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Initial Experience in GeminiOne^(™)Transcatheter Mitral Valve Edge-to-edge Repair Device

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Cardiology Discovery 2024年第3期4卷 250-252页

作者： Da Zhu Shouzheng Wang Jinping Liu Zhenfei Fang Mao Chen Ben He Xiangbin Pan department of Structure Heart Center Fuwai Yunnan HospitalChineseAcademy of Medical SciencesKunmingYunnan 650102China departmentof Cardiovascular Surgery Zhongnan Hospital of Wuhan UniversityWuhanHubei 430071China department of Cardiology the Second XiangyaHospital of Central South UniversityChangshaHunan 410011China department of Cardiology West China Hospital of Sichuan UniversityChengduSichuan 610041China department of Cardiology ShanghaiChest HospitalShanghai 200030China department of Structure HeartCenter Fuwai HospitalNational Center for Cardiovascular DiseasesChineseAcademy of Medical Sciences and Peking Union Medical CollegeBeijing100037China

Transcatheter edge-to-edge repair(TEER)of the mitral valve has emerged as a standard treatment for patients with severe degenerative mitral regurgitation at high or prohibitive surgical *** devices approved by the Food and Drug Administration including MitraClip(Abbott Vascular,California,USA)and PASCAL(Edwards Lifesciences,California,USA)cost over$33,000 in western countries.[1]This pricing presents a significant economic burden especially in developing countries,where TEER devices are typically not covered by health insurance.

关键词： PASCAL Mitra Abbott

Effect of long-acting polyethylene glycol recombinant human growth hormone dosages in pediatric practice: A pooled analysis of two phase IV randomized controlled trials

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中华医学杂志(英文版) 2024年第17期137卷 2024 Feb 29页

作者： Hou Ling Chen Xuefeng Du Hongwei Zhang Jianping Cheng Xinran Pan Jiayan Pan Hui Liao Wei Luo Xiaoping Fu Junfen department of Pediatrics Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China department of Endocrinology Children’s Hospital of Zhejiang University School of Medicine National Clinical Research Center for Child Health Zhejiang University School of Medicine Hangzhou Zhejiang China department of Paediatrics First Hospital of Jilin University Changchun Jilin China department of Pediatrics Ningbo Women &amp Children’s Hospital Ningbo Zhejiang China department of Pediatric Endocrine Genetics and Metabolism Chengdu Women’s and Children’s Center Hospital Chengdu Sichuan China department of Pediatrics Wuhu First People’s Hospital Wuhu Anhui China department of Endocrinology Key Laboratory of Endocrinology of National Health Commission State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College Beijing China department of Pediatrics The First Affiliated Hospital of Army Medical University (Third Military Medical University) Chongqing China

Efficacy of interleukin-17 inhibitors on radiographic progression in psoriatic arthritis:A systematic review and meta-analysis

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Chinese medical Journal 2024年第4期137卷 473-475页

作者： Han-Lei Jiang Yu Du Qiang Tong Sheng-Ming Dai department of Rheumatology and Immunology Shanghai Sixth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200233China

To the Editor:Psoriatic arthritis(PsA)is a highly heterogeneous inflammatory *** occurs in up to 30%of patients with psoriasis and can have severe impacts on peripheral joints,spine,tendon insertions,and fingers. ^([1])Radiographic progression is currently the preferred method for assessing structural damage of PsA. ^([2])Biologic treatment options for PsA include tumor necrosis factor-αinhibitors(TNFi),interleukin-12/23 inhibitors,and interleukin-17(IL-17)*** therapeutic effects of IL-17 inhibitors on structural damage were not consistent over multiple ***,a systematic review and meta-analysis of the available randomized controlled trials(RCTs)was conducted to quantify the overall effect of IL-17 inhibitors on structural damage in *** study was registered with PROSPERO(***42022301774).

关键词： damage analysis inhibitors

Rapamycin induces differentiation of glioma stem/progenitor cells by activating autophagy

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Chinese Journal of Cancer 2011年第10期30卷 712-720页

作者： Wen-Zhuo Zhuang Lin-Mei Long Wen-Jun Ji Zhong-Qin Liang department of pharmacology Medical School of Soochow University Suzhou Jiangsu 215123 P R. China

Glioma stem/progenitor cells(GSPCs) are considered to be responsible for the initiation,propagation,and recurrence of *** factors determining their differentiation remain poorly *** evidences indicate that alterations in autophagy may influence cell fate during mammalian development and ***,we investigated the role of autophagy in GSPC ***-2 cells were treated with rapamycin,3-methyladenine(3-MA) plus rapamycin,E64d plus rapamycin,or untreated as ***-2 cell xenografts in nude mice were treated with rapamycin or 3-MA plus rapamycin,or untreated as *** blotting and immunocytochemistry showed up-regulation of microtubule-associated protein light chain-3(LC3)-II in rapamycin-treated *** neurosphere formation rate and the number of cells in each neurosphere were significantly lower in the rapamycin treatment group than in other ***-time PCR and immunocytochemistry showed down-regulation of stem/progenitor cell markers and up-regulation of differentiation markers in rapamycin-treated *** electron microscopy revealed autophagy activation in rapamycin-treated tumor cells in *** revealed decreased Nestin-positive cells and increased GFAP-positive cells in rapamycin-treated tumor *** results indicate that rapamycin induces differentiation of GSPCs by activating autophagy.

