Impulse magnetic stimulation facilitates synaptic regeneration in rats following sciatic nerve injury

作     者：Sergey A.Zhivolupov Miroslav M.Odinak Nariman A.Rashidov Ludmila S.Onischenko Igor N.Samartsev Anton A.Jurin 

作者机构：Department of NeurologyMilitary-Medical AcademySaint-Petersburg194044Lesnoy prospect 2Russian Federation 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2012年第7卷第17期

页      面：1299-1303页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：The Ethics Committee of the Military Medical Academy,Saint-Petersburg,Russia(82 10.06.2009) 

主　　题：impulse magnetic stimulation experimental neuropathy sciatic nerve lesion neuroplasticity neuralregeneration 

摘      要：The current studies describing magnetic stimulation for treatment of nervous system diseases mainly focus on transcranial magnetic stimulation and rarely focus on spinal cord magnetic stimulation. Spinal cord magnetic stimulation has been confirmed to promote neural plasticity after injuries of spinal cord, brain and peripheral nerve. To evaluate the effects of impulse magnetic stimulation of the spinal cord on peripheral nerve regneration, we compressed a 3 mm segment located in the middle third of the hip using a sterilized artery forceps to induce ischemia. Then, all animals underwent impulse magnetic stimulation of the lumbar portion of spinal crod and spinal nerve roots daily for 1 month. Electron microscopy results showed that in and below the injuryed segment, the inflammation and demyelination of neural tissue were alleviated, apoptotic cells were reduced, and injured Schwann cells and myelin fibers were repaired. These findings suggest that high-frequency impulse magnetic stimulation of spinal cord and corresponding spinal nerve roots promotes synaptic regeneration following sciatic nerve injury.