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From strength to precision: A systematic review exploring the clinical utility of 7-Tesla magnetic resonance imaging in abdominal imaging

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World Journal of radiology 2024年第1期16卷 20-31页

作者： Arosh S Perera Molligoda Arachchige Ana Claudia Teixeira de Castro Gonçalves Ortega Federica Catapano Letterio S Politi Michael N Hoff Faculty of Medicine Humanitas UniversityPieve Emanuele 20072MilanItaly department of biomedical Sciences Humanitas UniversityPieve Emanuele 20072MilanItaly IRCCS Humanitas Research Hospital Rozzano 20089MilanItaly department of Neuroradiology IRCCS Humanitas Research HospitalRozzano 20089MilanItaly department of radiology and biomedical imaging University of CaliforniaSan FranciscoCA 94143United States

BACKGROUND After approval for clinical use in 2017 early investigations of ultra-high-field abdominal magnetic resonance imaging(MRI)have demonstrated the feasibility as well as diagnostic capabilities of liver,kidney,and prostate MRI at ***,the elevation of the field strength to 7-Tesla not only brought advantages to abdominal MRI but also presented considerable challenges and drawbacks,primarily stemming from heightened artifacts and limitations in Specific Absorption Rate,***,evidence in the literature is relatively scarce concerning human studies in comparison to phantom/animal studies which necessitates an investigation into the evidence so far in humans and summarizing all relevant *** To offer a comprehensive overview of current literature on clinical abdominal 7T MRI that emphasizes current trends,details relevant challenges,and provides a concise set of potential *** This systematic review adheres to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.A PubMed search,utilizing Medical Subject Headings terms such as"7-Tesla"and organ-specific terms,was conducted for articles published between January 1,1985,and July 25,*** criteria included studies exploring 7T MRI for imaging human abdominal organs,encompassing various study types(in-vivo/ex-vivo,method development,reviews/meta-analyses).Exclusion criteria involved animal studies and those lacking extractable *** selection involved initial identification via title/abstract,followed by a full-text review by two researchers,with discrepancies resolved through *** extraction covered publication details,study design,population,sample size,7T MRI protocol,image characteristics,endpoints,and *** The systematic review included a total of 21 *** distribution of clinical 7T abdominal imaging studies revealed a predominant focus on the prostate(n=8),followed by the kidney(n=6)and the hepato

关键词： 7-Tesla magnetic resonance imaging Abdominal Prostate Kidney Renal Pancreas Hepatobiliary Liver Small bowel

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Transperineal laser ablation of the prostate as a treatment for benign prostatic hyperplasia and prostate cancer: The results of a Delphi consensus project

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Asian Journal of Urology 2024年第2期11卷 271-279页

作者： Andrea Cocci Marta Pezzoli Fernando Bianco Franco Blefari Pierluigi Bove Francois Cornud Gaetano De Rienzo Paolo Destefanis Danilo Di Trapani Alessandro Giacobbe Luca Giovanessi Antonino Laganà Giovanni Lughezzani Guglielmo Manenti Gianluca Muto Gianluigi Patelli Novello Pinzi Stefano Regusci Giorgio I.Russo Juan I.M.Salamanca Matteo Salvi Luigi Silvestri Fabrizio Verweij Eric Walser Riccardo GBertolo Valerio Iacovelli Alessandro Bertaccini Debora Marchiori Hugo Davila Pasquale Ditonno Paolo Gontero Gennaro Iapicca Theo M De Reijke Vito Ricapito Pierluca Pellegrini Andrea Minervini Sergio Serni Francesco Sessa department of Urology Careggi HospitalUniversity of FlorenceFlorenceItaly Urology Section University of FlorenceFlorenceItaly Urological Research Network MiamiFLUSA Urology Section Prato HospitalPratoItaly Torvergata Oncoscience Research Centre of Excellence TORDepartment of Experimental MedicineUniversity of Rome Tor VergataRomeItaly department of Urology San Carlo di Nancy HospitalRomeItaly department of radiology Hôpital CochinParis Descartes UniversityParisFrance Urology and Andrology Unit II Department of Emergency and Organ TransplantationUniversity of BariBariItaly Unit of Urology Cittàdella Salute e della Scienza HospitalUniversity of TurinTurinItaly Urology Unit Buccheri La Ferla Fatebenefratelli HospitalPalermoItaly department of Urology Humanitas Gradenigo HospitalTurinItaly Urology Unit Surgical DepartmentFondazione Poliambulanza Istituto OspedalieroBresciaItaly Departement of Urology “S.Giovanni Evangelista”HospitalTivoliItaly Humanitas Clinical and Research CentereIRCCS Department of UrologyRozzanoItaly department of biomedical Sciences Humanitas UniversityPieve EmanueleItaly department of Biomedicine and Prevention University of Rome“Tor Vergata”RomeItaly department of Diagnostic imaging and Interventional radiology University of Rome“Tor Vergata”RomeItaly department of Interventional radiology Pesenti-Fenaroli Hospital-ASST Bergamo EstAlzano LombardoItaly department of Urology University of SienaSienaItaly Swiss International Prostate Center GenevaSwitzerland Clinique Générale Beaulieu GenevaSwitzerland department of Urology University of CataniaItaly department of Urology Puerta de Hierro-Majadahonda University HospitalMadridSpain Lyx Institute of Urology Universidad Francisco de VitoriaMadridSpain department of Medico-Surgical Sciences and Biotechnologies Sapienza University of RomeFaculty of Pharmacy and MedicineUrology Unit ICOTLatinaItaly department of Urology European Institute of Oncology(IEO)IRCCSMilanItaly department of radiology D

