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Disparities in chiropractic utilization by race,ethnicity and socioeconomic status:A scoping review of the literature

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Journal of Integrative medicine 2023年第2期21卷 159-167页

作者： Jordan A.Gliedt Antoinette L.Spector Michael J.Schneider Joni Williams Staci Young department of Neurosurgery Medical College of WisconsinMilwaukeeWI 53226USA department of Rehabilitation Sciences and Technology University of Wisconsin-MilwaukeeMilwaukeeWI 53201USA department of Physical therapy University of PittsburghPittsburghPA 15219USA Clinical and Translational Science Institute University of PittsburghPittsburghPA 15213USA department of medicine Division of Internal MedicineMedical College of WisconsinMilwaukeeWI 53226USA department of family and Community medicine Medical College of WisconsinMilwaukeeWI 53226USA

Background Chiropractic is the largest complementary and alternative medicine profession in the United States,with increasing global growth.A preliminary literature review suggests a lack of widespread diversity of chiropractic patient *** There have been no prior studies to comprehensively integrate the literature on chiropractic utilization rates by race,ethnicity,and socioeconomic *** purpose of this scoping review is to identify and describe the current state of knowledge of chiropractic utilization by race,ethnicity,education level,employment status,and income and poverty *** strategy Systematic searches were conducted in PubMed,Ovid MEDLINE,Cumulative Index of Nursing and Allied Health Literature(CINAHL),Cochrane Database of Systematic Reviews,and Index to Chiropractic Literature from inception to May *** criteria Articles that reported race or ethnicity,education level,employment status,income or poverty level variables and chiropractic utilization rates for adults(≥18 years of age)were eligible for this *** extraction and analysis Data extracted from articles were citation information,patient characteristics,race and ethnicity,education level,employment status,income and poverty level,and chiropractic utilization rate.A descriptive numerical summary of included studies is *** study provides a qualitative thematic narrative of chiropractic utilization with attention to race and ethnicity,education level,income and poverty level,and employment *** A total of 69 articles were eligible for *** articles were published since 2003 and reported data from study populations in the United *** the race,ethnicity and socioeconomic categories that were most commonly reported,chiropractic utilization was the highest for individuals identifying as European American/White/non-Hispanic White/Caucasian(median 20.00%;interquartile range 2.70%-64.60%),those with employment as a main income sourc

关键词： Chiropractic Utilization Health inequities Health disparities Low-back pain Neck pain

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Systematic review and meta-analysis of colon cleansing preparations in patients with inflammatory bowel disease

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World Journal of Gastroenterology 2017年第32期23卷 5994-6002页

作者： Sophie Restellini Omar Kherad Talat Bessissow Charles Ménard Myriam Martel Maryam Taheri Tanjani Peter L Lakatos Alan N Barkun division of gastroenterology department of medicine mcgill university health center division of internal medicine department of medicine la tour hospital and university of geneva division of gastroenterology department of medicine university of sherbrooke department of family medicine queens universitykingston department of clinical epidemiology mcgill university and the mcgill university health center

AIM To performed a systematic review and meta-analysis to determine any possible differences in terms of effectiveness, safety and tolerability between existing colon-cleansing products in patients with inflammatory bowel *** Systematic searches were performed( January 1980-September 2016) using MEDLINE, EMBASE, Scopus, CENTRAL and ISI Web of knowledge for randomized trials assessing preparations with or without adjuvants, given in split and non-split dosing, and in high(> 3 L) or low-volume(2 L or less) regimens. Bowel cleansing quality was the primary outcome. Secondary outcomes included patient willingness-torepeat the procedure and side effects/*** Out of 439 citations, 4 trials fulfilled our inclusion criteria(n = 449 patients). One trial assessed the impact of adding simethicone to polyethylene glycol(PEG) 4 L with no effect on bowel cleansing quality, but a better tolerance. Another trial compared senna to castor oil, again without any differences in term of bowel cleansing. Two trials compared the efficacy of PEG high-volume vs PEG low-volume associated to an adjuvant in split-dose regimens: PEG low-dose efficacy was not different to PEG high-dose; OR = 0.84(0.37-1.92). A higher proportion of patients were willing to repeat low-volume preparations vs high-volume; OR = 5.11(1.31-20.0). CONCLUSION In inflammatory bowel disease population, PEG lowvolume regimen seems not inferior to PEG high-volume to clean the colon, and yields improved willingness-torepeat. Further additional research is urgently required to compare contemporary products in this population.

