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In vitro and in vivo degradability,biocompatibility and antimicrobial characteristics of Cu added iron-manganese alloy

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Journal of Materials Science & technology 2021年第25期84卷 159-172页

作者： Santanu Mandal Vijay Kishore Madhuparna Bose Samit Kumar Nandi Mangal Ro department of Metallurgical and Materials Engineering Indian Institute of Technology-KharagpurKharagpur 721302India department of Veterinary Surgery&radiology West Bengal University of Animal&Fishery SciencesKolkata 700037India department of Biotechnology Indian Institute of TechnologyKharagpur 721302India

In recent years,iron(Fe)based degradable metal is explored as an alternative to permanent fracture fixation *** the present work,copper(Cu)is added in Fe-Mn system to enhance the degradation rate and antimicrobial ***-Mn-x Cu(x=0.9,5 and 10 wt.%)alloys are prepared by the meltingcasting-forging *** analysis confirms austenite phase stabilization due to the presence of Mn and *** predicted by Thermo-Calc calculations,Cu rich phase precipitations are noticed along the austenite grain *** behaviours of Cu added Fe-Mn alloys are investigated through static immersion and electrochemical polarization where enhanced degradation is found for higher Cu added *** challenged against *** bacteria,the Fe-Mn-Cu alloy media extract shows a significant bactericidal effect compare to the base *** vitro cytocompatibility studies,as determined using MG63 and MC3T3-E1 cell lines,indicate increased cell density as a function of time for all the *** implanted in rabbit femur,the newly developed alloy does not show any kind of tissue necrosis around the *** osteogenesis and higher new bone formation are observed with Fe-Mn-10 Cu alloy as evident from micro-computed tomography(μ-CT)and fluorochrome labelling.

关键词： Iron-manganese alloy Degradable metal In vitro Micro-CT

DFT Study on the Correlation between Thermodynamical Property and Molecular Structure of Polybromo-phenoxathiin

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Chinese Journal of Structural Chemistry 2010年第2期29卷 233-239页

作者：刘红艳易忠胜莫凌云 School of Chemical and Biological Engineering Guilin University of Technology Guangxi Key Laboratory of Environmental Engineering Protection and AssessmentGuilin Institute of Technology

Complete optimization was conducted for 136 polybromo-phenoxathiin congeners（PBPTs） on the B3LYP/6-31G＊ level with Gaussian 03 *** structural parameters and thermodynamical parameters of each molecule were obtained under the standard state of 298.15 K and 1.013×10^5 *** linear regression was employed to establish the quantitative structure-property correlation models between heat capacity at constant volume（CVθ）,entropy（Sθ）,standard heat of formation（△fHθ） and standard free energy of formation（△fGθ） of PBPTs and the structural parameters（the most negative atomic charge（q^-） and molecular average polarizability（α））.These models presented better correlations（r^2〉0.97）.And they were validated by variance inflation factor（VIF） and t-test,which can better explain the regularity of thermodynamical property of PBPTs,and has good stability and great prediction ability.

关键词： polybromo-phenoxathiin thermodynamical property structural parameter density functional theory(DFT)

An internal circulation iron-carbon micro-electrolysis reactor for aniline wastewater treatment:Parameter optimization,degradation pathways and mechanism

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Chinese Journal of Chemical Engineering 2023年第11期63卷 96-107页

作者： Yanhe Han Han Xu Lei Zhang Xuejiao Ma Yang Man Zhimin Su Jing Wang department of Environmental Engineering Beijing Institute of Petrochemical TechnologyBeijing 102617China SUEZ Environmental technology(Beijing)Company Limited Beijing 100026China Beijing Ecological Environment assessment and Complaint Center Beijing 100006China

