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Cooperative Sentinel Surveillance of Malaria in Laiza and Nearby Areas of Myanmar and Importation Threat Monitoring—China,2019–2023

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China CDC weekly 2024年第17期6卷 378-382页

作者： Peng Tian Shigang Li Yaowu Zhou Zurui Lin Xiaodong Sun Xiangrui Guo Chunli Ding Kaixia Duan Qiyan Chen Yulong Zhao Jing Wu Dakhidam Yaw Bee Jianwei Xu Yunnan Institute of Parasitic Diseases Yunnan Provincial Key Laboratory of Vector-borne Disease Control and ResearchYunnan International Joint Laboratory of Tropical Infectious DiseasesPuer CityYunnan ProvinceChina Yingjiang County Center for Disease control and Prevention Yingjiang CountyYunnan ProvinceChina Laiza City Hospital Laiza TownKachin Special Region IIMyanmar

Introduction:Laiza and nearby areas(LNA)in Myanmar are identified as the primary malaria hotspots in the bordering regions of Yunnan Province,***:Six sentinel surveillance sites were established at the China-Myanmar border in LNA to monitor *** from 2019 was used as a baseline to analyze malaria incidence and trends in LNA and Myanmar,as well as the importation of malaria cases into China from 2019 to ***:Plasmodium vivax was the predominant species,representing 99.95%(14,060/14,066)of confirmed malaria cases in LNA.A total of 8,356 malaria cases were identified in 2023,with an annual parasite incidence(API)of 19.78 per 100 *** to 2019,the incidence rate ratio was 21.47(95%confidence interval:18.84,24.48),indicating that the API in 2023 was 21.47 times higher than that in *** Yunnan,out of 1,016 reported cases,545 imported cases(53.64%)originated from LNA and spread to 18(13.95%)out of 129 *** provinces in China,including Yunnan,reported imported malaria cases from LNA in ***:The increase in population,particularly among internally displaced persons,along with inadequate healthcare services,has led to a notable resurgence of malaria in *** resurgence poses a risk to preventing the re-emergence of malaria transmission in *** is an urgent need for novel collaborative policies,as well as financial and technical assistance,to enhance malaria control efforts in LNA,Myanmar.

关键词： Malaria Myanmar originated

WNT/β-catenin signaling in hepatocellular carcinoma:The aberrant activation,pathogenic roles,and therapeutic opportunities

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Genes & Diseases 2024年第2期11卷 727-746页

作者： Anna Gajos-Michniewicz Malgorzata Czyz department of Molecular biology of Cancer Medical University of LodzLodz 92-215Poland

Hepatocellular carcinoma(HCC)is a liver cancer,highly heterogeneous both at the histopathological and molecular *** arises from hepatocytes as the result of the accumulation of numerous genomic alterations in various signaling pathways,including canonical WNT/β-catenin,AKT/mTOR,MAPK pathways as well as signaling associated with telomere maintenance,p53/cell cycle regulation,epigenetic modifiers,and oxidative *** role of WNT/β-catenin signaling in liver homeostasis and regeneration is well established,whereas in development and progression of HCC is extensively ***,we review recent advances in our understanding of how WNT/β-catenin signaling facilitates the HCC development,acquisition of stemness features,metastasis,and resistance to *** outline genetic and epigenetic alterations that lead to activated WNT/β-catenin signaling in *** discuss the pivotal roles of CTNNB1 mutations,aberrantly expressed non-coding RNAs and complexity of crosstalk between WNT/β-catenin signaling and other signaling pathways as challenging or advantageous aspects of therapy development and molecular stratification of HCC patients for treatment.

