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Myocardial metastasis from ZEB1-and TWIST-positive spindle cell carcinoma of the esophagus:A case report

World Journal of Gastroenterology 2024年第11期30卷 1636-1643页

作者： Yoshihiro Shibata Hirofumi Ohmura Kazuki Komatsu Kosuke Sagara Atsuji Matsuyama Ryuji Nakano Eishi Baba department of Medical Oncology Fukuoka Wajiro HospitalFukuoka 811-0213Japan department of Oncology and Social Medicine Kyushu University Graduate School of Medical SciencesFukuoka 812-8582Japan department of Pathology and Oncology University of Occupational and Environmental HealthKitakyushu 807-8555Japan department of Diagnostic Pathology Fukuoka Wajiro HospitalFukuoka 811-0213Japan

BACKGROUND Metastatic cardiac tumors are known to occur more frequently than primary cardiac tumors,however,they often remain asymptomatic and are commonly dis-covered on *** tumors with a relatively high frequency of cardiac metastasis include mesothelioma,melanoma,lung cancer,and breast cancer,whereas reports of esophageal cancer with cardiac metastasis are *** SUMMARY The case of a 60-year-old man who complained of dysphagia is *** gastrointestinal endoscopy showed a submucosal tumor-like elevated lesion in the esophagus causing ***-enhanced computed tomography showed left atrial compression due to the esophageal tumor,multiple liver and lung metastases,and a left pleural *** examination of a biopsy speci-men from the esophageal tumor showed spindle-shaped cells,raising suspicion of esophageal *** disease progressed rapidly,and systemic chemotherapy was deemed necessary,however,due to his poor general condition,adminis-tration of cytotoxic agents was considered *** his high Combined Positive Score,nivolumab was administered,however,the patient soon died from the *** autopsy confirmed spindle cell carcinoma(SCC)of the esophagus and cardiac metastasis with similar histological *** stem cell markers,ZEB1 and TWIST,were positive in both the primary tumor and the cardiac *** To the best of our knowledge,there have been no prior reports of cardiac metastasis of esophageal *** case highlights our experience with a patient with esophageal SCC who progressed rapidly and died from the disease,with the autopsy examination showing cardiac metastasis.

关键词： Spindle cell carcinoma Esophagus Myocardial metastasis Epithelial-mesenchymal transition Case report

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Current status of nerve infiltration by skip metastases in colorectal cancer

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Oncology and Translational Medicine 2024年第3期10卷 126-131页

作者： Jie Zhou Yan-Wei Gao Ya-Dong Ji Ri-Na Su Shuang Zhang Ze-He Li Inner Mongolia Medical University Hohhot 010000Inner MongoliaChina Abdominal tumor Surgery Inner Mongolia Autonomous Region People’s HospitalHohhot 010017Inner MongoliaChina Baotou Medical College Baotou 014000Inner MongoliaChina Gastroenterology department Arongqi People’s HospitalHulun Buir 021000Inner MongoliaChina

Colorectal cancer(CRC)is a prevalent malignant tumor,with the global new cases reaching 1.9316 million and deaths reaching 935,200 in *** China,therewere 555,500 new cases of CRC,with an age-standardized incidence rate of 24.07 per 10million,and 286,200 *** accounts for approximately 30%of new cases and deaths from CRC worldwide,with East Asia accounting for over 75%.Initially,CRC presents as local tumor growth,but it has the potential to spread to other body parts over *** infiltration(PNI)is a relatively less discussed route of diffusion,yet it plays a crucial role in the progression and prognosis of *** often occurs alongside local lymph nodes and distant metastases,posing challenges for treatment and *** symptoms,radiographic findings,and histopathological examination can be used to diagnose PNI with *** commonly include local pain,paresthesia,andmotor *** helps identify the mass’s location and relationship to nerves,whereas histopathological examination confirms the *** of PNI skipmetastases is similar to other CRC metastases,including surgical resection,chemotherapy,radiotherapy,and targeted *** resection is the primary therapeutic approach,but the wider range of metastasis in PNI skip transfer may limit its *** cases where surgical resection is not possible,chemotherapy,radiotherapy,and targeted therapy are used to control tumor *** conclusion,PNI skip metastases increase the risk of poor prognosis for CRC,requiring a comprehensive approach with multiple treatments to prevent disease *** detection and treatment are vital to improving prognosis.

