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Impulse magnetic stimulation facilitates synaptic regeneration in rats following sciatic nerve injury

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Neural Regeneration Research 2012年第17期7卷 1299-1303页

作者： sergey A.Zhivolupov miroslav m.Odinak Nariman A.Rashidov Ludmila s.Onischenko Igor N.s.m.rtsev Anton A.Jurin department of Neurology Military-Medical AcademySaint-Petersburg194044Lesnoy prospect 2Russian Federation

The current studies describing magnetic stimulation for treatment of nervous system diseases.m.inly focus on transcranial magnetic stimulation and rarely focus on spinal cord magnetic stimulation. spinal cord magnetic stimulation has been confirmed to promote neural plasticity after injuries of spinal cord, brain and peripheral nerve. To evaluate the effects of impulse magnetic stimulation of the spinal cord on peripheral nerve regneration, we compressed a 3 mm segment located in the middle third of the hip using a sterilized artery forceps to induce ischemia. Then, all animals underwent impulse magnetic stimulation of the lumbar portion of spinal crod and spinal nerve roots daily for 1 month. Electron microscopy results showed that in and below the injuryed segment, the inflammation and demyelination of neural tissue were alleviated, apoptotic cells were reduced, and injured schwann cells and myelin fibers were repaired. These findings suggest that high-frequency impulse magnetic stimulation of spinal cord and corresponding spinal nerve roots promotes synaptic regeneration following sciatic nerve injury.

关键词： impulse magnetic stimulation experimental neuropathy sciatic nerve lesion neuroplasticity neuralregeneration

Celastrol mitigates inflammation in sepsis by inhibiting the PKm2-dependent Warburg effect

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military medical Research 2023年第1期10卷 17-31页

作者： Piao Luo Qian Zhang Tian-Yu Zhong Jia-Yun Chen Jun-Zhe Zhang Ya Tian Liu-Hai Zheng Fan Yang Ling-Yun Dai Chang Zou Zhi-Jie Li Jing-Hua Liu Ji-Gang Wang Artemisinin Research Center and Institute of Chinese Materia MedicaChinese Academy of Chinese Medical SciencesBeijing 100700China Guangdong Provincial Key Laboratory of New Drug screening School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China Laboratory medicine the First Affiliated Hospital of Gannan Medical UniversityGanzhou 341000JiangxiChina department of Geriatric medicine Shenzhen People’s Hospitalthe Second Clinical Medical CollegeJinan University and the First Affiliated HospitalSouthern University of Science and TechnologyShenzhen 518020GuangdongChina Guangdong Provincial Key Laboratory of Proteomics School of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China Center for Reproductive medicine Dongguan Maternal and Child Health Care HospitalSouthern Medical UniversityDongguan 523125GuangdongChina Central People’s Hospital of Zhanjiang Zhanjiang 524037GuangdongChina

Background: sepsis involves life-threatening organ dysfunction and is caused by a dysregulated host response to infection. No specific therapies against sepsis have been reported. Celastrol(Cel) is a natural anti-inflammatory compound that shows potential against systemic inflammatory diseases. This study aimed to investigate the pharmacological activity and molecular mechanism of Cel in models of endotoxemia and ***: We evaluated the anti-inflammatory efficacy of Cel against endotoxemia and sepsis in mice and macrophage cultures treated with lipopolysaccharide(LPs). We screened for potential protein targets of Cel using activity-based protein profiling(ABPP). Potential targets were validated using biophysical methods such as cellular thermal shift assays(CETsA) and surface plasmon resonance(sPR). Residues involved in Cel binding to target proteins were identified through point mutagenesis, and the functional effects of such binding were explored through gene ***: Cel protected mice from lethal endotoxemia and improved their survival with sepsis, and it significantly decreased the levels of pro-inflammatory cytokines in mice and macrophages treated with LPs(P s424 of pyruvate kinase m2(PKm2), inhibiting the enzyme and thereby suppressing aerobic glycolysis(Warburg effect). Cel also bound to Cys106 in high mobility group box 1(HmGB1) protein, reducing the secretion of inflammatory cytokine interleukin(IL)-1β. Cel bound to the Cys residues in lactate dehydrogenase A(LDHA).Conclusions: Cel inhibits inflammation and the Warburg effect in sepsis via targeting PKm2 and HmGB1 protein.

