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A case of methicillin-resistant Staphylococcus aureus infection following bile duct stenting

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World Journal of Gastroenterology 2005年第9期11卷 1396-1398页

作者： Markus K Diener Alexis Ulrich Theresia Weber Moritz N Wente Markus W Büchler Helmut Friess department of general surgery

AIM: To present a case of methicillin-resistant Staphylococcus aureus (MRSA) infection following bile duct stenting in a patient with malignant biliary ***: A 78-year-old male patient was admitted to a community hospital with progredient painless jaundice lasting over two weeks, weight loss and sweating at *** a stent should be implanted pre-operatively in jaundiced patients or whether these patients should directly undergo surgical resection, was ***: ERC and a biopsy from the papilla of Vater revealed an adenocarcinoma. In addition, a 7-Ch plastic stent was placed into the common bile duct. Persistent abdominal pain, increasing jaundice, weakness and indigestion led to the transfer of the patient to our hospital.A pylorus-preserving pancreatoduodenectomy wasperformed. Intraoperatively, bile leaked out of the transected choledochus andthe stent was found to be dislocated in the duodenum. A smear of the bile revealed an infection with MRSA, leading to post-operative isolation of the ***:As biliary stents can cause severe infection of the bile, the need for pre-operative placement of biliary stents should be carefully evaluated in each individual case.

关键词： Methicillin-resistant Staphylococcus aureus Bile Infection Stent Biliary obstruction Malignancy surgery

Study on biological characters of SGC7901 gastric cancer cell-dendritic cell fusion vaccines

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World Journal of Gastroenterology 2006年第21期12卷 3438-3441页

作者： Kun Zhang Peng-Fen Gao Pei-Wu Yu Yun Rao Li-Xin Zhou department of Hepatobiliary surgery Fuzhou General Hospital Fuzhou 350025 Fujian Province China department of Ophthalmology Fuzhou General Hospital Fuzhou 350025 Fujian Province China department of general surgery Southwest Hospital Third Military Medical University Chongqing 400038 China

AIM： To detect the biological characters of the SGC7901 gastric cancer cell-dendritic cell fusion ***： The suspending living SGC7901 gastric cancer cells and dendritic cells were induced to be fusioned by polyethylene glycol. Pure fusion cells were obtained by selective culture with the HAT/HT culture systems. The fusion cells were counted at different time points of culture and their growth curves were drawn to reflect their proliferative activities. The fusion cells were also cultured in culture medium to investigate whether they could grow into cell clones. MTT method was used to test the stimulating abilities of the fusion cells on T lymphocytes＇ proliferations. Moreover, the fusion cells were planted into nude mice to observe whether they could grow into new planted tumors in this kind of immunodeficiency ***： The fusion cells had weaker proliferative activity and clone abilities than their parental cells. When they were cultured, the counts of cells did not increase remarkably, nor could they grow into cell clones in culture medium. The fusion cells could not grow into new planted tumors after planted into nude mice. The stimulating abilities of the fusion cells on T lymphocytes＇ proliferations were remarkably increased than their parental dendritic cells. CONCLUSION： The SGC7901 gastric cancer cell-dendritic cell fusion vaccines have much weaker proliferative abilities than their parental cells, but they keep strong abilities to irritate the T lymphocytes and have no abilities to grow into new planted tumors in immunodeficiency animals. These are the biological basis for their antitumor biotherapies.

关键词： Biological character SGC7901 cell Gastric cancer cell Dendritic cell Fusion vaccine

A novel flexible nerve guidance conduit promotes nerve regeneration while providing excellent mechanical properties

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Neural Regeneration Research 2025年第7期20卷 2084-2094页