Objective: To evaluate transperineal laser ablation (TPLA) with Echolaser® (Echolaser® TPLA, Elesta S.p.A., Calenzano, Italy) as a treatment for benign prostatic hyperplasia (BPH) and prostate cancer (PCa) using the Delphi consensus ***: Italian and international experts on BPH and PCa participated in a collaborative consensus project. During two rounds, they expressed their opinions on Echolaser® TPLA for the treatment of BPH and PCa answering online questionnaires on indications, methodology, and potential complications of this technology. Level of agreement or disagreement to reach consensus was set at 75%. If the consensus was not achieved, questions were modified after each round. A final round was performed during an online meeting, in which results were discussed and ***: Thirty-two out of forty invited experts participated and consensus was reached on all topics. Agreement was achieved on recommending Echolaser® TPLA as a treatment of BPH in patients with ample range of prostate volume, from 80 mL (80%), comorbidities (100%), antiplatelet or anticoagulant treatment (96%), indwelling catheter (77%), and strong will of preserving ejaculatory function (100%). Majority of respondents agreed that Echolaser® TPLA is a potential option for the treatment of localized PCa (78%) and recommended it for low-risk PCa (90%). During the final round, experts concluded that it can be used for intermediate-risk PCa and it should be proposed as an effective alternative to radical prostatectomy for patients with strong will of avoiding urinary incontinence and sexual dysfunction. Almost all participants agreed that the transperineal approach of this organ-sparing technique is safer than transrectal and transurethral approaches typical of other techniques (97% of agreement among experts). Pre-procedural assessment, technical aspects, post-procedural catheterization, pharmacological therapy, and expected outcomes were discussed, leading t

关键词： Transperineal laser ablation Prostatecancer Benignprostatic hyperplasia Delphi consensus

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Importance of Standardizing Analytical Characterization Methodology for Improved Reliability of the Nanomedicine Literature

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Nano-Micro Letters 2022年第11期14卷 18-32页

作者： Shahriar Sharifi Nouf N.Mahmoud Elizabeth Voke Markita P.Landry Morteza Mahmoudi department of radiology and Precision Health Program Michigan State UniversityEast LansingMIUSA Faculty of Pharmacy Al-Zaytoonah University of JordanAmman 11733Jordan department of biomedical Sciences College of Health SciencesQU HealthQatar University2713 DohaQatar department of Chemical and Biomolecular Engineering University of CaliforniaBerkeleyBerkeleyCAUSA Innovative Genomics Institute BerkeleyCAUSA california Institute for Quantitative Biosciences University of CaliforniaBerkeleyCAUSA Chan Zuckerberg Biohub San FranciscoCAUSA

