Importance of Standardizing Analytical Characterization Methodology for Improved Reliability of the Nanomedicine Literature

作     者：Shahriar Sharifi Nouf N.Mahmoud Elizabeth Voke Markita P.Landry Morteza Mahmoudi Shahriar Sharifi;Nouf N.Mahmoud;Elizabeth Voke;Markita P.Landry;Morteza Mahmoudi

作者机构：Department of Radiology and Precision Health ProgramMichigan State UniversityEast LansingMIUSA Faculty of PharmacyAl-Zaytoonah University of JordanAmman 11733Jordan Department of Biomedical SciencesCollege of Health SciencesQU HealthQatar University2713 DohaQatar Department of Chemical and Biomolecular EngineeringUniversity of CaliforniaBerkeleyBerkeleyCAUSA Innovative Genomics InstituteBerkeleyCAUSA California Institute for Quantitative BiosciencesUniversity of CaliforniaBerkeleyCAUSA Chan Zuckerberg BiohubSan FranciscoCAUSA 

出 版 物：《Nano-Micro Letters》 (纳微快报（英文版）)

年 卷 期：2022年第14卷第11期

页      面：18-32页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0836[工学-生物工程] 0702[理学-物理学] 

基　　金：support from the U.S. National Institute of Diabetes and Digestive and Kidney Diseases (Grant DK131417) (MM) support of a Burroughs Wellcome Fund Career Award at the Scientific Interface (CASI) (MPL) a Dreyfus foundation award (MPL) the Philomathia foundation (MPL) an NIH MIRA award R35GM128922 (MPL) an NIH R21 NIDA award 1R03DA052810 (MPL) an NSF CAREER award 2046159 (MPL) an NSF CBET award 1733575 (to MPL) a CZI imaging award (MPL) a Sloan Foundation Award (MPL) a USDA BBT EAGER award (MPL) a Moore Foundation Award (MPL) a DOE office of Science grant DE-SC0020366 (MPL) support from a Fulbright fellowship (NNM) 

主　　题：Characterization Nanomedicine Standard protocols Reproducibility Nanomedicine devices 

摘      要：Understanding the interaction between biological structures and nanoscale technologies,dubbed the nano-bio interface,is required for successful development of safe and efficient nanomedicine *** lack of a universal reporting system and decentralized methodologies for nanomaterial characterization have resulted in a low degree of reliability and reproducibility in the nanomedicine *** such,there is a strong need to establish a characterization system to support the reproducibility of nanoscience data particularly for studies seeking clinical ***,we discuss the existing key standards for addressing robust characterization of nanomaterials based on their intended use in medical devices or as *** also discuss the challenges surrounding implementation of such standard protocols and their implication for translation of nanotechnology into clinical ***,however,emphasize that practical implementation of standard protocols in experimental laboratories requires long-term planning through integration of stakeholders including institutions and funding agencies.