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Fisetin micelles precisely exhibit a radiosensitization effect by inhibiting PDGFRβ/STAT1/STAT3/Bcl-2 signaling pathway in tumor

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Chinese Chemical Letters 2025年第2期36卷 262-269页

作者： Yuanyuan Zeng Fang Liu Jun Wang Bianfei Shao Tao He Zhongzheng Xiang Yan Wang Shunyao Zhu Tian Yang Siting Yu Changyang Gong Lei Liu department of radiation oncology Cancer CenterState Key Laboratory of BiotherapyWest China HospitalSichuan University department of radiation oncology The Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer Hospital Chongqing Key Laboratory of translational Research for cancer Metastasis and individualized Treatment Chongqing University Cancer Hospital department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan University department of Pharmacy The First Affiliated Hospital of Wannan Medical CollegeYijishan Hospital of Wannan Medical College Institute of Surgery Research Daping HospitalThird Military Medical University

It is of great significance to find safe and effective radiosensitizers. A primary investigation has been made on fisetin's modification of radiation effect, but its radiosensitization and related mechanisms still need to be deeply clarified. Furthermore, fisetin with high hydrophobicity is difficult to dissolve in water,severely limiting its research and application. In this study, we fabricated a safe and soluble radiosensitizer fisetin micelle for precisely enhancing radiotherapy by inhibiting platelet-derived growth factor receptor-β(PDGFRβ)/signal transducer and activator of transcription 1(STAT1)/signal transducer and activator of transcription 3(STAT3)/B cell lymphoma 2(Bcl-2) signaling pathway in the tumor. Systematic and detailed studies were performed to verify its radiosensitization effect in vitro and in vivo. On the cellular level, fisetin micelles selectively increased the radiosensitivity of tumor cells(CT26 and 4T1 cells)and had little effect on the sensitivity of normal mouse cells(L929 cells) to radiation. In the mouse models of colon and breast cancers, fisetin micelles showed an efficient radiosensitization capacity without apparent toxicity. Additionally, we first found that fisetin micelles played a radiotherapy sensitization role by inhibiting the PDGFRβ/STAT1/STAT3/Bcl-2 pathway activity. In general, this work not only confirmed that fisetin micelles precisely exhibit a radiosensitization effect in vitro and in vivo, but also profoundly explored its mechanisms underlying, to provide a theoretical and experimental basis for the clinical application of fisetin micelles.

关键词： Fisetin Platelet-derived growth factor receptor-β Polymetric micelles Radiosensitizer Radiotherapy

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Improved treatment of colorectal liver metastases by early response evaluation and regimen adjustment: a prospective study of clinical functional MR-based modeling

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cancer Biology & Medicine 2025年第02期 166-176页

作者： Wenhua Li Huan Zhang Zhe Gong Yue Li Zhiyu Chen Xiaodong Zhu Mingzhu Huang Zhe Zhang Chenchen Wang Lixin Qiu Qirong Geng Jinjia Chang Xiaoying Zhao Xuedan Sheng Wen Zhang Tong Tong Weijian Guo department of Medical oncology Fudan University Shanghai Cancer Center department of oncology Shanghai Medical College Fudan University department of Radiology Fudan University Shanghai Cancer Center department of radiation oncology Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences

Objective: The aim of the study was to evaluate the feasibility of functional MR in predicting the clinical response to chemotherapy in patients with colorectal liver metastases(CLM).Methods: A total of 196 eligible patients were enrolled in the study between August 2016 and January 2023. Functional MR was performed at baseline and after one cycle of chemotherapy. The diffusion kurtosis radiomic texture features were extracted and a signature model was built using the R package. The initial 100 cases were designated as the training set, the following 48 cases were designated as the validation set, and the final 48 cases were designated as the intervention validation ***: Good performance for the response prediction(AUC = 0.818 in the training set and 0.755 in the validation set) was demonstrated. The objective response rates(ORRs) in the high-risk subgroup were significantly lower than the low-risk subgroup in the training and validation sets. Worse progression-free survival and overall survival rates were noted in the high-risk population. In the intervention set 22.9%(11/48) of the chemotherapy regimens for patients were changed in response to the model-predicted results and the ORR reached 77.1%(37/48), which was significantly higher than the training and validation sets [47.97%(71/148); P = 0.000].Conclusions: A functional MR signature effectively predicted the chemotherapy response and long-term survival. The adjustment of the regimen guided by the model significantly improved the ORR.

