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From mice to humans:a need for comparable results in mammalian neuroplasticity

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Neural Regeneration Research 2025年第2期20卷 464-466页

作者： Marco Ghibaudi Enrica Boda Luca Bonfanti Neuroscience Institute Cavalieri Ottolenghi OrbassanoItaly department of veterinary Sciences University of TurinTurinItaly department of Neuroscience Rita Levi-Montalcini University of TurinTurinItaly

Brain plasticity-A universal tool with many variations:The study of brain plasticity has been gaining interest since almost a century and has now reached a huge amount of information(>80,000 results in PubMed).Overall,different types of plasticity,including stem cell-driven genesis of new neurons(adult neurogenesis),cells in arrested maturation(dormant neurons),neuro-glial and synaptic plasticity,can coexist and contribute to grant plastic changes in the brain,from a cellular to system level(Benedetti and Couillard-Despres,2022;Bonfanti et al.,2023).

关键词： plasticity al. arrest

Role of copper chelating agents: between old applications and new perspectives in neuroscience

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Neural Regeneration Research 2025年第3期20卷 751-762页

作者： Rosalba Leuci Leonardo Brunetti Vincenzo Tufarelli Marco Cerini Marco Paparella Nikola Puvača Luca Piemontese department of Pharmacy-Pharmaceutical Science University of Bari Aldo MoroBariItaly department of Precision and Regenerative Medicine and Jonian Area(DiMePRe-J) Section of Veterinary Science and Animal ProductionUniversity of Bari Aldo MoroBariItaly department of Engineering Management in Biotechnology Faculty of Economics and Engineering Management in Novi SadUniversity Business Academy in Novi SadNovi SadSerbia

The role of copper element has been an increasingly relevant topic in recent years in the fields of human and animal health, for both the study of new drugs and innovative food and feed supplements. This metal plays an important role in the central nervous system, where it is associated with glutamatergic signaling, and it is widely involved in inflammatory processes. Thus, diseases involving copper(Ⅱ) dyshomeostasis often have neurological symptoms, as exemplified by Alzheimer's and other diseases(such as Parkinson's and Wilson's diseases). Moreover, imbalanced copper ion concentrations have also been associated with diabetes and certain types of cancer, including glioma. In this paper, we propose a comprehensive overview of recent results that show the importance of these metal ions in several pathologies, mainly Alzheimer's disease, through the lens of the development and use of copper chelators as research compounds and potential therapeutics if included in multi-target hybrid drugs. Seeing how copper homeostasis is important for the well-being of animals as well as humans, we shortly describe the state of the art regarding the effects of copper and its chelators in agriculture, livestock rearing, and aquaculture, as ingredients for the formulation of feed supplements as well as to prevent the effects of pollution on animal productions.

关键词： agriculture Alzheimer's disease chelators copper feed supplements multi-target

Bone Injury and Fracture Healing Biology

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Biomedical and Environmental Sciences 2015年第1期28卷 57-71页

作者： Ahmad Oryan Somayeh Monazzah Amin Bigham-Sadegh Comparative Pathology Department of Pathology School of Veterinary Medicine Shiraz University Shiraz 71345 Iran department of Pathology School of Veterinary Medicine Shiraz University Shiraz 71345 Iran veterinary Surgery Department of Veterinary Surgery and Radiology Faculty of Veterinary Medicine Shahrekord University Shahrekord *** Iran

Bones are organs of the skeletal system, providing shape, mechanical support, and protection to the body and facilitating the movement. In addition, bones contribute to the mineral homeostasis of the body and have recently been found to participate in endocrine regulation of energy metabolism. The well-known limitations associated with clinical use of autografts and allografts continue to drive efforts to develop bone graft substitutes, using the principles of biomaterials and tissue engineering. Under some stressful and continuous compressive conditions, the ability of the bone tissue to tolerate strength decreases. Whenever these forces overcome the toleration of the bone tissue, bone fracture occurs. years

关键词： bone Bone Injury and Fracture Healing Biology

Aldehyde dehydrogenase activity helps identify a subpopulation of murine adipose-derived stem cells with enhanced adipogenic and osteogenic differentiation potential

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World Journal of Stem Cells 2017年第10期9卷 179-186页

作者： Harumichi Itoh Shimpei Nishikawa Tomoya Haraguchi Yu Arikawa Shotaro Eto Masato Hiyama Toshie Iseri Yoshiki Itoh Munekazu Nakaichi Yusuke Sakai Kenji Tani Yasuho Taura Kazuhito Itamoto department of Small Animal Clinical Science Joint Faculty of Veterinary Medicine Yamaguchi University department of veterinary Surgery Joint Faculty of Veterinary Medicine Yamaguchi University department of veterinary radiology Joint Faculty of Veterinary Medicine Yamaguchi University department of veterinary Pathology Joint Faculty of Veterinary Medicine Yamaguchi University

AIMTo identify and characterize functionally distinct subpopulation of adipose-derived stem cells (ADSCs). METHODSADSCs cultured from mouse subcutaneous adipose tissue were sorted fluorescence-activated cell sorter based on aldehyde dehydrogenase (ALDH) activity, a widely used stem cell marker. Differentiation potentials were analyzed by utilizing immunocytofluorescece and its quantitative analysis. RESULTSApproximately 15% of bulk ADSCs showed high ALDH activity in flow cytometric analysis. Although significant difference was not seen in proliferation capacity, the adipogenic and osteogenic differentiation capacity was higher in ALDHHi subpopulations than in ALDHLo. Gene set enrichment analysis revealed that ribosome-related gene sets were enriched in the ALDHHi subpopulation. CONCLUSIONHigh ALDH activity is a useful marker for identifying functionally different subpopulations in murine ADSCs. Additionally, we suggested the importance of ribosome for differentiation of ADSCs by gene set enrichment analysis.

