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Taxonomic dependency and spatial heterogeneity in assembly mechanisms of bacteria across complex coastal waters

Ecological Processes 2024年第1期13卷 80-97页

作者： Huizhen Yan Dandan Lin Gaoke Gu Yujie Huang Xuya Hu Zhenhao Yu Dandi Hou Demin Zhang Barbara J.Campbell Kai Wang State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and safety of Agro-products School of Marine SciencesNingbo University Key Laboratory of Marine Biotechnology of Zhejiang Province School of Marine Sciences Ningbo University department of biological Sciences Clemson University

Background Understanding community assembly mechanisms across taxa and space is fundamental for microbial ecology. However, the variability and determinants of assembly processes over taxa and space remain unclear. Here, we investigated taxonomic dependency and spatial heterogeneity in bacterial assembly mechanisms across coastal waters in the East China Sea using neutral and null models with customized visualization *** Overall, bacterial assembly mechanisms varied across broad taxonomic groups(phyla and proteobacterial classes) and space at the regional scale. A determinism–stochasticity balanced mechanism governed total bacterial assembly, while taxonomic dependency existed in assembly mechanisms and ecological processes. Among community ecological features, niche breadth and negative-to-positive cohesion ratio were strongly associated with the determinism-to-stochasticity ratio of bacterial groups. Bacterial assembly mechanisms commonly exhibited spatial heterogeneity, the extent and determinants of which varied across taxonomic groups. Spatial assembly of total bacteria was directly driven by many environmental factors and potential interactions between taxa, but not directly by geographic factors. Overall, the bacterial groups with higher spatial heterogeneity in assembly mechanisms were more related to environmental and/or geographic factors(except Bacteroidetes), while those with lower heterogeneity were more related to ecological *** Our results confirm the pervasiveness of taxonomic dependency and spatial heterogeneity in bacterial assembly, providing a finer understanding about regulation across complex coastal waters.

关键词： Bacterioplankton Assembly mechanism Niche breadth Null model Environmental gradient Biogeography

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MicroRNAs in thyroid cancer with focus on medullary thyroid carcinoma:potential therapeutic targets and diagnostic/prognostic markers and web based tools

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Oncology research 2024年第6期32卷 1011-1019页

作者： ELHAM SHAKIBA SETI BOROOMAND SIMA KHERADMAND KIA MEHDI HEDAYATI department of Biochemistry Faculty of Biological SciencesNorth Tehran BranchIslamic Azad UniversityTehran***Iran department of Pathology and Laboratory Medicine Vancouver General HospitalVancouverV5Z 1M9Canada department of blood Cell research Laboratory for Red Blood Cell DiagnosticsSanquinAmsterdam1006 ANThe Netherlands Cellular and Molecular Endocrine research Center Research Institute for Endocrine SciencesShahid Beheshti University of Medical SciencesTehran***Iran

This review aimed to describe the inculpation of microRNAs(miRNAs)in thyroid cancer(TC)and its subtypes,mainly medullary thyroid carcinoma(MTC),and to outline web-based tools and databases for bioinformatics analysis of miRNAs in ***,the capacity of miRNAs to serve as therapeutic targets and biomarkers in TC management will be *** review is based on a literature search of relevant articles on the role of miRNAs in TC and its subtypes,mainly ***,web-based tools and databases for bioinformatics analysis of miRNAs in TC were identified and *** can perform as oncomiRs or antioncoges,relying on the target mRNAs they *** replacement therapy using miRNA mimics or antimiRs that aim to suppress the function of certain miRNAs can be applied to correct miRNAs aberrantly expressed in diseases,particularly in *** are involved in the modulation of fundamental pathways related to cancer,resembling cell cycle checkpoints and DNA repair *** are also rather stable and can reliably be detected in different types of biological materials,rendering them favorable diagnosis and prognosis biomarkers as *** have emerged as promising tools for evaluating medical outcomes in TC and as possible therapeutic *** contribution of miRNAs in thyroid cancer,particularly MTC,is an active area of research,and the utility of web applications and databases for the biological data analysis of miRNAs in TC is becoming increasingly important.

