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Effect and safety of sorafenib in patients with intermediate hepatocellular carcinoma who received transarterial chemoembolization: A retrospective comparative study

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World Journal of Clinical Cases 2018年第5期6卷 74-83页

作者： Xue-Fen Lei Yang Ke Tian-Hao Bao Hao-Ran Tang Xue-Song Wu Zhi-Tian Shi Jie Lin Zhi-Xian Zhang Hou Gu Lin Wang department of Medical Oncology The Second Affiliated Hospital of Kunming Medical University department of Hepatobiliary surgery The Second Affiliated Hospital of Kunming Medical University The Mental Health Center of Kunming Medical University Department of Hepatobiliary Surgery The Second Affiliated Hospital of Kunming Medical University department of Gastro- enterological surgery The Second Affiliated Hospital of Kunming Medical University

AIM To evaluate the safety and efficacy of sorafenib plus transarterial chemoembolization(TACE) treatment for intermediate hepatocellular carcinoma(HCC).METHODS Sixty-seven patients with intermediate-stage [Barcelona Clinic liver cancer stage B(BCLC-B)] HCC who were treated with sorafenib plus TACE or TACE alone between 2009 and 2011 were included in the study. Follow-up was until 2014 or patient death. Two groups were defined in the experiment: The experimental group, treated with sorafenib plus TACE, and the control group, treated with standard TACE *** The Kaplan-Meier survival analysis showed that the median overall survival(m OS) of the experimental group was 35.2 mo, while that of the control group was 22.0 mo(P < 0.05). Sorafenib plus TACE showed higher incidence rates of rash, hand-foot syndrome(HFS), and hypertension(P < 0.05) than TACE treatment *** Sorafenib plus TACE treatment for BCLC-B HCC significantly prolonged the m OS of patients compared to TACE treatment alone. The most common toxicities with sorafenib were rash(31.6%), HFS(39.5%) and hypertension(31.6%), but there were no intolerable adverse events. The Cox multivariate analysis showed that the survival of patients with BCLC-B HCC depended on the Child-Pugh classification, tumor diameter, and treatment with sorafenib plus TACE compared to TACE alone.

关键词： Sorafenib Hepatocellular carcinoma Transarterial chemoembolization Overall survival Adverse reaction

Prediction and stratification for the surgical adverse events after minimally invasive esophagectomy:A two-center retrospective study

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World Journal of Gastroenterology 2025年第3期31卷 50-61页

作者： Qi-Hong Zhong Jiang-Shan Huang Fei-Long Guo Jing-Yu Wu Mao-Xiu Yuan Jia-Fu Zhu Wen-Wei Lin Sui Chen Zhen-Yang Zhang Jiang-Bo Lin department of thoracic surgery Fujian Medical University Union HospitalFuzhou 350001Fujian ProvinceChina The Graduate School Fujian Medical UniversityFuzhou 350001Fujian ProvinceChina department of thoracic surgery Affiliated Hospital of Jinggangshan UniversityJi’an 343000Jiangxi ProvinceChina

BACKGROUND Minimally invasive esophagectomy(MIE)is a widely accepted treatment for esophageal cancer,yet it is associated with a significant risk of surgical adverse events(SAEs),which can compromise patient recovery and long-term *** preoperative identification of high-risk patients is critical for improving *** To establish and validate a risk prediction and stratification model for the risk of SAEs in patients with *** This retrospective study included 747 patients who underwent MIE at two centers from January 2019 to February *** were separated into a train set(n=549)and a validation set(n=198).After screening by least absolute shrinkage and selection operator regression,multivariate logistic regression analyzed clinical and intraoperative variables to identify independent risk factors for SAEs.A risk stratification model was constructed and validated to predict the probability of *** SAEs occurred in 10.2%of patients in train set and 13.6%in the validation *** with SAE had significantly higher complication rate and a longer hospital stay after *** key independent risk factors identified included chronic obstructive pulmonary disease,a history of alcohol consumption,low forced expiratory volume in the first second,and low albumin *** stratification model has excellent prediction accuracy,with an area under the curve of 0.889 for the training set and an area under the curve of 0.793 for the validation *** The developed risk stratification model effectively predicts the risk of SAEs in patients undergoing MIE,facilitating targeted preoperative interventions and improving perioperative management.