关键词： Neve invasion in colorectal Skip metastases Perineural infiltration

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New roles of tumor-derived exosomes in tumor microenvironment

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Chinese Journal of Cancer Research 2024年第2期36卷 151-166页

作者： Shiqian Chen Jinzhe Sun Huan Zhou Hongbin Lei Dan Zang Jun Chen department of Oncology the Second Hospital of Dalian Medical UniversityDalian 116023China department of Radiotherapy the Second Hospital of Dalian Medical UniversityDalian 116023China

Throughout tumorigenesis, the co-evolution of tumor cells and their surrounding microenvironment leads to the development of malignant phenotypes. Cellular communication within the tumor microenvironment(TME) plays a critical role in influencing various aspects of tumor progression, including invasion and metastasis. The release of exosomes, a type of extracellular vesicle, by most cell types in the body, is an essential mediator of intercellular communication. A growing body of research indicates that tumor-derived exosomes(TDEs) significantly expedite tumor progression through multiple mechanisms, inducing epithelial-mesenchymal transition and macrophage polarization, enhancing angiogenesis, and aiding in the immune evasion of tumor cells. Herein, we describe the formation and characteristics of the TME, and summarize the contents of TDEs and their diverse functions in modulating tumor development. Furthermore, we explore potential applications of TDEs in tumor diagnosis and treatment.

关键词： tumor-derived exosomes tumorigenesis tumor microenvironment diagnosis treatment

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Immunologic tumor microenvironment modulators for turning cold tumors hot

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Cancer Communications 2024年第5期44卷 521-553页

作者： Gholam-Reza Khosravi Samaneh Mostafavi Sanaz Bastan Narges Ebrahimi Roya Safari Gharibvand Nahid Eskandari department of Medical Immunology School of MedicineIsfahan University of Medical SciencesIsfahanIran department of Immunology Faculty of Medical SciencesTarbiat Modares UniversityTehranIran department of Immunology School of MedicineAhvaz Jundishapur University of Medical SciencesAhvazIran

tumors can be classified into distinct immunophenotypes based on the presence and arrangement of cytotoxic immune cells within the tumor microenvironment(TME).Hot tumors,characterized by heightened immune activity and responsiveness to immune checkpoint inhibitors(ICIs),stand in stark contrast to cold tumors,which lack immune infiltration and remain resistant to *** overcome immune evasion mechanisms employed by tumor cells,novel immunologic modulators have emerged,particularly ICIs targeting cytotoxic T-lymphocyte-associated protein 4(CTLA-4)and programmed cell death protein 1/programmed death-ligand 1(PD-1/PD-L1).These agents disrupt inhibitory signals and reactivate the immune system,transforming cold tumors into hot ones and promoting effective antitumor ***,challenges persist,including primary resistance to immunotherapy,autoimmune side effects,and tumor response *** these challenges requires innovative strategies,deeper mechanistic insights,and a combination of immune interventions to enhance the effectiveness of *** the landscape of cancer medicine,where immune cold tumors represent a formidable hurdle,understanding the TME and harnessing its potential to reprogram the immune response is *** review sheds light on current advancements and future directions in the quest for more effective and safer cancer treatment strategies,offering hope for patients with immune-resistant tumors.