关键词：雷帕霉素分化细胞脑胶质瘤祖细胞自噬激活诱导 Western印迹

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Neural Regeneration Research 2013年第25期8卷 2360-2369页

作者： Guanqun Qiao Qingquan Li Gang Peng Jun Ma Hongwei Fan Yingbin Li department of Neurosurgery the Second Affiliated Hospital of Nanjing Medical University department of pharmacology the Third Affiliated Hospital of Nanjing Medical University

Although it is believed that glioma is derived from brain tumor stem cells, the source and molecular signal pathways of these cells are still unclear. In this study, we used stable doxycycline-inducible transgenic mouse brain tumor models （c-myc/SV40Tag＋/Tet-on＋） to explore the malignant trans- formation potential of neural stem cells by observing the differences of neural stem cells and brain tumor stem cells in the tumor models. Results showed that chromosome instability occurred in brain tumor stem cells. The numbers of cytolysosomes and autophagosomes in brain tumor stem cells and induced neural stem cells were lower and the proliferative activity was obviously stronger than that in normal neural stem cells. Normal neural stem cells could differentiate into glial fibrillary acidic protein-positive and microtubule associated protein-2-positive cells, which were also negative for nestin. However, glial fibrillary acidic protein/nestin, microtubule associated protein-2/nestin, and glial fibrillary acidic protein/microtubule associated protein-2 double-positive cells were found in induced neural stem cells and brain tumor stem cells. Results indicate that induced neural stem cells are similar to brain tumor stem cells, and are possibly the source of brain tumor stem cells.

关键词： neural regeneration stem cells neural stern cells brain tumor stem cells subventricular zone braintumor transgenic mouse model multidirectional differentiation doxycycline neuroregeneration

Multicenter Clinical Randomized Controlled Trial and Network pharmacology.Analysis of Zhenzhu Qingyuan Granules for the Treatment of Gastroesophageal Reflux Disease

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Chinese Medicine and Natural Products 2024年第3期4卷 106-116页

作者： Mengge Li Zhibo Dang Peiguo Qian Zhenhuan Yang Lei Luo Bo Li Xingzhou Xia Yingjie Ma Zhongqin Dang Yuliang Wang The Second Clinical medical College Henan University of Chinese MedicineZhengzhouHenanChina department of Gastroenterology the Fifth Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanChina department of Gastroenterology the Fifth People’s Hospital of ZhengzhouZhengzhouHenanChina

Objective To evaluate the clinical efficacy and safety of Zhenzhu Qingyuan Granules through a clinical randomized controlled trial and to analyze the potential action targets and pathways of this formula using network *** Patients with gastroesophageal reflux disease(GERD)of liver–stomach stagnant heat pattern who met the inclusion and exclusion criteria were randomly divided into the control group and the observation *** control group received oral rabeprazole,whereas the observation group were given Zhenzhu Qingyuan Granules in addition to the *** treatment duration was 8 *** efficacy was observed in both groups after 8 *** pharmacology.was used to analyze the action targets of ZhenzhuQingyuanGranules and the genes related to GERD,and core targets were *** Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were conducted to explore the potential mechanisms of this *** The clinical research results showed that the total effective rate in the treatment group was 92.68%,compared with 70.00%in the control group,with a statistically significant difference(ppharmacology.identified effective components of Zhenzhu Qingyuan Granules for treating GERD,including quercetin,luteolin,andβ-sitosterol,with potential action targets such as tumor protein 53(TP53),protein kinase B(AKT1),and tumor necrosis *** Zhenzhu Qingyuan Granules can significantly improve clinical symptoms in patients with GERD of liver–stomach stagnated heat pattern,enhance clinical efficacy,and have high *** formula may exert therapeutic effects through multiple targets and pathways.

关键词： gastroesophageal reflux disease Zhenzhu Qingyuan Granules liver–stomach stagnated heat syndrome randomized controlled trial network pharmacology

Metal phthalocyanine as photosensitizer for photodynamic therapy （PDT）——Preparation,characterization and anticancer activities of an amphiphilic phthalocyanine ZnPcS2P2

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Science china Chemistry 2001年第2期44卷 113-122页

作者：黄金陵陈耐生黄剑东刘尔生薛金萍杨素苓黄自强孙建成 Institute of Research on Functional Materials department of Chemistry Fuzhou University Fuzhou 350002 China pharmacology.Research Section Fujian Medical University Fuzhou 350004 China

