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Contemporary techniques and outcomes of surgery for locally advanced renal cell carcinoma with focus on inferior vena cava thrombectomy:The value of a multidisciplinary team

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Asian Journal of Urology 2022年第3期9卷 272-281页

作者： Riccardo Campi Paolo Barzaghi Alessio Pecoraro Maria Lucia Gallo Damiano Stracci Alberto Mariotti Saverio Giancane Simone Agostini Vincenzo Li Marzi Arcangelo Sebastianelli pietro Spatafora Mauro Gacci Graziano Vignolini Francesco Sessa Paolo Muiesan Sergio Serni Unit of Urological Robotic surgery and Renal Transplantation University of FlorenceCareggi HospitalFlorenceItaly department of Experimental and Clinical Medicine University of FlorenceFlorenceItaly department of Radiology Unit of UrogenitalNephrological and Kidney Transplantation ImagingCareggi HospitalUniversity of FlorenceFlorenceItaly Hepatobiliary Unit Department of Clinical and Experimental MedicineUniversity of FlorenceAOU CareggiFlorenceItaly Liver Unit Queen Elizabeth HospitalBirminghamUK

Objective:To report the outcomes of surgery for a contemporary series of patients with locally advanced non-metastatic renal cell carcinoma(RCC)treated at a referral academic centre,focusing on technical nuances and on the value of a multidisciplinary ***:We queried our prospective institutional database to identify patients undergoing surgical treatment for locally advanced(cT3-T4 N0-1 M0)renal masses suspected of RCC at our centre between January 2017 and December ***:Overall,32 patients were included in the analytic *** these,12(37.5%)tumours were staged as cT3a,8(25.0%)as cT3b,5(15.6%)as cT3c,and 7(21.9%)as cT4;6(18.8%)patients had preoperative evidence of lymph node ***(28.1%)patients underwent nephron-sparing surgery while 23(71.9%)received radical nephrectomy.A template-based lymphadenectomy was performed in 12 cases,with evidence of disease in 3(25.0%)at definitive histopathological *** cases of RCC with level IV inferior vena cava thrombosis were successfully treated using liver transplant techniques without the need for extracorporeal *** intraoperative complications were recorded in 3(9.4%)patients,no postoperative major complications(Clavien-Dindo3)were *** histopathological analysis,2(6.2%)patients who underwent partial nephrectomy harboured oncocytoma,while the most common malignant histotype was clear cell RCC(62.5%),with a median Leibovich score of 6(interquartile range 5e7).Conclusion:Locally advanced RCC is a complex and heterogenous disease posing several challenges to surgical *** experience confirms that provided careful patient selection,surgery in experienced hands can achieve favourable perioperative,oncological,and functional outcomes.

关键词： Inferior vena cava Liver transplant Open surgery Nephrectomy Renal cell carcinoma Thrombectomy

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Comment on “A series of microRNA in the chromosome 14q32.2 maternally imprinted region related to progression of non-alcoholic fatty liver disease in a mouse model”

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Hepatoma Research 2016年第1期2卷 205-206页

作者： pietro Di Fazio Thaddeus Till Wissniowski department of Visceral Thoracic and Vascular SurgeryPhilipps University Marburg35043 MarburgGermany department of Gastroenterology Philipps University Marburg35043 MarburgGermany

Okamoto K,Koda M,Okamoto T,Onoyama T,Miyoshi K,Kishina M,Kato J,Tokunaga S,Sugihara TA,Hara Y,Hino K,Murawaki Y.A series of microRNA in the chromosome 14q32.2 maternally imprinted region related to progression of non-... 详细信息

关键词： 14q liver maternal

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New imaging technologies for robotic kidney cancer surgery

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Asian Journal of Urology 2022年第3期9卷 253-262页

