasma plant sterol levels and xanthomata,which is easily misdiagnosed as familial *** with homozygous phytosterolemia often have severe clinical manifestations,with xanthomata in childhood and premature *** patient had a milder clinical *** SUMMARY This report describes a patient with homozygous phytosterolemia who presented with only elevated cholesterol and low-density lipoprotein cholesterol(LDL-C)without xanthomata,arteriosclerosis,or hematological *** mutation of ABCG5 which encodes an ATP-binding cassette transporter,was detected by whole exome sequencing and diagnosed as *** of the patient’s plasma plant sterol levels detected significant elevations in stigmasterol,rapeseed oil-derived plant sterol,andβ-glutaminol *** was started and a low plant sterol diet was *** patient’s blood lipid profile was reexamined one month later and showed significant decreases in total cholesterol and LDL-C *** has similar clinical features as familial hypercholesterolemia,is highly susceptible to misdiagnosis,and has a very low incidence,and therefore clinicians need to consider a genetic diagnosis of a definitively hyperlipidemic disorder when statin drugs fail to lower lipid *** Phytosterolemia is easily misdiagnosed as familial hypercholesterolaemia and can be treated by dietary modification and cholesterol absorption inhibitors to lower blood lipids.

关键词： Hypercholesterolemia Cholesterol Low-density lipoprotein Phytosterolemia Liquid chromatography ABCG5/ABCG8 Sitosterolemia

Sex modification of the association of the radial augmentation index and incident hypertension in a Chinese community-based population

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Journal of Geriatric Cardiology 2021年第1期18卷 39-46页

作者： Qiao QIN Fang-Fang FAN Meng-Yuan LIU Bo LIU Jia JIA Long ZHANG Yu-Xi LI Yi-Meng JIANG Peng-Fei SUN Dan-Mei HE Jian-Ping LI Ming CHEN Bo ZHENG Yan ZHANG department of Cardiology Institute of Cardiovascular DiseasePeking University First HospitalBeijingChina

BACKGROUND Arterial stiffness,as assessed by aortic ultrasound and pulse wave velocity,is associated with incident ***,there is still no consensus on whether the augmentation index(AI)affects new onset of *** study investigated the relationship of radial AI(r AI)and incident hypertension in a Chinese community-based population without hypertension at *** A total of 1,615 Chinese non-hypertensive participants from an atherosclerosis cohort in Beijing,China were included in our *** r AI normalized to heart rate of 75 beats/min(r AIp75)was obtained using HEM-9000 ***-onset hypertension was defined as blood pressure≥140/90 mm Hg or self-reported hypertension or taking anti-hypertensive medications at the follow up *** regression models were used to evaluate the impact of r AIp75 on the risk of new-onset *** After a mean 2.35-year follow-up,213(13.19%)participants developed incident *** significant relation between r AIp75 and incident hypertension was observed in the whole population after adjustment for possible confounders(adjusted odds ratio(OR)and 95%confidence interval(CI):1.09[0.95-1.27];P=0.2260).However,r AIp75 was significantly associated with incident hypertension in women,but not in men(adjusted OR and 95%CI:1.29[1.06-1.56],P=0.0113 for women;0.91[0.72-1.15],P=0.4244 for men;P for interaction=0.0133).CONCLUSIONS Sex modified the effect of the r AI on incident hypertension in a Chinese,community-based,non-hypertensive *** of the r AI could be considered in women with a high risk of hypertension for the purpose of primary intervention.

关键词： Sex modification of the association of the radial augmentation index and incident hypertension in a Chinese community-based population

The L-shaped association between superoxide dismutase levels and blood pressure in older Chinese adults:community-based,cross-sectional study

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Journal of Geriatric Cardiology 2022年第1期19卷 71-82页

作者： Ying HUANG Wei LAI Hong CHEN Qi-Fan LIU Ju-Xiang LI Jin-Zhu HU department of cardiovascular Medicine the Second Affiliated Hospital of Nanchang UniversityNanchang of JiangxiChina

BACKGROUND As an antioxidant,serum superoxide dismutase(SOD)have been found to be associated with *** The data were derived from the Chinese Longitudinal Healthy Longevity Survey(CLHLS),a prospective cohort study in *** explored the association between serum SOD and blood pressure(BP)using multivariable correction analysis in an older Chinese *** We observed a significantly gradual downward trend in the association between serum SOD levels and diastolic BP(DBP)in participants with lower serum SOD levels(58 IU/mL).Similar results showed a significant gradual downward trend in associations between serum SOD levels and the risk of diastolic hypertension only at SOD58 IU/mL)were an effect modifier of the association between serum SOD and DBP(interaction P=0.0038)or the risk of diastolic hypertension(interaction P=0.0050).CONCLUSIONS Our study indicated for the first time that there was an L-shaped association between serum SOD levels and the risk of diastolic hypertension in the older Chinese population.

