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Development and Validation of a Carbohydrate Metabolism-Related Model for Predicting Prognosis and Immune Landscape in Hepatocellular Carcinoma Patients

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Current Medical Science 2024年第4期44卷 771-788页

作者： Hong-xiang HUANG Pei-yuan ZHONG Ping LI Su-juan PENG Xin-jing DING Xiang-lian CAI Jin-hong CHEN Xie ZHUI Zhi-hui LUI Xing-yu TAO Yang-yang LIU Li CHEN department of Oncology The First Affiliated Hospital of Nanchang UniversityNanchang330006China Jiangxi Institute of respiratory Disease The First Affiliated Hospital of Nanchang UniversityNanchang330006China department of Oncology Jiangxi Provincial People’s HospitalThe First Affiliated Hospital of Nanchang Medical CollegeNanchang330006China department of respiratory and Critical Care medicine The First Affiliated Hospital of Nanchang UniversityNanchang330006China

Objective The activities and products of carbohydrate metabolism are involved in key processes of ***,its relationship with hepatocellular carcinoma(HCC)is *** The cancer genome atlas(TCGA)-HCC and ICGC-LIRI-JP datasets were acquired via public *** expressed genes(DEGs)between HCC and control samples in the TCGA-HCC dataset were identified and overlapped with 355 carbohydrate metabolism-related genes(CRGs)to obtain differentially expressed CRGs(DE-CRGs).Then,univariate Cox and least absolute shrinkage and selection operator(LASSO)analyses were applied to identify risk model genes,and HCC samples were divided into high/low-risk groups according to the median risk ***,gene set enrichment analysis(GSEA)was performed on the risk model *** sensitivity of the risk model to immunotherapy and chemotherapy was also *** A total of 8 risk model genes,namely,G6PD,PFKFB4,ACAT1,ALDH2,ACYP1,OGDHL,ACADS,and TKTL1,were ***,the risk score,cancer status,age,and pathologic T stage were strongly associated with the prognosis of HCC *** the stromal score and immune score had significant negative/positive correlations with the risk score,reflecting the important role of the risk model in immunotherapy ***,the stromal and immune scores had significant negative/positive correlations with risk scores,reflecting the important role of the risk model in immunotherapy ***,we found that high-/low-risk patients were more sensitive to 102 drugs,suggesting that the risk model exhibited sensitivity to chemotherapy *** results of the experiments in HCC tissue samples validated the expression of the risk model *** Through bioinformatic analysis,we constructed a carbohydrate metabolism-related risk model for HCC,contributing to the prognosis prediction and treatment of HCC patients.

关键词： hepatocellular carcinoma carbohydrate metabolism the cancer genome atlas bioinformatics

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Sex-biased single-cell genetic landscape in mice with autism spectrum disorder

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Journal of Genetics and Genomics 2024年第3期51卷 338-351页

作者： Qian Zhang Yongjie Wang Jie Tao Ruixue Xia Yijie Zhang Zhirui Liu Jiwei Cheng department of Neurology and Central Laboratory Putuo HospitalShanghai University of Traditional Chinese MedicineShanghai 200062China School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang 311121China department of respiratory and Critical Care medicine Henan University Huaihe HospitalKaifengHenan 475099China

Autistic spectrum disorder(ASD)is a male-biased,heterogeneous neurodevelopmental disorder that affects approximately 1%e2%of the *** exposure to valproic acid(VPA)is a recognized risk factor for ASD,but the cellular and molecular basis of VPA-induced ASD at the single-cell resolution is ***,we aim to compare the cellular and molecular differences in the hippocampus between male and female prenatal mice with ASD at the single-cell transcriptomic *** transcriptomes of more than 45,000 cells are assigned to 12 major cell types,including neurons,glial cells,vascular cells,and immune *** type-specific genes with altered expression after prenatal VPA exposure are analyzed,and the largest number of differentially expressed genes(DEGs)are found in neurons,choroid plexus epithelial cells,and *** microglia,several pathways related to inflammation are found in both males and females,including the tumor necrosis factor(TNF),nuclear factor kappa B(NF-kB),toll-like receptor(TLR),and mitogen-activated protein kinase(MAPK)signaling pathways,which are important for the induction of autistic-like ***,we note that several X-linked genes,including Bex1,Bex3,and Gria3,were among the male-specific DEGs of *** pioneering study describes the landscape of the transcriptome in the hippocampus of autistic *** elucidation of sexual differences could provide innovative strategies for the prevention and treatment of ASD.

