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Alisol B 23-acetate promotes white adipose tissue browning to mitigate high-fat diet-induced obesity by regulating mTOR-SREBP1 signaling

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Journal of Integrative Medicine 2024年第1期22卷 83-92页

作者： Lu-lu Han Xin Zhang Hui Zhang Ting Li Yi-chen Zhao Ming-hui Tian Feng-lei Sun Bo Feng department of Neurology Three The Fifth People’s Hospital of JinanJinan 250013Shandong ProvinceChina department of Gastroenterology Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan 250014Shandong ProvinceChina The First Clinical Medical College Shandong University of Traditional Chinese MedicineJinan 250014Shandong ProvinceChina department of geriatrics the First Affiliated Hospital of Shandong First Medical University(Shandong Provincial Qianfoshan Hospital)Jinan 250014Shandong ProvinceChina Chinese Medicine Culture and Literature Research Institute Shandong University of Traditional Chinese MedicineJinan 250014Shandong ProvinceChina department of General Medicine Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan 250014Shandong ProvinceChina department of Traditional Chinese Medicine the Second People’s Hospital of Haibei PrefectureZangzu Autonomous Prefecture of Haibei810300Qinghai ProvinceChina

Objective Obesity is a global health concern with management strategies encompassing bariatric surgery and anti-obesity drugs;however,concerns regarding complexities and side effects persist,driving research for more effective,low-risk *** promotion of white adipose tissue(WAT)browning has emerged as a promising ***,alisol B 23-acetate(AB23A)has demonstrated efficacy in addressing metabolic disorders,suggesting its potential as a therapeutic agent in obesity ***,in this study,we aimed to investigate the therapeutic potential of AB23A for mitigating obesity by regulating metabolic phenotypes and lipid distribution in mice fed a high-fat diet(HFD).Methods An obesity mouse model was established by administration of an *** and insulin metabolism were assessed via glucose and insulin tolerance *** size was determined using hematoxylin and eosin *** expression of browning markers in WAT was evaluated using Western blotting and quantitative real-time polymerase chain *** cage monitoring involved the assessment of various parameters,including food and water intake,energy metabolism,respiratory exchange rates,and physical ***,oil red O staining was used to evaluate intracellular lipid accumulation.A bioinformatic analysis tool for identifying the molecular mechanisms of traditional Chinese medicine was used to examine AB23A targets and associated signaling *** AB23A administration significantly reduced the weight of obese mice,decreased the mass of inguinal WAT,epididymal WAT,and perirenal adipose tissue,improved glucose and insulin metabolism,and reduced adipocyte ***,treatment with AB23A promoted the expression of browning markers in WAT,enhanced overall energy metabolism in mice,and had no discernible effect on food intake,water consumption,or physical *** 3T3-L1 cells,AB23A inhibited lipid accumulation,and both AB23A and rapamycin inhibited t

关键词： Obesity Alisol B 23-acetate Adipose tissue mTOR-SREBP1 High-fat diet

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Non-alcoholic fatty liver disease: The diagnosis and management

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World Journal of Hepatology 2015年第6期7卷 846-858页

作者： Shehab M Abd El-Kader Eman M Salah El-Den Ashmawy department of physical therapy Faculty of Applied Medical Sciences King Abdulaziz University department of physical therapy for cardiopulmonary disorders and geriatrics Faculty of Physical Therapy Cairo University