作者： Stefano Puliatti Ahmed Eissa Enrico Checcucci pietro Piazza Marco Amato Stefania Ferretti Simone Scarcella Juan Gomez Rivas Mark Taratkin Jose Marenco Ines Belenchon Rivero Karl-Friedrich Kowalewski Giovanni Cacciamani Ahmed El-Sherbiny Ahmed Zoeir Abdelhamid MEl-Bahnasy Ruben De Groote Alexandre Mottrie Salvatore Micali Urology department University of Modena&Reggio EmiliaModenaItaly ORSI Academy MelleBelgium Urology department Faculty of MedicineTanta UniversityTantaEgypt department of surgery Candiolo Cancer InstituteFPO-IRCCSCandioloTurinItaly Division of Urology IRCCS Azienda Ospedaliero-Universitaria di BolognaBolognaItaly department of Urology Polytechnic University of Marche RegionUmberto I Hospital“Ospedali Riuniti”AnconaItaly Uro-technology and SoMe Working Group of the Young Academic Urologists Working Party European Association of UrologyArnhemthe Netherlands department of Urology Hospital Clinico San CarlosMadridSpain Institute for Urology and Reproductive Health Sechenov UniversityMoscowRussia department of Urology Fundacio´n Instituto Valenciano de Oncologı´aValenciaSpain Urology and Nephrology department Virgen del Rocı´o University HospitalManuel Siurot Sin NumeroSevilleSpain department of Urology and Urological surgery University Medical Centre MannheimMannheimGermany USC Institute of Urology University of Southern CaliforniaLos AngelesCAUSA department of Urology Onze-Lieve-VrouwziekenhuisAalstBelgium

Objective:Kidney cancers account for approximately 2%of all newly diagnosed cancer in *** the primary treatment options for kidney cancer,urologist may choose between radical or partial nephrectomy,or ablative ***,robotic-assisted partial nephrectomy(RAPN)for the management of renal cancers has gained popularity,up to being considered the gold ***,RAPN is a challenging procedure with a steep learning ***:In this narrative review,different imaging technologies used to guide and aid RAPN are ***:Three-dimensional visualization technology has been extensively discussed in RAPN,showing its value in enhancing robotic-surgery training,patient counseling,surgical planning,and intraoperative *** imaging technologies such as intracorporeal ultrasound,near-infrared fluorescent imaging,and intraoperative pathological examination can also be used to improve the outcomes following ***,artificial intelligence may play a role in the field of RAPN ***:RAPN is a complex surgery;however,many imaging technologies may play an important role in facilitating it.

关键词： Kidney cancer Imaging Technology Robotic

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Liver involvement in patients with COVID-19 infection:A comprehensive overview of diagnostic imaging features

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World Journal of Gastroenterology 2023年第5期29卷 834-850页

作者： Davide Ippolito Cesare Maino Federica Vernuccio Roberto Cannella Riccardo Inchingolo Michele Dezio Riccardo Faletti pietro Andrea Bonaffini Marco Gatti Sandro Sironi Milano Bicocca School of Medicine and surgery Milano 20126Italy Fondazione IRCCS San Gerardo dei Tintori Monza 20900Italy Institute of Radiology(DIMED) University Hospital of PadovaPadova 35128Italy Section of Radiology-department of Biomedicine Neuroscience and Advanced Diagnostics(BiND)University of PalermoPalermo 90127Italy department of Health Promotion Mother and Child CareInternal Medicine and Medical Specialties(PROMISE)University of PalermoPalermo 90127Italy Division of Interventional Radiology Department of RadiologyMadonna delle Grazie HospitalMatera 75100Italy department of Surgical Sciences University of TurinTurin 10126Italy department of Diagnostic Radiology Papa Giovanni XXIII HospitalBergamo 24127Italy department of Diagnostic Radiology University of TurinTurin 10126Italy

During the first wave of the pandemic,coronavirus disease 2019(COVID-19)infection has been considered mainly as a pulmonary ***,different clinical and radiological manifestations were observed over time,including involvement of abdominal ***,the liver is considered one of the main affected abdominal *** involvement may be caused by either a direct damage by the virus or an indirect damage related to COVID-19 induced thrombosis or to the use of different *** clinical assessment,radiology plays a key role in the evaluation of liver ***(US),computed tomography(CT)and magnetic resonance imaging(MRI)may be used to evaluate liver *** is widely available and it is considered the first-line technique to assess liver involvement in COVID-19 infection,in particular liver steatosis and portal-vein *** and MRI are used as second-and third-line techniques,respectively,considering their higher sensitivity and specificity compared to US for assessment of both parenchyma and *** review aims to the spectrum of COVID-19 liver involvement and the most common imaging features of COVID-19 liver damage.