关键词： Autistic spectrum disorder(ASD) Sex Single cell Neurons Microglia

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Clinical evolution of antisynthetase syndrome-associated interstitial lung disease after COVID-19 in a man with Klinefelter syndrome:A case report

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World Journal of Clinical Cases 2024年第6期12卷 1144-1149页

作者： Xiang-Xiang Wu Jian Cui Shi-Yao Wang Tian-Tian Zhao Ya-Fei Yuan Long Yang Wei Zuo Wen-Jian Liao department of respiratory and Critical Care The First Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina China-Japan Friendship Jiangxi hospital Nanchang 330006Jiangxi ProvinceChina department of Pulmonary and Critical Care medicine Center of Respiratory MedicineChina-Japan Friendship HospitalBeijing 100029China

BACKGROUND This study presents a case of rapidly developing respiratory failure due to antisynthetase syndrome(AS)following coronavirus disease 2019(COVID-19)in a 33-year-old man diagnosed with Klinefelter syndrome(KS).CASE SUMMARY A 33-year-old man with a diagnosis of KS was admitted to the department of Pulmonary and Critical Care medicine of a tertiary hospital in China for fever and shortness of breath 2 wk after the onset of *** tomography of both lungs revealed diffuse multiple patchy heightened shadows in both lungs,accompanied by signs of partial bronchial *** next-generation sequencing of the bronchoalveolar lavage fluid suggested absence of pathogen.A biopsy specimen revealed organizing pneumonia with alveolar septal ***,extensive auto-antibody tests showed strong positivity for anti-SSA,anti-SSB,anti-Jo-1,and *** multidisciplinary discussions,the patient received a final diagnosis of AS,leading to rapidly progressing respiratory *** This study underscores the clinical progression of AS-associated interstitial lung disease subsequent to viral infections such as COVID-19 in patients diagnosed with KS.

关键词： Antisynthetase syndrome COVID-19 Klinefelter syndrome Interstitial lung disease Anti-Jo-1 Case report

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Therapeutic potentials of peptide-derived nanoformulations in atherosclerosis:present status and future directions

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International Journal of Smart and Nano Materials 2024年第3期15卷 610-651页

作者： Xue Liu Weijiao Wang Qiang Li Hongtao Niu Weili Zhang department of Cardiovascular medicine Yantaishan HospitalYantaiChina department of Otolaryngology Yantaishan HospitalYantaiChina department of Geriatric medicine Yantaishan HospitalYantaiChina

Atherosclerosis is a severe cardiovascular disease followed by the accumulation of atherosclerotic plaques within the lumen of blood vessels resulting in reduced blood flow thus initiating a series of *** therapies for atherosclerosis encounter multiple chal-lenges,especially difficulty in precisely concentrating in certain affected regions and the potential for unwanted side ***,scientists are focused on developing nanoformulations for atherosclerosis diagnosis and ***-based nanomedi-cines improve conventional therapies by offering improved structural and therapeutic stability and enabling target-specific *** inherent biocompatibility and biodegradability additionally render them desirable materials intended for in vivo *** review manu-script aims to provide an in-depth overview of peptide-based nano-medicines for atherosclerosis,focusing on targeted cells like endothelial cells,macrophages,and monocytes and their interaction with different plaque ***,the manuscript also highlights the latest progress in multimodal techniques and provides a comprehensive overview of limitations associated with their practical implementation.