关键词： Inflammatory bowel disease Polyethylene glycol Colonoscopy Meta-analysis

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Systematic overview of hepatitis C infection in the Middle East and North Africa

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World Journal of Gastroenterology 2018年第27期24卷 3038-3054页

作者： Karima Chaabna Sohaila Cheema Amit Abraham Hekmat Alrouh Albert B Lowenfels Patrick Maisonneuve Ravinder Mamtani Institute for Population Health Weill Cornell Medicine-Qatar department of Surgery and the department of family medicine New York Medical College Division of Epidemiology and Biostatistics European Institute of Oncology

AIM To assess the quality of and to critically synthesize the available data on hepatitis C infections in the Middle East and North Africa(MENA) region to map evidence *** We conducted an overview of systematic reviews(SRs) following an a priori developed protocol(CRD42017076736). Our overview followed the preferred reporting items for systematic reviews and metaanalyses guidelines for reporting SRs and abstracts and did not receive any funding. Two independent reviewers systematically searched MEDLINE and conducted a multistage screening of the identified articles. Out of 5758 identified articles, 37 SRs of hepatitis C virus(HCV) infection in populations living in 20 countries in the MENA region published between 2008 and 2016 were included in our overview. The nine primary outcomes of interest were HCV antibody(anti-) prevalences and incidences in different at-risk populations; the HCV viremic(RNA positive) rate in HCV-positive individuals; HCV viremic prevalence in the general population(GP); the prevalence of HCV co-infection with the hepatitis B virus, human immunodeficiency virus, or schistosomiasis; the HCV genotype/subtype distribution; and the risk factors for HCV transmission. The conflicts of interest declared by the authors of the SRs were also extracted. Good quality outcomes reported by the SRs were defined as having the population, outcome, study time and setting defined as recommended by the PICOTS framework and a sample size > *** We included SRs reporting HCV outcomes with different levels of quality and precision. A substantial proportion of them synthesized data from mixed populations at differing levels of risk for acquiring HCV or at different HCV infection stages(recent and prior HCV transmissions). They also synthesized the data over long periods of time(e.g., two decades). Anti-HCV prevalence in the GP varied widely in the MENA region from 0.1%(study dates not reported) in the United Arab Emirates to 2.1%-13.5%(2003-2006) in

关键词： Hepatitis C meta-research risk factors incidence genotype Middle East and North Africa systematic review Micro-elimination Pakistan Gulf Cooperation Council

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CircTHSD4 promotes the malignancy and docetaxel (DTX) resistance in prostate cancer by regulating miR-203/HMGA2 axis

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Oncology Research 2024年第3期32卷 529-544页

作者： JIANYUN XIE LINIE LU JIALI ZHANG QIRUI LI WEIDONG CHEN Depatment of Urology The Affliated People's Hospital of Fujian University of Traditional Chinese MedicineFuzhouChina department of Internal medicine outpatient ainic The Afliated People's Hospital of Fujian University of Traditional Chinese MedicineFuzhouChina

Objective:Circular ribose nudeic acids(circRNAs)are implicated in tumor progression and drug resistance of prostate cancer(PCa).The current work explored the function of circ_0005203(aircTHSD4)in the malignancy and docetaxel(DTX)resistance of ***:circTHSD4 expression within PCa as well as matched non-carcinoma samples was measured through real time reverse transcription quantitative polymerase chain reaction(RT-qPCR).In addition,a subcellular fraction assay was conducted to determine circTHSD4 subcellular localization within PCa *** addition,we performed a Western blot(WB)assay to detect high *** A2 protein(HMGA2)***,functional associations of two molecules were investigated through dual luciferase reporter *** Counting Kit(CCK)-8,colony formation together with Transwell assay was conducted to assess malignant phenotypes of PCa cells,whereas flow cytometry was performed to determine cell ***,a xenograft mouse model was constructed to verify the effect of circTHSD4 on the carcinogenesis of PCa ***:According to RT-qPCR results,circTHSD4 was up-regulated within PCa tissues and cells,which predicted the dismal prognostic outcome of PCa ***4 silencing within PCa cells markedly suppressed cell growth,migration,and colony ***4 silencing remarkably elevated PCa cell apoptosis and carcinogenesis within the xenograft ***,circTHSD4 silencing enhanced docetaxel(DTX)sensitivity in PCa ***,we demonstrated that circTHSD4 modulated the malignancy of PCa cells by regulating HMGA2 expression through sponging miR ***:Together,our findings suggest that cirCTHSD4 overexpression could promote the malignant phenotype and DTX resistance in PCa through the regulation of the miR 203/HMGA2 axis.