Aniline is a vital industrial raw ***,highly-toxic aniline wastewater usually deteriorated effluent quality,posed a threat to human health and ecosystem ***,this study reported a novel internal circulation iron-carbon micro-electrolysis(ICE)reactor to treat aniline *** effects of reaction time,pH,aeration rate and iron-carbon(Fe/C)ratio on the removal rate of aniline and the chemical oxygen demand were investigated using single-factor *** process exhibited high aniline degradation performance of approximately 99.86% under optimal operating conditions(reaction time=20 min,pH=3,aeration rate=0.5 m3·h^(-1),and Fe/C=1:2).Based on the experimental results,the response surface method was applied to optimize the aniline removal *** Box–Behnken method was used to obtain the interaction effects of three main *** result showed that the reaction time had a dominant effect on the removal rate of *** highest aniline removal rate was obtained at pH of 2,aeration rate of 0.5 m^(3)·h^(-1)and reaction time of 30 *** optional experimental conditions,the aniline content of effluent was reduced to 3 mg·L^(-1)and the removal rate was as high as 98.24%,within the 95% confidence interval(97.84%-99.32%)of the predicted *** solution was treated and the reaction intermediates were identified by high-performance liquid chromatography,ultraviolet-visible spectroscopy,Fourier-transform infrared spectroscopy,gas chromatography-mass spectrometry,and ion *** main intermediates were phenol,benzoquinone,and carboxylic *** were used to propose the potential mechanism of aniline degradation in the ICE *** results obtained in this study provide optimized conditions for the treatment of industrial wastewater containing aniline and can strengthen the understanding of the degradation mechanism of iron-carbon micro-electrolysis.

关键词： Aniline Iron-carbon micro-electrolysis Circulating fluidized bed Waste water Degradation

Nonlinear profile order for three-dimensional hybrid radial acquisition applied to self-gated free-breathing cardiac cine MRI

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Chinese Physics B 2017年第1期26卷 568-573页

作者： Yanchun Zhu Pascal Spincemaille Jing Liu Shuo Li Thanh D Nguyen Martin R Prince Yaoqin Xie Yi Wang institute of Biomedical and Health Engineering Shenzhen Institute of Advanced Technology Chinese Academy of Sciences Shenzhen 518055 China department of radiology Weill Cornell Medical College New York 10021 United States

This paper presents a nonlinear profile order scheme for three-dimensional（3D） hybrid radial acquisition applied to self-gated, free-breathing cardiac cine magnetic resonance imaging（MRI）. In self-gated, free-breathing cardiac cine MRI,respiratory and cardiac motions are unpredictable during acquisition, especially for retrospective reconstruction. Therefore,the non-uniformity of the k-space distribution is an issue of great concern during retrospective self-gated reconstruction. A nonlinear profile order with varying azimuthal increments was provided and compared with the existing golden ratio-based profile order. Optimal parameter values for the nonlinear formula were chosen based on simulations. The two profile orders were compared in terms of the k-space distribution and phantom and human image results. An approximately uniform distribution was obtained based on the nonlinear profile order for persons with various heart rates and breathing *** nonlinear profile order provides more stable profile distributions and fewer streaking artifacts in phantom images. In a comparison of human cardiac cine images, the nonlinear profile order provided results comparable to those provided by the golden ratio-based profile order, and the images were suitable for diagnosis. In conclusion, the nonlinear profile order scheme was demonstrated to be insensitive to various motion patterns and more useful for retrospective reconstruction.

关键词： nonlinear profile order hybrid radial self-gating cardiac cine MRI

Biological evaluation of 2-methylpyrimidine derivatives as active pan Bcr-Abl inhibitors

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Science China Chemistry 2014年第6期57卷 823-832页

作者： ZOU DingBiao QIU YaTao TU ZhengChao LIAO ChenZhong LUO JinFeng MENG QingQing YAO RiSheng LI Zheng JIANG Sheng Laboratory of Medicinal Chemistry Guangzhou Institute of Biomedicine and HealthChinese Academy of Sciences School of Medical Engineering Hefei University of Technology department of radiology the Methodist Hospital Research Institute

We designed a series of 2-methylpyrimidine derivatives as new BCR-ABL inhibitors using scaffold-hopping *** synthetic compounds exhibited significant inhibition against a broad spectrum of Bcr-Abl mutants including the gatekeeper T315I *** 7u showed very potent kinase inhibitory activities against Bcr-Abl WT,Bcr-Abl E255K,Bcr-Abl Q252H,Bcr-Abl G250E and Bcr-Abl T315I,with IC50 values of 0.13 nM,0.17 nM,0.24 nM,0.19 nM and 0.65μM,*** compound also displayed anti-proliferation activity against K562 cell line with an IC50 value of 1.1 nM,thus representing a new lead for further optimization.