Understanding the interaction between biological structures and nanoscale technologies,dubbed the nano-bio interface,is required for successful development of safe and efficient nanomedicine *** lack of a universal reporting system and decentralized methodologies for nanomaterial characterization have resulted in a low degree of reliability and reproducibility in the nanomedicine *** such,there is a strong need to establish a characterization system to support the reproducibility of nanoscience data particularly for studies seeking clinical ***,we discuss the existing key standards for addressing robust characterization of nanomaterials based on their intended use in medical devices or as *** also discuss the challenges surrounding implementation of such standard protocols and their implication for translation of nanotechnology into clinical ***,however,emphasize that practical implementation of standard protocols in experimental laboratories requires long-term planning through integration of stakeholders including institutions and funding agencies.

关键词： Characterization Nanomedicine Standard protocols Reproducibility Nanomedicine devices

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Visualization of pleural fissures in infants on computed tomography

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World Journal of Pediatric Surgery 2019年第1期2卷 24-27页

作者： Andrew Phelps Cynthia Tan Saveen Ahuja Dean Kolnick Jesse Courtier John D MacKenzie department of radiology and biomedical imaging University of CaliforniaSan FranciscoCaliforniaUSA departmentof radiology BayImaging Consultants Medical Groups IncWalnutCreekUSA departmentof radiology SouthernCalifornia Physician Medical GroupFontanaUSA department of radiology Simon Med ImagingSanRafaelUSA

Purpose For infants with prenatally detected lung lesions,a chest CT is performed prior to *** chest CT is performed as close to the surgery date as possible,because it is presumed that the visualization of lung fissures would be poor in the immediate neonatal ***,this presumption has never been formally *** purpose of this study is to assess differences in lung fissure visualization on chest CT in different infant age *** This was a retrospective study of clinically indicated chest CT approved by the institutional review board performed in infants of different *** visibility of pleural fissures was subjectively assessed by three pediatric radiologists who were blinded to age *** In the 0-2 months age group,80%of all fissure segments were visible versus 92%in the 5-6 months group(p=0.04)and 95%in the 7-9 months group(p=0.01).Conclusions The ability to visualize pleural fissures on CT increases with infant *** observation should be taken into consideration when choosing the optimal timing of preoperative CT for asymptomatic congenital lung lesions.

关键词： pleural visibility formally

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Renal ablation using magnetic resonance-guided high intensity focused ultrasound: Magnetic resonance imaging and histopathology assessment

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World Journal of radiology 2016年第3期8卷 298-307页

作者： Maythem Saeed Roland Krug Loi Do Steven W Hetts Mark W Wilson department of radiology and biomedical imaging School of Medicine University of California San Francisco

AIM: To use magnetic resonance-guided high intensity focused ultrasound(MRg-HIFU), magnetic resonance imaging(MRI) and histopathology for noninvasively ablating, quantifying and characterizing ablated renal tissue. METHODS: Six anesthetized/mechanically-ventilated pigs underwent single/double renal sonication(n = 24) using a 3T-MRg-HIFU(1.1 MHz frequency and 3000J-4400 J energies). T2-weighted fast spin echo(T2-W), perfusion saturation recovery gradient echo and contrast enhanced(CE) T1-weighted(T1-W) sequences were used for treatment planning, temperature monitoring, lesion visualization, characterization and quantification, respectively. Histopathology was conducted in excised kidneys to quantify and characterize cellular and vascular changes. Paired Student's t-test was used and a P-value < 0.05 was considered statistically ***: Ablated renal parenchyma could not be differentiated from normal parenchyma on T2-W or nonCE T1-W sequences. Ablated renal lesions were visible as hypoenhanced regions on perfusion and CE T1-W MRI sequences, suggesting perfusion deficits and necrosis. Volumes of ablated parenchyma on CE T1-W images invivo(0.12-0.36 cm3 for single sonication 3000 J, 0.50-0.84 cm3, for double 3000 J, 0.75-0.78 cm3 for single 4400 J and 0.12-2.65 cm3 for double 4400J) and at postmortem(0.23-0.52 cm3, 0.25-0.82 cm3, 0.45-0.68 cm3 and 0.29-1.80 cm3, respectively) were comparable. The ablated volumes on 3000 J and 4400 J double sonication were significantly larger than single(P < 0.01), thus, the volume and depth of ablated tissue depends on the applied energy and number of sonication. Macroscopic and microscopic examinations confirmed the locations and presence of coagulation necrosis, vascular damage and interstitial hemorrhage, ***: Contrast enhanced MRI provides assessment of MRg-HIFU renal ablation. Histopathology demonstrated coagulation necrosis, vascular damage and confirmed the volume of damage seen on MRI.

