检索结果-南通市图书馆

Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease

Neural Regeneration Research 2025年第6期20卷 1644-1664页

作者： Gabriela Seplovich Yazan Bouchi Juan Pablo de Rivero Vaccari Jennifer C.Munoz Pareja Andrew Reisner Laura Blackwell Yehia Mechref Kevin K.Wang J.Adrian Tyndall Binu Tharakan Firas Kobeissy department of Surgery Morehouse School of MedicineAtlantaGAUSA department of Neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA department of Neurological Surgery and the Miami Project to Cure Paralysis University of Miami Miller School of MedicineMiamiFLUSA Division of Pediatric Critical Care Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA department of pediatrics Emory UniversityAtlantaGAUSA department of Neurosurgery Children’s Healthcare of AtlantaAtlantaGAUSA department of Chemistry and Biochemistry Texas Tech UniversityLubbockTXUSA Morehouse school of Medicine AtlantaGAUSA

Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease are three distinct neurological disorders that share common pathophysiological mechanisms involving neuroinflammation. One sequela of neuroinflammation includes the pathologic hyperphosphorylation of tau protein, an endogenous microtubule-associated protein that protects the integrity of neuronal cytoskeletons. Tau hyperphosphorylation results in protein misfolding and subsequent accumulation of tau tangles forming neurotoxic aggregates. These misfolded proteins are characteristic of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease and can lead to downstream neuroinflammatory processes, including assembly and activation of the inflammasome complex. Inflammasomes refer to a family of multimeric protein units that, upon activation, release a cascade of signaling molecules resulting in caspase-induced cell death and inflammation mediated by the release of interleukin-1β cytokine. One specific inflammasome, the NOD-like receptor protein 3, has been proposed to be a key regulator of tau phosphorylation where it has been shown that prolonged NOD-like receptor protein 3 activation acts as a causal factor in pathological tau accumulation and spreading. This review begins by describing the epidemiology and pathophysiology of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease. Next, we highlight neuroinflammation as an overriding theme and discuss the role of the NOD-like receptor protein 3 inflammasome in the formation of tau deposits and how such tauopathic entities spread throughout the brain. We then propose a novel framework linking traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease as inflammasomedependent pathologies that exist along a temporal continuum. Finally, we discuss potential therapeutic targets that may intercept this pathway and ultimately minimize long-term neurological decline.

关键词： Alzheimer's disease caspase-1 chronic traumatic encephalopathy inflammasomes neurodegeneration neuroinflammation NLRP1 NLRP3 pyroptosis tauopathy traumatic brain injury

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Role of ion channels in gastrointestinal cancer

引用

World Journal of Gastroenterology 2019年第38期25卷 5732-5772页

作者： Kyle J Anderson Robert T Cormier Patricia M Scott department of Biomedical Sciences University of Minnesota Medical School

In their seminal papers Hanahan and Weinberg described oncogenic processes a normal cell undergoes to be transformed into a cancer *** functions of ion channels in the gastrointestinal(GI)tract influence a variety of cellular processes,many of which overlap with these hallmarks of *** this review we focus on the roles of the calcium(Ca^2+),sodium(Na^+),potassium(K^+),chloride(Cl^-)and zinc(Zn^2+)transporters in GI cancer,with a special emphasis on the roles of the KCNQ1 K+channel and CFTR Cl-channel in colorectal cancer(CRC).Ca^2+is a ubiquitous second messenger,serving as a signaling molecule for a variety of cellular processes such as control of the cell cycle,apoptosis,and *** members of the TRP superfamily,including TRPM8,TRPM7,TRPM6 and TRPM2,have been implicated in GI cancers,especially through overexpression in pancreatic adenocarcinomas and down-regulation in colon ***-gated sodium channels(VGSCs)are classically associated with the initiation and conduction of action potentials in electrically excitable cells such as neurons and muscle *** VGSC NaV1.5 is abundantly expressed in human colorectal CRC cell lines as well as being highly expressed in primary CRC *** have demonstrated that conductance through NaV1.5 contributes significantly to CRC cell invasiveness and cancer ***2+transporters of the ZIP/SLC39A and ZnT/SLC30A families are dysregulated in all major GI organ cancers,in particular,ZIP4 up-regulation in pancreatic cancer(PC).More than 70 K+channel genes,clustered in four families,are found expressed in the GI tract,where they regulate a range of cellular processes,including gastrin secretion in the stomach and anion secretion and fluid balance in the intestinal *** distinct types of K+channels are found dysregulated in the GI *** are hERG1 upregulation in PC,gastric cancer(GC)and CRC,leading to enhanced cancer angiogenesis and invasion,and KCNQ1 down-regulation in CR

