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A study of scientific publications on the greater cane rat (Thryonomys swinderianus, Temminck 1827)

Animal Models and Experimental Medicine 2020年第1期3卷 40-46页

作者： Oluwaseun Ahmed Mustapha Ebunoluwa Elizabeth Teriba Oluwaseun Samuel Ezekiel Ayokunle Matthew Olude Adebayo Koyuum Akinloye James Olukayode Olopade Department of Veterinary Anatomy College of Veterinary MedicineFederal University of AgricultureAbeokutaNigeria Department of Veterinary Anatomy Faculty of Veterinary MedicineUniversity of IbadanIbadanNigeria department of Animal Production and Health Federal University of Technology AkureAkureNigeria

Background:The greater cane rat(GCR),reputed to be African's second largest rodent,is a precocial hystricomorph with an uncommon phenotype and life history.Scientific and socio-economic interests in the GCR have led to heightened research efforts targeted towards a better understanding of its biology and exploration of its economic and translational usefulness.Methods:Records of all online scientific publications on the GCR from Google,Google Scholar,PubMed,science.gov,Ebscohost and Worldwide science,with the exception of research theses,proceedings,unpublished projects and abstracts,were collated and analyzed using descriptive statistics.Results:A total of 146 published scholarly articles spanning about six decades were retrieved,with 98%of the GCR publications originating from African countries.Nigeria boasts the highest number of publications(58.22%)followed by Ghana(21.23%)and South Africa(5.48%)while Senegal contributed the least(0.69%).Publications were sorted into ten field categories.The field with the highest number of articles(41.78%)was animal breeding and management recording,closely followed by anatomy(37.67%).Lesser contributions were made by parasitology(5.48%),biochemistry/hematology(4.8%),pharmacology/toxicology(4.11%),pathology(2.06%),and surgery/anesthesia and physiology(1.37%apiece).The fields with fewest contributions were microbiology and developmental biology(0.69%each).Conclusion:This study chronicles the spectrum of knowledge available on the GCR,highlighting the knowledge gap that still exists in various fields in order to provide advocacy for new frontiers in research efforts on this rodent.We suggest the need for a clearly defined and well integrated national/regional policy aimed at establishing Africa's foremost micro-livestock rodent,the greater cane rat,on the world's scientific radar.

关键词： African rodent grasscutter greater cane rat micro-livestock review wildlife

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Ninjurin-1: a biomarker for reflecting the process of neuroinflammation after spinal cord injury

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Neural Regeneration Research 2021年第7期16卷 1331-1335页

作者： Poornima D.E.Weerasinghe-Mudiyanselage Jeongtae Kim Yuna Choi Changjong Moon Taekyun Shin Meejung Ahn Department of Veterinary Anatomy College of Veterinary Medicine and Veterinary Medical Research InstituteJeju National UniversityJejuRepublic of Korea Department of Veterinary Anatomy College of Veterinary Medicine and BK21 Plus Project TeamChonnam National UniversityGwangjuRepublic of Korea department of anatomy Kosin University College of MedicineBusanRepublic of Korea department of Animal Science College of Life ScienceSangji UniversityWonjuRepublic of Korea

Previous studies have shown that Ninjurin-1 participates in cell trafficking and axonal growth following central and peripheral nervous system neuroinflammation.But its precise roles in these processes and involvement in spinal cord injury pathophysiology remain unclear.Western blot assay revealed that Ninjurin-1 levels in rats with spinal cord injury exhibited an upregulation until day 4 post-injury and slightly decreased thereafter compared with sham controls.Immunohistochemistry analysis revealed that Ninjurin-1 immunoreactivity in rats with spinal cord injury sharply increased on days 1 and 4 post-injury and slightly decreased on days 7 and 21 post-injury compared with sham controls.Ninjurin-1 immunostaining was weak in vascular endothelial cells, ependymal cells, and some glial cells in sham controls while it was relatively strong in macrophages, microglia, and reactive astrocytes.These findings suggest that a variety of cells, including vascular endothelial cells, macrophages, and microglia, secrete Ninjurin-1 and they participate in the pathophysiology of compression-induced spinal cord injury.All experimental procedures were approved by the Care and Use of Laboratory Animals of Jeju National University(approval No.2018-0029) on July 6, 2018.

