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Fabrication of micro spherulitic particles of carbamazepine-hesperetin cocrystal via QESD with enhanced manufacturability and dissolution

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Particuology 2024年第10期93卷 11-21页

作者： Jinbo Ouyang Lishan Liu Zichen Ning Zhuoshan Gong Limin Zhou Feiqiang He Zhi Gao Li Xu Shichao Du Huaiyu Yang Jiangxi Province Key Laboratory of Functional Organic Polymers East China University of TechnologyNanchang330013China School of pharmaceutical Science Qilu University of TechnologyJinan250353China department of Chemical engineering Loughborough UniversityLeicestershireLE113TUUK

Granulation is an effective method for improving the flowability of drugs, particularly when they are in needle form. Carbamazepine-hesperetin (CBZ-HPE) cocrystal is a needle-like crystal with low solubility and poor flowability, which limits its application. To address this issue, this study aimed to obtain CBZ-HPE microspheres using the quasi-emulsion solvent diffusion (QESD) technique. The preparation process was monitored using polarized light microscopy, and the formation mechanism was elucidated using the radial distribution function (RDF). The microspheres were extensively characterized using PXRD, DSC, TGA, and SEM. Furthermore, the effects of surfactants, contents, and rotational speeds on the morphology and particle size distribution of microspheres were analyzed to determine the optimal experimental conditions. Based on these findings, naringenin and quercetin, the active ingredients of traditional Chinese medicine, were chosen to successfully prepare CBZ-HPE multicomponent microspheres. This research provides a foundation for increasing drug powder properties and drug conjugation through the preparation of microspheres.

关键词： Carbamazepine-hesperetin cocrystal Quasi-emulsion solventdiffusion(QESD) technique Microspheres Flowability Dissolution rate

Cascade equilibrium stage relaxation method by introducing equilibrium efficiency parameter

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Chinese Journal of Chemical engineering 2024年第2期66卷 145-156页

作者： Xuepu Cao Shengkun Jia Xing Qian Yiqing Luo Xigang Yuan College of Chemical and pharmaceutical Hebei University of Science&TechnologyShijiazhuang 050018China School of Chemical engineering and technology State Key Laboratory of Chemical EngineeringTianjin UniversityTianjin 300072China College of Information Science and technology Beijing University of Chemical TechnologyBeijing 100029China

Optimizing multistage processes,such as distillation or absorption,is a complex mixed-integer nonlinear programming(MINLP)*** integer into continuous variables and solving the easier nonlinear programming(NLP)problem is an optimization idea for the multistage *** this article,we propose a relaxation method based on the efficiency *** the efficiency parameter is 1or 0,the proposed model is equivalent to the complete existence or inexistence of the equilibrium *** non-integer efficiency represents partial existence.A multi-component absorption case shows a natural penalty for non-integer efficiency,which can assist the efficiency parameter converging to 0 or ***,its penalty is weaker than the existing relaxation models,such as the bypass efficiency *** a simple distillation case,we show that this property can weaken the nonconvexity of the optimization problem and increase the probability of obtaining better optimization results.

关键词： Mathematical modeling Absorption Distillation Optimization

Robust Malicious Executable Detection Using Host-Based Machine Learning Classifier

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Computers, Materials & Continua 2024年第4期79卷 1419-1439页

作者： Khaled Soliman Mohamed Sobh Ayman M.Bahaa-Eldin department of Computer and Systems engineering Ain Shams UniversityCairo11517Egypt department of Computer engineering technology ElSewedy University of TechnologyCairo44629Egypt