关键词： cold tumor hot tumor immunologic modulator immunotherapy therapeutic strategy tumor microenvironment

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IGF2BPs as novel m^(6)A readers:Diverse roles in regulating cancer cell biological functions,hypoxia adaptation,metabolism,and immunosuppressive tumor microenvironment

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Genes & Diseases 2024年第2期11卷 890-920页

作者： Meiqi Duan Haiyang Liu Shasha Xu Zhi Yang Fusheng Zhang Guang Wang Yutian Wang Shan Zhao Xiaofeng Jiang department of General Surgery The Fourth Affiliated Hospital of China Medical UniversityShenyangLiaoning 110032China department of Gastroendoscopy The Fourth Affiliated Hospital of China Medical UniversityShenyangLiaoning 110032China department of Rheumatology and Immunology The First Affiliated Hospital of China Medical UniversityShenyangLiaoning 110002China

m^(6)A methylation is the most frequent modification of mRNA in eukaryotes and plays a crucial role in cancer progression by regulating biological ***-like growth factor 2 mRNA-binding proteins(IGF2BP)are newly identified m^(6)A‘readers’.They belong to a family of RNA-binding proteins,which bind to the m^(6)A sites on different RNA sequences and stabilize them to promote cancer *** this review,we summarize the mechanisms by which different upstream factors regulate IGF2BP in *** current literature analyzed here reveals that the IGF2BP family proteins promote cancer cell proliferation,survival,and chemoresistance,inhibit apoptosis,and are also associated with cancer glycolysis,angiogenesis,and the immune response in the tumor ***,with the discovery of their role as‘readers’of m^(6)A and the characteristic re-expression of IGF2BPs in cancers,it is important to elucidate their mechanism of action in the immunosuppressive tumor *** also describe in detail the regulatory and interaction network of the IGF2BP family in downstream target RNAs and discuss their potential clinical applications as diagnostic and prognostic markers,as well as recent advances in IGF2BP biology and associated therapeutic value.

关键词： Cancer IGF2BP Immunosuppressive TME m^(6)A Molecular mechanism Therapy

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Fifty-five cases of hepatic alveolar echinococcosis combined with lymph node metastasis:A retrospective study

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World Journal of Gastroenterology 2024年第23期30卷 2981-2990页

作者： Yilizhati Aimaitijiang Tie-Min Jiang Ying-Mei Shao Tuerganaili Aji State Key Laboratory on Pathogenesis Prevention and Treatment of High Incidence Diseases in Central AsiaThe First Clinical CollegeXinjiang Medical UniversityUrumqi 830011Xinjiang Uygur Autonomous RegionChina The First Ward of Hepatobiliary and Pancreatic Surgery Tumor Hospital Affiliated to Xinjiang Medical UniversityUrumqi 830011Xinjiang Uygur Autonomous RegionChina department of Hepatobiliary&Hydatid Diseases Digestive&Vascular Surgery CenterThe First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054Xinjiang Uygur Autonomous RegionChina Xinjiang Clinical Research Center for Echinococcosis and Hepatobiliary Diseases The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054Xinjiang Uygur Autonomous RegionChina

BACKGROUND Lymph node metastasis is a specific type of metastasis in hepatic alveolar echinococcosis(AE).Currently,there is a scarcity of describing the clinical characteristics and lymph node metastasis rules of patients with hepatic AE combined with lymph node metastasis and its mechanism and management are still *** hepatectomy combined with regional lymph node dissection is a better *** To analyse the clinical features of hepatic AE combined with lymph node metastasis to explore its treatment and *** A total of 623 patients with hepatic AE admitted to the First Affiliated Hospital of Xinjiang Medical University from 1 January 2012 to 1 January 2022 were retrospectively ***-five patients with combined lymph node metastasis were analysed for their clinical data,diagnosis and treatment methods,follow-up efficacy,and characteristics of lymph node ***,we comparatively analysed the lymph node metastasis rates at different *** variables are expressed as frequencies and percentages,and the analysis of difference was performed using theχ2 *** Bonferroni method was used for pairwise comparisons when statistical differences existed between multiple categorical *** A lymph node metastasis rate of 8.8%(55/623)was reported in patients with hepatic AE,with a female predilection(69.1%)and a statistically significant sex difference(χ2=8.018,P=0.005).Of the 55 patients with lymph node metastasis,72.7%had a parasite lesion,neighbouring organ invasion,and metastasis stage of P3N1M0 and above,of which 67.3%,78.2%,and 34.5%of hepatic AE lesions invaded the bile ducts,blood vessels,and distant metastases,*** rates of lymph node metastasis of 16.4%,21.7%,and 34.2%were reported for a preoperative abdominal ultrasound,magnetic resonance imaging,and computed tomography *** patients were intraoperatively suspected with enlarged lymph nodes and underwent radica

