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Interferon-λ3 polymorphisms in pegylated-interferon-α plus ribavirin therapy for genotype-2 chronic hepatitis C

World Journal of Gastroenterology 2015年第13期21卷 3904-3911页

作者： Haruya Ishiguro Hiroshi Abe Nobuyoshi Seki Tomonori Sugita Yuta Aida Munenori Itagaki Satoshi Sutoh Noritomo Shimada Tomomi Furihata Akihito Tsubota Yoshio Aizawa Division of Gastroenterology and Hepatology Department of Internal MedicineJikei University School of Medicine Katsushika Medical CenterTokyo 125-8506Japan department of Gastroenterology and Hepatology Shinmatsudo Central General HospitalChiba 270-0034Japan Laboratory of pharmacology and toxicology Graduate School of Pharmaceutical SciencesChiba UniversityChiba 260-8675Japan Core Research Facilities for Basic Science Research Center for Medical ScienceJikei University School of MedicineTokyo 105-8461Japan

AIM: To evaluate interferon-λ3(IFNL3) polymorphisms in response-guided pegylated interferon-α plus ribavirin(Peg-IFNα/RBV) therapy for genotype 2(G2) chronic hepatitis ***: Between January 2006 and June 2012, a total of 180 patients with chronic infections of G2 hepatitis C virus(HCV) were treated with responseguided Peg-IFNα/RBV therapy. The treatment duration was 24 wk for patients who achieved rapid virologic response(RVR), and 36 or 48 wk for patients who did not. Then, the impact of the IFNL3 single nucleotide polymorphism genotype(TT/non-TT at rs8099917) on treatment outcomes was evaluated in the 180 patients, and between patients infected with either HCV subgenotype 2a or ***: Of the 180 patients evaluated, 111 achieved RVR, while the remaining 69 patients did not. In RVR patients, the sustained virologic response(SVR) rate was 96.4%, and the IFNL3 genotype did not influence the SVR rate(96.6% vs 95.8% in IFNL3 genotype TT vs non-TT). However, in non-RVR patients, the SVR rate decreased to 72.5%(P 2.9%, P = 0.0146). Multivariate regression analysis in non-RVR patients identified the IFNL3 genotype TT as the only baseline-significant factor associated with SVR(OR = 5.39, 95%CI: 1.29-22.62; P = 0.0189). In analysis according to HCV sub-genotype, no significant difference in the SVR rate was found between HCV sub-genotypes 2a and ***: In response-guided Peg-IFNα/RBV combination therapy for chronically HCV G2-infected patients, the impact of the IFNL3 genotype on SVR was limited to non-RVR patients.

关键词： Hepatitis C virus genotype 2 Interferon-λ3 single

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Biological nano agent produced by hypoxic preconditioning stem cell for stroke treatment

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Nano Research 2023年第5期16卷 7413-7421页

作者： Xin-Chi Jiang Hong-Hui Wu Tianyuan Zhang Yun-Fei Dong Yao-Sheng Li Ting Huang An-Hao Tian Peng-Xiang Chen Xian-Ming Lin Ying-Zhi Huang Chong Liu Xiang-Nan Zhang Zhong Chen Yasuhiko Tabata Jian-Qing Gao Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Dr.Li Dak Sum&Yip Yio Chin Center for Stem Cell and Regenerative medicine Zhejiang UniversityHangzhou 310058China department of Pathology and Pathophysiology and department of Neurosurgery of the Second Affiliated Hospital Zhejiang University School of MedicineHangzhou 310058China The Third Affiliated Hospital of Zhejiang Chinese Medical university Hangzhou 310058China SinoCell Biotechnology Ltd. Ningbo 315000China Key Laboratory of Medical Neurobiology of the Ministry of Health of China Institute of Pharmacology&ToxicologyCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Laboratory of Biomaterials Department of Regeneration Science and EngineeringInstitute for Frontier Life and Medical SciencesKyoto UniversityKyoto 606-8501Japan