关键词： Atherosclerosis anti-atherosclerotic drugs bioavailability peptide-based nanomedicines drug targeting

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Current Mycoplasma pneumoniae epidemic among children in Shanghai:unusual pneumonia caused by usual pathogen

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World Journal of Pediatrics 2024年第1期20卷 5-10页

作者： Xiao-Bo Zhang Wen He Yong-Hao Gui Quan Lu Yong Yin Jian-Hua Zhang Xiao-Yan Dong Ying-Wen Wang Ying-Zi Ye Hong Xu Jia-Yu Wang Bing Shen Dan-Ping Gu Li-Bo Wang Yi Wang department of respiratory medicine Children's Hospital of Fudan University399 Wanyuan RoadShanghai 201102China State Key Laboratory of Genetic Engineering at School of Life Sciences Institute of Reproduction&DevelopmentChildren's Hospital of Fudan UniversityShanghaiChina department of respiratory medicine Children's Hospital of Shanghai Jiao Tong UniversityShanghaiChina department of respiratory medicine Shanghai Children's Medical CenterAffiliated to Shanghai Jiaotong University School of MedicineShanghaiChina department of Pediatric respiratory Xinhua HospitalAffiliated to Shanghai Jiaotong University School of MedicineShanghaiChina department of Nursing Children's Hospital of Fudan UniversityShanghaiChina department of Infectious Diseases Children's Hospital of Fudan UniversityShanghaiChina department of Nephrology Children's Hospital of Fudan UniversityShanghaiChina NHC Key Laboratory of Neonatal Diseases Children's Hospital of Fudan UniversityShanghaiChina Shanghai Shenkang hospital Development Center ShanghaiChina Center for Medical Quality Control Management of Shanghai ShanghaiChina department of Neurology Children's Hospital of Fudan University399Wanyuan RoadShanghai 201102China

Mycoplasma pneumoniae(***),primarily transmitted through respiratory droplets when infected individuals cough or sneeze,is a common cause of communityacquired pneumonia,especially among school-age children and *** infection occurs endemically with an epidemic peak every few *** worldwide incidence confirmed by direct test methods was reported to be 8.61%between 2017 and 2020 across all age groups[1].

关键词： pneumonia epidemic respiratory

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Effect of early stepwise cardiopulmonary rehabilitation on function and quality of life in sepsis patients

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World Journal of Clinical Cases 2024年第4期12卷 729-736页

作者： Ming-Hui Zheng Wen-Jun Liu Juan Yang Division of Cardiovascular First Ward departments of Internal medicine Liyuan HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430077Hubei ProvinceChina department of respiratory medicine PuRen Hospital Affiliated to Wuhan University of Science and Technology/Respiratory MedicineWuhan 430000Hubei ProvinceChina department of Cardiology Huanggang Central HospitalHuanggang 438000Hubei ProvinceChina

BACKGROUND Sepsis,as a non-limiting host infection disease,can be accompanied by serious complications such as organ failure,which seriously threatens patient quality of *** To investigate the effect of early stepwise cardiopulmonary rehabilitation on cardiopulmonary function and quality of life in patients evacuated from mechanical ventilation with *** A total of 80 patients with sepsis who were hospitalized in our hospital from January 2021 to January 2022 were selected and divided into the observation group(n=40)and the control group(n=40)according to the random number table *** observation group was treated with early stepwise cardiopulmonary rehabilitation,and the control group was treated with a conventional treatment *** function indexes(central venous pressure,cardiac troponin I,B-type brain natriuretic peptide),lung function indicators(diaphragmatic mobility,changes in central venous oxygen saturation,oxygenation index),and quality of life(Quality of Life Evaluation Scale)were compared between the two groups after *** After treatment,the central venous pressure,diaphragm mobility,central venous oxygen saturation,oxygenation index,and Quality of Life Evaluation Scale scores in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The observation group was less than that of the control group for other parameters,and the differences were statistically significant(P<0.05).CONCLUSION Early stepwise cardiopulmonary rehabilitation can effectively enhance cardiac and pulmonary function and improve the quality of life in patients evacuated from mechanical ventilation with sepsis.