关键词： Liver Fatty liver Hepatomegaly Hepatic infarction Liver diseases Liver failure Biliary tract diseases COVID-19 SARS-CoV-2 Infection X-Ray computed tomography Magnetic resonance imaging Ultrasonography Adults Pediatrics

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Tissue-engineered constructs for peripheral nerve repair:current research concepts and future perspectives

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Plastic and Aesthetic Research 2015年第1期2卷 213-219页

作者： Alba C.de Luca Wassim Raffoul Francesco Giacalone Maddalena Bertolini pietro G.di Summa EPFL Centre for NeuroprostheticsLaboratory for Soft Bioelectronic Interfaces1015 LausanneSwitzerland department of Plastic Reconstructive and Hand SurgeryUniversity Hospital of Lausanne(Centre Hospitalier Universitaire Vaudois)1011 LausanneSwitzerland department of Hand surgery and Microsurgery CTO-Maria Adelaide Trauma Center10126 TorinoItaly

Traumatic injuries resulting in peripheral nerve lesions lead to important morbidity with devastating social and economic *** the lesioned nerve cannot be sutured directly,a nerve graft is generally required to bridge the *** autologous nerve grafting is still the first choice for reconstruction,it has the severe disadvantage of the sacrifice of a functional *** in tissue engineering and nerve regeneration may have a dramatic impact on clinical and surgical treatment of such nerve *** authors review the latest concepts in tissue engineering for nerve repair,including scaffold engineering of neural guides,biomaterial modification,cell therapy,growth factors delivery,and electrical *** literature is reviewed in detail,pointing out the most interesting present achievements and perspectives for future clinical *** search of the literature was performed using MEDLINE,Embase,and the Cochrane Library to identify research studies on peripheral nerve regeneration through tissue-engineered *** following medical subject headings were used to carry out a systematic search of the literature:“nerve regeneration”,“stem cells”,“biomaterial”,“extracellular matrix”,“functional regeneration”,“growth factors”and“microchannels”.Included literature was published between 1991 and *** reference lists from the retrieved articles were also reviewed for additional *** total,76 articles were included in this study.

关键词： Cell transplantation extracellular matrix growth factors nerve guidance conduit peripheral nerve repair surface modification

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Rectal neuroendocrine tumors:Current advances in management,treatment,and surveillance

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World Journal of Gastroenterology 2022年第11期28卷 1123-1138页

作者： Camilla Gallo Roberta Elisa Rossi Federica Cavalcoli Federico Barbaro Ivo Boškoski pietro Invernizzi Sara Massironi Division of Gastroenterology and Center for Autoimmune Liver Diseases Department of Medicine and SurgeryUniversity of Milano-BicoccaEuropean Reference Network on Hepatological DiseasesSan Gerardo HospitalMonza 20900Italy Division of HPB surgery Hepatology and Liver TransplantationDepartment of Pathophysiology and TransplantationUniversity of MilanENETS Center of ExcellenceFondazione IRCCS Istituto Nazionale Tumori(INTNational Cancer Institute)Milan 20133Italy Diagnostic and Therapeutic Endoscopy Unit Fondazione IRCCS Istituto Nazionale TumoriMilan 20133Italy Digestive Endoscopy Unit UniversitàCattolica del Sacro Cuore di RomaCenter for Endoscopic Research Therapeutics and TrainingFondazione Policlinico Universitario Agostino Gemelli IRCSSRome 00168Italy

Rectal neuroendocrine neoplasms(r-NENs)are considered among the most frequent digestive NENs,together with small bowel *** incidence has increased over the past few years,and this is probably due to the widespread use of endoscopic screening for colorectal cancer and the advanced endoscopic procedures available *** to the current European Neuroendocrine Tumor Society(ENETS)guidelines,well-differentiated r-NENs smaller than 10 mm should be endoscopically removed in view of their low risk of local and distant invasion.R-NENs larger than 20 mm are candidates for surgical resection because of their high risk of distant spreading and the involvement of the muscularis *** is an area of uncertainty regarding tumors between 10 and 20 mm,in which the metastatic risk is intermediate and the endoscopic treatment can be *** removed,the indications for surveillance are scarce and poorly codified by international guidelines,therefore in this paper,a possible algorithm is proposed.