Exosomes make a significant contribution during stem cell-based therapy due to the abundant *** evidence implies exosomes can act as potential biological nano *** herein propose hypoxic preconditioning for neural stem cells(NSCs)that could produce hypoxic exosomes for efficient treatment of ischemic *** preconditioning on NSCs significantly altered the miRNAs encapsulated in ***,hypoxic exosomes could target the injured brain to regulate the microenvironment to inhibit neuroinflammation and promote blood–brain barrier permeability ***,the autologous NSCs in Nestin-CreER mice could be activated by hypoxic exosomes to facilitate nerve *** hypoxic preconditioning,exosomes further exerted therapeutic effects on both survival(25%)and behavioral outcomes in ischemic stroke ***,hypoxic preconditioning NSCs can produce effective nano agent and may represent a promising strategy for clinical neurorestorative therapy.

关键词： exosomes hypoxia-preconditioning stem cells ischemic stroke microenvironment

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Inhibition of cytochrome P450 by furanocoumarins in grapefruit juice and herbal medicines

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Acta Pharmacologica Sinica 2004年第2期25卷 3-10页

作者： Lian-qing GUO1, Yasushi YAMAZOE2department of Clinical pharmacology, Jinling Hospital, Nanjing 210002, China 2Division of Drug Metabolism and Moleculartoxicology, Graduate school of Pharmaceutical Sciences, Tohoku university, Sendai 980-8578, japan department of Clinical pharmacology Jinling Hospital Nanjing 210002 Division of Drug Metabolism and Molecular toxicology Graduate School of Pharmaceutical Sciences Tohoku University Sendai 980-8578 日本

Furanocoumarins (psoralens) exist in various plants and some of them are used to cure skin diseases. Thesechemicals draw attentions recently because of their abilities to arouse drug interaction through inhibition of cyto-chrome P450. Grapefruit juice is a well-known example for food-drug interaction. But in vitro and in vivo studieshave shown that the causative components are mainly furanocoumarin derivatives with geranyloxy side chains. Invitro experiments confirmed that furanocoumarins from grapefruit juice are both competitive and mechanism-based inhibitors of CYP3A4. Although the inhibition appeared to be stronger in the dimers than that in the monomers,all contribute comprehensively to the grapefruit juice-drug interaction. Further experiments with other furanocoumarinsand related citrus fruits or umbelliferous herbal medicines indicate that drug interaction might also occur with stuffsother than grapefruit juice, especially with traditional medicine.

关键词： psoralens grapefruit juice herbal medicine enzyme inhibitors cytochrome P-450 enzyme system drug interaction

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Anti-hepatocarcinoma activity of TT-1,an analog of melittin,combined with interferon-α via promoting the interaction of NKG2D and MICA

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Journal of Zhejiang university-Science B(Biomedicine & Biotechnology) 2017年第6期18卷 522-531页

作者： Lan-lan WAN Da-qi ZHANG Jin-nan ZHANG Li-qun REN department of Experimental pharmacology and toxicology School of Pharmaceutical SciencesJilin UniversityChangchun 130021China department of Anesthesiology the Second Hospital of Jilin UniversityChangchun 130041China department of Thyroid Surgery China-Japan Union Hospital of Jilin UniversityJilin Provincial Key Laboratory of Surgical Translational MedicineChangchun 130033China department of Neurosurgery China-Japan Union Hospital of Jilin UniversityChangchun 130033China

Hepatocarcinoma is one of the malignant cancers with significant morbidity and *** has emerged in clinical treatment,owing to the limitation and severe side effects of *** the immune system,natural killer（NK）cells are important effectors required to eliminate malignant tumor cells without the limitation of major histocompatibility complex（MHC）molecule ***,treatment which could stimulate NK cells is of great ***,we investigated the efficacy of the combined therapy of TT-1（a mutant of melittin）and interferon-α（IFN-α）on NK cells and human liver cancer HepG-2/Huh7 cells in vitro and in vivo,as well as the mechanism *** combination therapy significantly inhibited the growth of HepG-2/Huh7 cells in vivo,but this effect was impaired after depleting NK ***-1 not only up-regulated MHC class I-related chain molecules A（MICA）expression,but also prevented the secretion of soluble MICA（sM ICA）.Both the mR NA and protein of a disintegrin and metallopeptidase 10（ADAM 10）in HepG-2/Huh7 cells were decreased after TT-1 *** combined therapy of TT-1 and IFN-αcould suppress the growth of HepG-2/Huh7 xenografted tumor effectively via promoting the interaction of NK group 2,member D（NKG2D）and MICA,indicating that TT-1＋IFN-αwould be a potential approach in treating liver cancer.