关键词： Adipose-derived stem/stromal cell Aldehyde dehydrogenase activity Flow cytometry Subpopulation Ribosome

Mechanical properties and in vivo biodegradability of Mg-Zr-Y-Nd-La magnesium alloy produced by a combined severe plastic deformation

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Rare Metals 2021年第3期40卷 651-662页

作者： A.Torkian G.Faraji M.S.Pedram School of Mechanical Engineering College of EngineeringUniversity of TehranTehran 11155-4563Iran department of veterinary Surgery and radiology Faculty of Veterinary MedicineUniversity of Tehran14199-63111Iran

Permanent implants are going to be replaced by the implementation of biodegradable magnesium-based implants in fixation of internal bone fractures because of many concerns associated with conventional ***,biodegradable magnesium-based biomaterials exhibit higher biodegradation rate and low mechanical properties which are the main *** work aims to almost overcome both disadvantageous by grain refining of a WE43 magnesium alloy containing 93.04 wt% Mg,4.12 wt% Y,2.15 wt% Nd,0.43 wt% Zr,and 0.26 wt%*** this study,the consequences of combined severe plastic deformation(SPD) on the mechanical properties,microstructure,and in vivo degradation behavior of WE43 magnesium alloy were *** do so,WE43 magnesium alloy was chosen and processed through multipass equal channel angular pressing(ECAP) at 330℃ for up to four passes followed by an extrusion *** results showed that higher strength and hardness with minimum ductility less was obtained in the sample processed via two-pass ECAP followed by *** vivo biodegradation experiments showed higher degradation rate for the unprocessed coarse-grained(CG) WE43 *** two-pass ECAP and extruded sample with ultrafine-grained(UFG) structure exhibited the lowest in vivo biodegradation rate besides appropriate mechanical *** may be concluded that the WE43 magnesium alloy processed via two-pass ECAP and extrusion could be a very promising candidate for biodegradable implants from both mechanical and biocorrosion viewpoints.

关键词： Implant Severe plastic deformation WE43 Grain refinement Hardness Mechanical properties

Hesperidin attenuates arsenic trioxide-induced cardiac toxicity in rats

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Asian Pacific Journal of Tropical Biomedicine 2023年第4期13卷 156-164页

作者： Gayatri Khuntia Jeevan Ranjan Dash Biswadeep Jena Uma Kanta Mishra Subash Chandra Parija department of Pharmacology and Toxicology College of Veterinary Sciences and Animal HusbandryOUATBhubaneswarIndia department of veterinary Surgery and radiology College of Veterinary Sciences and Animal HusbandryOUATBhubaneswarIndia department of veterinary Anatomy and Histology College of Veterinary Sciences and Animal HusbandryOUATBhubaneswarIndia

Objective:To explore the cardioprotective effect of hesperidin against arsenic trioxide-induced cardiac toxicity in ***:Cardiac toxicity was induced by oral administration of 4 mg/kg arsenic trioxide for 30 ***,biochemical,electrocardiography,echocardiography,and histopathological examinations were ***:Hesperidin decreased the neutrophil-to-lymphocyte ratio,calcium,creatine kinase-myoglobin binding,lactate dehydrogenase,IL-6,and lipid peroxidation,as well as increased sodium and potassium concentration and superoxide dismutase and catalase activity in arsenic trioxide-intoxicated ***,it reduced peak systolic velocity and end-diastolic velocity while increasing heart *** trioxide-induced histopathological damage to cardiac tissue was prominently alleviated by hesperidin ***:Hesperidin attenuates arsenic trioxide-induced cardiac toxicity in ***,it can be further explored as a cardioprotective agent.

关键词： Arsenic trioxide Hesperidin Cardiotoxicity ECG CK-MB LDH

Testicular vascularization at two locations in relation to hormonal levels,and pixel echotexture in bulls at different ages

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Asian pacific Journal of Reproduction 2022年第4期11卷 193-200页

作者： Elshymaa A.Abdelnaby Ibrahim A.Emam department of Theriogenology Faculty of Veterinary MedicineCairo UniversityEgypt department of Surgery and RadiologyFaculty of Veterinary MedicineCairo UniversityGizaEgypt