关键词： astrocytes clip compression injury macrophage microglia neuroinflammation Ninjurin-1 rat spinal cord

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Glucose metabolism and neurogenesis in the gerbil hippocampus after transient forebrain ischemia

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Neural Regeneration Research 2016年第8期11卷 1254-1259页

作者： Dae Young Yoo Kwon Young Lee Joon Ha Park Hyo Young Jung Jong Whi Kim Yeo Sung Yoon Moo-Ho Won Jung Hoon Choi In Koo Hwang department of anatomy and Cell Biology College of Veterinary Medicineand Research Institute for Veterinary ScienceSeoul National University department of anatomy College of Veterinary Medicine and Institute of Veterinary ScienceKangwon National University department of Neurobiology School of MedicineKangwon National University

Recent evidence exists that glucose transporter 3（GLUT3） plays an important role in the energy metabolism in the brain.Most previous studies have been conducted using focal or hypoxic ischemia models and have focused on changes in GLUT3 expression based on protein and m RNA levels rather than tissue levels.In the present study,we observed change in GLUT3 immunoreactivity in the adult gerbil hippocampus at various time points after 5 minutes of transient forebrain ischemia.In the sham-operated group,GLUT3 immunoreactivity in the hippocampal CA1 region was weak,in the pyramidal cells of the CA1 region increased in a time-dependent fashion 24 hours after ischemia,and in the hippocampal CA1 region decreased significantly between 2 and 5 days after ischemia,with high level of GLUT3 immunoreactivity observed in the CA1 region 10 days after ischemia.In a double immunofluorescence study using GLUT3 and glial-fibrillary acidic protein（GFAP）,we observed strong GLUT3 immunoreactivity in the astrocytes.GLUT3 immunoreactivity increased after ischemia and peaked 7 days in the dentate gyrus after ischemia/reperfusion.In a double immunofluorescence study using GLUT3 and doublecortin（DCX）,we observed low level of GLUT3 immunoreactivity in the differentiated neuroblasts of the subgranular zone of the dentate gyrus after ischemia.GLUT3 immunoreactivity in the sham-operated group was mainly detected in the subgranular zone of the dentate gyrus.These results suggest that the increase in GLUT3 immunoreactivity may be a compensatory mechanism to modulate glucose level in the hippocampal CA1 region and to promote adult neurogenesis in the dentate gyrus.

关键词： nerve regeneration transient forebrain ischemia glucose transporter 3 pyramidal cells astrocytes neuroblasts neural regeneration

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Hesperidin attenuates arsenic trioxide-induced cardiac toxicity in rats

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Asian Pacific Journal of Tropical Biomedicine 2023年第4期13卷 156-164页

作者： Gayatri Khuntia Jeevan Ranjan Dash Biswadeep Jena Uma Kanta Mishra Subash Chandra Parija department of Pharmacology and Toxicology College of Veterinary Sciences and Animal HusbandryOUATBhubaneswarIndia department of veterinary Surgery and Radiology College of Veterinary Sciences and Animal HusbandryOUATBhubaneswarIndia Department of Veterinary Anatomy and Histology College of Veterinary Sciences and Animal HusbandryOUATBhubaneswarIndia

Objective:To explore the cardioprotective effect of hesperidin against arsenic trioxide-induced cardiac toxicity in rats.Methods:Cardiac toxicity was induced by oral administration of 4 mg/kg arsenic trioxide for 30 days.Hematological,biochemical,electrocardiography,echocardiography,and histopathological examinations were performed.Results:Hesperidin decreased the neutrophil-to-lymphocyte ratio,calcium,creatine kinase-myoglobin binding,lactate dehydrogenase,IL-6,and lipid peroxidation,as well as increased sodium and potassium concentration and superoxide dismutase and catalase activity in arsenic trioxide-intoxicated rats.Moreover,it reduced peak systolic velocity and end-diastolic velocity while increasing heart rate.Arsenic trioxide-induced histopathological damage to cardiac tissue was prominently alleviated by hesperidin treatment.Conclusions:Hesperidin attenuates arsenic trioxide-induced cardiac toxicity in rats.Therefore,it can be further explored as a cardioprotective agent.