关键词： Rectal neuroendocrine tumors Endoscopy Endoscopic submucosal dissection Resectable advanced disease Systemic therapy

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Clinical challenge for gastroenterologists–Gastrointestinal manifestations of systemic mastocytosis:A comprehensive review

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World Journal of Gastroenterology 2022年第29期28卷 3767-3779页

作者： Alessandra Elvevi Elena Maria Elli Martina Luca Miki Scaravaglio Fabio Pagni Stefano Ceola Laura Ratti pietro Invernizzi Sara Massironi Gastroenterology Division San Gerardo HospitalUniversity of Milano-Bicocca School of MedicineMonza 20900Italy Hematology Division and Bone Marrow Transplant Unit San Gerardo HospitalMonza 20900Italy department of Medicine and surgery Section of PathologySan Gerardo HospitalUniversity of Milano-Bicocca School of MedicineMonza 20900Italy

Mastocytosis is a rare and heterogeneous disease characterized by various clinical and biological features that affect different prognoses and *** disease is usually divided into 2 principal categories:cutaneous and systemic disease(SM).Clinical features can be related to mast cell(MC)mediator release or pathological MC *** is a disease often hard to identify,and the diagnosis is based on clinical,biological,histological,and molecular criteria with different specialists involved in the patient’s clinical *** all manifestations of the disease,gastrointestinal(GI)symptoms are common,being present in 14%-85% of patients,and can significantly impair the quality of *** we review the data regarding GI involvement in SM,in terms of clinical presentations,histological and endoscopic features,the pathogenesis of GI symptoms,and their treatment.

关键词： Systemic mastocytosis Gastrointestinal involvement Gastrointestinal symptoms

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Defining metabolic activity of nephrolithiasis--Appropriate evaluation and follow-up of stone formers

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Asian Journal of Urology 2018年第4期5卷 235-242页

作者： Daniel A.Wollin Adam G.Kaplan Glenn M.Preminger pietro Manuel Ferraro Antonio Nouvenne Andrea Tasca Emanuele Croppi Giovanni Gambaro Ita P.Heilberg Duke Comprehensive Kidney Stone Center Division of Urologic SurgeryDuke University Medical CenterDurhamNCUSA Columbus-Gemelli University Hospital Division of NephrologyDepartment of Medical SciencesRomeItaly University of Parma Department of Clinical and Experimental MedicineParmaItaly S.Bortolo Hospital Department of UrologyVicenzaItaly Universidade Federal de Sao Paulo Nephrology DivisionSao PauloBrazil

Considering the variation in metabolic evaluation and medical management of kidney stone disease,this consensus review was created to discuss the metabolic activity of nephrolithiasis,define the difference between single and recurrent stone formers,and develop a schema for metabolic and radiologic follow-up.A systematic review of the literature was performed to identify studies of metabolic evaluation and follow-up of patients with *** single and recurrent stone formers share many similarities in metabolic *** study group determined that based on an assessment of risk for stone recurrence and metabolic activity,single and recurrent stone formers should be evaluated comprehensively,including two 24 h urine studies on a random *** medication and dietary recommendations are effective for many patients in reducing the risk of stone ***-up of those with stone disease should be obtained depending on the level of metabolic activity of the patient,the risk of chronic kidney disease and the risk of osteoporosis/osteopenia.A standard scheme includes a baseline metabolic profile,a repeat study 3e6 months after initiation of treatment,and then yearly when stable,with abdominal imaging obtained every 1-2 years.