关键词： Ion channels Gastrointestinal cancer Colorectal cancer Gastric cancer Pancreatic cancer Esophageal cancer Hepatocellular carcinoma Prognostic biomarker Novel therapies Clinical targets

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Saccharomyces boulardii as a single trigger of food protein-induced enterocolitis syndrome: Seven case reports

引用

World Journal of Clinical Cases 2025年第6期13卷 35-40页

作者： Jin-Bok Hwang Hyo-Jeong Jang department of pediatrics Keimyung University School of MedicineDongsan Medical CenterDaegu 42601South Korea

BACKGROUND Food protein-induced enterocolitis syndrome(FPIES)is the most serious type of non-immunoglobulin E(IgE)-mediated food allergic reaction manifesting as sepsis-like symptom,which can lead to *** boulardii(***),a probiotic prescribed frequently in clinical settings,has been reported to trigger FPIES in an infant with soy-triggered *** this report,we describe a new clinical FPIES in which *** was the sole triggering factor of acute FPIES adverse reaction in seven healthy *** SUMMARY Seven FPIES cases triggered by only *** were gathered from 2011 to the *** of the patients had previously experienced any allergic reaction to cow’s milk,soy,or complementary *** age of the patients was 4-10-months old,and the symptoms of FPIES developed after ingestion of ***,which is mostly prescribed for the treatment of gastroenteritis or antibiotic-associated *** patients experienced severe repetitive vomiting 1-3 hours after *** *** lethargy,marked pallor,and cyanosis were also *** IgE-mediated hypersensitivity developed in any *** was followed by initial intense vomiting in approximately 5-10 hours after *** ingestion,and only one case showed bloody,purulent,and foul-smelling *** patients stabilized quickly,mostly within 6 *** got all improved within 24 hours after discontinuation of *** *** can be the sole trigger of acute FPIES and be prescribed cautiously even in healthy children without FPIES.

关键词： Food protein-induced enterocolitis syndrome Food hypersensitivity Saccharomyces boulardii Probiotics Child Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

CRABP1-mediated non-canonical retinoic acid signaling in motor neurons and neural stem cells

引用

Neural Regeneration Research 2024年第6期19卷 1169-1170页

作者： Li-Na Wei department of Pharmacology University of Minnesota Medical SchoolMinneapolisMNUSA

Retinoic acid(RA),the active metabolite of vitamin A(the retinoids),elicits a wide spectrum of biological activities critical to the development and health of most of the organ systems including the nervous systems(Corcoran et al.,2002).The effects of RA are mediated by two very distinct pathways;the first is manifested in the nucleus by binding to a large family of nuclear RA receptors(RARs)to regulate proper expression of RAtargeted genes.

关键词： canonical spectrum critical

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A comprehensive review on biomarkers associated with painful temporomandibular disorders

引用

International Journal of Oral Science 2021年第3期13卷 230-242页

作者： Mayank Shrivastava Ricardo Battaglino Liang Ye department of Diagnostic and Biological Sciences School of DentistryUniversity of MinnesotaMinneapolisMNUSA department of Rehabilitation Medicine Medical SchoolUniversity of MinnesotaMinneapolisMNUSA

Pain of the orofacial region is the primary complaint for which patients seek *** all the orofacial pain conditions,one condition that possess a significant global health problem is temporomandibular disorder(TMD).Patients with TMD typically frequently complaints of pain as a *** can occur due to complex interplay between peripheral and central sensitization,endogenous modulatory pathways,and cortical *** diagnosis of TMD pain a descriptive history,clinical assessment,and imaging is ***,due to the complex nature of pain an additional step is needed to render a definitive TMD *** this review we explicate the role of different biomarkers involved in painful *** painful TMD conditions,the role of biomarkers is still *** believe that the identification of biomarkers associated with painful TMD may stimulate researchers and clinician to understand the mechanism underlying the pathogenesis of TMD and help them in developing newer methods for the diagnosis and management of ***,to understand the potential relationship of biomarkers,and painful TMD we categorize the biomarkers as molecular biomarkers,neuroimaging biomarkers and sensory *** addition,we will briefly discuss pain genetics and the role of potential microRNA(miRNA)involved in TMD pain.