关键词： TT-1 Interferon-α(IFN-α) Natural killer (NK) cells Hepatocarcinoma Immunotherapy

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Efficacy of Herbal medicine for Depression in Parkinson's Disease:A Systematic Review of Clinical Trials in China

Efficacy of Herbal Medicine for Depression in Parkinson's Di...

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第三届中国药理学会补益药药理专业委员会学术研讨会

作者： Yi Zhang Zhen-Zhen Wang Hong-Mei Sun Ping Li Yun-Feng Li Nai-Hong Chen department of Anatomy School of Preclinical MedicineBeijing University of Chinese Medicine department of pharmacology Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical College department of pharmacology Institute of Clinical Medical SciencesChina-Japan Friendship Hospital department of New Drug Evaluation Beijing Institute of Pharmacology and Toxicology

Objective:Depression is the most common non-motor syndrome of Parkinson’s *** medicine(HM) has been used to treat depression for more than 2000 ***,a few evidence-based reviews on HM for depression have been ***,there is no review focused on the effectiveness of HM for depression in Parkinson’s disease(dPD).To investigate the effectiveness of HM in the treatment of dPD,a systematic review of clinical trials was ***:A systematic search,including English and Chinese literature,was performed to identify clinical trials examining the effectiveness of HM for *** methodological quality and risk of bias of included studies was assessed using the Jadad scale and Cochrane risk of bias assessment,*** mean difference(WMD) with 95% confidence interval(CI) was used as the effect ***:A total of 10 studies involving 582 patients were identified in *** of the included studies were of high risk of bias with flawed study design and poor methodological *** pooled results revealed that HM combined with Western medicine significantly improved the total scores of Unified Parkinson’s Disease Rating Scale(WMD = -7.35;95%CI:-11.24 to -3.47) and the score of Hamilton rating scale for depression (WMD = -4.15;95%CI:-5.19 to -3.12) compared with Western medicine, ***:There are preliminary evidences that HM may be benefit in the treatment of ***,according to the poor quality of the included trials,it might be uncertainty that there was a superiority of HM for treating *** rigorous trials are needed to accurately determine the advantage and disadvantage of HM for dPD.

关键词： Parkinson’s disease depression Herbal medicine systematic review

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Systematic review of efficacy of Chinese herbal preparations on depression in Parkinson’s disease

Systematic review of efficacy of Chinese herbal preparations...

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中国神经科学学会第十届全国学术会议

作者： Yi ZHANG Zhen-Zhen WANG Hong-Mei SUN Ping LI Yun-Feng LI Nai-Hong CHEN department of Anatomy School of Preclinical MedicineBeijing University of Chinese Medicine State Key Laboratory of Bioactive Substances and Functions of Natural medicines Department of PharmacologyInstitute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical College department of pharmacology Institute of Clinical Medical SciencesChina-Japan Friendship Hospital department of New Drug Evaluation Beijing Institute of Pharmacology and Toxicology