关键词： Arsenic trioxide Hesperidin Cardiotoxicity ECG CK-MB LDH

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Osteocyte viability and bone density in cadmium chloride-induced osteoporosis ameliorated with Pilostigma thonningii stem bark-extracted D-3-O-methy-chiroinositol

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Animal Models and Experimental Medicine 2019年第1期2卷 25-33页

作者： Edwin Aihanuwa Uwagie-Ero Clifford Nwabugwu Abiaezute Chinaka O.Nwaehujor Theophilus Okafor Nnaji Eugene Amienwanlen Odigie Oyetunde Kazeem Ekeolu Ohiemi Benjamin Ocheja department of Surgery Faculty of Veterinary MedicineUniversity of Benin department of anatomy Faculty of Veterinary MedicineUniversity of Nigeria department of Biochemistry College of Basic Medical SciencesUniversity of Calabar department of Surgery Faculty of Veterinary MedicineUniversity of Nigeria department of anatomy Faculty of Veterinary MedicineUniversity of Benin department of Physiology and Biochemistry Faculty of Veterinary MedicineUniversity of Benin

Background : This study examined the ameliorative effect of D-3-O-methylchiroinositol, isolated from the stem bark of Piliostigma thonningii, on cadmium chloride-induced osteoporosis in male Wistar rats. Methods : Thirty-six rats were assigned to three treatment groups(n = 12). Group A(2 mL distilled water), group B:(2.5 mg/kg b.w. CdCl_2) and group C:(2.5 mg/kg b.w. CdCl_2 and D-3-O-methyl-chiroinositol 2 mg/kg b.w.). Bone ash, calcium, phosphate, magnesium, and zinc content, as well as bone histological changes were determined at the end of months 1, 2, and 3. Results : There were significant differences( P ≤ 0.05) in the weight of the cervical, tibia, and femoral bones in all groups. The serum concentration of CdCl_2 was significantly different across the three groups with time. There was significant variation( P < 0.005) in the mean bone ash across groups. The concentration of OH-proline was significantly different( P < 0.0001) across groups. There were significant differences( P < 0.0001) in bone calcium, magnesium, zinc, and phosphorus concentrations. Histology revealed high levels of bone mineralisation in the CdCl_2-treated group, indicative of osteoporosis with hypertrophied osteocytes, while the femur of Wistar rats treated with D-3-O-methyl-chiroinositol showed bone trabeculae and viable osteocytes. Conclusion : The study concluded that D-3-O-methyl-chiroinositol extract from Piliostigma thionningii stem bark ameliorated cadmium chloride-induced osteoporosis in male Wistar rats.

关键词： cadmium chloride D-3-O-methyl-chiroinositol osteocytes osteoporosis toxicity amelioration

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Beta-nerve growth factor gene therapy alleviates pyridoxine-induced neuropathic damage by increasing doublecortin and tyrosine kinase A in the dorsal root ganglion

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Neural Regeneration Research 2020年第1期15卷 162-168页

作者： Hyun-Kee Cho Woosuk Kim Kwon-Young Lee Jin-Ok Ahn Jung Hoon Choi In Koo Hwang Jin-Young Chung department of veterinary Internal Medicine and Institute of veterinary Science College of Veterinary MedicineKangwon National UniversityChuncheonKangwon-doSouth Korea department of anatomy and Cell Biology College of Veterinary MedicineResearch Institute for Veterinary ScienceSeoul National UniversitySeoulSouth Korea department of anatomy College of Veterinary MedicineKangwon National UniversityChuncheonKangwon-doSouth Korea

