Oncogenic MORC2 in cancer development and beyond
作者机构：Key Laboratory of Cell BiologyDepartment of Cell BiologyMinistry of Public Health and Key Laboratory of Medical Cell BiologyMinistry of EducationChina Medical UniversityShenyangLiaoning 110122China Department of Breast SurgeryThe First Affiliated Hospital of China Medical UniversityShenyangLiaoning 110001China
出 版 物：《Genes & Diseases》 (基因与疾病（英文）)
年 卷 期：2024年第11卷第2期
页 面：861-873页
核心收录：
学科分类：0710[理学-生物学] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：financially supported in part by grants from the National Natural Science Foundation of China(No.81572611 and 81828009) the Foundation Committee of Basic Research of Liaoning Province,China(No.LJKMZ20221205) the Application Foundation Plan Project of Liaoning Provincial Department of Science and Technology(China)(No.2023JH2/101300012)
主 题：Cancer development Hallmarks of cancer MORC2 Therapeutic target Treatment resistance
摘 要：Microrchidia CW-type zinc finger 2(MORC2)is a member of the MORC superfamily of nuclear *** evidence has shown that MORC2 not only participates in gene transcription and chromatin remodeling but also plays a key in human disease and tumor development by regulating the expression of downstream oncogenes or tumor *** present review provides an updated overview of MORC2 in the aspect of cancer hallmark and therapeutic resistance and summarizes its upstream regulators and downstream target *** systematic review may provide a favorable theoretical basis for emerging players of MORC2 in tumor development and new insight into the potential clinical application of basic science discoveries in the future.
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