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Journal of Clinical and Nursing Research 2024年第4期8卷 231-236页

作者： Jia Meng Jianglin Zang Tianyu Gao Boyang Wu Xiaoyang Guo Wei Liu radiation Therapy department Affiliated Hospital of Hebei UniversityBaoding 071000China

Objective: To explore the effect of bundled nursing intervention on lung cancer patients with a high risk of PICC-related thrombosis. Methods: Eighty-six PICC patients were selected and randomly divided into a control group and an observation group of 43 patients each. The control group received general nursing care and the observation group received bundled nursing intervention based on the control group. The occurrence of venous thrombosis, quality of life score, Zung self-rating depression scale (SDS) score, self-rating anxiety (SAS) score, and nursing satisfaction after treatment were compared between the two groups. Results: The incidence rate of PICC-related venous thrombosis in the observation group (2/4.652%) was lower than that of the control group (13/30.231%) after nursing intervention (P < 0.05). After the intervention, the quality-of-life scores of the observation group were higher than those of the control group (P < 0.001). After the intervention, the SDS and SAS scores of the observation group were lower than those of the control group (P < 0.001). The nursing satisfaction rate of the observation group (41/ 4.652%) was higher than that of the control group (35/18.604%) (P < 0.05). The difference is statistically significant. Conclusion: In the care of lung cancer patients with a high risk of PICC-related thrombosis, bundled nursing care achieved better results.

关键词： Care bundle Lung cancer PICC Thrombosis

Monte Carlo method for evaluation of surface emission rate measurement uncertainty

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Nuclear Science and Techniques 2024年第7期35卷 126-136页

作者： Yuan-Qiao Li Min Lin Li-Jun Xu Rui Luo Yu-He Zhang Qian-Xi Ni Yun-Tao Liu China Institute of Atomic Energy Beijing102413China National Key Laboratory for Metrology and Calibration Techniques Beijing102413China department of radiation Oncology Hunan Cancer HospitalChangsha410031China The Affiliated Cancer Hospital of Xiangya School of Medicine Central South UniversityChangsha410031China

The aim of this study is to evaluate the uncertainty of 2πcx and 2πβsurface emission rates using the windowless multiwire proportional counter *** study used the Monte Carlo method(MCM)to validate the conventional Guide to the Expression of Uncertainty in Measurement(GUM)method.A dead time mea surement model for the two-source method was established based on the cha racteristics of a single--channel measurement systemn,and the voltage threshold correction factor measurement function was indi rectly obtained by fitting the threshold correction *** uncertainty in the surface emission rate was calculated using the GUM method and the law of propagation of *** MCM provided clear definitions for each input quantity and its uncertainty distribution,and the simulation training was realized witha complete and complex mathematical *** results of the surface emission rate uncertainty evaluation for four radioactive plane sources using both methods showed the uncertainty's consistency E_(n)<0.070 for the comparison of each source,and the uncertainty results ofthe GUM were all lower than those of the ***,the MCM has a more objective evaluation process and can serve as a validation tool for GUM results.

关键词： Surface emission rate Monte Carlo method Metrology Probability distribution function Dead time Low-energy loss correction Least-squares method

Bioinspired zinc-mediated umpolung thiolation of alkyl electrophiles: reaction development, scope and mechanism

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Science China Chemistry 2024年第3期67卷 898-907页

作者： Yuenian Xu Yan Zhang Yong Liu Wen-Wu Sun Jie Huang Hui He Yingjie Wu Wen Liu Shao-Fei Ni Xu-Qiong Xiao Xinxin Shao College of Material Chemistry and Chemical EngineeringKey Laboratory of Organosilicon Chemistry and Material Technology of Ministry of EducationHangzhou Normal UniversityHangzhou 311121China School of Pharmaceutical Sciences South-Central Minzu UniversityWuhan 430074China department of Chemistry and Key Laboratory for Preparation and application of Ordered Structural Materials of Guang-dong Province Shantou UniversityShantou 515063China

Zinc-promoted umpolung thiolation of alkyl electrophiles with masked sulfur transfer reagents in the absence of nickel or copper catalysis is described. This protocol proceeds via a SET process of Zn to electrophilic sulfur reagent followed by insertion of Zn into disulfide and nucleophilic thiolation, providing straightforward access to a wide range of alkyl sulfides with broad substrate scope. A neutral TMEDA-ligated four-coordinated zinc thiolate with tetrahedra geometry was synthesized, isolated and fully characterized by NMR, IR and X-ray analysis. More importantly, the chemical reactivity of this active intermediate has been investigated, enabling the construction of C-Se, C-Te, Sb-S and Bi-S bonds to prepare valuable sulfur-containing molecules and beyond.