关键词： Magnetic resonance-guided high intensity focused ultrasound Renal ablation Magnetic resonance imaging Microscopy High intensity focused ultrasound

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Coronary Embolization and Myocardial Microinfarction: MR imaging and Histopathologic Characterization

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International Journal of Clinical Medicine 2016年第6期7卷 399-418页

作者： Maythem Saeed Steven W. Hetts Anqi Liang Mark W. Wilson department of radiology and biomedical imaging School of Medicine University of California San Francisco San Francisco CA USA

Magnetic resonance imaging (MRI) has been proven to reliably assess regional perfusion and left ventricular (LV) function of microembolized myocardium. The visibility of microinfarct on delayed enhancement MRI (DE-MRI) is limited and dependent on technical and biological issues. Furthermore, MRI underestimates total microinfarct size compared with microscopy. MRI studies revealed that the presence of microemboli in pre-existing acute infarct delays infarct healing and magnifies LV remodeling. Discrimination of acute from chronic microinfarct is based on presence of inflammatory cells, edema and scar tissue, respectively. These noninvasive findings highlight the importance of prognostic utility of MRI and warrant larger clinical studies or registries to evaluate the significance of presence of focal microinfarct. Serial microscopic studies revealed that intravascular microemboli migrate into the extravascular space and this migration process is a function of time. This phenomenon may limit the use of microemboli therapy in occluding hemorrhagic blood vessels or treating tumors. Despite current standard of care, existing methods and therapies do not prevent coronary embolization nor reverse their deleterious effects.

关键词： Percutaneous Coronary Revascularization Coronary Microembolization Myocardial Microinfarct Magnetic Resonance imaging Microscopy

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Monitoring the Sequelae of Coronary Microembolization on Myocardium Using Noninvasive imaging (Review)

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World Journal of Cardiovascular Diseases 2014年第12期4卷 601-622页

作者： M. Saeed M. W. Wilson Interventional radiology Laboratory Department of Radiology and Biomedical Imaging University of California San Francisco CA USA

Acute myocardial infarction (AMI) is a leading cause of death worldwide. It has been clinically classified into 1) ischemic from a primary coronary event (e.g., plaque rupture or thrombotic occlusion), 2) ischemic from a supply-and-demand mismatch and c) ischemic from a percutaneous coronary interventions (PCI). Catheter-based PCI has been frequently used as an alternative to conventional bypass surgery for patients at high risk. However, this method of treatment is associated with microvascular obstruction (MVO) by dislodged microemboli that results in left ventricular (LV) dysfunction/remodeling, perfusion deficits, microinfarction and arrhythmia. The contributions of microemboli after revascularization of AMI have been acknowledged by major cardiac and interventional societies. Recent studies showed that Emboli Detection and Classification (EDAC) Quantifier offers increased sensitivity and capability for detecting dislodged coronary microemboli during PCI. Coronary microembolization can be detected directly by monitoring intra-myocardial contrast opacification on contrast echocardiography, increasing F-18 fluorodeoxyglucose (FDG) uptake on positron emission tomography, loss/diminution of signal on first pass perfusion and hypoenhanced zone on contrast enhanced magnetic resonance imaging (MRI) and multidetector computed tomography (MDCT) and indirectly by ST-segment elevation on electro-cardiography (ECG). The relations between volumes/sizes of microemboli, visibility of microinfarct, myocardial perfusion and LV function are still under intensive discussions. Non-invasive imaging can play important role in assessing these parameters. This review shed the light on the techniques used for detecting coronary microemboli, microvascular obstruction and microinfarct and the short- and long-term effects of microemboli on LV function, structure and perfusion.