The continuous development of cyberattacks is threatening digital transformation endeavors worldwide and leadsto wide losses for various organizations. These dangers have proven that signature-based approaches are insufficientto prevent emerging and polymorphic attacks. Therefore, this paper is proposing a Robust Malicious ExecutableDetection (RMED) using Host-based Machine Learning Classifier to discover malicious Portable Executable (PE)files in hosts using Windows operating systems through collecting PE headers and applying machine learningmechanisms to detect unknown infected files. The authors have collected a novel reliable dataset containing 116,031benign files and 179,071 malware samples from diverse sources to ensure the efficiency of RMED *** most effective PE headers that can highly differentiate between benign and malware files were selected totrain the model on 15 PE features to speed up the classification process and achieve real-time detection formalicious executables. The evaluation results showed that RMED succeeded in shrinking the classification timeto 91 milliseconds for each file while reaching an accuracy of 98.42% with a false positive rate equal to 1.58. Inconclusion, this paper contributes to the field of cybersecurity by presenting a comprehensive framework thatleverages Artificial Intelligence (AI) methods to proactively detect and prevent cyber-attacks.

关键词： Portable executable malware intrusion detection cybersecurity zero-day threats Host IntrusionDetection System(HIDS) machine learning Anomaly-based Intrusion Detection System(AIDS) deep learning

Experimental study on the dynamic response of a 3-D wedge under asymmetric impact

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Journal of Hydrodynamics 2024年第2期36卷 263-274页

作者： Saeed Hosseinzadeh Kristjan Tabri Maritime engineering Research Group School of EngineeringUniversity of SouthamptonSouthamptonUK department of Civil engineering and Architecture Tallinn University of TechnologyTallinnEstonia Marine technology Competence Center Tallinn University of TechnologyKuressaareEstonia

Water entry problems represent complex multiphase flows involving air,water,and structure interaction,occurring rapidly in rough seas,and potentially effecting structural integrity of floating *** paper experimentally investigates asymmetric slamming loads acting on a 3-D elastic wedge *** specimen,featuring two different bottom plates(stiffened and unstiffened),each 4 mm thick,aims to assess the effect of structural stiffness on dynamic *** experiments are conducted at different drop heights of 25 cm and 50 cm and varying heel angles from 5°to 25°.The paper describes the experimental conditions,including wedge geometry,material properties,and the test *** study explores the influence of heel angle on impact acceleration,revealing an increase in peak acceleration with a higher inclination angle,particularly in the vertical ***,the hydrodynamic pressure resulting from asymmetric slamming is *** pressure results analyzed and compared at different locations along the length of the *** experimental findings indicate that,despite the leeward side(stiffened)experiencing a smaller hydrodynamic load,the heel angle significantly affects pressure results on the windward side(unstiffened),leading to a more pronounced dynamic *** time history of pressure results emphasizes the effect of elastic vibrations,particularly noticeable on the unstiffened bottom *** study contributes to a deeper understanding of asymmetric slamming on aluminum structures,facilitating the enhancement of mathematical models and the validation of numerical simulations.

关键词： Flexible fluid structure interactions(FFSI) experimental study asymmetric impact hydrodynamic pressure slamming loads

An Overview of PRP-Delivering Scaffolds for Bone and Cartilage Tissue engineering

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Journal of Bionic engineering 2024年第2期21卷 674-693页

作者： Somayeh Baghersad Behzad Bolandi Rana Imani Shabnam Afaghi Samira Davoudinia department of Textile engineering Amirkabir University of Technology(Tehran Polytechnic)Tehran159163-4311Iran department of Biomedical engineering Amirkabir University of Technology(Tehran Polytechnic)Tehran159163-4311Iran

Tissue engineering is nowadays an emerging approach that aims to replace or regenerate diseased or damaged organs with engineered constructs. Considering the key role of growth factors (GFs) in the tissue regeneration process, these biomolecules are considered an important part of the tissue engineering process, so the presence of growth factors in engineered scaffolds can accelerate tissue regeneration by influencing the behavior of cells. Platelet-rich plasma (PRP), as an autologous source of a variety of growth factors, is considered a therapeutic agent for the treatment of degenerative diseases. Regarding its ability to promote the healing process and tissue regeneration, PRP therapy has attracted great attention in bone and cartilage tissue engineering. Incorporating PRP and its derivatives into engineered scaffolds not only bioactivates the scaffold, but the scaffold matrix also acts as a sustained and localized growth factor release system. In addition, the presence of a scaffold can promote the bioactivity of GFs by providing an environment that facilitates their interaction, leading to enhanced effects compared to their free form. This review presents a brief overview of PRP's role in bone and cartilage tissue regeneration with the main focus on scaffold-mediated PRP delivery. In addition, the classification of platelet-rich products, current extraction techniques, terminology, and scaffold bioactivation methods are presented to provide a better understanding of the basics and the key aspects that may affect the effectiveness of therapy in bone and cartilage tissue engineering.