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Advances in basic and translational research into nasopharyngeal carcinoma

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oncology and Translational Medicine 2025年第1期11卷 10-16页

作者： Zhe Li Yupei Chen Jun Ma department of radiation oncology State Key Laboratory of Oncology in South ChinaGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhouChina

According to the International cancer Research Institute of the World Health Organization data,nasopharyngeal carcinoma(NPC)remains a significant health concern,particularly in regions such as Southeast Asia and southern ***,substantial progress has been made in the field of basic and translational research on NPC,enhancing our understanding of the molecular mechanisms underlying the disease and paving the way for precise therapeutic *** review summarizes the advances in NPC research,focusing on key areas that include radiotherapy and chemotherapy resistance and tumor metastasis,microenvironment,metabolism,microbiome,and ***,future research directions in NPC are discussed to provide valuable insights to advance the field further.

关键词： Nasopharyngeal carcinoma Treatment resistance Tumor biomarkers Tumor microenvironment

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Turning the tide:From cervical cancer's grip to complete response:A case report

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World Journal of Clinical oncology 2025年第2期16卷 152-157页

作者： Shatha Abutaha Abdulla Alzibdeh Issa Mohamad Lina Wahbeh Samer Salah Ramiz Abuhijlih Fawzi Abuhijla department of radiation oncology King Hussein Cancer CenterAmman 11941Jordan department of Medical oncology King Fahad Specialist HospitalDammam 32210Saudi Arabia

BACKGROUND Cervical cancer is a formidable global health issue,particularly affecting women in lower-middle-income countries with little or no access to preventative vaccines,screening programs,and treatment *** case report presents a unique case of a large cervical cancer achieving complete response(CR)with concurrent chemoradiotherapy(CCRT),highlighting the effectiveness of this treatment approach even in advanced stages and underscoring the importance of adaptive radiotherapy(RT)in optimizing patient *** SUMMARY We present the case of a 53-year-old woman who presented with four years of abnormal vaginal bleeding and was found to have p16-positive,moderately differentiated cervical squamous cell *** tumor measured 14 cm×12 cm×8 cm,the largest size reported in the literature to achieve CR with *** this monumental feat,the patient remained disease-free and is currently on follow-up for 2 years;however,she continued to suffer from substantial morbidity caused by a vesicovaginal fistula and hydronephrosis,underscoring the continuing impact of cervical cancer on quality of *** In this case report,we highlight the effectiveness of CCRT in achieving CR,even in cases of bulky cervical cancer,with adaptive RT offering a customized strategy to improve patient *** also emphasize the necessity for multidisciplinary team discussions and highlight the need for strategies to mitigate treatment-related toxicities and long-term complications.

关键词： Cervical cancer Chemoradiotherapy Adaptive radiotherapy Case report

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Identification of common genetic variants in KCNQ family genes associated with gastric cancer survival in a Chinese population

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Journal of Biomedical Research 2025年第1期39卷 76-86页

作者： Yuetong Chen Chen Li Yi Shi Jiali Dai Yixuan Meng Shuwei Li Cuiju Tang Dongying Gu Jinfei Chen department of radiation oncology the Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou Municipal HospitalGusu SchoolNanjing Medical UniversitySuzhouJiangsu 215008China department of oncology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu 210006China department of oncology the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang 325015China department of oncology the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China department of Environmental Genomics Jiangsu Key Laboratory of Cancer BiomarkersPrevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineNanjing Medical UniversityNanjingJiangsu 211166China department of Genetic Toxicology the Key Laboratory of Modern Toxicology of Ministry of EducationCenter for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China