Objective Depression is the most common non-motor syndrome of Parkinson’s *** herbal preparation（CHP） has been used to treat depression for more than 2000 ***,a few evidence-based reviews on CHP for depression have been ***,there is no review focused on the effectiveness of CHP for depression in Parkinson’s disease（dPD）.To investigate the effectiveness of CHP in the treatment of dPD,a systematic review of clinical trials was *** A systematic search,including Enghsh and Chinese hterature,was performed to identify clinical trials examining the effectiveness of CHP for *** methodological quality and risk of bias of included studies was assessed using the Jadad scale and Cochrane risk of bias assessment,*** mean difference（WMD） with 95%confidence interval（CI） was used as the effect *** A total of 10 studies involving 582 patients were *** of the included studies were of high risk of bias with flawed study design and poor methodological *** pooled results revealed that CHP combined with Western medicine significantly improved the total scores of Unified Parkinson’s Disease Rating Scale（WMD =-7.35;95%CI:-11.24 to-3.47） and the score of Hamilton rating scale for depression（WMD =-4.15;95%CI:-5.19 to-3.12） compared with Western medicine,*** There are preliminary evidences that CHP may be benefit in the treatment of ***,according to the poor quality of the included trials,it might be uncertainty that there was a superiority of CHP for treating *** rigorous trials are needed to accurately determine the advantage and disadvantage of CHP for dPD.

关键词： Parkinson’s disease depression Chinese herbal preparation systematic review

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Systematic Review of Chinese Medicinal Formula for Depression in Parkinson＇s Disease

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中国药理通讯 2013年第3期30卷 44-45页

作者： Yi Zhang Zhenzhen Wang Hongmei Sun Ping Li Yunfeng Li Naihong Chen department of Anatomy School of Preclinical Medicine Beijing University of Chinese Medicine Beijing 100029 China State Key Laboratory of Bioactive Substances and Functions of Natural medicines Department of Pharmacology Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050 China department of pharmacology Institute of Clinical Medical Sciences China Japan Friendship Hospital Beijing 100029 China department of New Drug Evaluation Beijing Institute of Pharmacology and Toxicology Beijing 100850 China

Aim of the Study:Depression is the most common non-motor syndrome of Parkinson' s *** medicinal formula (CMF) has been used to treat depression for more than 2000 years. Recently, a few evidence-based reviews on CMF f... 详细信息

关键词：姜黄素中脑胶质细胞保护作用 CYP2E1表达活性

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Ascochlorin overcomes chemoresistance and regulates the plasticity of doxorubicin induced EMT via modulation of the NF-кB pathway in hepatocellular carcinoma

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中国药理学与毒理学杂志 2015年第S1期29卷 79-80页

作者： Xiao-yunDAI KwangSeokAHN ChulwonKIM MuthuKSHANMUGAM FengLI Ji-zhongSHI AlanPremKUMAR Ling-zhiWANG BoonCherGOH JunjiMAGAE TinaHONG KamMHUI GautamSETHI department of pharmacology Yong Loo Lin school of medicine National university of Singapore Singapore 117597 College of Oriental medicine Kyung Hee university Seoul 130-701 Republic of Korea Cancer Science Institute of Singapore Cancer Science Singapore 117599 department of Haematology-Oncology National university Health System Singapore 117599 Magae Bioscience Institute 49-4 Fujimidai Tsukuba 300-1263 Japan Division of Cellular and Molecular Research Humphrey Oei Institute of Cancer Research National Cancer Centre Singapore 169610

OBJECTIVE Doxorubicin-based therapy has been found to be not significantly effective for the treatment of advanced stage hepatocellular carcinomas(HCCs),which often undergo epithelial-mesenchymal transition(EMT)during tumor *** evidence suggest(s)that epithelial cell transformation to mesenchymal state canenhance the ability to self-renew and confer greater resistance to the conventional chemotherapeutic *** aim of this study was to examine the potential efficacyof ascochlorin,an isoprenoid antibiotic to overcome drug resistance induced by doxorubicin in HCC cell lines and to elucidate its underlying mechanism(s)of *** The effect of doxorubicin and ascochlorin on HCC cell lines was determined by MTT,Western blotting,immunofluorescence and NF-кB DNA binding *** Our results indicate that HCC cells that show a mesenchymal-like phenotype,are resistance to the doxorubicin therapy which directly correlated with an increased slug *** also observed that activation of NF-кB pathway plays an essential role in doxorubicin induced-chemoresistance and pharmacological inhibition of this pathway with ascochlorin can significantly reverse drug-induced invasion/migration and resistance in HCC *** Our results indicate that combination treatment of doxorubicin with ascochlorin has the potential to inhibit HCC growth and metastasis.