关键词： umpolung thiolation C(sp^(3))-S bond formation masked sulfur reagents reductive coupling

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Targeting the organelle for radiosensitization in cancer radiotherapy

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Asian Journal of Pharmaceutical Sciences 2024年第2期19卷 52-71页

作者： Xiaoyan Sun Linjie Wu Lina Du Wenhong Xu Min Han Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China department of Pharmaceutical Sciences Beijing Institute of Radiation MedicineBeijing 100850China department of radiation Oncology Key Laboratory of Cancer Prevention and InterventionThe Second Afliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310058China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China

Radiotherapy is a well-established cytotoxic therapy for local solid cancers, utilizing high-energy ionizing radiation to destroy cancer cells. However, this method has several limitations, including low radiation energy deposition, severe damage to surrounding normal cells, and high tumor resistance to radiation. Among various radiotherapy methods, boron neutron capture therapy (BNCT) has emerged as a principal approach to improve the therapeutic ratio of malignancies and reduce lethality to surrounding normal tissue, but it remains deficient in terms of insufficient boron accumulation as well as short retention time, which limits the curative effect. Recently, a series of radiosensitizers that can selectively accumulate in specific organelles of cancer cells have been developed to precisely target radiotherapy, thereby reducing side effects of normal tissue damage, overcoming radioresistance, and improving radiosensitivity. In this review, we mainly focus on the field of nanomedicine-based cancer radiotherapy and discuss the organelle-targeted radiosensitizers, specifically including nucleus, mitochondria, endoplasmic reticulum and lysosomes. Furthermore, the organelle-targeted boron carriers used in BNCT are particularly presented. Through demonstrating recent developments in organelle-targeted radiosensitization, we hope to provide insight into the design of organelle-targeted radiosensitizers for clinical cancer treatment.

关键词： Cancer radiotherapy Organelle-target Radiosensitization Boron neutron capture therapy Nanomedicines

Investigation of MXene nanosheets based radio-frequency electronics by skin depth effect

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Nano Research 2024年第4期17卷 3061-3067页

作者： Rongguo Song Yunfa Si Wei Qian Haoran Zu Bilei Zhou Qinglei Du Daping He Yongliang Wang Air Force Early Warning Academy Wuhan 430019China Hubei Engineering Research Center of RF-Microwave Technology and application Wuhan University of TechnologyWuhan 430070China Hainan Research Institute Wuhan University of TechnologySanya 572000China

Various new conductive materials with exceptional properties are utilized for the preparation of electronic *** ultra-high conductivity is crucial to attain excellent electrical ***,there is a lack of systematic research on the impact of conductor material thickness on device ***,we investigate the effect of conductor thickness on power transmission and radiation in radio-frequency(RF)and microwave electronics based on MXene nanosheets material transmission lines and *** MXene transmission line with thickness above the skin depth exhibits a good transmission coefficient of approximately-3 dB,and the realized gain of MXene antennas exceeds 2 ***,the signal transmission strength of MXene antenna with thickness above the skin depth is higher than 5-μm MXene antenna approximately 5.5 *** lines and antennas made from MXene materials with thickness above the skin depth exhibit stable and reliable performance,which has significant implications for obtaining high-performance RF and microwave electronics based on new conductive materials.

关键词： MXene film radiao-frequency electronics antenna transmission line skin depth

Curcumin modulates oxidative stress to inhibit pyroptosis and improve the inflammatory microenvironment to treat endometriosis

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Genes & Diseases 2024年第3期11卷 102-105页

作者： Jie Ding Shanshan Mei Kaili Wang Wen Cheng Shuai Sun Zhexin Ni Xiaoqiu Wang Chaoqin Yu department of Gynecology of Traditional Chinese Medicine Changhai Hospital Affiliated to Naval Medical UniversityShanghai 200433China Obstetrics and Gynecology department The First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhouZhejiang 310006China department of Pharmaceutical Sciences Beijing Institute of Radiation MedicineBeijing 100850China Obstetrics and Gynecology Hospital of Fudan University Shanghai 200433China

Endometriosis(EM)is a common disease that affects approximately 10%-15%of women of childbearing *** pathogenesis of EM is unclear,but studies have shown a strong association between EM and inflammation,as well as oxidative stress.^(1) Pyroptosis is also called inflammatory cell *** pyroptosis occurs,it activates a strong inflammatory *** is associated with oxidative stress,and Ros act as intermediate triggers to activate pyroptosi.