The KCNQ family of genes(KCNQ1–KCNQ5),encoding voltage-gated K+(Kv)channels,have been demonstrated to play potential pathophysiological roles in ***,the associations between genetic variants located in KCNQ family genes and gastric cancer survival remain *** this study,a large-scale cohort comprising 1135 Chinese gastric cancer patients was enrolled to identify genetic variants in KCNQ family genes associated with overall survival(OS).Based on the survival evaluation of all five KCNQ family genes,KCNQ1 was selected for subsequent genetic *** both Cox regression model and stepwise Cox regression model used to evaluate survival-related genetic variants,we found that KCNQ1 rs10832417G>T was associated with an increased OS in gastric cancer patients(adjusted hazards ratio[HR]=0.84,95%confidence interval[CI]:0.72–0.98,P=0.023).Subsequently,a nomogram was constructed to enhance the prognostic capacity and clinical translation of rs10832417 *** rs10832417 T allele was predicted to increase the minimum free energy of the secondary ***,we observed that gastric cancer patients with downregulated KCNQ1expression had a poorer survival across multiple public *** findings of the present study indicate that KCNQ1 rs10832417 may serve as an independent prognostic predictor of gastric cancer,providing novel insights into the progression and survival of the disease.

关键词： gastric cancer survival genetic variants ionic channels

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Development and validation of a nomogram model for predicting overall survival in patients with gastric carcinoma

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World Journal of Gastrointestinal oncology 2025年第2期17卷 132-143页

作者： Guan-Zhong Liang Xiao-Sheng Li Zu-Hai Hu Qian-Jie Xu Fang Wu Xiang-Lin Wu Hai-Ke Lei Chongqing Key Laboratory of Translational Research for cancer Metastasis and Individualized Treatment Chongqing University Cancer HospitalChongqing 400030China Chongqing cancer Multi-omics Big Data Application Engineering Research center Chongqing University Cancer HospitalChongqing 400030China department of Health Statistics School of Public HealthChongqing Medical UniversityChongqing 400016China Research center for Medicine and Social Development School of Public HealthChongqing Medical UniversityChongqing 400016China The Research center of Big Data Chongqing University Cancer HospitalChongqing 400030China

BACKGROUND The prevalence and mortality rates of gastric carcinoma are disproportionately elevated in China,with the disease's intricate and varied characteristics further amplifying its health *** forecasting of overall survival(OS)is of paramount importance for the clinical management of individuals afflicted with this *** To develop and validate a nomogram model that provides precise gastric cancer prevention and treatment guidance and more accurate survival outcome prediction for patients with gastric *** Data analysis was conducted on samples collected from hospitalized gastric cancer patients between 2018 and *** absolute shrinkage and selection operator,univariate,and multivariate Cox regression analyses were employed to identify independent prognostic factors.A nomogram model was developed to predict gastric cancer patient *** model's predictability and discriminative ability were evaluated via receiver operating characteristic *** evaluate the clinical utility of the model,Kaplan-Meier and decision curve analyses were *** A total of ten independent prognostic factors were identified,including body mass index,tumor-node-metastasis(TNM)stage,radiation,chemotherapy,surgery,albumin,globulin,neutrophil count,lactate dehydrogenase,and platelet-to-lymphocyte *** area under the curve(AUC)values for the 1-,3-,and 5-year survival prediction in the training set were 0.843,0.850,and 0.821,*** AUC values were 0.864,0.820,and 0.786 for the 1-,3-,and 5-year survival prediction in the validation set,*** model exhibited strong discriminative ability,with both the time AUC and time C-index exceeding *** with TNM staging,the model demonstrated superior clinical ***,a nomogram was developed via a web-based *** This study established and validated a novel nomogram model for predicting the OS of gastric cancer patients,which demonstrat