关键词： Platelet-rich plasma Growth factors delivery Scaffold Bone Cartilage

A novel mouse model of PEDF-associated serious liver inflammation,hepatic tumorigenesis and cardiovascular injury mimics human nonalcoholic steatohepatitis

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Genes & Diseases 2024年第1期11卷 11-14页

作者： Xinghui Li Haiping Wang Yandi Wu Li Zou Shijie Dengg Xintu Fu Tongsheng Huang Conghui Shen Teng Wu Weibin Cai Guangdong engineering&technology Research Center for Disease-Model Animals Laboratory Animal CenterZhongshan School of MedicineSun Yat-sen UniversityGuangzhouGuangdong 510080China department of Biochemistry Zhongshan School of MedicineSun Yat-sen UniversityGuangzhouGuangdong 510080China School of Pharmacy Guangdong Pharmaceutical UniversityGuangzhouGuangdong 510006China Guangdong Provincial Key Laboratory of Digestive Cancer Research The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhenGuangdong 518107China

There are no approvedtherapeuticdrugs for nonalcoholic steatohepatitis(NASH)due to the many bottlenecks,including the lack of preclinical animal models that can perfectly mimic human NASH features,such as systemic metabolic disorders,hepatic steatosis,intense liver inflammation and fibrosis,liver tumorigenesis,and cardiovascularcomplications.i,2"Pigment"epitheliumderived factor(PEDF)is a lipid metabolism regulator with high expression in the liver,and its reduced expression in the liver is closely related to the development of nonalcoholic fatty liver disease(NAFLD).

关键词： inflammation PEDF hepatic

F-doped orthorhombic Nb_(2)O_(5) exposed with 97% (100) facet for fast reversible Liþ-Intercalation

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Green Energy & Environment 2024年第4期9卷 723-731页

作者： Xiaodi Liu Yufeng Tang Dan Zhang Guangyin Liu Xinwei Luo Yi Shang Xiu Li Jianmin Ma College of Chemistry and pharmaceutical engineering Nanyang Normal UniversityNanyang473061China School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu611731China

Orthorhombic Nb_(2)O_(5)(T-Nb_(2)O_(5))is attractive for fast-charging Li-ion batteries,but it is still hard to realize rapid charge transfer kinetics for Li-ion ***,F-doped T-Nb_(2)O_(5) microﬂowers(F-Nb_(2)O_(5))are rationally synthesized through topotactic ***,F-Nb_(2)O_(5) are assembled by single-crystal nanoﬂakes with nearly 97%exposed(100)facet,which maximizes the exposure of the feasible Li^(+)transport pathways along loosely packed 4g atomic layers to the electrolytes,thus effectively enhancing the Li^(+)-intercalation ***,the band gap of F-Nb_(2)O_(5) is reduced to 2.87 eV due to the doping of F atoms,leading to enhanced electrical *** synergetic effects between tailored exposed crystal facets,F-doping,and ultrathin building blocks,speed up the Li^(+)/electron transfer kinetics and improve the pseudocapacitive properties of F-Nb_(2)O_(5).Therefore,F-Nb_(2)O_(5) exhibit superior rate capability(210.8 and 164.9 mAh g^(-1) at 1 and 10 C,respectively)and good long-term 10 C cycling performance(132.7 mAh g^(-1) after 1500 cycles).