关键词： Thyroid cancer MicroRNAs Biomarker Bioinformatics analysis Medullary thyroid carcinoma(MTC) OncomiRs Antioncoges

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New food sources and production systems:a comparison of international regulations and China’s advancements in novel foods with synthetic biology

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Food Science and Human Wellness 2024年第5期13卷 2519-2542页

作者： Xin Liu Di Wu Yi Shao Yongning Wu Key Laboratory for Deep Processing of Major Grain and Oil(The Chinese Ministry of Education) College of Food Science and EngineeringWuhan Polytechnic UniversityWuhan 430023China Institute for Global Food Security School of Biological SciencesBelfast B795DLUnited Kingdom NHC Key Laboratory of Food safety Risk Assessment China National Center for Food Safety Risk AssessmentBeijing 100021China department of Nutrition and Food safety Peking Union Medical CollegeResearch Unit of Food SafetyChinese Academy of Medical SciencesBeijing 100021China

The global shift towards sustainable food systems has sparked innovations in food sources and production systems,including cell-based meat,plant-based food products,precision fermentation,and 3D food *** advancements pose regulatory challenges and opportunities,with China emerging as a critical player in adopting and regulating new food *** review explores the international landscape of new food sources and production systems(NFPS),focusing on China’s role and regulatory approaches compared to global *** this comparative analysis,we aim to contribute to the ongoing dialogue on food safety regulation,offering insights and recommendations for policymakers,industry stakeholders,and researchers engaged in the global food system’s *** comprehensive overview underscores the dynamic nature of regulatory frameworks governing NFPS,highlighting the international efforts to ensure food safety,consumer protection,and the sustainable evolution of the food industry.

关键词： New food sources Food production system Food safety International regulation Synthetic biology China

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An efficient approach for the treatment of radioactive waste perfluoropolyether lubricants via a synergistic effect of thermal catalysis and immobilization

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Journal of Environmental Sciences 2024年第2期136卷 512-522页

作者： Xinhang Du Wenhua Tong Xinyu Zhou Jia Luo Yuqiu Liu Yabo Wang Panyu Li Yongkui Zhang department of Pharmaceutical&biological Engineering School of Chemical EngineeringSichuan UniversityChengdu 610065China

Perfluoropolyether(PFPE)lubricants are a kind of high-molecular polymer with many excellent ***,the use of PFPEs in the nuclear industry can lead to partial decomposition and carrying radionuclides,resulting in a large amount of radioactive waste PFPE lubricants ***,radioactive waste PFPE lubricants are difficult to be effectively treated due to their high stability,the risk of possible leakage of radionuclides,and hypertoxic fluorine-containing *** this study,without any precedent,a strategy of Mn O_(2)-catalyzed decomposition and Na_(2)CO_(3)-immobilized conversion was proposed for PFPE lubricant decomposition and fluorine immobilization simultaneously based on the Lewis acid-base and oxygen vacancies concept.A high fluorine conversion efficiency of 95.4%was ***,the mechanism of decomposition suggested that Mn O_(2)mainly provided Lewis acid sites and attacked the(basic)fluorine or oxygen atoms in PFPE *** decomposition of PFPE chains was proceed down and volatile fluorine-containing gas was released by partial electron transfer,intramolecular disproportionation reaction,and unzipping ***,gas by-products could be further oxidized and then immobilized into fluoride salts by carbonate solid ***,this study provides a simple,safe,and potentially practical strategy for the harmless conversion of refractory fluorinated organic wastes,especially perfluoropolymers.