关键词： Surgical adverse events Minimally invasive esophagectomy Esophageal cancer Stratification model Perioperative management

EFFECTIVENESS OF ELECTROCHEMICAL TREATMENT OF PRIMARY PULMONARY MALIGNANT TUMORS

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Chinese Medical Journal 1995年第1期108卷 66-67页

作者：宋玉忱张逊杜喜群王增林陈宇 department of thoracic surgery Fourth Affiliated Hospital Hebei Medical College Shijiazhuang.

Electrochemical therapy is a new therapy for the treatment of *** January 1989 to November 1991

关键词： In EFFECTIVENESS OF ELECTROCHEMICAL TREATMENT OF PRIMARY PULMONARY MALIGNANT TUMORS

The Role of Exportin-5 in MicroRNA Biogenesis and Cancer

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Genomics, Proteomics & Bioinformatics 2018年第2期16卷 120-126页

作者： Ke Wu Juan He Wenchen Pu Yong Peng department of thoracic surgery State Key Laboratory of Biotherapy West China Hospital Sichuan University

MicroRNAs （miRNAs） are conserved small non-coding RNAs that play an important role in the regulation of gene expression and participate in a variety of biological processes. The biogenesis of miRNAs is tightly controlled at multiple steps, such as transcription of miRNA genes, processing by Drosha and Dicer, and transportation of precursor miRNAs （pre-miRNAs） from the nucleus to the cytoplasm by exportin-5 （XPO5）. Given the critical role of nuclear export of premiRNAs in miRNA biogenesis, any alterations of XPO5, resulting from either genetic mutation, epigenetic change, abnormal expression level or posttranslational modification, could affect miRNA expression and thus have profound effects on tumorigenesis. Importantly, XPO5 phosphorylation by ERK kinase and its cis/trans isomerization by the prolyl isomerase Pinl impair XPO5＇s nucleo-to-cytoplasmic transport ability of pre-miRNAs, leading to downregulation of mature miRNAs in hepatocellular carcinoma. In this review, we focus on how XPO5 transports pre-miRNAs in the cells and summarize the dysregnlation of XPO5 in human tumors.

关键词： Exportin-5 MicroRNA Biogenesis Dysregulation Cancer

Oesophageal flap valvuloplasty and wrapping suturing prevent gastrooesophageal reflux disease in dogs after oesophageal anastomosis

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World Journal of Gastroenterology 2014年第46期20卷 17434-17438页

作者： Ji-Gang Dai Quan-Xing Liu Xu-Feng Den Jia-Xin Min department of thoracic surgery Xinqiao Hospitalthe Third Military Medical University

AIM: To examine the efficiency of oesophageal flap valvuloplasty and wrapping suturing technique in decreasing the rate of postoperative gastrooesophageal reflux disease in a dog model.

关键词： Oesophageal anastomosis Oesophagectomy Gastrooesophageal reflux

A　PROGNOSTIC　EVALUATION　ON　ESOPHAGEAL　CARCINOMA　WITH　LYMPH　NODE　METASTASIS──AN　ANALYSIS　OF　212　CASES

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Chinese Journal of Cancer Research 1995年第4期7卷 284-286页

作者：陈建华王文光卫功铨陈明耀高宗人许金良程金华 department of thoracic surgery Henan Tumor Hospital Zhengzhou

The authors studied retrospcctively lymph node metastatic status impacting on survival of 212 patients with thoracic esophageal squamous cell carcinoma 663 (19.4%) of the total 3, 419 lymph nodes examined (an average of 16. per patient) were proved to be *** overall 5-year survival rate was 19.3% (41/212).The results showed that no difference in survival was observed in relation to the site of the involved lymph *** in survival based on the number of metastatic lymph nodes (1 or ≥2) and the frequence of Positive nodes ≤ 10% or≥10%) is statistically significant. The results indicated that the clinical staging of esophagcal carcinoma should be made according to the absolute number and the relative frequency of lymph nodes involved. The effectiveness and limitation of extended lymph node dissection in relation to prognosis was discussed.

关键词： Esophageal neoplasms Lymph node metastasis Prognosis Squamous cell carcinoma.