A series of sulfonated (S) phthalimidomethyl (P) zinc phthalocyanines (Pc) was synthesized in a reaction, in which both kinds of substituents were introduced to ZnPc simultaneously. The products were separated by HPLC. The five different fractions obtained were further purified by a membrane separation method, and then characterized by UV/Vis, IR, element analysis and the abilities to generate singlet oxygen upon irradiation by light as well as a preliminary determination of in vitro antitumor activities. The results show that one of the five separating parts with formula of ZnPcS2P2 exhibited rather good PDT activity. The compound was further characterized by NMR, MS and thermal analysis. Studies on in vivo antitumor activities of ZnPcS2P2 as photosensi-tizer show that its inhibitory rate was up to 89.8% and 90.8% for S180 and U14 solid tumors transplanted in mice respectively when the dosage of drug was 2 mg/kg and the dosage of laser light with 670 nm wavelength was 72 J/cm2. Several structural factor

关键词： metal phthalocyanine photodynamic therapy amphiphilicity anticancer photosensitizer.

Erratum to: Low-intensity pulsed ultrasound ameliorates angiotensin II-induced cardiac fibrosis by alleviating inflammation via a caveolin-1-dependent pathway

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Journal of Zhejiang university-Science B(Biomedicine & Biotechnology) 2024年第9期25卷 800-800页

作者： Kun ZHAO Jing ZHANG Tianhua XU Chuanxi YANG Liqing WENG Tingting WU Xiaoguang WU Jiaming MIAO Xiasheng GUO Juan TU Dong ZHANG Bin ZHOU Wei SUN Xiangqing KONG department of Cardiology the First Afiliated Hospital of Nanjing Medical UniversityNanjing 210029China Key Laboratory of Modern Acoustics Department of PhysicsCollaborative Innovation Center of Advanced MicrostructureNanjing UniversityNanjing 210093China departments of Genetics Pediatricsand Medicine(Cardiology)Wif Cardiovascular Research InstituteAlbert Einstein College of MedicineBronxNY 10461USA

The original version of this article(Zhao et al.,2021)unfortunately contained two mistakes.(1)In p.826,the hematoxylin eosin(HE)staining figure of the fourth panel(the Ang Ⅱ+LIPUS group)in Fig.3a was incorrect.

关键词： inflammation al. cardiac

Phosphorylated heat shock protein 27 is involved in enhanced heart tolerance to ischemia in short-term type 1 diabetic rats

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Acta Pharmacologica Sinica 2005年第7期26卷 806-812页

作者： Hong CHEN~(2,4,5) Xing-jun WU~2 Xi-yuan LU~3 Liang ZHU~2 Li-ping WANG~2 Huang-tian YANG~3 Hong-zhuan CHEN~(2,6) Wenjun YUAN~(4,6) 2 department of pharmacology.Shanghai Second medical university,Shanghai 200025 3 Laboratory of Molecular Cardiology,Health Science Center,Shanghai Second medical university,Shanghai Institute for Biological Sciences,Chinese Academy of Sciences,Shanghai 200025 4 department of Physiology,Second Military medical university,Shanghai 200433,china 5 Now in department of pharmacology.at Shanghai Second medical university,Shanghai 200025,china. department of pharmacology Shanghai Second Medical University Shanghai China department of Physiology Second Military Medical University Shanghai China Laboratory of Molecular Cardiology Health Science Center Shanghai Second Medical University Shanghai Institute for Biological Sciences Chinese Academy of Sciences Shanghai China

Aim:To examine the tolerance of type 1 diabetic hearts to ischemia and *** contents of 27-kDa and 70-kDa heat shock proteins（hsp）aswell as phosphorylated hsp27 were also ***:Hearts from hyper-glycemic rats 3 weeks after streptozocin injection and age-matched normal ratswere subjected to ischemia and reperfusion in *** function and electro-cardiogram were recorded throughout *** heat shock pro-teins were detected with Western ***:Despite depressed systolic func-tion at the baseline,diabetic hearts exhibited considerable enhancement in post-ischemic heart function,manifested by an increase in the maximal rate of leftventricular pressure rise and fall(post-ischemic dp/dtmaxand dp/dtminwere 560±117and-313±68 mmHg/s in control,n=7,1249±57 and-1204±36 mmHg/s in diabetes,n=10,P<0.01).Reperfusion ventricular fibrillation in the diabetic group were at-tenuated compared with controls（1.5±0.3 vs 7.2±2.1 min in control,P<0.01）.Theincreased heart resistance to ischemia in diabetes was associated with hypergly-cemia and accompanied by enhanced expression of myocardial phosphorylatedhsp27 with normal aortic vessel *** was abrogated bymetabolic correction with insulin and accompanied by phospho-hsp27 ***:Heart resistance to ischemia is increased in type 1 diabetes,andhyperglycemia may present a mild yet stressful stimulus leading to upregulationof endogenous stress protein,which may play a potential role in cardioprotectionand compensate for detrimental effects of hyperglycemia in diabetes.

关键词： type 1 diabetes mellitus ischemia reperfusion heart heat shock proteins