关键词： Celastrol sepsis Pyruvate kinase m2 High mobility group box 1 Aerobic glycolysis

Wear resistance,hardness,and microstructure of carbide dispersion strengthened high-entropy alloys

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Journal of Central south University 2022年第11期29卷 3529-3543页

作者： A.Hegazy KHALLAF m.BHLOL O.m.DAWOOD Omayma A.ELKADY mechanical Engineering department Egyptian Academy for Engineering and Advanced Technology(EAE&AT)Affiliated to Ministry of Military ProductionCairoEgypt mechanical Engineering department Faculty of EngineeringUniversity of HelwanHelwanCairo 11792Egypt Powder Technology department Central Metallurgical R&D InstituteP.O.87Helwan11421 CairoEgypt

(CrFeCoNi)high-entropy alloy(HEA)was reinforced with various contents of WC particles from 5 wt%to 20 wt%,and prepared by powder *** mixed powders were compacted under 700 mPa and then sintered at 1200℃in a vacuum furnace for 90 ***,phase composition,and microstructure of sintered s.m.les were ***,compressive strength,wear resistance and coefficient of thermal expansion(CTE)were *** results revealed the improvement of the density with the addition of *** results revealed the formation of new FCC chromium carbide *** electron microscopy(s.m.results show a good distribution of the carbide phases over the alloy *** CTE was decreased gradually by increasing the WC *** strength was improved by WC addition.A mathematical model was established to predict the behavior of the strength of the HEA *** hardness of the investigated HEAs was increased gradually with the increasing of WC content about 20.35%.Also,the wear rate of HEA without WC is 1.70×10^(−4)mm^(3)/(N·m),which is approximately 4.5 times the wear rate of 20 wt%WC HEA(3.81×10^(−5)mm^(3)/(N·m)),which means that wear resistance was significantly improved with the increase of WC content.

关键词： high-entropy alloy powder metallurgy micro-hardness microstructure wear resistance compression regression analysis

Lesions requiring wound management in a central tertiary neonatal intensive care unit

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World Journal of Pediatrics 2017年第2期13卷 165-172页

作者： Angéla meszes Gyula Tálosi Krisztina máder Hajnalka Orvos Lajos Kemény Zsanett Renáta Cs.m. department of Dermatology and Allergology University of SzegedSzegedHungary department of Pediatrics University of SzegedSzegedHungary department of Obstetrics and Gynecology University of SzegedSzegedHungary department of Dermatology and Allergology University of SzegedSzegedHungary mTA-sZTE Dermatological Research Group SzegedHungary

Background:most of the skin disorders that occur in neonatal intensive care units are due in part to the immaturity and vulnerability of the neonatal *** iatrogenic diagnostic and therapeutic procedures are also conducive to iatrogenic *** study was to review the neonates admitted to our neonatal intensive care unit who needed wound management,and to assess the most common skin injuries and wounds,and their ***:Data were extracted from medical records of neonates who needed wound management in our Neonatal Intensive Care Unit between January 31,2012 and January 31,*** about gestational age,sex,birth weight,area of involvement,wound aetiology,and therapy were ***:Among the 211 neonates observed,wound management was required in 10 cases of diaper dermatitis,7 epidermal stripping,6 extravasation injuries,5 pressure ulcers,1 surgical wound and infection,1 thermal burn,and 5 other ***:International guidelines in neonatal wound care practice are not available,and further research concerns are clearly *** and antiseptic agents should be chosen with great care for application to neonates,with particular attention to the prevention of adverse events in this sensitive *** work among dermatologists,neonatologists and nurses is crucial for the successful treatment of neonates.

关键词： epidermal stripping extravasation injury neonatal intensive care unit surgical wound wound care in neonates