关键词： Stepwise cardiopulmonary rehabilitation Sepsis Evacuation of mechanical ventilation Cardiopulmonary function Quality of life

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Pulmonary alveolar proteinosis induced by X-linked agammaglobulinemia:A case report

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World Journal of Clinical Cases 2024年第9期12卷 1644-1648页

作者： Ting Zhang Ming Li Li Tan Xin Li department of respiratory medicine Kunming Children´s HospitalKunming 650228Yunnan ProvinceChina department of Emergency Kunming Children's HospitalKunming 650228Yunnan ProvinceChina

BACKGROUND Pulmonary alveolar proteinosis(PAP)and X-linked agammaglobulinemia(XLA)are rare diseases in *** theories infer that immunodeficiency can induce PAP,but these reports are almost all review articles,and there is little clinical *** report the case of a child with both PAP and *** SUMMARY A 4-month-old boy sought medical treatment due to coughing and difficulty in breathing for>2 *** had been hospitalized multiple times due to respiratory infections and *** computed tomography and alveolar lavage fluid showed typical PAP-related *** testing confirmed that the boy also had *** total lung alveolar lavage and intravenous immunoglobulin replacement therapy,the boy recovered and was *** the follow-up period,the number of respiratory infections was significantly reduced,and PAP did not *** XLA can induce PAP and improving immune function contributes to the prognosis of children with this type of PAP.

关键词： Pulmonary alveolar proteinosis X-linked agammaglobulinemia Children Immunodeficiency Alveolar lavage Case report

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Cardiac infiltration of diffuse large B-cell lymphoma manifesting as sustained ventricular tachycardia:a case report

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Journal of Geriatric Cardiology 2024年第2期21卷 242-245页

作者： Wei CHEN Kun HUANG Wei-Wei GUO Fan ZHOU De-Ning LIAO department of Cardiology Shanghai Jingan District Zhabei Central HospitalShanghaiChina department of Cardiology Shanghai Changzheng HospitalShanghaiChina department of Hematology Shanghai Jingan District Zhabei Central HospitalShanghaiChina

Cardiac tumors are ***,cardiac metastases can occur in up to 10%of patients with *** cardiac neoplasms,metastases are much more common than primary cardiac tumors.[1]Metastatic cardiac neoplasms most frequently metast... 详细信息

关键词： neoplasms sustained cardiac

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评价散寒化湿颗粒与奈玛特韦-利托那韦对照治疗轻型/中型新型冠状病毒感染有效性和安全性的随机、开放、多中心临床研究

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Science Bulletin 2024年第12期69卷 1954-1963页

作者：邹晓辉常康范国辉郑欢伟神和正唐亮杨映映王业明赵林华吕红周昕沈小明陈利强仝小林曹彬 National Center for respiratory medicine State Key Laboratory of Respiratory Health and MultimorbidityNational Clinical Research Center for Respiratory DiseasesInstitute of Respiratory MedicineChinese Academy of Medical SciencesLaboratory of Clinical Microbiology and Infectious DiseasesDepartment of Pulmonary and Critical Care MedicineCenter of Respiratory MedicineChina-Japan Friendship HospitalBeijing 100029China National Center for respiratory medicine State Key Laboratory of Respiratory Health and MultimorbidityNational Clinical Research Center for Respiratory DiseasesInstitute of Respiratory MedicineChinese Academy of Medical SciencesDepartment of Clinical Research and Data Management Center of Respiratory MedicineCenter of Respiratory MedicineChina-Japan Friendship HospitalBeijing 100029China Shijiazhuang hospital of Traditional Chinese medicine Shijiazhuang 050051China Linyi Traditional Chinese medicine hospital Linyi 276000China Wuxi Traditional Chinese medicine hospital Wuxi 214071China National Center for respiratory medicine State Key Laboratory of Respiratory Health and MultimorbidityNational Clinical Research Center for Respiratory DiseasesInstitute of Respiratory MedicineChinese Academy of Medical SciencesDepartment of Traditional Chinese Medicine for Pulmonary DiseasesCenter of Respiratory MedicineChina-Japan Friendship HospitalBeijing 100029China Institute of Metabolic Diseases Guang’anmen Hospital of ChinaAcademy of Chinese Medical SciencesBeijing 100053China Taicang Traditional Chinese medicine hospital Taicang 215400China The First hospital of Qiqihar Qiqihar 161005China The Second Affiliated hospital of Jiaxing University Jiaxing 314000China Huizhou First hospital Huizhou 516003China National Center for Integrated Traditional Chinese medicine and Western medicine China-Japan Friendship HospitalBeijing 100029China