关键词： chronic myeloid leukemia(CML) anticancer agents Bcr-Abl imatinib resistance

Dietary carbohydrate intake and risk of type 2 diabetes:a 16-year prospective cohort study

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Science China Life Sciences 2025年

作者： Lu Gan Yi Yang Bin Zhao Kai Yu Kehua Guo Fang Fang Zhiguang Zhou Demetrius Albanes Jiaqi Huang Key Laboratory of Diabetes Immunology Ministry of Education and Department of Metabolism and Endocrinology The Second Xiangya Hospital of Central South University CSU-Sinocare Research Center for Nutrition and Metabolic Health Xiangya School of Public Health Central South UniversityFurong Laboratory Division of Cancer Epidemiology and Genetics National Cancer Institute NIH Department of Health and Human Services School of Computer Science and Engineering Central South University institute of Environmental Medicine Karolinska Institute National Clinical Research Center for Metabolic Diseases Key Laboratory of Diabetes Immunology Ministry of Education and Department of Metabolism and Endocrinology The Second Xiangya Hospital of Central South University

Despite considerable research underscoring the importance of carbohydrate intake in relation to the risk of type 2 diabetes(T2D), a comprehensive assessment of this relationship is currently lacking. We aimed to examine the associations of various types and food sources of dietary carbohydrate intake with the risk of T2D, to evaluate potential effect modification by other factors, including genetic susceptibility,and to explore the potential mediators for such associations. The present study included 161,872 participants of the UK Biobank who were free of prevalent cancer, cardiovascular disease, or diabetes, and had at least one validated 24-h dietary recall assessment. Multivariableadjusted age-stratified Cox proportional hazard regression models were applied to estimate hazard ratios(HRs) and 95% confidence intervals(CI) for the associations of various types and food sources of dietary carbohydrate intake with risk of T2D. During a median follow-up of13.6 years, 4,176 incident cases of T2D were identified. In the multivariable-adjusted models, a greater intake of fiber, carbohydrates from whole grains, and carbohydrates from non-starchy vegetables was significantly associated with a lower risk of T2D(highest vs. lowest quantile, HR [95% CI]=0.70 [0.62–0.79], 0.74 [0.67–0.82], and 0.83 [0.75–0.92], respectively, all P for trend <0.005). In contrast, a higher intake of starch and carbohydrate from starchy vegetables was associated with an increased risk of T2D(highest vs. lowest quantile, HR [95%CI]=1.31 [1.16–1.48] and 1.19 [1.09–1.31], respectively, both P for trend <0.005). Replacing one serving of refined grains or starchy vegetables with an equal amount of whole grains or non-starchy vegetables was associated with 4% to 10% lower risk of T2D(all P values <0.001).The observed associations were generally similar across population subgroups, including individuals with different genetic susceptibility to T2D. Mediation analyses of the inverse association between T

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Exploring the potential of artificial intelligence techniques in prediction of the removal efficiency of vortex tube silt ejector

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International Journal of Sediment Research 2023年第4期38卷 615-627页

作者： Sanjeev Kumar Chandra Shekhar Prasad Ojha Nand Kumar Tiwari Subodh Ranjan department of Civil Engineering Indian Institute of Technology department of Civil Engineering National Institute of Technology

A vortex tube silt ejector is a curative hydraulic structure used to remove sediment deposits from canals and is recognized as one of the most efficient substitutes for physically removing canal sediment. The spatially varied flow in the channel and the rotational flow behavior in the tube make the silt removal process complex. It is even harder to accurately predict the silt removal efficiency by traditional models accurately. However, artificial intelligence(AI) and machine learning approaches have emerged as robust substitutes for studying complex processes. Therefore, this research makes use of AI approaches; support vector machine(SVM), random forest(RF), random tree(RT), and multivariate adaptive regression spline(MARS) to compute the vortex tube silt ejection efficiency using the laboratory data sets. The outcomes of the artificial intelligence(AI)-based techniques also were compared with traditional models. It was found that the RT model(root mean square error, RMSE = 2.165, Nash Sutcliffe efficiency, NSE = 0.98) outperforms the other applied approaches which had relatively more significant result errors. The sensitivity analysis of the process depicts the extraction ratio as the key parameter in the computation of vortex tube silt ejector removal efficiency. The findings of the AI-based approaches discussed in the current study might be helpful for hydraulic engineers as well as researchers in the assessment of the removal efficiency of vortex tube silt ejectors.