关键词： Exposed facets Orthorhombic Nb_(2)O_(5) F-doping Pseudocapacitive intercalation anode Li-ion storage

Resilence Control of DC Microgrid Integrated with Multi-Nanogrids Considering Connected-Islanded States

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 786-796页

作者： Hossien Faraji Reza Hemmati Pierluigi Siano department of Electrical engineering Amirkabir University of TechnologyTehranIran department of Electrical engineering Kermanshah University of TechnologyKermanshahIran department of Management&Innovation Systems University of Salernoand also with the Department of Electrical and Electronic Engineering ScienceUniversity of JohannesburgJohannesburg 2006South Africa

In this paper, a DC microgrid (DCMG) integrated with a set of nano-grids (NG) is studied. DCMG exchanges predetermined active and reactive power with the upstream network. DCMG and NGs are coordinately controlled and managed in such a way the exchanged P-Q power with external grid are kept on scheduled level following all events and operating conditions. The proposed control system, in addition to the ability of mutual support between DCMG and NGs, makes NGs support each other in critical situations. On the other hand, in all operating conditions, DCMG not only feeds three-phase loads with time-varying active and reactive power on the grid side but also injects constant active power into the grid. During events, NGs support each other, NGs support DCMG, and DCMG supports NGs. Such control strategies are realized by the proposed control method to increase resilience of the system. For these purposes, all resources and loads in DCMG and NGs are equipped with individual controllers. Then, a central control unit analyzes, monitors, and regularizes performance of individual controllers in DCMG and NGs. Nonlinear simulations show the proposed model can effectively control DCMG and NGs under normal and critical conditions.

关键词： Control system DC microgrid nanogrid resilience

Continuous flow pyrolysis of virgin and waste polyolefins:a comparative study,process optimization and product characterization

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Frontiers of Chemical Science and engineering 2024年第6期18卷 133-149页

作者： Ecrin Ekici Güray Yildiz Magdalena Joka Yildiz Monika Kalinowska ErolŞeker Jiawei Wang Karlsruhe Institute of technology Institute of Catalysis Research and TechnologyEggenstein-Leopoldshafen 76344Germany Izmir Institute of technology Faculty of EngineeringDepartment of Energy Systems EngineeringIzmir 35430Türkiye department of Materials engineering and Production Faculty of Mechanical EngineeringBialystok University of TechnologyBialystok 15-351Poland department of Agricultural and Food engineering and Environmental Development Institute of Civil Engineering and EnergeticsFaculty of Civil Engineering and Environmental SciencesBialystok University of Technology15-351 BialystokPoland department of Chemistry Biology and BiotechnologyInstitute of Civil Engineering and EnergeticsFaculty of Civil Engineering and Environmental SciencesBialystok University of TechnologyBialystok 15-351Poland Izmir Institute of technology Faculty of EngineeringDepartment of Chemical EngineeringIzmir 35430Türkiye Energy and Bioproducts Research Institute(EBRI) Aston UniversityBirmingham B47ETUnited Kingdom

Under optimal process conditions,pyrolysis of polyolefins can yield ca.90 wt%of liquid product,i.e.,combination of light oil fraction and heavier *** this work,the experimental findings reported in a selected group of publications concerning the non-catalytic pyrolysis of polyolefins were collected,reviewed,and compared with the ones obtained in a continuously operated bench-scale pyrolysis *** process parameters were used for the pyrolysis of waste and virgin counterparts of high-density polyethylene,low-density polyethylene,polypropylene and a defined mixture of those(i.e.,25:25:50 wt%,respectively).To mitigate temperature drops and enhance heat transfer,an increased feed intake is employed to create a hot melt plastic *** 1.5 g·min^(-1) feed intake,1.1 L·min^(-1) nitrogen flow rate,and a moderate pyrolysis temperature of 450℃,the formation of light hydrocarbons was favored,while wax formation was limited for polypropylene-rich *** of virgin plastics yielded more liquid(maximum 73.3 wt%)than that of waste plastics(maximum 66 wt%).Blending polyethylenes with polypropylene favored the production of liquids and increased the formation of gasoline-range *** products were mainly composed of C3 hydrocarbons,and no hydrogen production was detected due to moderate pyrolysis temperature.

关键词： waste plastics polyolefins chemical recycling pyrolysis alternative fuels waste-to-energy