关键词： Gastric carcinoma Prediction Overall survival Nomogram Prospective

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Advancing precision medicine: the transformative role of artificial intelligence in immunogenomics, radiomics, and pathomics for biomarker discovery and immunotherapy optimization

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cancer Biology & Medicine 2025年第1期 33-47页

作者： Luchen Chang Jiamei Liu Jialin Zhu Shuyue Guo Yao Wang Zhiwei Zhou Xi Wei department of Diagnostic and Therapeutic Ultrasonography Tianjin Medical University Cancer Institute & Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and TherapyTianjin Tianjin's Clinical Research Center for Cancer departments of Biochemistry and radiation oncology UT Southwestern Medical Center

Artificial intelligence(AI) is significantly advancing precision medicine, particularly in the fields of immunogenomics, radiomics, and pathomics. In immunogenomics, AI can process vast amounts of genomic and multi-omic data to identify biomarkers associated with immunotherapy responses and disease prognosis, thus providing strong support for personalized treatments. In radiomics, AI can analyze high-dimensional features from computed tomography(CT), magnetic resonance imaging(MRI), and positron emission tomography/computed tomography(PET/CT) images to discover imaging biomarkers associated with tumor heterogeneity, treatment response, and disease progression, thereby enabling non-invasive, real-time assessments for personalized therapy. Pathomics leverages AI for deep analysis of digital pathology images, and can uncover subtle changes in tissue microenvironments, cellular characteristics, and morphological features, and offer unique insights into immunotherapy response prediction and biomarker discovery. These AI-driven technologies not only enhance the speed, accuracy, and robustness of biomarker discovery but also significantly improve the precision, personalization, and effectiveness of clinical treatments, and are driving a shift from empirical to precision medicine. Despite challenges such as data quality, model interpretability, integration of multi-modal data, and privacy protection, the ongoing advancements in AI, coupled with interdisciplinary collaboration, are poised to further enhance AI's roles in biomarker discovery and immunotherapy response prediction. These improvements are expected to lead to more accurate, personalized treatment strategies and ultimately better patient outcomes, marking a significant step forward in the evolution of precision medicine.

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Safety and efficacy of intraoperative radiation therapy using a low-energy X-ray source for resectable pancreatic cancer: an interim evaluation of an ongoing prospective phase Ⅱ study

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cancer Biology & Medicine 2025年第1期 67-76页

作者： Xingyun Chen Shuo Li Chuntao Gao Wei Wang Haorui Li Yuxiao Liu Rui Liu Jihui Hao department of Pancreatic cancer Tianjin Medical University Cancer Institute & Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and TherapyTianjin Tianjin's Clinical Research Center for Cancer department of radiation oncology Tianjin Medical University Cancer Institute & Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and TherapyTianjin Tianjin's Clinical Research Center for Cancer department of Gastrointestinal oncology Tianjin Medical University Cancer Institute &Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and TherapyTianjin Tianjin's Clinical Research Center for Cancer Tianjin Key Laboratory of Digestive Cancer

Objective: The role of intraoperative radiation therapy(IORT) in the management of resectable pancreatic cancer(RPC) remains unclear. To date, the application of IORT using a low-energy X-ray source has not been extensively investigated. Therefore, this study was conducted to evaluate the safety and efficacy of IORT using a 50 k V X-ray source in treating ***: Patients with RPC who underwent radical pancreatectomy and IORT were enrolled. The primary endpoint was time to treatment failure(TTF) survival, whereas the secondary endpoints were safety and overall survival(OS).Results: By November 2023, 35 patients with RPC were treated according to the study protocol. The median TTF was 11.67 months, whereas the median OS for the cohort was 22.2 months. The local recurrence rate was 20%. The most common postoperative complication was pancreatic fistula. The incidence of delayed gastric emptying was 20%. Within 30 days after surgery, one patient experienced abdominal pain, another experienced vomiting, and one died because of abdominal infection and a grade C pancreatic fistula. Carcinoembryonic antigen(CEA) and D-dimer levels significantly correlated with TTF and OS in multivariate analyses. The carbohydrate antigen 19-9(CA19-9) level was another prognostic factor significantly associated with OS. Patients with low D-dimer and normal CA19-9 levels showed prolonged OS with an IORT dose ≤ 15 ***: This study supports use of IORT with a 50 k V X-ray source in treating RPC. IORT using a low-energy X-ray source was well-tolerated and feasible. Additionally, D-dimer, CEA, and CA19-9 levels may help identify patient profiles potentially benefitting from IORT.