Beta-nerve growth factor(β-NGF)is known to be a major leading cause of neuronal plasticity.To identify the possible action mechanisms ofβ-NGF gene therapy for sciatic nerve recovery,experimental dogs were randomly divided into control,pyridoxine,and pyridoxine+β-NGF groups.We observed chronological changes of morphology in the dorsal root ganglia in response to pyridoxine toxicity based on cresyl violet staining.The number of large neurons positive for cresyl violet was dramatically decreased after pyridoxine intoxication for 7 days in the dorsal root ganglia and the neuron number was gradually increased after pyridoxine withdrawal.In addition,we also investigated the effects ofβ-NGF gene therapy on neuronal plasticity in pyridoxine-induced neuropathic dogs.To accomplish this,tyrosine kinase receptor A(TrkA),βIII-tubulin and doublecortin(DCX)immunohistochemical staining was performed at 3 days after the last pyridoxine treatment.TrkA-immunoreactive neurons were dramatically decreased in the pyridoxine group compared to the control group,but strong TrkA immunoreactivity was observed in the small-sized dorsal root ganglia in this group.TrkA immunoreactivity in the dorsal root ganglia was similar betweenβ-NGF and control groups.The numbers ofβⅢ-tubulin-and DCX-immunoreactive cells decreased significantly in the pyridoxine group compared to the control group.However,the reduction ofβⅢ-tubulin-and DCX-immunoreactive cells in the dorsal root ganglia in theβ-NGF group was significantly ameliorated than that in the pyridoxine group.These results indicate thatβ-NGF gene therapy is a powerful treatment of pyridoxine-induced neuropathic damage by increasing the TrkA and DCX levels in the dorsal root ganglia.The experimental protocol was approved by the Institutional Animal Care and Use Committee(IACUC)of Seoul National University,South Korea(approval No.SNU-060623-1,SNU-091009-1)on June 23,2006 and October 9,2009,respectively.

关键词： β-nerve growth factor βⅢ-tubulin doublecortin gene therapy neuron-glial antigen 2 neuropathy pyridoxine

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Effects of cancer therapy on hippocampus-related function

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Neural Regeneration Research 2015年第10期10卷 1572-1573页

作者： Miyoung Yang Changjong Moon department of anatomy School of Medicine Wonkwang University Department of Veterinary Anatomy and Animal Behavior College of Veterinary Medicine Chonnam National University

Cancer treatments such as chemotherapy and radiotherapy are widely used to treat primary and metastatic cancers.Epidemiological studies have demonstrated that these types of treatment can effectively and successfully extend the lifespan of cancer patients,but they are also associated with various neurological complications such as cognitive deficits, seizures, and emotional problems （Taphoorn and Klein, 2004; Yang and Moon, 2013; Son et al., 2015b）.

关键词： Effects of cancer therapy on hippocampus-related function MTX BDNF

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Brain-derived neurotropic factor and GABAergic transmission in neurodegeneration and neuroregeneration

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Neural Regeneration Research 2017年第10期12卷 1733-1741页

作者： Jinwook Kim Sueun Lee Sohi Kang Sung-Ho Kim Jong-Choon Kim Miyoung Yang Changjong Moon departments of veterinary anatomy and veterinary Toxicology College of Veterinary Medicine and BK21 PLUS Project TeamChonnam National University department of anatomy School of Medicine and Institute for Environmental ScienceWonkwang University

Neurotoxicity induced by stress,radiation,chemicals,or metabolic diseases,is commonly associated with excitotoxicity,oxidative stress,and neuroinflammation.The pathological process of neurotoxicity induces neuronal death,interrupts synaptic plasticity in the brain,and is similar to that of diverse neurodegenerative diseases.Animal models of neurotoxicity have revealed that clinical symptoms and brain lesions can recover over time via neuroregenerative processes.Specifically,brain-derived neurotropic factor（BDNF） and gamma-aminobutyric acid（GABA）-ergic transmission are related to both neurodegeneration and neuroregeneration.This review summarizes the accumulating evidences that suggest a pathogenic role of BDNF and GABAergic transmission,their underlying mechanisms,and the relationship between BDNF and GABA in neurodegeneration and neuroregeneration.This review will provide a comprehensive overview of the underlying mechanisms of neuroregeneration that may help in developing potential strategies for pharmacotherapeutic approaches to treat neurotoxicity and neurodegenerative disease.