关键词： doxorubicin ascochlorin chemoresistance EMT NF-кB

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Traditional Chinese medicine Euodiae Fructus:botany,traditional use,phytochemistry,pharmacology,toxicity and quality control

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Natural Products and Bioprospecting 2023年第1期13卷 665-707页

作者： Si-Jia Xiao Xi-Ke Xu Wei Chen Jia-Yun Xin Wen-Lin Yuan Xian-Peng Zu Yun-Heng Shen department of Natural Medicinal Chemistry School of PharmacyNaval Medical UniversityNo.325 Guohe RoadYangpu DistrictShanghai 200433China school of Pharmacy Shandong University of Traditional Chinese MedicineJinan 250355China

Euodiae Fructus,referred to as“Wuzhuyu”in Chinese,has been used as local and traditional herbal medicines in many regions,especially in China,japan and Korea,for the treatment of gastrointestinal disorders,headache,emesis,aphtha,dermatophytosis,dysentery,*** investigations into their chemical and pharmacological properties have been ***,interest in this plant has been focused on the different structural types of alkaloids like evodiamine,rutaecarpine,dehydroevodiamine and 1-methyl-2-undecyl-4(1H)-quinolone,which exhibit a wide range of pharmacological activities in preclinical models,such as anticancer,antibacterial,anti-inflammatory,anti-cardiovascular disease,*** review summarizes the up-to-date and comprehensive information concerning the botany,traditional uses,phytochemistry,pharmacology of Euodiae Fructus together with the toxicology and quality control,and discusses the possible direction and scope for future research on this plant.

关键词： Euodiae Fructus Traditional uses Phytochemistry pharmacology toxicology

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糖尿病大鼠输精管平滑肌收缩超反应性及钙通道特性(英文)

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中国药理学与毒理学杂志 1991年第4期5卷 261-268页

作者： Yasushi SAKAI Masato INAZU Ikuo HOMMA ro whom correspondence should be sent Present address: POLA Pharmaceutical R & D Laboratory 560 Kashio-cho Totsuka-ku Yokohama 244 JapanSecond Department of Physiology Showa University School of Medicine 1-5 Hatanodai Tokyo 142 Japan

为对解糖尿病对输精管平滑肌功能的影响及其机理，我们比较了链脲菌素（streptozotocin)所致糖尿病大鼠及其同龄对照组大鼠输精管平滑肌对电场刺激，氯化钾，去氧肾上腺素的反应及钙通道的改变，电场刺激引起的收缩反应是单收缩之后继... 详细信息

为对解糖尿病对输精管平滑肌功能的影响及其机理，我们比较了链脲菌素（streptozotocin)所致糖尿病大鼠及其同龄对照组大鼠输精管平滑肌对电场刺激，氯化钾，去氧肾上腺素的反应及钙通道的改变，电场刺激引起的收缩反应是单收缩之后继以连续性收缩，糖尿病组单收缩幅度较大，两组连续收缩几乎相同。1μmol/L Bay K8644使糖尿病鼠输精管产生单收缩，对照组无影响。氯化钾引起的收缩和钙内流在两组都强，但在1μmol/L Bay K8644存在时，糖尿病组比对照组增加明显。10μmol/L去氧肾上腺素引起的收缩可完全被0．1μmol/L硝苯啶阻断。100μmol/L新霉素在对照组可完全抑制去氧肾上腺素引起的收缩，但在糖尿病组只能部分抑制，并使单收缩增强，用钙通道拮抗剂配体[^3H]PN200-110所做的结合实验表明，对照或糖尿病组钙通道的亲和力和结合位的数量都滑有明显的不同，在输精管可溶性成分中，蛋白激酶C含量在糖尿病组是对粗的两倍。这些结果提示在没有神经病变及钙通道数量不变吓，氯化钾增强链脲菌素所致糖尿病大鼠输糖管的收缩反应部分是由于钙通道开放的概率和蛋白激酶C活性增强所致。

关键词：糖尿病输精管钙通道超反应性

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