关键词： inflammatory death oxidative

Changes in acute and late toxicity and patient-reported health-related quality of life following radiotherapy in women with breast cancer:A 1-year longitudinal study

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Journal of Integrative Nursing 2024年第1期6卷 15-21页

作者： Gonca Hanedan USLU Aydanur AYDIN Ayla GÜRSOY department of radiation Oncology Faculty of MedicineRecep Tayyip Erdogan UniversityRizeTurkey department of Nursing Antalya Bilim UniversityFaculty of Health SciencesGumushane UniversityGumushaneTurkey department of Nursing Faculty of Health SciencesAntalya Bilim UniversityAntalyaTurkey

Objective:The objective of this study was to investigate the frequency of acute and late toxicities,as well as changes in the quality of life(QOL)for breast cancer patients following radiotherapy(RT).Materials and Methods:A total of 108 breast cancer women were recruited for this prospective *** were collected at various intervals;prior to,and 1,3,6 months,and 1 year after radiation *** primary outcomes were toxicity radiation therapy oncology group/European Organization for Research and Treatment of Cancer(EORTC)*** secondary outcome was QOL,measured using EORTC QLQ-C30 and Edmonton Symptom Assessment *** employed Friedman’s two-way analysis to evaluate the changes in QOL over the course of 1 ***:The early toxicities that are most commonly experienced include pharyngeal,skin,and mucous membrane *** toxicities frequently involve skin and submucosal *** measure patient functionality,all functional subscale scores except for the patient’s emotional state increased over time compared to *** of the patients,which were included in the QOL symptom scale,decreased during the follow-up period,except for fatigue;however,changes in pain,insomnia,and loss of appetite did not significantly *** identified the analogous symptom profiles in *** patients’overall health scores declined in the 1st and 3rd months after radiotherapy(RT),they rebounded at 6 and 12 ***:For breast cancer patients,RT did not adversely affect functional capacity or exacerbate symptoms,but persistent fatigue did increase during the observation ***-care professionals ought to devise strategies to assist patients with skin toxicity and fatigue.

关键词： Breast cancer health‑related quality of life radiotherapy toxicity

Analyzing the surface passivity effect of germanium oxynitride:a comprehensive approach through first principles simulation and interface state density

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Nuclear Science and Techniques 2024年第5期35卷 74-84页

作者： Sheng-Jie Du Xiu-Xia Li Yang Tian Yuan-Yuan Liu Ke Jia Zhong-Zheng Tang Jian-Ping Cheng Zhi Deng Yu-Lan Li Zheng-Cao Li Sha-Sha Lv College of Nuclear Science and Technology Joint Laboratory of Jinping Ultra‑Low radiation Background Measurement of Ministry of Ecology and Environment Key Laboratory of Beam Technology of Ministry of Education Beijing Normal UniversityBeijing Normal UniversityBeijing 100875China Joint Research Center Nuctech Company LimitedBeijing 100084China department of Engineering Physics Key Laboratory of Particle&Radiation Imaging of Ministry of EducationTsinghua UniversityBeijing 100084China Key Laboratory of Advanced Materials(MOE) School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China

High-purity germanium(HPGe)detectors,which are used for direct dark matter detection,have the advantages of a low threshold and excellent energy *** surface passivation of HPGe has become crucial for achieving an extremely low energy *** this study,first-principles simulations,passivation film preparation,and metal oxide semiconductor(MOS)capacitor characterization were combined to study surface *** calculations of the energy band structure of the -H,-OH,and -NH_(2) passivation groups on the surface of Ge were performed,and the interface state density and potential with five different passivation groups with N/O atomic ratios were accurately analyzed to obtain a stable surface *** on the theoretical calculation results,the surface passivation layers of the Ge_(2)ON_(2) film were prepared via magnetron sputtering in accordance with the optimum atomic ratio *** microstructure,C-V,and I-V electrical properties of the layers,and the passivation effect of the Al/Ge_(2)ON_(2)/Ge MOS were characterized to test the interface state *** mean interface state density obtained by the Terman method was 8.4×10^(11) cm^(-2) eV^(-1).The processing of germanium oxynitrogen passivation films is expected to be used in direct dark matter detection of the HPGe detector surface passivation technology to reduce the detector leakage currents.