作者： Tong Li Quhan Cheng Jingai Zhang Boxin Liu Yu Shi Haoxue Wang Lijie Huang Su Zhang Ruixin Zhang Song Wang Guangxu Lu Peifu Tang Zhongyang Liu Kai Wang department of Orthopedics the Fourth Medical Center of Chinese PLA General HospitalBeijingChina department of Training and Sports Medicine Characteristic Medical Center of Chinese People’s Armed Police ForceTianjinChina Medical School of Chinese PLA BeijingChina Key Laboratory of Bioactive Materials for the Ministry of Education College of Life SciencesNankai UniversityTianjinChina department of Orthopedics Tianjin HospitalTianjinChina department of Rehabilitation Medicine Er Quan Hospital of PAPWuxiJiangsu ProvinceChina

Autografting is the gold standard for surgical repair of nerve defects>5 mm in length;however,autografting is associated with potential complications at the nerve donor *** an alternative,nerve guidance conduits may be *** ideal conduit should be flexible,resistant to kinks and lumen collapse,and provide physical cues to guide nerve *** designed a novel flexible conduit using electrospinning technology to create fibers on the innermost surface of the nerve guidance conduit and employed melt spinning to align ***,we prepared disordered electrospun fibers outside the aligned fibers and helical melt-spun fibers on the outer wall of the electrospun fiber *** presence of aligned fibers on the inner surface can promote the extension of nerve cells along the *** helical melt-spun fibers on the outer surface can enhance resistance to kinking and compression and provide *** novel conduit promoted nerve regeneration and functional recovery in a rat sciatic nerve defect model,suggesting that it has potential for clinical use in human nerve injuries.

关键词： aligned fibers anti-kinking helical fibers nerve guidance conduit nerve regeneration peripheral nerve injury topological guidance

Cholangiocarcinoma:principles and current trends

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Hepatobiliary & Pancreatic Diseases International 2011年第1期10卷 10-20页

作者： George N Zografos Athanasios Farfaras Flora Zagouri Dimosthenis Chrysikos Kostas Karaliotas third department of surgery Athens General HospitalAthensGreece department of Clinical Therapeutics Alexandra HospitalAthensGreece department of surgery Red Cross HospitalAthensGreece

BACKGROUND:Cholangiocarcinoma(CCA)is a lethal cancer of the biliary epithelium,originating from the liver(intrahepatic),at the confluence of the right and left hepatic ducts(hilar)or in the extrahepatic bile *** is a rare malignancy associated with poor *** SOURCES:We searched the PubMed/MEDLINE database for relevant articles published from 1989 to *** search terms used were related to 'cholangiocarcinoma' and its ' treatment'.Although no language restrictions were imposed initially,for the full-text review and final analysis,our resources only permitted the review of articles published in *** review deals with the treatment of cholangiocarcinoma,the principles and the current ***:The risks and prognostic factors,symptoms and differential diagnosis are thoroughly *** addition,the tools of preoperative diagnosis such as endoscopic retrograde cholangiopancreatography,digital image analysis,fluorescence in situ hybridization and magnetic resonance cholangiopancreatography are ***,the treatment of CCA is ***:The only curative treatment available is surgical ***,many patients present with unresectable tumors,the majority of whom die within a year of *** treatment involves major resections of the liver,pancreas and bile duct,with considerable mortality and ***,in selected cases and where indicated,appropriate management with aggressive surgery may achieve a good outcome with a prolonged survival expectancy.

关键词： cholangiocarcinoma treatment prognostic factors risk factors surgery

Irreversible electroporation for metastatic pancreatic carcinoma with liver metastasis:What does the evidence say

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World Journal of Clinical Cases 2025年第3期13卷 30-34页

作者： Ranit Seal Akash Bararia Bitan Kumar Chattopadhyay Nilabja Sikdar department of general surgery IPGME&R and SSKM HospitalKolkata 700020West BengalIndia Human Genetics Unit Indian Statistical InstituteKolkata 700108West BengalIndia Estaurine and Coastal Studies Foundation Howrah 711101India

Irreversible electroporation is a promising non-thermal ablation method that has been shown to increase overall survival in locally advanced pancreatic cancer in some ***,higher quality studies with proper controls and randomization are required to establish its superiority when added with neoadjuvant chemotherapy over the current management of choice,which is chemotherapy *** studies are required before establishment of any survival benefit in metastatic pancreatic carcinoma,and such evidence is lacking at present.