Objective:To assess the hemodynamic changes that occurred in the main testicular artery at two different locations such as supra and marginal ones in bulls at three different ***:Eighteen Baladi bulls were divided according to their age into three different age groups:1 year[n=6;groupⅠwith bodyweight(380±10)kg],3 years[n=6;groupⅡwith bodyweight(570±10)kg],and 6 years old[n=6;groupⅢwith bodyweight(650±10)kg]Baladi *** of the scrotum,thickness of the mediastinum,testicular dimensions,vascularity,and hormonal levels were *** hemodynamics were assessed by Doppler ultrasound ***:Testicular width,length,and volume were significantly different among the three age groups,with the highest in bulls of groupⅢ(P<0.05).The bulls in groupⅢhad significantly higher mediastinal line thickness and scrotal circumference than groupⅠ(P<0.05),but there was no significant difference between groupⅡand groupⅢ.Bulls in groupⅡshowed a decline in Doppler indices(resistance and pulsatility indexes)at both testicular branches compared to the other two groups(P<0.05).Supra and marginal end diastolic velocities in the three age groups were significantly different,with the highest in groupⅡ(P<0.05).Time average velocity(cm/s)was significantly elevated in groupⅡcompared to the other two groups(P<0.05).Both testicular echotextures were significantly decreased in groupⅡ(P<0.05).Estradiol and nitric oxide metabolites were significantly high in groupⅡcompared to the other two groups(P<0.05).Meanwhile,the level of plasma testosterone was maximum in groupⅢ(P<0.05).Positive correlations were found between supratesticular artery resistance and pulsatility indexes(r=0.81;P<0.001),while both resistance and pulsatility indexes had correlated negative with estradiol(r=-0.71 and r=-0.91;P<0.001),and nitric oxide metabolites(r=-0.92 and r=-0.72;P<0.001).Conclusions:Three-year old Baladi bull has the lesser Doppler indices with lesser echotexture and greater ni

关键词： Bull Doppler indices End diastolic velocity Estradiol Testicular blood flow Resistance index Pulsatility index

Cross-species hybridization of woodchuck hepatitis virus-induced hepatocellular carcinoma using human oligonucleotide microarrays

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World Journal of Gastroenterology 2006年第29期12卷 4646-4651页

作者： Paul W Anderson Bud C Tennant Zhenghong Lee department of radiology University Hospitals of Cleveland Cleveland OH 44106United States department of Clinical Sciences College of Veterinary Medicine Cornell UniversityIthaca NY 14853 United States

AIM： To demonstrate the feasibility of using woodchuck samples on human microarrays, to provide insight into pathways involving positron emission tomography （PET） imaging tracers and to identify genes that could be potential molecular imaging targets for woodchuck hepatocellular carcinoma. METHODS： Labeled cRNA from woodchuck tissue samples were hybridized to Affymetrix U133 plus 2.0 GeneChips. Ten genes were selected for validation using quantitative RT-PCR and literature review was made. RESULTS： Testis enhanced gene transcript （BAX Inhibitor 1）, alpha-fetoprotein, isocitrate dehydrogenase 3 （NAD＋） beta, acetyI-CoA synthetase 2, carnitine palmitoyltransferase 2, and N-myc2 were up-regulated and spermidine/spermine N1-acetyltransferase was down-regulated in the woodchuck HCC. We also found previously published results supporting 8 of the 10 most up-regulated genes and all 10 of the 10 most downregulated genes. CONCLUSION： Many of our microarray results were validated using RT-PCR or literature search. Hence, we believe that woodchuck HCC and non-cancerous liver samples can be used on human microarrays to yield meaningful results.

关键词： Cross-species hybridization Gene expression Woodchuck hepatitis virus Hepatocellular carcinoma Woodchuck Marmota monax

Clinical and hematological study of canine Ehrlichiosis with other hemoprotozoan parasites in Kolkata,West Bengal,India

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Asian Pacific Journal of Tropical Biomedicine 2013年第11期3卷 913-915页

作者： Mousam Das Sabyasachi Konar department of veterinary Microbiology West Bengal University of Animal and Fishery Sciences department of veterinary Surgery and radiology West Bengal University of Animal and Fishery Sciences

Objective:To observe other hemoprotozoan diseases with canine ehrlichiosis und to evaluate the clinical and hematological aspects of dogs naturally infected with ehrlichiosis with other hemoprotozoun ***:Blood was collected for hematological value and Giemsa stained blood smear was made for diagnosis of Ehrlichia *** other hemoprotozoan parasites from naturally infected *** history was taken from the owner and clinical signs and symptoms were ***:A total of 47 cases of ehrlichiosis in dogs were reported with babesiosis(8.51%)and hepatozoonosis(6.38%)hemoprotozoan *** cams,Ehrlichia ewingii,Brucella canis,Babesia gibsoni and Hepatozoon canis were observed under oil immersion lense of microscope in Giemsa stained peripheral blood *** anaemia and neutrophilic leukocytosis were ***:The results of this study stated that clinical and haeinatological changes occurred in canine ehrlichiosis with babesiosis and hepatozoonosis due to *** mixed infection,the disease more severe,and also it depended on immunity of *** gibsoni and Hepatozoon canis with Ehrlichia *** first reported from West Bengal state of India by this study.

关键词： Canine Clinical Ehrlichiosis Hematological Hemoprotozoan Kolkata