Non-alcoholic fatty liver disease(NAFLD) is now the most frequent chronic liver disease that occurs across all age groups and is recognized to occur in 14%-30% of the general population, representing a serious and growing clinical problem due to the growing prevalence of obesity and overweight. Histologically, it resembles alcoholic liver injury but occurs in patients who deny significant alcohol consumption. NAFLD encompasses a spectrum of conditions, ranging from benign hepatocellular steatosisto inflammatory nonalcoholic steatohepatitis, fibrosis, and cirrhosis. The majority of hepatocellular lipids are stored as triglycerides, but other lipid metabolites, such as free fatty acids, cholesterol, and phospholipids, may also be present and play a role in disease progression. NAFLD is associated with obesity and insulin resistance and is considered the hepatic manifestation of the metabolic syndrome, a combination of medical conditions including type 2 diabetes mellitus, hypertension, hyperlipidemia, and visceral adiposity. Confirmation of the diagnosis of NAFLD can usually be achieved by imaging studies; however, staging the disease requires a liver biopsy. Current treatment relies on weight loss and exercise, although various insulin-sensitizing agents, antioxidants and medications appear promising. The aim of this review is to highlight the current information regarding epidemiology, diagnosis, and management of NAFLD as well as new information about pathogenesis, diagnosis and management of this disease.

关键词：非酒精的脂肪肝疾病非酒精的 steatohepatitis 肝疾病

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Occurrence and influential factors of depression in patients with Alzheimer disease

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Neural Regeneration Research 2006年第8期1卷 766-768页

作者： Jihui Lü Junpeng Xing Weishan Wang Zhihui Hao Li Zhao Li Zhang Wenjie Li Yu Xue Ward of Dementia Beijing Geriatrics Hospital Beijing 100095 China Ward of Dementia Beijing Geriatrics Hospital Beijing 100095 China Ward of Dementia Beijing Geriatrics Hospital Beijing 100095 China Ward of Dementia Beijing Geriatrics Hospital Beijing 100095 China Ward of Dementia Beijing Geriatrics Hospital Beijing 100095 China Ward of Dementia Beijing Geriatrics Hospital Beijing 100095 China Ward of Dementia Beijing Geriatrics Hospital Beijing 100095 China Ward of Dementia Beijing Geriatrics Hospital Beijing 100095 China

BACKGROUND: The differential diagnosis between depressive pseudodementia and Alzheimer disease (AD) is a clinical problem, and it is more difficult to diagnose depression in AD. OBJECTIVE: To analyze the incidence and characters of depression in AD patients, and investigate the correlative factors. DESIGN: A randomized controlled study. SETTING: Beijing geriatrics Hospital. PARTICIPANTS: From October 2005 to July 2006, 34 patients with probable AD were selected from the department of Dementia, Beijing geriatrics Hospital according to National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer Disease and Related disorders Association (NINCDS-ADRDA) criteria for AD. There were 16 males and 18 females, aged 63-85 years. Meanwhile, 30 patients with other chronic neurological disorders (CND) were selected from our hospital as the CND control group, there were 16 males and 14 females, aged 55-85 years, including 18 cases of cerebrovascular sequela, 9 of Parkinson disease and 3 of migraineurs. Another 30 patients with chronic physical diseases (CPD) were enrolled as the CPD control group, there were 15 males and 15 females, aged 57-83 years, including 15 cases of chronic bronchitis, 8 of hypertension and 7 of diabetes mellitus. Besides, 30 physical examinees were enrolled as the healthy control group, including 15 males and 15 females, aged 55-80 years. All the subjects were informed and agreed with the detection. METHODS: ① All the subjects underwent the Hamilton rating scale for depression (HAMD) (24 items) assessment, and the total score < 8 points was regarded as no depression, 8-20 as mild depression, 20-35 as moderate depression, ≥ 35 as severe depression. ② All the AD patients were assessed with Cornell scale for depression in dementia (CSDD) (19 items), and the total score < 8 points was regarded as no depression, and ≥ 8 as depression. CSDD consisted of five subscales, including mood-related signs, behavioral disturbance, cyclic functions,

关键词： ADL Occurrence and influential factors of depression in patients with Alzheimer disease MMSE CDSS

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Quality of life, physical performance and nutritional status in older patients hospitalized in a cardiology department

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Journal of Geriatric Cardiology 2020年第7期17卷 410-416页