关键词： Perfluoropolyether lubricants Catalyzed decomposition Fluorine-containing gas Immobilized conversion Fluoride

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Antibiotic ciprofloxacin removal from aqueous solutions by electrochemically activated persulfate process:Optimization,degradation pathways,and toxicology assessment

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Journal of Environmental Sciences 2024年第9期143卷 85-98页

作者： Elif Yakamercan Ahmet Aygün Halis Simsek Environmental Engineering department Bursa Technical UniversityBursaTurkey Agricultural and biological Engineering department Purdue UniversityWest LafayetteINUSA

Ciprofloxacin(CIP)is a commonly used antibiotic in the fluoroquinolone group and is widely used in medical and veterinary medicine disciplines to treat bacterial *** CIP is discharged into the sewage system,it cannot be removed by a conventional wastewater treatment plant because of its recalcitrant *** this study,boron-doped diamond anode and persulfate were used to degrade CIP in an aquatic solution by creating an electrochemically activated persulfate(EAP)*** added to the system as a coactivator and the process was called EAP+*** effects of independent variables,including pH,Fe^(2+),persulfate concentration,and electrolysis time on the systemwere optimized using the response surface *** results showed that the EAP+Fe process removed 94%of CIP under the following optimum conditions:A pH of 3,persulfate/Fe^(2+)concentration of 0.4 mmol/L,initial CIP concentration 30 mg/L,and electrolysis time of 12.64 *** removal efficiency was increased from 65.10%to 94.35%by adding Fe^(2+)as a transition *** degradation products,7 pathways,and 78 intermediates of CIP were studied,and three of those intermediates(m/z 298,498,and 505)were *** toxicological analysis based on toxicity estimation software results indicated that some degradation products of CIP were toxic to targeted animals,including fathead minnow,Daphnia magna,Tetrahymena pyriformis,and *** optimumoperation costswere similar in EAP and EAP+Fe processes,approximately 0.54€/m^(3).

关键词： Ciprofloxacin Response surface methodology Electrochemically activated persulfate Electrooxidation

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Expression and characterization of a novel GH128 laminarinase OUC-BsLam26 harboring both hydrolyzing and transferring activities

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Food Science and Human Wellness 2024年

作者： Yueyang Dong Yongyi Quan Hong Jiang Hamed I.Hamouda Zewei Lu Yimiao Chen Chengqiang Li Xiangzhao Mao State Key Laboratory of Marine Food Processing and safety Control， College of Food Science and Engineering， Ocean University of China Qingdao Key Laboratory of Food Biotechnology Sanya Ocean research Institute， Ocean University of China Processes Design and Development department， Egyptian Petroleum research Institute Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology Key Laboratory of biological Processing of Aquatic products，China National Light Industry

Laminarin oligosaccharides (LOSs) with a specific degree of polymerization prepared through the laminarin degradation via laminarinase present more significant nutritional functions and application values. Human intestinal bacteria are promising potential producers of novel carbohydrate-active enzymes with unique properties. Here， a novel glycoside hydrolase family 128 (GH128) laminarinase OUC-BsLam26 from the intestinal bacterium Bacteroides sp. CBA7301 was heterologously expressed and characterized. The recombinant OUC-BsLam26 with a molecular mass of 49.86 kDa exhibits highest activity (6.60 U/mg) at 45 ℃ and pH 6.0， which shows noticeable temperature and pH stability. The purified OUC-BsLam26 could degrade laminarin via an endo-type mode with the generation of laminaripentaose， laminaritetraose， laminaritriose， and laminaribiose， among them， laminaritetraose is the principal product， which accounts for 45.25% of the total products， which is significantly different from the reported GH128 laminarinases. The minimum recognition substrate of OUC-BsLam26 is laminarihexaose. Furthermore， OUC-BsLam26 also could catalyze the transglycosylation process with the production of some novel glycosides. Altogether， the intestinal bacterium Bacteroides sp. CBA7301 contains laminarinase with unique product composition and OUC-BsLam26 is a hopeful bio-catalyst with the potential to produce laminaritetraose and some novel glycosides.