关键词： Vortex tube silt ejector Support vector machine Random forest Random tree Multivariate adaptive regression spline

Therapeutic efficacy and stent patency of transhepatic portal vein stenting after surgery

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World Journal of Gastroenterology 2016年第44期22卷 9822-9828页

作者： Ung Bae Jeon Chang Won Kim Tae Un Kim Ki Seok Choo Joo Yeon Jang Kyung Jin Nam Chong Woo Chu Je Ho Ryu department of radiology Pusan National University Yangsan Hospital department of radiology Medical Research Institute Pusan National University School of Medicine and Research Institute for Convergence of Biomedical Science and Technology Pusan National University Hospital department of Surgery Pusan National University Yangsan Hospital

AIM To evaluate portal vein(PV) stenosis and stent patency after hepatobiliary and pancreatic surgery, using abdominal computed tomography(CT).METHODS Percutaneous portal venous stenting was attempted in 22 patients with significant PV stenosis(> 50%)-after hepatobiliary or pancreatic surgery- diagnosed by abdominal CT. Stents were placed in various stenotic lesions after percutaneous transhepatic portography. Pressure gradient across the stenotic segment was measured in 14 patients. Stents were placed when the pressure gradient across the stenotic segment was > 5 mm Hg or PV stenosis was > 50%, as observed on transhepatic portography. Patients underwent followup abdominal CT and technical and clinical success, complications, and stent patency were *** Stent placement was successful in 21 patients(technical success rate: 95.5%). Stents were positioned through the main PV and superior mesenteric vein(n = 13), main PV(n = 2), right and main PV(n = 1), left and main PV(n = 4), or main PV and splenic vein(n = 1). Patients showed no complications after stent placement. The time between procedure and final follow-up CT was 41-761 d(mean: 374.5 d). Twenty stents remained patent during the entire follow-up. Stent obstruction-caused by invasion of the PV stent by a recurrent tumor- was observed in 1 patient in a follow-up CT performed after 155 d after the procedure. The cumulative stent patency rate was 95.7%. Small in-stent low-density areas were found in 11(55%) patients; however, during successive follow-up CT, the extent of these areas had *** Percutaneous transhepatic stent placement can be safe and effective in cases of PV stenosis after hepatobiliary and pancreatic surgery. Stents show excellent patency in follow-up abdominal CT, despite development of small in-stent low-density areas.

关键词： Liver Vein Stent Computed tomography Surveillance Efficace

Multi-scale study of ductility-dip cracking in nickel-based alloy dissimilar metal weld

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Journal of Materials Science & technology 2019年第4期35卷 545-559页

作者： Yifeng Li Jianqiu Wang En-Hou Han Wenbo Wu Hannu Hanninen Key Laboratory of Nuclear Materials and Safety assessment Institute of Metal ResearchChinese Academy of Sciences School of Materials Science and Engineering University of Science and Technology of China department of Mechanical Engineering Aalto University

A ductility-dip-cracking(DDC)-concentrated zone(DCZ) in a width of about 3 mm was observed adjacent to the AISI 316 L/52 Mw fusion boundary(FB) in 52 Mw. The morphology, microstructure, mechanical and thermal properties and corrosion behavior in simulated primary water of DDC/DCZ were investigated by scanning electron microscopy(SEM), transmission electron microscopy(TEM), 3 D X-ray tomography(XRT), 3 D atom probe(3 DAP), slow strain rate tensile(SSRT) testing and thermal dilatometry. The results indicate that DDCs are random-shaped and disc-like cavities with corrugated structure of inner surface and are parallel in groups along straight high-angle boundaries of columnar grains, ranging from micrometers to millimeters in size. Large-size M_(23)C_6 carbides dominate on the grain boundaries rather than MC(M=Nb, Ti), and thus the bonding effect of carbides is absent for the straight grain *** impurity segregation of O is confirmed for the inner surfaces of DDC. The oxide film formed on the inner surface of DDC(about 50 nm) is approximately twice as thick as that on the matrix(about 25 nm)in simulated primary water. The yield strength, tensile strength and elongation to fracture of 52 MwDCZ(400 MPa, 450 MPa and 20 %, respectively) are lower than those of 52 Mw-MZ(460 MPa, 550 MPa and 28 %, respectively). The intrinsic high-restraint weld structure, the additional stress/strain caused by the thermal expansion difference between AISI 316 L and 52 Mw as well as the detrimental carbide precipitation and the resulting grain boundary structure all add up to cause the occurrence of DCZ in the dissimilar metal weld.

关键词： Dissimilar metal weld Nickel-base alloy Ductility-dip cracking(DDC) Slow strain rate tensile(SSRT) testing Thermal expansion coefficient