作者： Matthieu Lilamand Mariannick Saintout Marie Vigan Astrid Bichon Laure Tourame Aurélie Brembilla Diet Bernard Iung Dominique Himbert Cédric Laouenan Agathe Raynaud-Simon Assistance Publique Hôpitaux de Paris Nord Department of GeriatricsBichat University HospitalFrance University of Paris France Assistance Publique Hôpitaux de Paris Nord Department of EpidemiologyBiostatistics and Clinical ResearchBichat University HospitalFrance Assistance Publique Hôpitaux de Paris Nord Department of CardiologyBichat University HospitalFrance

Objectives Quality of life(QoL) is a priority outcome in older adults suffering from cardiovascular diseases. Frailty and poor nutritional status may affect the QoL through mobility disorders and exhaustion. The objective of this study was to determine if physical frailty and nutritional status were associated with QoL, in older cardiology patients. Methods Cross sectional, observational study conducted in a cardiology department from a university hospital. Participants(n = 100) were aged 70 and older. Collected data included age, sex, cardiac diseases, New York Heart Association(NYHA) classification, comorbidities(Charlson Index) and disability. A Short physical Performance Battery(SPPB), including walking speed assessment was performed;handgrip strength were measured as well as Fried’s frailty phenotype. Nutritional status was assessed using the Mini Nutritional Assessment(MNA) and Body Mass Index(BMI), inflammation by C-reactive protein(CRP). QoL was assessed using the EORTC–QLQ questionnaire. Univariate and multivariate analyses were performed to study the associations between all recorded parameters and QoL. Results In participants(mean age: 79.3 ± 6.7 years;male: 59%), Charlson index, arrhythmia, heart failure, NYHA class III-IV, MNA, disability, walking speed, SPPB score, frailty and CRP were significantly associated with QoL in univariate analysis. Multivariate analysis showed that NYHA class III-IV(P physical interventions on QoL in this population.

关键词： Cardiovascular diseases Frailty Muscle strength Nutrition Older adults Quality of life

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Neuro-11:a new questionnaire for the assessment of somatic symptom disorder in general hospitals

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General Psychiatry 2023年第4期36卷 248-259页

作者： Silin Zeng Yian Yu Shan Lu Sirui Zhang Xiaolin Su Ge Dang Ying Liu Zhili Cai Siyan Chen Yitao He Xin Jiang Chanjuan Chen Lei Yuan Peng Xie Jianqing Shi Qingshan Geng Rafael H Llinas Yi Guo department of Neurology Shenzhen People's HospitalThe second Affiliated Hospitals of Jinan UniversityThe first Affiliated Hospitals of Southern University of Science and TechnologyShenzhenGuangdongChina Jinan University GuangzhouGuangdongChina department of Statistics and Data Science Southern University of Science and TechnologyShenzhenGuangdongChina Institute of Neurological Diseases Shenzhen Bay LaboratoryShenzhenGuangdongChina department of neurology The Johns Hopkins University School of MedicineBaltimoreMarylandUSA department of geriatrics Shenzhen People's HospitalThe second Affiliated Hospitals of Jinan UniversityThe first Affiliated Hospitals of Southern University of Science and TechnologyShenzhenChina NHC Key Laboratory of Diagnosis and Treatment on First Affiliated Hospital of Chongqing Medical University ChongqingChongqingChina National Center for Applied Mathematics ShenzhenGuangdongChina

Background Somatic symptom disorder(SSD)commonly presents in general hospital settings,posing challenges for healthcare professionals lacking specialised psychiatric *** Neuro-11 Neurosis Scale(Neuro-11)offers promise in screening and evaluating psychosomatic symptoms,comprising 11 concise items across three dimensions:somatic symptoms,negative emotions and adverse *** research has validated the scale’s reliability,validity and theoretical framework in somatoform disorders,indicating its potential as a valuable tool for SSD screening in general *** This study aimed to establish the reliability,validity and threshold of the Neuro-11 by comparing it with standard questionnaires commonly used in general hospitals for assessing *** this comparative analysis,we aimed to validate the effectiveness and precision of the Neuro-11,enhancing its utility in clinical *** Between November 2020 and December 2021,data were collected from 731 patients receiving outpatient and inpatient care at Shenzhen People’s Hospital in China for various physical *** patients completed multiple questionnaires,including the Neuro-11,Short Form 36 Health Survey,Patient Health Questionnaire 15 items,Hamilton Anxiety Scale and Hamilton Depression ***-trained clinicians conducted structured interviews and clinical examinations to establish a gold standard diagnosis of *** The Neuro-11 demonstrated strong content reliability and structural consistency,correlating significantly with internationally recognised and widely used *** its brevity,the Neuro-11 exhibited significant correlations with other questionnaires.A test-retest analysis yielded a correlation coefficient of 1.00,Spearman-Brown coefficient of 0.64 and Cronbach’sαcoefficient of 0.72,indicating robust content reliability and internal *** factor analysis confirmed the validity of the three-dimensional structure(p<0.001,co