关键词： hypertension shaped Serum

Spinal cord hemorrhage: a rare complication of dual antiplatelet therapy for non-ST elevation myocardial infarction

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Journal of Geriatric Cardiology 2019年第5期16卷 437-438页

作者： Xing YU Jian-Yi ZHENG Gui-Ping ZHU cardiovascular department of First Affiliated Hospital of Guangdong Pharmaceutical University

Dual antiplatelet therapy(DAPT)with aspirin and clopidogrel has been widely used after percutaneous coronary intervention(PCI).The bleeding complications caused by it cannot be ignored and the incidence is as high as 32.4%.[1]Among them,spinal cord hemorrhage is rare,acute and *** herein report a case of spinal cord hemorrhage caused by DAPT with aspirin and clopidogrel used after PCI for non-ST elevation myocardial infarction(NSTEMI).

关键词： Antiplatelet agent Aspirin Clopidogrel Spinal cord hemorrhage Paraplegia

COMPARATIVE EXPERIMENTAL STUDY OF HO-YAG LASER AND TRUE- CUT BIOPSY NEEDLE IN MYOCARDIAL REVASCULARIZATION

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Chinese Medical Sciences Journal 2001年第3期16卷 135-140页

作者：王立清胡盛寿常欣吴清玉李澎谢峰郭加强 department of Surgery Cardiovascular Institute Fu Wai Hospital

*** study the mechanism and effects of blood perfusion on acute ischemic region of myocardium through channel created by Ho- Yag laser and True- cut biopsy needles with myocardial contrast echocardiography. Methods. We partially ligated the left anterior descending coronary artery of canine hearts between the lst and 2nd diagonal branches to produce two groups of acute myocardial ischemia models and then performed tran- smyocardial revascularization (TMR) on this region with Ho- Yag laser and True- cut biopsy needles. Myocardial contrast echocardiography was performed with a new generation of ultrasound contrast agent and second harmonic imaging of this region before, during ischemia and after revascularization. Pictures were taken with“ R” wave trigger skill. Results. Acoustic density (dB) in the ischemic region (anterior wall) with myocardial contrast echocardiography decreased obviously after the left anterior descending artery was ligated (Laser group: 5.40± 1.81, Needle group: 7.11± 2.51) compared with that before (Laser group: 11.69± 1.61, Needle group: 12.96± 2.88, P0.05). We found that the acoustic density of the contrast developed one picture (one cardiac cycle) ahead in the transmyocardial revascularization region than that in the lateral and other region of the left ventricle wall in the scan of both groups. Conclusions. Acute ischemic myocardium can be perfused immediately by oxygenated blood from the left ventricle through channels created with both Ho- Yag laser and True- cut biopsy needles. Evidence of blood perfusion through these channels mainly during systolic phase was detected, and myocardial contrast ultrasound using intravenous perfluorocarbon- exposed sonicated dextrose albumin was regarded as a reliable method i

关键词： Ho- Yag laser True- cut biopsy needle transmyocardial revascularization

Serum sodium concentration is significantly associated with the angiographic characteristics of coronary atherosclerosis

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Acta Pharmacologica Sinica 2007年第8期28卷 1136-1142页

作者： En-zhi JIA~2 Zhi-jian YANG Tie-bing ZHU Lian-sheng WANG Bo CHEN Ke-jiang CAO Jun HUANG Wen-zhu MA department of cardiovascular Medicine,First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China department of cardiovascular Medicine First Affiliated Hospital of Nanjing Medical University Nanjing China

Aim:To explore the relationship between serum sodium concentration and coro-nary ***:The study population consisted of 896 consecu-tive patients(684 males and 212 females)who underwent coronary angiographyfor suspected or known coronary *** and drinking *** anthropometric measurements,including body mass index,systolic blood pressure and diastolic blood pressure,and the serum measurements,including sodium,potassium,chlorine,lipids,blood glucose,urea,creatinine,anduric acid for every patient were *** severity of coronary atheroscle-rosis was defined by the Gensini score *** statistical methods,includingone-way ANOVA,Kruskal-Wallis test,Spearman correlation analysis,partial cor-relation analysis,multivariate stepwise linear regression analysis,and multinomiallogistic regression analysis were employed to explore the relationship betweenserum sodium concentration and the Gensini ***:The analysis of theKruskal-Wallis test indicated that the distribution of the Gensini score(P=0.000)differed among the groups according to serum sodium concentration,quartilevalues of which were used as cut-off *** Spearman correlation and partialcorrelation analysis controlling for gender,smoking status,and drinking statusindicated that the Gensini score significantly correlated with the sodium concen-tration(r=-0.241,P=0.000 for the Spearman correlation,r=-0.114,P=0.000 for thepartial correlation).The results from the multivariate stepwise linear regressionanalysis showed that the left ventricular ejection fraction(β=-0.228,P=0.000),age(β=0.137,P=0.010),glucose level(β=0.129,P=0.000),and sodium level(β=-0.106,P=0.004)were significantly and independently associated with the Gensini *** results of the multinomial logistic regression analysis suggested that thehyponatremia was the risk factor for the higher Gensini ***:Theserum sodium concentration was significantly and negatively ass

关键词： sodium coronary atherosclerosis Gensini score