关键词： diagnosis endogenous facial

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

What is the appropriate strategy for diagnosing NAFLD using ultrasonography in obese children?

引用

World Journal of pediatrics 2017年第3期13卷 248-254页

作者： Jee Hyun Lee Su Jin Jeong department of pediatrics Ansan HospitalKorea University Medical CenterCollege of MedicineKorea University department of pediatrics Bundang CHA Medical CenterCHA University School of MedicineKorea

Background:The aim of this study is to identify obese children who are candidates for a potential diagnosis of non-alcoholic fatty liver disease (NAFLD).Methods:We enrolled 242 obese children (122 boys and 120 girls) aged 7-16 years who were examined with abdominal ultrasonography in our pediatric obesity *** compared patients in the normal group with those in the NAFLD group (mild disease,moderate to severe disease) and identified the optimal anthropometric parameters among height,weight,body mass index (BMI),waist circumference,hip circumference,waist to height ratio (WHtR),and waist to hip ratio to predict NAFLD using a receiver operating characteristic curve *** also investigated risk factors associated with NAFLD for the anthropometric parameters and the biochemical model using logistic ***:The high-and low-risk groups for hepatic steatosis relative to a WHtR of 0.56 as the standard point showed significant differences in hepatic steatosis severity grade (P0.56 (2.25,1.05-4.81),and waist circumference >90th percentile (20.22,9.21-44.36) in the anthropometric parameter model and elevated alanine aminotransferase levels (boys >25.8 U/L,girls >22.1 U/L) (6.93,2.52-19.03),hypertriglyceridemia (>110 mg/dL) (3.80,1.23-11.75),and triglyceride to HDL cholesterol ratio >3 (9.23,2.95-8.83) in the biochemical parameter ***:A diagnostic approach to hepatic steatosis is recommended as part of the proper screening and stratification of risk factors in obese *** is a simple and convenient method of effectively identifying obese children who are candidates for hep

关键词： hepatic steatosis non-alcoholic fatty liver disease obesity waist-to-height ratio

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Application of the modified vaccination technique for the prevention and cure of chronic ailments

引用

Asian Pacific Journal of Tropical Medicine 2010年第2期3卷 160-166页

作者： Arpad Z Barabas Chad D Cole Arpad D Barabas Richard M Graeff Rene Lafreniere Donald M Weir department of Surgery University of Calgary department of Neurosurgery University of Utah department of Pharmacology University of Minnesota university of Edinburgh medical school

Over the years vaccination has proven to be the most successful health protection program for large populations,to prevent them from acquiring serious infectious and contagious diseases caused by exogenous antigens(ags) such as bacteria and *** is generally achieved by an active immunization program,though passive immunization has also been employed, especially in the past,to combat diseases caused by certain bacterial infections(***, diphtheria,etc.). Most recently,encouraging research data suggests that therapeutic approaches employing vaccination techniques can also be used to correct or deal with mishaps induced by or involving endogenous ***,most attempts at employing conventional vaccination techniques to do so have proven less than *** the case of cancer,one of the reasons for this is that the presentation of cancer related ags in presently available immunization frameworks is unable to evoke a powerful,specific cancer killing ***,drug treatments have been required in order to achieve additional beneficial effects. Recently,the Barabas group has developed a new vaccination technique(the third vaccination method,after active and passive immunization) called Modified Vaccination Technique(MVT). In experiments the MVT has been able to prevent-and with equal effectiveness,terminatemishaps induced by or involving endogenous ags,*** an experimental autoimmune kidney disease called slowly progressive Heymann nephritis(SPHN). The MVT is safe,and is able to initiate a specific immune response in the injected host(provided the injected components are in pure form).The MVT promises to provide the next generation of vaccines for the prevention,treatment,and termination of chronic disorders in humans,such as autoimmune diseases,cancer,and chronic infections.