关键词： Irreversible electroporation Locally advanced pancreatic carcinoma Metastatic pancreatic carcinoma Advanced pancreatic carcinoma Chemotherapy

Serum HER2 as a predictive biomarker for tissue HER2 status and prognosis in patients with gastric cancer

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World Journal of Gastroenterology 2017年第10期23卷 1836-1842页

作者： Hong-Zhi Shi Yu-Ning Wang Xiao-Hui Huang Ke-Cheng Zhang Hong-Qing Xi Jian-Xin Cui Guo-Xiao Liu Wen-Tao Liang Bo Wei Lin Chen department of general surgery Chinese PLA General Hospital department of general surgery General Hospital of Armed Police Force department of surgery Chinese PLA General Hospital Institute of general surgery Chinese PLA General Hospital

AIM To investigate the association between serum human epidermal growth factor receptor 2(HER2) extracellular domain(ECD) and tissue HER2 status, and the prognostic value of serum HER2 ECD in patients with gastric *** A total of 239 patients with gastric cancer were enrolled from December 2012 to June 2013. Serum HER2 ECD was determined by chemiluminescent assay, and tissue HER2 status was evaluated by immunohistochemistry and fluorescence in situ hybridization assay. A receiver operating characteristic(ROC) curve was plotted to identify the optimal cut-off value for serum HER2 ECD assay for predicting survival in gastric cancer *** Serum HER2 ECD was significantly correlated with tissue HER2 status(P < 0.001), tumor size(P < 0.001), and intestinal type of gastric cancer(P =0.021). Serum HER2 ECD levels differed significantly between patients with HER2-positive tissue expression and those with HER2-negative tissue expression. ROC analysis yielded an area under the curve value of 0.79(95%CI: 0.71-0.87, P < 0.001), with a sensitivity and specificity of 0.54(95%CI: 0.37-0.70) and 0.93(95%CI: 0.88-0.96), respectively. With a cut-off value of 24.75 ng/m L, high serum HER2 ECD had a negative impact on overall survival of the patients(HR: 1.93, 95%CI: 1.32-4.38, P = 0.006). CONCLUSION Serum HER2 ECD could be a highly specific surrogate biomarker for tissue HER2 status in gastric cancer. Optimal cut-off criteria for predicting survival should be established.

关键词： Gastric cancer Serum HER2 extracellular domain Tissue HER2 status Prognosis

Obesity and cancer stem cells:Roles in cancer initiation,progression and therapy resistance

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World Journal of Stem Cells 2023年第4期15卷 120-135页

作者： Wen-Jie Xie Jian Li department of general surgery The Third Hospital of MianyangSichuan Mental Health CenterMianyang 621000Sichuan ProvinceChina

Obesity,the global pandemic since industrialization,is the number one lifestylerelated risk factor for premature death,which increases the incidence and mortality of various diseases and conditions,including *** recent years,the theory of cancer stem cells(CSCs),which have the capacity for self-renewal,metastasis and treatment resistance,has been bolstered by increasing ***,research on how obesity affects CSCs to facilitate cancer initiation,progression and therapy resistance is still in its infancy,although evidence has already begun to *** the ever-increasing burden of obesity and obesity-related cancer,it is pertinent to summarize evidence about the effects of obesity on CSCs,as elucidating these effects will contribute to the improvement in the management of obesity-related *** this review,we discuss the association between obesity and CSCs,with a particular focus on how obesity promotes cancer initiation,progression and therapy resistance through CSCs and the mechanisms underlying these *** addition,the prospect of preventing cancer and targeting the mechanisms linking obesity and CSCs to reduce cancer risk or to improve the survival of patients with cancer is considered.