关键词： validity dimensions spite

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Sexual health in Polish elderly men with coronary artery disease:importance, expectations,and reality

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Asian Journal of Andrology 2020年第5期22卷 526-531页

作者： Lestaw Rusiecki Romuald Zdrojowy Jana Gebala Michal Rabijewski Matgorzata Sobieszczariska Ryszard Smolinski Witold Pilecki Wioletta Dziubek Anna Janocha Maciej Womperski Dariusz Kalka Cardiosexology Unit Department of PathophysiologyWroclaw Medical UniversityWroclaw 50-368Poland department and Clinic of Urology Wroclaw Medical UniversityWroclaw 50-556Poland Cardiosexology Students'Scientific Club Wroclaw Medical UniversityWroclaw 50-368Poland department of Reproductive Health Centre of Postgraduate Medical EducationWarsaw 01-004Poland department of geriatrics Wroclaw Medical UniversityWroclaw 50-369Poland Consultant Sexologist Clinical Hospital Wroclaw Medical UniversityWroclaw 50-556Poland Departm ent of Physiotherapy University School of Physical EducationWroclaw 51-612Poland department of Physiology Wroclaw Medical UniversityWroclaw 50-368Poland Lower Silesian Center for Mental Health Wroclaw 50-226Poland Centre for Men's Health Wroclaw 53-151Poland.

Deterioration in overall health,hormonal disturbances,and erectile dysfunction(ED)contributes to limitations in sexual activity in the elderly,which is further limited by incorrect beliefs about the hazards of sexual activity in cardiac *** aimed to analyze the occurrence of ED in elderly men,their perception of the relevance of good sexual function,and their expectations of physicians.A cross-sectional study encompassed 731 patients with coronary artery disease(CAD)subjected to cardiac *** data and data on modifiable risk factors and patient expectations were *** was assessed using the IIEF-5 *** among the risk factors for ED,occurrence of ED,and patient expectations,as well as the changes in the indicators between 2012 and 2016,were *** mean age of men was 70.7±5.1 *** prevalence of ED was 93.0%.The IIEF-5 score was significantly associated with age,tobacco smoking,exercise tolerance,time to diagnosis of CAD,and treatment with calcium channel blockers and *** declared that sexual activity was overall important(47.9%)or very important(25.6%).Three hundred and sixty(49.3%)patients expected their physician to show interest in their sexual health,but the topic was addressed in only 12.5%.Over the past few years,we have observed an increase in the awareness and importance of sexual health as well as a significant increase in patients’expectations of physicians to show interest in their sexual ***’expectations of discussing and receiving treatment for ED remain an unmet medical need.

关键词： advanced age cardiac rehabilitation erectile dysfunction ischemic heart disease sexual disorders

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Anxiety disorders in patients with cardiopulmonary diseases:A brief review

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Sports Medicine and Health Science 2020年第2期2卷 72-79页

作者： Ashley Grace Swavely J.Larry Durstine Cardiac Diagnostic Unit-Clinic 2K Duke Clinic Duke University HospitalDurhamNCUSA cardiopulmonary Rehabilitation New Hanover Regional Medical CenterWilmingtonNCUSA department of Exercise Science University of South CarolinaNorman J.Arnold School of Public HealthColumbiaSCUSA