关键词： Echinococcosis Radical hepatectomy Lymph node metastasis Lymph node dissection Alveolar echinococcosis Hepatic

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M1-polarized macrophage-derived cellular nanovesicle-coated lipid nanoparticles for enhanced cancer treatment through hybridization of gene therapy and cancer immunotherapy

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3169-3183页

作者： Ha Eun Shin Jun-Hyeok Han Seungyong Shin Ga-Hyun Bae Boram Son Tae-Hyung Kim Hee Ho Park Chun Gwon Park Wooram Park department of Integrative Biotechnology Sungkyunkwan University(SKKU)SuwonGyeonggi 16419Republic of Korea Deparment of Inteligent Precision Healthcare Convergence SKKUSuwonGyeonggi 16419Republic of Korea department of MetaBioHealth SKKU Institute for ConvergenceSKKUSuwonGyeonggi 16419Republic of Korea department of Bioengineering Hanyang UniversitySeoul 04763Republic of Korea department of Integrative Engineering Chung-Ang UniversitySeoul 06974Republic of Korea department of Biomedical Engineering SKKUSuwonGyeonggi 16419Republic of Korea Korea Institute of Science and Technology(KIST) Seoul 02792Republic of Korea

Optimum genetic delivery for modulating target genes to diseased tissue is a major obstacle for profitable gene *** nanoparticles(LNPs),considered a prospective vehicle for nucleic acid delivery,have demonstrated efficacy in human use during the COVID-19 *** study introduces a novel biomaterial-based platform,M1-polarized macrophage-derived cellular nanovesicle-coated LNPs(M1-C-LNPs),specifically engineered for a combined gene-immunotherapy approach against solid *** dual-function system of M1-C-LNPs encapsulates Bcl2-targeting siRNA within LNPs and immune-modulating cytokines within M1 macrophage-derived cellular nanovesicles(M1-NVs),effectively facilitating apoptosis in cancer cells without impacting T and NK cells,which activate the intratumoral immune response to promote granule-mediating killing for solid tumor *** retention within tumor was observed upon intratumoral administration of M1-C-LNPs,owing to the presence of adhesion molecules on M1-NVs,thereby contributing to superior tumor growth *** findings represent a promising strategy for the development of targeted and effective nanoparticle-based cancer genetic-immunotherapy,with significant implications for advancing biomaterial use in cancer therapeutics.

关键词： Genetic-immunotherapy M1 macrophage-derived cellular nanovesicles Lipid nanoparticles(LNPs) Gene therapy siRNA Cancer immunotherapy Solid tumor tumor microenvironment(TME)

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Predicting distant metastasis in nasopharyngeal carcinoma using gradient boosting tree model based on detailed magnetic resonance imaging reports

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World Journal of Radiology 2024年第6期16卷 203-210页

作者： Yu-Liang Zhu Xin-Lei Deng Xu-Cheng Zhang Li Tian Chun-Yan Cui Feng Lei Gui-Qiong Xu Hao-Jiang Li Li-Zhi Liu Hua-Li Ma department of Nasopharyngeal Head and Neck tumor Radiotherapy Zhongshan City People's HospitalZhongshan 528400Guangdong ProvinceChina School of Public Health Sun Yat-sen UniversityGuangzhou 510060Guangdong ProvinceChina department of Radiology Sun Yatsen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangzhou 510060Guangdong ProvinceChina