关键词： Follow-up Medical management Metabolic evaluation Urolithiasis

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Spatial distribution and network morphology of epicardial,endocardial,interstitial,and Purkinje cell-associated elastin fibers in porcine left ventricle

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Bioactive Materials 2023年第1期19卷 348-359页

作者： Xiaodan Shi Song Zhang Yue Liu Bryn Brazile Jim Cooley J.Ryan Butler Sara R.McMahan Karla L.Perez Jiazhu Xu Timothy Eastep Kytai T.Nguyen pietro Bajona Matthias Peltz Huajian Gao Yi Hong Jun Liao department of Bioengineering University of Texas at ArlingtonArlingtonTX76010USA College of Engineering and College of Veterinary Medicine Mississippi State UniversityMississippi StateMS39762USA School of Engineering Brown UniversityProvidenceRI02912USA College of Engineering Nanyang Technical University308232Singapore department of Cardiovascular and Thoracic surgery University of Texas Southwestern Medical CenterDallasTX75390USA Allegheny Health Network-Drexel University College of Medicine PittsburghPA15212USA

Cardiac extracellular matrices(ECM)play crucial functional roles in cardiac *** studies have mainly focused on collagen,the major structural ECM in heart *** role of elastin in cardiac mechanics,however,is poorly *** this study,we investigated the spatial distribution and microstructural morphologies of cardiac elastin in porcine left *** demonstrated that the epicardial elastin network had location-and depth-dependency,and the overall epicardial elastin fiber mapping showed certain correlation with the helical heart muscle fiber *** compared to the epicardial layer,the endocardial layer was thicker and has a higher elastin-collagen ratio and a denser elastin fiber network;moreover,the endocardial elastin fibers were finer and more wavy than the epicardial elastin fibers,all suggesting various interface *** myocardial interstitial elastin fibers co-exist with the perimysial collagen to bind the cardiomyocyte bundles;some of the interstitial elastin fibers showed a locally aligned,hinge-like structure to connect the adjacent cardiomyocyte *** collagen-elastin combination reflects an optimal design in which the collagen provides mechanical strength and elastin fibers facilitate recoiling during ***,cardiac elastin fibers,along with collagen network,closely associated with the Purkinje cells,indicating that this ECM association could be essential in organizing cardiac Purkinje cells into“fibrous”and“branching”morphologies and serving as a protective feature when Purkinje fibers experience large deformations in *** short,our observations provide a structural basis for future in-depth biomechanical investigations and biomimicking of this long-overlooked cardiac ECM component.

关键词： Heart ECM Epicardial elastin Endocardial elastin Interstitial elastin Purkinje-cell associated elastin

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Hepatocellular carcinoma and liver transplant: beyond the Milan criteria and the risk of "short-blanket" syndrome

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Hepatobiliary surgery and Nutrition 2020年第4期9卷 518-521页

作者： Stefano Gitto Stefano Di Sandro Paolo Magistri pietro Andreone Fabrizio Di Benedetto department of Experimental and Clinical Medicine University of FlorenceFlorenceItaly Hepato-Pancreato-Biliary surgery and Liver Transplantation Unit AOU di Modena and University of Modena and Reggio EmiliaModenaItaly Internal and Metabolic Medicine AOU di Modena and University of Modena and Reggio EmiliaModenaItaly

Liver transplant(LT)is considered the best option for patients with hepatocellular carcinoma(HCC)confined into the liver and generally associated with liver cirrhosis(1).The Milan criteria(MC)represent a milestone in the selection of these patients(2).Therefore,basing on MC,the 5-year survival rate after LT could increase to 70%,with a HCC recurrence rate lower than 10%(2).Despite that,too many patients affected by HCC may not benefit from LT due to a tumor stage beyond the selection *** the last two decades,authors and physicians tried to overcome the MC exploring the opportunity to safely transplant patients beyond(3).Notably,the donor shortage and the competition between patients listed due to HCC and those listed for other indications,force physicians in selecting candidates with the best transplant benefit(3).

关键词： beyond listed overcome

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