Sanhan Huashi granules(SHG)demonstrated therapeutic effects against coronavirus disease 2019(COVID-19)in observational *** order to compare the effectiveness and safety of SHG and nirmatrelvir–ritonavir in treating adults with mild-to-moderate COVID-19,we conducted a randomized,activecontrolled,open-label,multi-center trial conducted between February and July in *** patients were randomized in a 1:1 ratio to the SHG group and the nirmatrelvir–ritonavir group.A total of 400participants were randomized,among which 200 participants ultimately received SHG and 198 received nirmatrelvir–*** primary outcome was time to sustained clinical recovery through day *** significantly shortened the median time to sustained clinical recovery compared to nirmatrelvir–ritonavir(6.0(95%CI,5.0 to 6.0)vs.8.0(95%CI,6.0 to 9.0)d;P=0.001),particularly for individual symptoms including fever,sore throat,cough and *** participants in either group died and incidence of severe COVID-19 showed no difference between two *** who received nirmatrelvir–ritonavir demonstrated a higher rate of virus clearance on day 5 compared to those received SHG(46.4%(95%CI,39.1 to 53.7)vs.65.6%(95%CI,58.3 to 72.4);P<0.001).Most adverse events were mild in both *** summary,SHG was superior to nirmatrelvir–ritonavir in shortening the time to sustained clinical recovery in participants with mild-to-moderate COVID-19,despite a lower virus clearance rate observed after 5 d of treatment(Chinese Clinical Trial Registry Identifier:Chi CTR2300067872).

关键词： Traditional Chinese medicine COVID-19 Nirmatrelvir-Ritonavir Sustained clinical recovery

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Overview of the immunological mechanisms in hepatitis B virus reactivation:Implications for disease progression and management strategies

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World Journal of Gastroenterology 2024年第10期30卷 1295-1312页

作者： Hui Ma Qing-Zhu Yan Jing-Ru Ma Dong-Fu Li Jun-Ling Yang department of Clinical Laboratory The Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina department of Ultrasound medicine The Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Digestive Diseases Center Department of Hepatopancreatobiliary MedicineThe Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina department of respiratory and Critical Care medicine The Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina

Hepatitis B virus(HBV)reactivation is a clinically significant challenge in disease *** review explores the immunological mechanisms underlying HBV reactivation,emphasizing disease progression and *** delves into host immune responses and reactivation’s delicate balance,spanning innate and adaptive *** factors’disruption of this balance,as are interac-tions between viral antigens,immune cells,cytokine networks,and immune checkpoint pathways,are ***,the roles of T cells,natural killer cells,and antigen-presenting cells are discussed,highlighting their influence on disease *** reactivation’s impact on disease severity,hepatic flares,liver fibrosis progression,and hepatocellular carcinoma is *** strategies,including anti-viral and immunomodulatory approaches,are critically *** role of prophylactic anti-viral therapy during immunosuppressive treatments is explored alongside novel immunotherapeutic interventions to restore immune control and prevent *** conclusion,this compre-hensive review furnishes a holistic view of the immunological mechanisms that propel HBV *** a dedicated focus on understanding its implic-ations for disease progression and the prospects of efficient management stra-tegies,this article contributes significantly to the knowledge *** more profound insights into the intricate interactions between viral elements and the immune system will inform evidence-based approaches,ultimately enhancing disease management and elevating patient *** dynamic landscape of management strategies is critically scrutinized,spanning anti-viral and immunomodulatory *** role of prophylactic anti-viral therapy in preventing reactivation during immunosuppressive treatments and the potential of innovative immunotherapeutic interventions to restore immune control and proactively deter reactivation.

关键词： Hepatitis B virus reactivation Immunological mechanisms Disease progression Management strategies Immune response

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