BACKGROUND Development of distant metastasis(DM)is a major concern during treatment of nasopharyngeal carcinoma(NPC).However,studies have demonstrated im-proved distant control and survival in patients with advanced NPC with the addition of chemotherapy to concomitant ***,precise prediction of metastasis in patients with NPC is *** To develop a predictive model for metastasis in NPC using detailed magnetic resonance imaging(MRI)*** This retrospective study included 792 patients with non-distant metastatic NPC.A total of 469 imaging variables were obtained from detailed MRI *** were stratified and randomly split into training(50%)and testing *** boosting tree(GBT)models were built and used to select variables for predicting DM.A full model comprising all variables and a reduced model with the top-five variables were *** performance was assessed by area under the curve(AUC).RESULTS Among the 792 patients,94 developed DM during *** number of metastatic cervical nodes(30.9%),tumor invasion in the posterior half of the nasal cavity(9.7%),two sides of the pharyngeal recess(6.2%),tubal torus(3.3%),and single side of the parapharyngeal space(2.7%)were the top-five contributors for predicting DM,based on their relative importance in GBT *** testing AUC of the full model was 0.75(95%confidence interval[CI]:0.69-0.82).The testing AUC of the reduced model was 0.75(95%CI:0.68-0.82).For the whole dataset,the full(AUC=0.76,95%CI:0.72-0.82)and reduced models(AUC=0.76,95%CI:0.71-0.81)outperformed the tumor node-staging system(AUC=0.67,95%CI:0.61-0.73).CONCLUSION The GBT model outperformed the tumor node-staging system in predicting metastasis in *** number of metastatic cervical nodes was identified as the principal contributing variable.

关键词： Nasopharyngeal carcinoma Distant metastasis Machine learning Detailed magnetic resonance imaging report Gradient boosting tree model

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Association of complement components with risk of colorectal cancer:A systematic review and meta-analysis

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2168-2180页

作者： Xiao-Lin Zhu Lu Zhang Su-Xia Qi department of Gastroenterology Qingdao Municipal HospitalQingdao 266071Shandong ProvinceChina department of Medical Administration Qingdao Municipal HospitalQingdao 266071Shandong ProvinceChina

BACKGROUND Complement components could contribute to the tumor microenvironment and the systemic immune ***,their role in colorectal cancer(CRC)remains a contentious *** To elucidate the relationship between complement components and CRC risk and clinical *** Searches were conducted in PubMed,the Cochrane Library,and the China National Knowledge Infrastructure database until June 1,*** included cohort studies encompassing participants aged≥18 years,investigating the association between complement components and *** studies were of moderate quality or above,as determined by the Agency for Healthcare Research and *** meta-analysis employed fixed-effects or random-effects models based on the I^(2)test,utilizing risk ratio(RR)and their corresponding 95%confidence interval(CI)for *** and subgroup analyses were performed to validate the robustness of the collective estimates and identify the source of *** Data from 15 studies,comprising 1631 participants that met the inclusion criteria,were included in the *** findings indicated that protein levels of cluster of differentiation 46(CD46)(RR=3.66,95%CI:1.75-7.64,Pmetastasis,whereas strong CD46 expression correlated with a higher incidence of tumor differentiation compared to low CD46 expression(P<0.05 for all).Although specific pooled results demonstrated notable heterogeneity,subgroup analyses pointed to regional differences as the primary source of inconsistency among the *** Our analysis underscores that increased levels of specific complement components are

关键词： Complement components Colorectal cancer Lymph node metastasis Systematic review Meta-analysis

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Traction force with extracellular matrix mediated by cytoskeleton influences metastasis through SLC8A1 induced Wnt-b-catenin pathway in endometrial cancer

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Genes & Diseases 2024年第5期11卷 98-101页

作者： Xingchen Li Xin Xu Jianliu Wang department of Obstetrics and Gynecology Peking University People’s HospitalBeijing 100044China department of Obstetrics and Gynecology Beijing ChaoYang HospitalCapital Medical UniversityBeijing 100020China

Endometrial cancer(EC)is one of the most prominent malignancies in ***,despite these advancements in understanding EC pathogenesis,mortality rates have not *** force(TF)refers to endogenous mechanical forces exerted by cells.1 These forces act on the extracellular matrix and the extracellular tumor microenvironment through focal adhesions,thereby regulating cell proliferation and ***,the TF characteristics of endometrial cancer cells and their heterogeneity remain unclear.

关键词： endometrial metastasis endogenous

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