关键词： Cancer stem cells CTNNB1 mutations Liver cancer Non-coding RNA Tumor heterogeneity

Unveiling ferroptosis as a promising therapeutic avenue for colorectal cancer and colitis treatment

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Acta Pharmaceutica Sinica B 2024年第9期14卷 3785-3801页

作者： Aaron T.Kaoy Christian V.Cabanlongy Kendra Padilla Xiang Xue department of Biochemistry and Molecular biology University of New MexicoAlbuquerqueNM 87131USA

Ferroptosis is a novel type of regulated cell death(RCD)involving iron accumulation and lipid *** its discovery in 2012,various studies have shown that ferroptosis is associated with the pathogenesis of various *** cell death has also been linked to intestinal dysfunction but can act as either a positive or negative regulator of intestinal disease,depending on the cell type and disease *** continued investigation of mechanisms underlying ferroptosis provides a wealth of potential for developing novel *** the growing prevalence of intestinal diseases,particularly colorectal cancer(CRC)and inflammatory bowel disease(IBD),this review article focuses on potential therapeutics targeting the ferroptotic pathway in relation to CRC and IBD.

关键词： Ferroptosis Colorectal cancer Inflammatory bowel disease Cell death Molecular mechanisms Iron metabolism Drug therapies Targeted therapeutics

The effect of Common Cuckoo parasitism on the annual productivity of a host population

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Avian Research 2024年第2期15卷 287-291页

作者： Alfred Trnka department of biology University of TrnavaPriemyselna 491843TrnavaSlovakia

Avian interspecific brood parasitism is an excellent system for studying coevolutionary processes in nature because brood parasites directly affect host reproductive *** research on avian brood parasitism has,therefore,focused primarily on specific host anti-parasite behaviours and parasite ***,the population-level consequences of brood parasitism for host species are poorly *** study investigated the effect of Common Cuckoo(Cuculus canorus)parasitism on the productivity of a local population of the Great Reed Warbler(Acrocephalus arundinaceus)host in south-western Slovakia.A total of 495 females nesting at the studied site successfully fledged 1321 of their own young and 63 young of the Common Cuckoo over the course of 15 years(2008-2022),and the annual rate of successful parasitism ranged from 18% to 44% over this *** predicted,higher rates of successful cuckoo parasitism significantly reduced the annual productivity of the local Great Reed Warbler population,and its contribution to decreased host reproductive success was at about the same rate as overall nest failure caused by predation and other environmental *** a heavily parasitized population was probably maintained by immigrants from other populations and density-dependent selection,which is also consistent with source-sink ***,further long-term studies monitoring parasitized populations are required to confirm these findings.

关键词： Acrocephalus arundinaceus Cuculus canorus Great Reed Warbler Population growth Reproductive success

No evidence of predator odor avoidance in a North American bird community

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Avian Research 2024年第1期15卷 133-138页

作者： Austin Dotta Batur Yaman Alex Van Huynh department of biology DeSales University2755 Station AvenueCenter ValleyPAUSA

Recent advances in our understanding of avian chemical communication have highlighted the importance of olfaction in many aspects of avian *** studies investigating predator avoidance behaviors in response to predator odor cues have produced mixed results across species and *** we assess if a community of birds in eastern Pennsylvania displays avoidance behaviors towards predator odor cues in a natural foraging *** use clay caterpillars to measure foraging activity by birds in the presence of predator(bobcat)urine,non-predator(rabbit)urine,and water controls in two different environmental contexts(field ***).Although we detected a weak trend for birds to forage less at predator urine-treated sites,we found no significant difference in avian foraging between the site *** did find that foraging rates between environmental contexts changed significantly over the course of the experiment,with forest sites showing decreasing foraging rates and field sites showing increasing foraging *** results reinforce the published literature that avoidance of predator odors by birds may not be ubiquitous across contexts and species.

关键词： Foraging Odor Olfaction Predation Predator-avoidance

Microglial autophagy in neurogenesis:a new player in Alzheimer's disease

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Neural Regeneration Research 2024年第12期19卷 2573-2574页

作者： Xin Tang Aarti Nagayach Chenran Wang department of Cancer biology University of Cincinnati College of MedicineCincinnatiOHUSA

While extensive studies have illuminated the impact of Alzheimer's disease(AD) on neuronal survival,there is growing evidence that abnormal postnatal neurogenesis in early AD brains contributes to disease *** neurogenesis serves as a mechanism to replace dead or damaged *** neurons generated from neural stem cells(NSCs) in the subgranular zone(SGZ) of the dentate gyrus integrate into the existing hippocampal circuit.