关键词： Autoimmunity Modified vaccination technique Prophylactic Therapeutic

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chemotherapy brings virtual memory T cells into reality for cancer therapy

引用

Cellular & Molecular Immunology 2021年第5期18卷 1339-1340页

作者： Zoe C.Schmiechen Adam L.Burrack Ingunn M.Stromnes department of Microbiology and Immunology University of Minnesota Medical SchoolMinneapolis55414MNUSA Center for Immunology University of Minnesota Medical SchoolMinneapolis55414MNUSA Center for Genome Engineering University of Minnesota Medical SchoolMinneapolis55414MNUSA Masonic Cancer Center University of Minnesota Medical SchoolMinneapolis55414MNUSA

The anticancer effect of chemotherapy has been historically attributed to directly inducing proliferating cancer cell death.1 Accumulating evidence suggests that chemotherapy also engages the immune *** chemotherapies can induce immunogenic cell death,leading to tumor antigen uptake and presentation by dendritic cells to activate tumor-reactive T cells.2 A new study by Wang et *** another dimension to this paradigm by demonstrating that chemotherapy pretreatment of cancer cells can directly activate virtual memory(VM)CD8^(+)T cells to mediate tumor cytotoxicity in an antigen-independent manner.

关键词： chemotherapy cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rescue case of low birth weight infant with acute hepatic failure

引用

World Journal of Gastroenterology 2017年第40期23卷 7337-7342页

作者： Noriki Okada Yukihiro Sanada Taizen Urahashi Yoshiyuki Ihara Naoya Yamada Yuta Hirata Takumi Katano Kentaro Ushijima Shinya Otomo Shujiro Fujita Koichi Mizuta department of Transplant Surgery Jichi Medical University department of Clinical Pharmacology Jichi Medical University department of Pharmacy Jichi Medical University department of pediatrics Yokohama City University School of Medicine

We report a case involving a rescued low birth weight infant(LBWI) with acute liver failure. Case: The patient was 1594 g and 32^(3/7) gestational wk at birth. At the age of 11 d, she developed acute liver failure due to gestational alloimmune liver disease. Exchange transfusion and high-dose gamma globulin therapy were initiated, and body weight increased with enteral nutrition. Exchange transfusion was performed a total of 33 times prior to living donor liver transplantation(LDLT). Her liver dysfunction could not be treated by medications alone. At 55 d old and a body weight of 2946 g, she underwent LDLT using an S2 monosegment graft from her mother. Three years have passed with no reports of intellectual disability or liver dysfunction. LBWIs with acute liver failure may be rescued by LDLT after body weight has increased to over 2500 g.

关键词： Liver transplantation Acute liver failure Low birth weight infant Transplantable body weight Monosegment graft

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Can Kallmann syndrome be occasionally diagnosed during childhood？ Genetic diagnosis in a child with associated renal agenesis and mirror movements

引用

Asian Journal of Andrology 2009年第4期11卷 521-523页

作者： Neoklis A. Georgopoulos Vasiliki Koika Petros Vamavas Alexandra Eflhymiadou Dimitra J. Marioli Stefanos Mantagos Dionysios Chrysis department of Obstetrics and Gynecology Division of Reproductive Endocrinology University of Patras Medical School Rio 26500 Greece department of pediatrics Division of Endocrinology University of Patras Medical School Rio 26500 Greece department of pediatrics University of Patras Medical School Rio26500 Greece

Dear Sir,I am Neoklis A. Georgopoulos, from department of Obstetrics and Gynaecology, Division of Reproductive Endocrinology, university of Patras medical school, Greece. We present an early prepubertal diagnosis of Kallmann syndrome （KS） in a child with anosmia, renal agenesis and mirror movements. KS is a congenital defect characterized by the presence of hypogonadotropic hypogonadism and anosmia or hyposmia [1]. Besides hypogonadism and anosmia, the clinical phenotype is characterized by the presence of other associated features, including, among others, mirror movements （synkinesis）, cleft palate and renal agenesis/ dysgenesis.

关键词： no english key word

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：