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Rosmarinic acid improves tracheal smooth muscle responsiveness and lung pathological changes in ovalbumin-sensitized rats

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Asian Pacific Journal of Tropical Biomedicine 2024年第3期14卷 100-105页

作者： Vahideh Abbasnia Mohsen Foadoddini Delaram Eslimi Esfahani Mohammad Reza Khazdair Shahrbanoo Oryan department of Biology Payame Noor UniversityTehranIran Cardiovascular Diseases research Center Birjand University of Medical SciencesBirjandIran department of Animal Sciences Faculty of Biological SciencesKharazmi UniversityTehranIran

Objective:To evaluate the effect of rosmarinic acid on tracheal smooth muscle responsiveness and lung pathological changes in ovalbumin-sensitized ***:Rats were randomly divided into six groups:the control group,the asthmatic group,and the asthmatic groups treated with dexamethasone(1 mg/kg;oral gavage)or three doses of rosmarinic acid(0.5,1,and 2 mg/kg;oral gavage).For induction of asthma,rats received intraperitoneal injections and inhalation of *** 21 days,bronchoalveolar lavage fluid and lung samples were collected for histopathological ***,total and differential white blood cell counts were ***:The rosmarinic acid-treated group had significantly lower tracheal smooth muscle responses to methacholine than the asthmatic *** addition,rosmarinic acid reduced white blood cell count and the percentages of eosinophils,monocytes,and neutrophils while increasing the percentage of ***-induced lung pathological changes were significantly improved by treatment with rosmarinic ***:Rosmarinic acid improves tracheal smooth muscle responsiveness and lung pathological changes in ovalbumin-sensitized rats.

关键词： Rosmarinic acid Asthma Ovalbumin Tracheal responsiveness Inflammation White blood cell

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Tremella polysaccharide mitigates high fat diet-induced anxiety-like behavior through the microbiota-gut-brain axis

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Food Science and Human Wellness 2024年

作者： Haicui Wu Shuyu Chen Wenxiu Zhang Yuqing Lu Jiayi Zheng Jinhui Chang Jiachi Chiou research Institute for Future Food， The Hong Kong Polytechnic University Shenzhen Key Lab for Food biological safety Control， The Hong Kong Polytechnic University Shenzhen research Institute Bo InnoHealth Biotechnology Company Limited， Hong Kong Science Park department of Food Science and Nutrition， The Hong Kong Polytechnic University department of Neurology， The Second Affiliated Hospital of Guangzhou University of Chinese Medicine

High-fat diet (HFD) consumption induces gut microbiota dysbiosis and neuropsychiatric disorders， including anxiety. Previous research found that Tremella polysaccharide (TP) exhibited neuroprotective effects in vitro and in vivo. This study aimed to investigate the beneficial effects of TP on HFD-induced anxiety-like behaviors and elucidate the underlying mechanisms from the point view of the microbiota-gut-brain axis. Two groups of HFD-induced obese mice were orally gavaged with low dose (TPL， 40 mg/kg) and high dose (TPH， 400 mg/kg) of TP. A 12-week administration of TPH could significantly improve anxiety-like behaviors in HFD mice. In the hippocampus， microglia activation， the expression of blood-brain barrier (BBB) markers， and the levels of two neurotransmitters (serotonin and norepinephrine) were countered by TPH in mice consuming HFD. Furthermore， TPH improved the intestinal permeability and immune response of the enterocytes in HFD-fed mice. The gut microbiota dysbiosis induced by HFD was also rebalanced by TP treatments， especially in Proteobacteria and its lower taxa. The correlational analysis also suggested that shifts of some microbial genera were closely associated with body weight and the parameters of behavioral tests. Interestingly， fecal microbiota transplantation (FMT) results indicated that fecal microbiota from TPH-treated obese mice could prevent HFD-induced anxiety-like behaviors， suppressing microglia activation and intestinal permeability. In conclusion， the present study indicated that TP intake is a promising dietary intervention strategy to prevent HFD-induced anxiety via the microbiota-gut-brain axis.