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Advances of stereotactic body radiotherapy in pancreatic cancer

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Chinese Journal of cancer Research 2015年第4期27卷 349-357页

作者： Qichun Wei Wei Yu Lauren M.Rosati Joseph M.Herman department of radiation oncology the Second Affiliated Hospital Zhejiang University School of Medicine department of radiation oncology & Molecular radiation Sciences Sidney Kimmel Comprehensive Cancer Center Johns Hopkins University School of Medicine

Pancreatic cancer（PCA） is one of the most aggressive tumors with few effective treatment modalities. It is the 4th and 7th leading cause of cancer death in the United States and China, respectively. At the time of diagnosis, only 20% of cases present with a resectable tumor, and about 40% with a locally advanced tumor that is considered unresectable. Even resected patients still have a poor prognosis, with an incidence of local recurrence ranging from 20% to 60%. It is also reported that up to 30% of PCA patients die from locally obstructive disease with few or no distant metastases. These findings have highlighted the importance of local radiation therapy in the treatment of PCA. As the role of conventional chemoradiotherapy remains controversial, the dawn of the pancreas stereotactic body radiation therapy（SBRT） era represents a potential paradigm shift in the management of PCA. SBRT delivers a higher biological effective dose to the tumor with sharp dose escalation in a shorter treatment time course. Pancreas SBRT is a novel therapeutic option to achieve local tumor control with minimal toxicity. Herein, we review the advancement of SBRT for PCA patients with different stages of pancreatic adenocarcinoma.

关键词： Stereotactic body radiation therapy(SBRT) pancreatic cancer(PCA)

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Sparing lung tissue with virtual block method in VMAT planning for locally advanced non-small cell lung cancer

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Nuclear Science and Techniques 2022年第4期33卷 136-150页

作者： Jia-Yun Chen Da-Quan Wang Xiao-Dong Zhang Qi Fu Xue-Na Yan Kuo Men Jian-Rong Dai Nan Bi department of radiation oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China department of radiation oncology State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer CenterGuangzhou 510060China department of radiation Physics The University of Texas MD Anderson Cancer CenterHoustonTXUSA

This study aimed to exploit a new virtual block method to spare normal lung tissue in VMAT planning for patients with locally advanced non-small cell lung cancer(LA-NSCLC).The previous method was used to manually restrict the angle of the beam passing through,which ignored the location and shape of large targets that varied between different slices and did not block the beamlets *** the previous method,this new virtual block method was used to block the beamlets when necessary by closing the multi-leaf collimator(MLC)at prerequisite *** algorithm for closing the MLC depended on the thickness of the beamlets passing through the lungs and avoided only the entrance radiation ***,this block can be automatically contoured.A retrospective study was performed to compare the VMAT plans with and without the virtual block method for 17 LANSCLC patients,named the block plan(B-plan)/non-block plan(N-plan).All cases were selected in this study because of the large tumor size and unmet dose constraints of the *** addition to the maximum dose constraint for the virtual block,B-plans adopted identical optimization parameters to N-plans for each *** two types of plans were compared in terms of dosimetric indices and plan *** results were statistically analyzed using the Wilcoxon nonparametric signed-rank test.B-plans have advantages in the following dosimetric metrics that have statistical significance(pradiation-related toxicity in p

关键词： Virtual block VMAT Normal tissue sparing Lung cancer

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