A REPORT OF 39 CASES OF BRONCHIOLOALVEOLAR CARCINOMA

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Chinese Medical Sciences Journal 1994年第2期9卷 135-136页

作者：任华李泽坚张志庸孙成孚徐乐天 department of thoracic surgery PUMC Hospital Beijing.

ＡＲＥＰＯＲＴＯＦ３９ＣＡＳＥＳＯＦＢＲＯＮＣＨＩＯＬＯＡＬＶＥＯＬＡＲＣＡＲＣＩＮＯＭＡ￥ＲｅｎＨｕａ（任华）；ＬｉＺｅｊｉａｎ（李泽坚）；ＺｈａｎｇＺｈｉｙｏｎｇ（张志庸）；ＳｕｎＣｈｅｎｇｆｕ（孙成孚）ａｎｄＸ... 详细信息

ＡＲＥＰＯＲＴＯＦ３９ＣＡＳＥＳＯＦＢＲＯＮＣＨＩＯＬＯＡＬＶＥＯＬＡＲＣＡＲＣＩＮＯＭＡ￥ＲｅｎＨｕａ（任华）；ＬｉＺｅｊｉａｎ（李泽坚）；ＺｈａｎｇＺｈｉｙｏｎｇ（张志庸）；ＳｕｎＣｈｅｎｇｆｕ（孙成孚）ａｎｄＸｕＬｅｔｉａｎ（徐乐天）（Ｄｅｐａ...

关键词： neoplasms bronchioloalveolar carcinoma

Construction of B7x Gene Overexpression Lentiviral-based Vector

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Chemical Research in Chinese Universities 2011年第4期27卷 623-627页

作者： SUN Mei JIANG Rui SUN Li-hua LI Jin-dong WANG Bin JIN Cheng-yan ZHANG Xing-yi department of Pathology the Second Hospital of Jilin University Changchun 130041 P.R. China department of Orthopedic surgery China-Japan Union Hospital of Jilin University Changchun 130033 P. R. China department of Anesthesia the Second Hospital of Jilin University Changchun 130041 P. R. China department of thoracic surgery the Second Hospital of Jilin University Changchun 130041 P. R. China

To construct overexpression lentiviral-based vector carrying rat B7x gene,B7x gene precursor sequences amplified by polymerse chain reaction（PCR） were ligated with pLVTHM to generate pLVTHM-B7x gene expression lentiviral-based *** positive clones were selected to be submitted to DNA ***293T cells were co-transfected with pLVTHM-B7x and two packaging plasmids psPAX2 and pMD2G to produce lentivirus which express B7x *** mRNA expression levels of B7x gene and virus titer were detected by real-time PCR in HEK293T *** B7x protein levels were detected by Western blot analysis in HEK293T *** identification of restriction enzyme digestion and DNA sequencing confirmed that pLVTHM-B7x lentiviral-based vector was successfully *** fluorescence was observed in HEK293T packaging cells by means of an inverted fluorescence microscope and the virus titer measured was 2×108 TU/*** will establish the foundation for studing deeply the biological function of B7x to construct successfully B7x expression lentiviral-based vector.

关键词： B7x gene Lentivirus Overexpression

Laparoscopic retrosternal gastric pull-up for fistulized mediastinal mass

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World Journal of Gastrointestinal surgery 2017年第3期9卷 92-96页

作者： Benedetto Mungo Arianna Barbetta Anne O Lidor Miloslawa Stem Daniela Molena Division of thoracic surgery Department of Surgery Johns Hopkins University School of Medicine thoracic surgery Service Department of Surgery Memorial Sloan Kettering Cancer Center department of surgery Johns Hopkins University School of Medicine Baltimore

We describe the case of a patient successfully reconstructed with laparoscopic retrosternal gastric pull-up after esophagectomy for unresectable posterior mediastinal inflammatory myofibroblastic tumor, eroding into the esophagus and compressing the airways. A partial esophagectomy with esophagostomy was performed for treatment of esophageal pleural fistula and empyema, while the airways were managed with the placement of an endobronchial stent. Gastrointestinal reconstruction was performed using a laparoscopic approach to create a retrosternal tunnel for gastric conduit pull-up and cervical anastomosis. The patient was discharged uneventfully after 6 d, and has done very well at home with normal diet.

关键词： Esophageal surgery Minimally invasive surgery Esophageal fistula Laparoscopic retrosternal bypass Gastric conduit