This manuscript reviews the current literature involving clinical anxiety and cardiopulmonary disease,considers the hypothesized physiological mechanisms for anxiety,and discusses the use of exercise as a treatment for both anxiety and cardiopulmonary *** literature summary consists of original investigations,meta-analysis,commentaries,and review publications in order to better understand the biological and psychological mechanisms for using exercise as treatment and to provide details specific to cardiopulmonary disease and anxiety management.A gap in the literature exists concerning the anxiolytic effects of exercise as a psychological and physical treatment in cardiopulmonary *** findings from this review support further investigation into the use of exercise to ameliorate the burden of anxiety in cardiopulmonary disease *** review evaluates the current literature surrounding cardiopulmonary disease and anxiety.A systematic literature search identified articles discussing the prevalence,association,and risk of anxiety in cardiopulmonary *** depression is often studied in this population,recent investigation supports a need for further research regarding anxiety in cardiopulmonary *** to manage patients’psychological profile can reduce exacerbations of known disease,reduce hospital readmission,and improve functional capacity,and overall quality of life.

关键词： Anxiety cardiopulmonary disease CAD COPD Exercise

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The landscape of aging

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Science China(Life Sciences) 2022年第12期65卷 2354-2454页

作者： Yusheng Cai Wei Song Jiaming Li Ying Jing Chuqian Liang Liyuan Zhang Xia Zhang Wenhui Zhang Beibei Liu Yongpan An Jingyi Li Baixue Tang Siyu Pei Xueying Wu Yuxuan Liu Cheng-Le Zhuang Yilin Ying Xuefeng Dou Yu Chen Fu-Hui Xiao Dingfeng Li Ruici Yang Ya Zhao Yang Wang Lihui Wang Yujing Li Shuai Ma Si Wang Xiaoyuan Song Jie Ren Liang Zhang Jun Wang Weiqi Zhang Zhengwei Xie Jing Qu Jianwei Wang Yichuan Xiao Ye Tian Gelin Wang Ping Hu Jing Ye Yu Sun Zhiyong Mao Qing-Peng Kong Qiang Liu Weiguo Zou Xiao-Li Tian Zhi-Xiong Xiao Yong Liu Jun-Ping Liu Moshi Song Jing-Dong J.Han Guang-Hui Liu State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China Frontier Science Center for Immunology and Metabolism Medical Research InstituteCollege of Life SciencesWuhan UniversityWuhan 430071China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China CAS Key Laboratory of Tissue Microenvironment and Tumor Shanghai Institute of Nutrition and HealthChinese Academy of SciencesShanghai 200031China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Peking University International Cancer Institute Peking University Health Science CenterPeking UniversityBeijing 100191China School of Pharmaceutical Sciences Tsinghua UniversityBeijing 100084China State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China School of Pharmaceutical Sciences Beijing Advanced Innovation Center for Structural BiologyMinistry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical BiologyTsinghua UniversityBeijing 100084China Colorectal Cancer Center/department of Gastrointestinal Surgery Shanghai Tenth People’s Hospital Affiliated to Tongji UniversityShanghai 200072China department of geriatrics Medical Center on Aging of Shanghai Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai 200025China International Laboratory in Hematology and Cancer Shanghai Jiaotong University School of Med

Aging is characterized by a progressive deterioration of physiological integrity,leading to impaired functional ability and ultimately increased susceptibility to *** is a major risk factor for chronic human diseases,including cardiovascular disease,diabetes,neurological degeneration,and ***,the growing emphasis on “healthy aging” raises a series of important questions in life and social *** recent years,there has been unprecedented progress in aging research,particularly the discovery that the rate of aging is at least partly controlled by evolutionarily conserved genetic pathways and biological *** an attempt to bring full-fledged understanding to both the aging process and age-associated diseases,we review the descriptive,conceptual,and interventive aspects of the landscape of aging composed of a number of layers at the cellular,tissue,organ,organ system,and organismal levels.

关键词： aging mechanism intervention

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