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Pyrazine-fused polycyclic aromatic hydrocarbons towards efficient multiple-resonance narrowband deep-blue emission

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Science China Chemistry 2024年

作者： Yajie Wang Wei Yang He Zhang Nengquan Li Shaolong Gong Xiang Gao Chuluo Yang department of Chemistry Renmin Hospital of Wuhan University Wuhan University Shenzhen Key Laboratory of New Information Display and Storage Materials College of Materials Science and EngineeringShenzhen University College of biological and Pharmaceutical Science Hubei Key Laboratory of Natural Products Research and DevelopmentChina Three Gorges University department of Pharmacy Renmin Hospital of Wuhan University

Developing organic multiple-resonance(MR) deep-blue emitters with narrow full widths at half maximum(FWHMs) is crucial for enhancing the color purity of organic light-emitting diodes(OLEDs). However, the exploration of new MR cores remains very limited to date. Furthermore, redshifting the emission color of MR emitters is also a formidable challenge. Pyrazine,characterized by its planar and rigid structure, exhibits a strong electronegativity, which may make it a promising candidate for constructing MR emitters with a red shifted emission compared to indolo[3,2,1-jk]carbazole(ICz)-based MR molecules. Herein,a series of polycyclic aromatic hydrocarbons(PAHs) with MR characteristics are designed and synthesized by integrating a pyrazine core with various electron-donating segments, which exhibit the narrowband deep-blue emission peaks ranging from423 to 459 nm with FWHMs < 50 nm in toluene. It is demonstrated that increasing donor strength and changing meta-to paraoriented nitrogen atom can induce the bathochromic emission. Theoretical investigations reveal that the non-bonding orbital characteristic of pyrazine suppress the undesired stretching vibration and promote resonance effect. The optimized deep-blue OLEDs fabricated with the pyrazine-embedded MR emitters demonstrate a high external quantum efficiency(EQE) of 23.5%,and narrowband emission with an electroluminescence peak at 454 nm.

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Double-side role of short chain fatty acids on host health via the gut-organ axes

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Animal Nutrition 2024年第3期18卷 322-339页

作者： Yanan Gao Qianqian Yao Lu Meng Jiaqi Wang Nan Zheng Key Laboratory of Quality&safety Control for Milk and Dairy products of Ministry of Agriculture and Rural Affairs Institute of Animal SciencesChinese Academy of Agricultural SciencesBeijing 100193China Milk and Milk products Inspection Center of Ministry of Agriculture and Rural Affairs Institute of Animal SciencesChinese Academy of Agricultural SciencesBeijing 100193China State Key Laboratory of Animal Nutrition Institute of Animal SciencesChinese Academy of Agricultural SciencesBeijing 100193China department of Food Science Faculty of Veterinary MedicineUniversity of LiègeLiège 4000Belgium

Short chain fatty acids(SCFA)exist in dietary foods and are produced by the fermentation of gut microbiota,and are considered an important element for regulating host *** blood circulation,SCFA produced in the gut and obtained from foods have an impact on the intestinal health as well as vital organs of the *** has been recognized that the gut is the“vital organ”in the *** the gut microbial metabolites,SCFA could create an“axis”connecting the gut and to other ***,the“gut-organ axes”have become a focus of research in recent years to analyze organism *** this review,we summarized the sources,absorption properties,and the function of SCFA in both gut and other peripheral tissues(brain,kidney,liver,lung,bone and cardiovascular)in the way of“gut-organ axes”.Short chain fatty acids exert both beneficial and pathological role in gut and other organs in various ways,in which the beneficial effects are more *** addition,the beneficial effects are reflected in both preventive and therapeutic *** importantly,the mechanisms behinds the gut and other tissues provided insight into the function of SCFA,assisting in the development of novel preventive and therapeutic strategies for maintaining the host health.

关键词： Short chain fatty acid Intestinal barrier Gut-organ axis Host health Beneficial effect Pathological effect

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