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Changes of evoked potential in different hippocampal regions induced by electrostimulation at medial mamillary nucleus of rats

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Neural Regeneration Research 2006年第1期1卷 87-89页

作者： Xinxin Li Lihong Shang Liang Zhang Fengzhi Cui department of physiology Shenyang Medical College Shenyang 110034 Liaoning Province China department of physiology. sujiatun distdct health school Shenyang 110101. Liaoning Province China

BACKGROUND： Morphological data have shown that the most important afferent fibers of papillary body come from hippocampal structure.OBJECTIVE： To observe the changes of evoked potential in hippocampus and the significance after electrostimulation at medial mamillary nucleus. DESIGN： An observational control experiment.SETTING： department of physiology. Shenyang Medical College.MATERIALS ： Twenty-three male or female Wistar rats, 3-4 months old, weighing 270-350 g, were provided by bhe animal room of Shenyang Medical College [the license number was scxk（Liao）2003-0016]. METHODS： The Wistar rats were anaesthetized by intraperintoneal injection of 20% urethane （1 g/kg）, tracheal intubation was also given. The self-made double-pole metal stimulating electrode with the point diameter of 1 mm was inserted into medial mamillary nucleus, the wanted hippocampal guidance spot was found within the rang of the hippocampal region at the same side of tee mamillary body range （CA1-CA4）, inserted with same-core guidance electrode, a sole square-wave stimulation of wave wide 0.2 ms stimulated with electrodes at the applied intensity of 7-9 V, the evoked potential was induced through guidance electrodes, and then input to the ATAC-350 data-processing machine for memory showing wave processing, the memory recorded wave recording graph was separately drawn up by the X-Y recording instrument to observe the latency, time procedure and amplitude of the evoked potential in each hippocampal region of the rats and calculate the percentage of the evoked potential in each hippocampal region. Totally 78 guidance spots in hippocampus were recorded, including 30 positive reaction spots and 48 negative ones. MAIN OUTCOME MEASURES： ① Latency, time procedure and amplitude of the evoked potentials in each hippocampal region of rats; ②percentage of the evoked potentials in each hippocampal region; ③ the wave shapes of the evoked potentials in each hippocampal region from different arrangem

关键词： Changes of evoked potential in different hippocampal regions induced by electrostimulation at medial mamillary nucleus of rats body

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Interventional effect of scorpion venom from Buthus martensii Karsch in Liaoning on somatic pain

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Neural Regeneration Research 2006年第2期1卷 166-168页

作者： Xinxin Li Fengzhi Cui department of physiology Shenyang Medical CollegeShenyang 110034 Liaoning Province China department ofphysiology Sujiatun Distnct Health School of ShenyangShenyang 110101 Liaoning Province China

BACKGROUND： Scorpion venom from Buthus martensii Karsch is a kind of protein toxin secreted by scorpion tail. According to records of Pen-ts ＇ao Kan-mu, the dried scorpion＇s body and tail are used as medicine, which mainly treating rheumatism numbness, pain and convulsion. Some researches consider that scorpion toxin is the main pharmacological active component of the dried scorpion, and it has 4 times stronger analgesic effect on somatic pain than morphine. OBJECTIVE： To observe the interventional effect of scorpion venom of Buthus martensii Karsch analgesic active peptide on somatic pain. DESIGN： A randomized and controlled trial SETTING： department of physiology. Shenyang Medical College MATERIALS： Totally 80 Wistar rats （provided by Animal Center of Shenyang Medical College）, male and female in half, aged 3 to 4 months, weighed 250 to 350 g, were used in this trial. They were randomly divided into 4 groups： experimental group, control group, morphine group and naloxone group, with 20 in each group. Analgesia active peptide from buthus martensii karsch venom （provided by Biochemical department of Shenyang Pharmaceutical University, 1 mL/dosage）, morphine （produced by Shanghai First Pharmaceutical Manufacturing Plant）, naloxone （opium acceptor inhibitor, American Sigma Corporation）, AT- AC-350 data-processing machine （Nihon Kohden Corporation）, X-Y recording instrument （Nihon Kohden Corporation）. METHODS： The experiment was conducted in the department of physiology. Shenyang Medical College from July 2003 to July 2005. ① After all the animals were anesthetized, common peroneal nerve is dissected and ligated at middle part. Posterior nucleus group of thalamus （PO） and the tail nuclear were oriented according to G. Paxino rat brain three-dimensional orientation atlas, Glass micro electrode was inserted into PO as guiding electrode, connected with ATAC-350 data-processing machine and X-Y recording instrument, to record the unit evoked potential of PO, taking

关键词： venom Liaoning somatic naloxone analgesic injected analgesia endogenous inhib anesthesia

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