关键词： Alzheimer replace integrate

Phylogenetic placement of bizarre karschiellid earwigs

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Insect Science 2024年第3期31卷 989-992页

作者： Petr Kocárek Ivona Horká Vojtěch Bonczek Markéta Kirstová department of biology and Ecology University of OstravaOstravaCzech Republic

Dear Editor,Karschiellidae are a mysterious group of earwigs that attract attention not only because of their interesting appearance and unexplained way of life but also mainly due to their unclear *** phylogenetic relationships of karschiellids remain speculative even 120 years since the family was described,above all due to the unavailability of DNA-grade material for molecular phylogenetic *** study includes successfully sequenced representatives of the Karschiellidae for the first time,and a probable evolutionary scheme and natural classification of karschiellids are proposed based on the constructed multigene phylogeny.

关键词： classification. phylogeny evolutionary

Oncogenic MORC2 in cancer development and beyond

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Genes & Diseases 2024年第2期11卷 861-873页

作者： Shan Zhang Ayao Guo Huan Wang Jia Liu Chenshuang Dong Junyi Ren Guiling Wang Key Laboratory of Cell biology Department of Cell BiologyMinistry of Public Health and Key Laboratory of Medical Cell BiologyMinistry of EducationChina Medical UniversityShenyangLiaoning 110122China department of Breast Surgery The First Affiliated Hospital of China Medical UniversityShenyangLiaoning 110001China

Microrchidia CW-type zinc finger 2(MORC2)is a member of the MORC superfamily of nuclear *** evidence has shown that MORC2 not only participates in gene transcription and chromatin remodeling but also plays a key in human disease and tumor development by regulating the expression of downstream oncogenes or tumor *** present review provides an updated overview of MORC2 in the aspect of cancer hallmark and therapeutic resistance and summarizes its upstream regulators and downstream target *** systematic review may provide a favorable theoretical basis for emerging players of MORC2 in tumor development and new insight into the potential clinical application of basic science discoveries in the future.

关键词： Cancer development Hallmarks of cancer MORC2 Therapeutic target Treatment resistance

A novel alcohol dehydrogenase in the hyperthermophilic crenarchaeon Hyperthermus butylicus

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mLife 2024年第2期3卷 317-325页

作者： Ching Tse Kesen Ma department of biology University of WaterlooWaterlooOntarioCanada

Hyperthermus butylicus is a hyperthermophilic crenarchaeon that produces 1-butanol as an end product.A thermostable alcohol dehydrogenase(ADH)must be present in *** to act as the key enzyme responsible for this production;however,the gene that encodes the ADH has not yet been identified.A novel ADH,HbADH2,was purified from a cell-free extract of ***,and its characteristics were *** gene that encodes HbADH2 was demonstrated to be HBUT_RS04850 and annotated as a hypothetical protein in ***2 was found to be a primary-secondary ADH capable of using a wide range of substrates,including butyraldehyde and *** had the highest specificity constant,calculated as k_(cat)/K_(m),with kcat and apparent K_(m) values of 8.00±0.22 s^(-1) and 0.59±0.07 mM,*** apparent Km values for other substrates,including ethanol,1-propanol,2-propanol,butanol,acetaldehyde,propanal,and acetone,were 4.36±0.42,4.69±0.41,3.74±0.46,2.44±0.30,1.27±0.18,1.55±0.20,and 0.68±0.04 mM,*** optimal pH values for catalyzing aldehyde reduction and alcohol oxidation were 6.0 and 9.0,respectively,while the optimal temperature was higher than 90°C due to the increase in enzymatic activity from 60℃ to 90℃.Based on its substrate specificity,enzyme kinetics,and thermostability,HbADH2 may be the ADH that catalyzes the production of 1-butanol in *** putative conserved motif sites for NAD(P)^(+)and iron binding were identified by aligning HbADH2 with previously characterized Fe-containing ADHs.

关键词： butanol hyperthermophile Hyperthermus butylicus novel alcohol dehydrogenase thermostability