关键词： brain-derived neurotropic factor neurotoxicity gamma-aminobutyric acid-ergic transmission neurodegenerative diseases neural regeneration

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Understanding the spectrum of non-motor symptoms in multiple sclerosis:insights from animal models

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Neural Regeneration Research 2024年第1期19卷 84-91页

作者： Poornima D.E.Weerasinghe-Mudiyanselage Joong-Sun Kim Taekyun Shin Changjong Moon Department of Veterinary Anatomy and Animal Behavior College of Veterinary Medicine and BK21 FOUR programChonnam National UniversityGwangjuRepublic of Korea Department of Veterinary Anatomy College of Veterinary Medicine and Veterinary Medical Research InstituteJeju National UniversityJejuRepublic of Korea

Multiple sclerosis is a chronic autoimmune disease of the central nervous system and is generally considered to be a non-traumatic,physically debilitating neurological disorder.In addition to experiencing motor disability,patients with multiple sclerosis also experience a variety of nonmotor symptoms,including cognitive deficits,anxiety,depression,sensory impairments,and pain.However,the pathogenesis and treatment of such non-motor symptoms in multiple scle rosis are still under research.Preclinical studies for multiple sclerosis benefit from the use of disease-appropriate animal models,including experimental autoimmune encephalomyelitis.Prior to understanding the pathophysiology and developing treatments for non-motor symptoms,it is critical to chara cterize the animal model in terms of its ability to replicate certain non-motor features of multiple sclerosis.As such,no single animal model can mimic the entire spectrum of symptoms.This review focuses on the non-motor symptoms that have been investigated in animal models of multiple sclerosis as well as possible underlying mechanisms.Further,we highlighted gaps in the literature to explain the nonmotor aspects of multiple sclerosis in expe rimental animal models,which will serve as the basis for future studies.

关键词： anxiety cognitive deficit depression experimental autoimmune encephalomyelitis motor disability neurological disorder pain pathophysiology preclinical study sensory impairments

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Temporal profiles of synaptic plasticity-related signals in adult mouse hippocampus with methotrexate treatment

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Neural Regeneration Research 2012年第21期7卷 1651-1658页

作者： Miyoung Yang Juhwan Kim Sung-Ho Kim Joong-Sun Kim Taekyun Shin Changjong Moon Department of Veterinary Anatomy College of Veterinary Medicine and Animal Medical Institute Chonnam National University department of Experimental Radiation Research Center Dongnam Institute of Radiological & Medical Sciences (DIRAMS) Department of Veterinary Anatomy College of Veterinary Medicine Jeju National University

Methotrexate, which is used to treat many malignancies and autoimmune diseases, affects brain functions including hippocampal-dependent memory function. However, the precise mechanisms underlying methotrexate-induced hippocampal dysfunction are poorly understood. To evaluate temporal changes in synaptic plasticity-related signals, the expression and activity of N-methyI-D-aspartic acid receptor 1, calcium/calmodulin-dependent protein kinase II, extracellular signal-regulated kinase 1/2, cAMP responsive element-binding protein, glutamate receptor 1, brain-derived neurotrophic factor, and glial cell line-derived neurotrophic factor were examined in the hippocampi of adult C57BL/6 mice after methotrexate （40 mg/kg） intraperitoneal injection. Western blot analysis showed biphasic changes in synaptic plasticity-related signals in adult hippocampi following methotrexate treatment. N-methyI-D-aspartic acid receptor 1, calcium/calmodulin-dependent protein kinase II, and glutamate receptor 1 were acutely activated during the early phase （1 day post-injection）, while extracellular signal-regulated kinase 1/2 and cAMP responsive element-binding protein activation showed biphasic increases during the eady （1 day post-injection） and late phases （7-14 days post-injection）. Brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor expression increased significantly during the late phase （7-14 days post-injection）. Therefore, methotrexate treatment affects synaptic plasticity-related signals in the adult mouse hippocampus, suggesting that changes in synaptic plasticity-related signals may be associated with neuronal survival and plasticity-related cellular remodeling.

关键词： hippocampus methotrexate neurotrophic factor synaptic plasticity-related signal neuralregeneration

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