关键词： Surface passivation High purity germanium detector Germanium nitrogen oxide Interface state density

Insights into ionic association boosting water oxidation activity and dynamic stability

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Journal of Energy Chemistry 2024年第2期89卷 99-109,I0004页

作者： Zanling Huang Shuqi Zhu Yuan Duan Chaoran Pi Xuming Zhang Abebe Reda Woldu Jing-Xin Jian Paul K.Chu Qing-Xiao Tong Liangsheng Hu Xiangdong Yao department of Chemistry and Key Laboratory for Preparation and application of Ordered Structural Materials of Guangdong Province Shantou UniversityShantou 515063GuangdongChina Chemistry and Chemical Engineering Guangdong Laboratory Shantou 515063GuangdongChina State Key Laboratory of Refractories and Metallurgy and Institute of Advanced Materials and Nanotechnology Wuhan University of Science and TechnologyWuhan 430081HubeiChina department of Physics Department of Materials Science and Engineeringand Department of Biomedical EngineeringCity University of Hong KongTat Chee AvenueKowloonHong KongChina School of Advanced Energy Sun Yat-sen University(Shenzhen)Shenzhen 518107GuangdongChina

There have been reports about Fe ions boosting oxygen evolution reaction(OER)activity of Ni-based catalysts in alkaline conditions,while the origin and reason for the enhancement remains ***,we attempt to identify the activity improvement and discover that Ni sites act as a host to attract Fe(Ⅲ)to form Fe(Ni)(Ⅲ)binary centres,which serve as the dynamic sites to promote OER activity and stability by cyclical formation of intermediates(Fe(Ⅲ)→Fe(Ni)(Ⅲ)→Fe(Ni)-OH→Fe(Ni)-O→Fe(Ni)OOH→Fe(Ⅲ))at the electrode/electrolyte interface to emit O_(2).Additionally,some ions(Co(Ⅱ),Ni(Ⅱ),and Cr(Ⅲ))can also be the active sites to catalyze the OER process on a variety of *** Fe(Ⅲ)-catalyzed overall water-splitting electrolyzer comprising bare Ni foam as the anode and Pt/Ni-Mo as the cathode demonstrates robust stability for 1600 h at 1000 mA cm^(-2)@~1.75 *** results provide insights into the ioncatalyzed effects boosting OER performance.

关键词： Oxygen evolution reaction Fe(Ⅲ)-catalysis Ni-Fe binary active centers Ion-catalyzed effects Robust stability

CA IX-targeted Ag_(2)S quantum dots bioprobe for NIR-II imaging-guided hypoxia tumor chemo-photothermal therapy

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Journal of Pharmaceutical Analysis 2024年第6期14卷 878-888页

作者： Xinyue Cui Zhuang Hu Ruihan Li Peng Jiang Yongchang Wei Zilin Chen department of radiation and Medical Oncology Zhongnan Hospital of Wuhan University and School of Pharmaceutical SciencesWuhan UniversityWuhan430071China Key Laboratory of Combinatorial Biosynthesis and Drug Discovery Ministry of EducationHubei Province Engineering and Technology Research Center for Fluorinated PharmaceuticalsWuhan430071China

Hypoxia is the common characteristic of almost all solid tumors,which prevents therapeutic drugs from reaching the ***,the development of new targeted agents for the accurate diagnosis of hypoxia tumors is widely *** carbonic anhydrase IX(CA IX)is abundantly distributed on the hypoxia tumor cells,it is considered as a potential tumor biomarker.4-(2-Aminoethyl)benzenesulfonamide(ABS)as a CA IX inhibitor has inherent inhibitory activity and good targeting *** this study,Ag_(2)S quantum dots(QDs)were used as the carrier to prepare a novel diagnostic and therapeutic bioprobe(Ag_(2)S@polyethylene glycol(PEG)-ABS)through ligand exchange and amide condensation ***_(2)S@PEG-ABS can selectively target tumors by surface-modified ABS and achieve accurate tumor imaging by the near infrared-II(NIR-II)fluorescence characteristics of Ag_(2)S *** modification of Ag_(2)S QDs greatly improves its water solubility and stability,and therefore achieves high photothermal stability and high photothermal conversion efficiency(PCE)of 45.17%.Under laser irradiation,Ag_(2)S@PEG-ABS has powerful photothermal and inherent antitumor combinations on colon cancer cells(CT-26)in *** also has been proved that Ag_(2)S@PEG-ABS can realize the effective treatment of hypoxia tumors in vivo and show good ***,it is a new efficient integrated platform for the diagnosis and treatment of hypoxia tumors.

关键词： CA IX-targeted Hypoxia tumor combination therapy NIR-II imaging Photothermal effect