关键词： Coronary Artery Disease Coronary Emboli Interventions Magnetic Resonance imaging and Multi-Detector Computed Tomography

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骨骼肌的11C-L-甲基蛋氨酸PET/CT动态显像:观察蛋白质补充对骨骼肌的影响并与L-[环13C6]苯丙氨酸输注后多次骨骼肌活组织检查结果进行比较

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中华核医学与分子影像杂志 2017年第12期37卷 826-827页

作者：唐军 Emily J.Arentson-Lantz Isra H.Saeed Lynda A.Frassetto Umesh Masharani Roy J.Harnish Youngho Seo Henry F.VanBrocklin Randall A.Hawkins Carina Mari-Aparici Miguel H.Pampaloni James Slater Douglas Paddon-Jones Thomas F.Lang 上海交通大学附属苏州九龙医院核医学科 department of radiology and biomedical imaging University of CaliforniaSan FranciscoUSA

目的评价骨骼肌蛋白质合成的传统方法是在静脉输注L-[环13C6]苯丙氨酸(13C6-Phe)后做骨骼肌活组织检查,通过多次活组织检查计算蛋白质合成的分数合成率（FSR）。通过对健康老年女性行11C-L-甲基蛋氨酸(11C-MET)PET/CT动态显像,估算进食... 详细信息

目的评价骨骼肌蛋白质合成的传统方法是在静脉输注L-[环13C6]苯丙氨酸(13C6-Phe)后做骨骼肌活组织检查,通过多次活组织检查计算蛋白质合成的分数合成率（FSR）。通过对健康老年女性行11C-L-甲基蛋氨酸(11C-MET)PET/CT动态显像,估算进食后和吸收后的骨骼肌蛋白质合成水平,旨在评价上述2种方法的一致性。方法 13名老年女性[年龄（73±5）岁]禁食后口服25 g乳清蛋白,1 h后行11C-MET PET/CT动态显像,作图分析动态图像,通过计算Patlak系数Ki估算11CMET进入股中肌束的量。间隔2周,在相同条件下口服25 g乳清蛋白,1h后行稳定同位数药物13C6-Phe的输注,并进行股外侧肌活组织检查,计算FSR。结果口服乳清蛋白后的Ki值及FSR[（0.009 5±0.001）/min和（0.083±0.008）%/h]比吸收后的高[（0.007 85±0.001）/min和（0.049±0.006）%/h,P<0.05或P<0.001]。Ki和FSR升高的百分数有显著相关性（r=0.79,P=0.015）。结论 11C-MET PET/CT动态显像可以估算口服蛋白质后的骨骼肌蛋白质合成情况,其结果与传统的有创活组织检查法一致。研究结果表明,11C-MET PET/CT动态显像今后可用于无创地评价骨骼肌蛋白质合成的影响因素。

关键词： PET/CT 人骨骼肌蛋白质合成 FSR

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Association of body shape and fracture risk

Association of body shape and fracture risk

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第六届国际骨质疏松及骨矿盐疾病学术会议

作者： Bo Fan Joseph P Wilson John A Shepherd department of radiology & biomedical imaging University of California San FranciscoUSA department of radiology & biomedical imaging University of California San FranciscoUSA UC Berkeley-UCSF Graduate Program in BioengineeringSan FranciscoCA US

＜正＞Objective:To examine theindependent association ofbody shape（total volume,trunk volume,and trunk to leg volume ratio）tofracture risk. Methods:We performed a cross-sectional study of the NHANES 1999-2004 survey data downloaded from the study *** individualshad both a valid dual-energy Xray absorptiometry（DXA） scan and known fracture status. The body shape measureswere derived using DXA whole

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前列腺MRI的PI-RADS在26个中心检测的阳性预测值差异:腹部放射学学会前列腺疾病聚焦小组的经验

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国际医学放射学杂志 2020年第5期 609-610页

作者： A.C.Westphalen C.E.McCulloch J.M.Anaokar S.Arora N.S.Barashi J.O.Barentsz 刘思睿 departments of radiology and biomedical imaging University of CaliforniaSan Francisco

摘要前列腺MRI广泛应用于指导前列腺癌病人的组织活检、病情监测和肿瘤分期。前列腺成像报告和数据系统(PI-RADS)有助于提供一种标准化的概率性方法来识别有

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