A comprehensive review on biomarkers associated with painful temporomandibular disorders

作     者：Mayank Shrivastava Ricardo Battaglino Liang Ye Mayank Shrivastava;Ricardo Battaglino;Liang Ye

作者机构：Department of Diagnostic and Biological SciencesSchool of DentistryUniversity of MinnesotaMinneapolisMNUSA Department of Rehabilitation MedicineMedical SchoolUniversity of MinnesotaMinneapolisMNUSA 

出 版 物：《International Journal of Oral Science》 (国际口腔科学杂志（英文版）)

年 卷 期：2021年第13卷第3期

页      面：230-242页

核心收录：

学科分类：1003[医学-口腔医学] 100302[医学-口腔临床医学] 10[医学] 

主　　题：diagnosis endogenous facial 

摘      要：Pain of the orofacial region is the primary complaint for which patients seek *** all the orofacial pain conditions,one condition that possess a significant global health problem is temporomandibular disorder(TMD).Patients with TMD typically frequently complaints of pain as a *** can occur due to complex interplay between peripheral and central sensitization,endogenous modulatory pathways,and cortical *** diagnosis of TMD pain a descriptive history,clinical assessment,and imaging is ***,due to the complex nature of pain an additional step is needed to render a definitive TMD *** this review we explicate the role of different biomarkers involved in painful *** painful TMD conditions,the role of biomarkers is still *** believe that the identification of biomarkers associated with painful TMD may stimulate researchers and clinician to understand the mechanism underlying the pathogenesis of TMD and help them in developing newer methods for the diagnosis and management of ***,to understand the potential relationship of biomarkers,and painful TMD we categorize the biomarkers as molecular biomarkers,neuroimaging biomarkers and sensory *** addition,we will briefly discuss pain genetics and the role of potential microRNA(miRNA)involved in TMD pain.