关键词： Obesity High-fat diet Cancer stem cells Carcinogenesis Metastasis

High-intensity focused ultrasound treatment for patients with unresectable pancreatic cancer

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Hepatobiliary & Pancreatic Diseases International 2012年第6期11卷 655-660页

作者： Peng-Zhou Li, Shai-Hong Zhu, Wei He, Li-Yong Zhu, Sheng-Ping Liu, Yan Liu, Guo-Hui Wang, Fei Ye department of general surgery ,department of Radiology, third Xiangya Hospital, Central South University, Changsha 410013, China department of general surgery Third Xiangya Hospital Central South University Changsha 410013 China department of Radiology Third Xiangya Hospital Central South University Changsha 410013 China

BACKGROUND: High-intensity focused ultrasound (HIFU) is a non-invasive method of solid tissue ablation therapy. However, only a few studies have reported the effect of HIFU for unresectable pancreatic cancer. This study aimed to evaluate the clinical benefits, survival time and complications associated with the use of HIFU ablation in patients with unresectable pancreatic cancer. METHODS: Twenty-five patients with unresectable pancreatic cancer were enrolled in our study. All patients received HIFU therapy for tumors at least once. The therapeutic effects of HIFU was evaluated in terms of Karnofsky performance status (KPS) scores, pain relief, serum CA19-9, and imaging by B-US and CT before and after the therapy. We also recorded median overall survival time and complications caused by the treatment. RESULTS: In the 25 patients, KPS scores were above 60, and increased KPS was observed in 23 patients after treatment. Pain relief occurred in 23 patients. Serum CA19-9 levels were significantly reduced one month after HIFU treatment and became negative in 5 patients. B-US revealed enhanced tumor echogenicity in 13 patients and decreased tumor blood supply in 9. Tumor necrosis was confirmed by CT in 8 patients one month after HIFU treatment. The median overall survival time was 10 months, and the 1-year survival rate was 42%. No severe complications were observed after HIFU treatment. CONCLUSION: HIFU can effectively relieve pain, increase KPS, decrease tumor growth and prolong the survival time of patients with unresectable pancreatic cancer.

关键词： pancreatic cancer high-intensity focused ultrasound therapy

Digestive cancer incidence and mortality among young adults worldwide in 2020:A population-based study

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World Journal of Gastrointestinal Oncology 2022年第1期14卷 278-294页

作者： Jian Li department of general surgery The Third Hospital of MianyangThe Mental Health Center of SichuanMianyang 621000Sichuan ProvinceChina

BACKGROUND Digestive cancer has traditionally been thought of as a disease that mainly occurs in elderly individuals,and it has been ignored in young adults by both patients and *** To describe the worldwide profile of digestive cancer incidence,mortality and corresponding trends among 20–39-year-olds,with major patterns highlighted by age,sex,development level,and geographical *** I performed a population-based study to quantify the burden of young adult digestive cancers ***,regional,sex,and country-specific data estimates of the number of new cancer cases and cancer-associated deaths that occurred in 2020 were extracted from the GLOBOCAN Cancer Today *** assess long-term trends in young adult digestive cancer,cancer incidence data and mortality data were obtained from the Cancer in Five Continents Plus database and the World Health Organization mortality database,*** associations between the human development index(HDI)and digestive cancer burden in young adults were evaluated by linear regression *** In 2020,there were an estimated 19292789 new cancer cases,resulting in 9958133 deaths worldwide,which equated to an age-standardized incidence rate(ASIR)of 5.16 and age-standardized mortality rate(ASMR)of 3.04,accounting for 12.24%of all new cancer cases and 25.26%of all cancer deaths occurring in young *** burden was disproportionally greater among males,with male:female ratios of 1.34 for incidence and 1.58 for *** ASIRs were 2.1,1.4,and 1.0 per 100000 people per year,whereas the ASMRs were 0.83,1.1,and 0.62 per 100000 people per year for colorectal,liver,and gastric cancer,*** assessed by geographical region and HDI levels,the cancer profile varied substantially,and a strong positive correlation between the mortality-to-incidence ratio of digestive cancer and HDI ranking was found(R^(2)=0.7388,P<0.001).CONCLUSION The most common digestive cancer types are colorecta

关键词： Digestive cancer Incidence Mortality Young adults GLOBOCAN Mortality-to-incidence ratio