关键词： circTHSD4 Docetaxel resistance Prostate cancer miR-203 HMGA2

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Inverse relationship between bioavailable testosterone and subclinical coronary artery calcification in non-obese Korean men

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Asian Journal of Andrology 2012年第4期14卷 612-615页

作者： Byoung-Jin Park Jae-Yong Shim Yong-Jae Lee Jung-Hyun Lee Hye-Ree Lee department of family medicine Yonsei University College of Medicine Seou1135-720 Korea department of Health Promotion Center Gangnam Severance Hospita Yonsei University College of Medicine Seou1135-720 Korea

Although low testosterone levels in men have been associated with high risk for cardiovascular disease, little is known about the association between male sex hormones and subclinical coronary disease in men with apparently low cardiometabolic risk. This study was performed to investigate the association between male sex hormones and subclinical coronary artery calcification measured as coronary calcium score in non-obese Korean men. We examined the relationship of total testosterone, sex hormone-binding globulin, bioavai lable testosterone and free testosterone with coronary calcium score in 291 non-obese Korean men （mean age： 52.8--- 9.3 years） not having a history of cardiovascular disease. Using multiple linear regression, we evaluated associations between log （sex hormone） levels and log （coronary calcium score） after adjusting for confounding variables in 105 men with some degree of coronary calcification defined as coronary calcium score ~〉 1. In multiple linear regression analysis, bioavailable testosterone was inversely associated with coronary calcium score （P=0.046） after adjusting for age, body mass index, smoking status, alcohol consumption, regular exercise, mean blood pressure, resting heart rate, C-reactive protein, fasting plasma glucose, total cholesterol, triglyceride, high-density lipoprotein （HDL） cholesterol, hypertension medication and hyperlipidernia medication, whereas total testosterone, sex hormone-binding globulin and free testosterone were not （P=0.674, P=O. 121 and P=O. 102, respectively）. Our findings indicate that bioavailable testosterone is inversely associated with the degree of subclinical coronary artery calcification in non-obese men.

关键词： bioavailable testosterone cardiovascular disease coronary calcium score male sex hormone subclinical coronary arterydisease testosterone

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Pre-existing diabetes mellitus increases the risk of gastric cancer:A meta-analysis

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World Journal of Gastroenterology 2013年第6期19卷 936-945页

作者： Jae Moon Yoon Ki Young Son Chun Sick Eom Daniel Durrance Sang Min Park department of family medicine Seoul National University HospitalSeoul National University College of MedicineSeoul 110-744South Korea Center for Health Promotion Seoul National University HospitalSeoul 110-744South Korea department of family medicine Hallym UniversityChuncheon Sacred Heart HospitalChunCheon 200-704South Korea family medicine Graduate School of Korea University College of MedicineSeoul 110-799South Korea

AIM:To systematically assess the association between diabetes and incidence of gastric ***:We searched MedLine (PubMed),EMBASE,and the Cochrane Library without any limitations with respect to publication date or language,we also searched the references of qualifying *** studies and cohort studies comparing the risk of gastric cancer between diabetic patients and control subjects were *** excluded studies reporting only standardized incidence ratios without control groups and those that investigated only mortality but not *** studies met our criteria,and the qualities of these studies were assessed using theNewcastle-Ottawa Quality Assessment *** performed a meta-analysis of pre-existing diabetes and gastric cancer incidence using the DerSimonian-Laird method for *** subgroup analyses,we separated the studies by study type,region,sex and method to determine confounding factors and *** also conducted subgroup analyses to examine the effects of smoking,Helicobacter pylori (***) infection,and cancer *** bias was evaluated using Begg's ***:A random-effects model meta-analysis showed an increased gastric cancer risk in diabetic patients [relative risk (RR)=1.19;95%CI:1.08-1.31].Subgroup analyses indicated that this result persisted in cohort studies (RR=1.20;95%CI:1.08-1.34),in studies on populations of both Western (RR=1.18;95%CI:1.03-1.36) and Eastern countries (RR=1.19;95%CI:1.02-1.38),in a female subgroup (RR=1.24;95%CI:1.01-1.52),and in highly qualified studies (RR=1.17;95%CI:1.05-1.31).Moreover,these results persisted when the analysis was confined to studies adjusted for well-known gastric cancer risk factors such as smoking (RR=1.17;95%CI:1.01-1.34) and *** infection (RR=2.35;95%CI:1.24-4.46).CONCLUSION:Pre-existing diabetes mellitus may increase the risk of gastric cancer by approximately 19%.This effect seems to be unrelated to geographical region.

关键词： Disease association Diabetes mellitus Gastric cancer Incidence Risk Meta-analysis

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Hyperuricemia Prediction Using Photoplethysmogram and Arteriograph

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Computers, Materials & Continua 2022年第4期71卷 287-304页

作者： Hafifah Ab Hamid Nazrul Anuar Nayan Mohd Zubir Suboh Nurin Izzati Mohamad Azizul Mohamad Nazhan Mohd Nizar Amilia Aminuddin Mohd Shahrir Mohamed Said Saharuddin Ahmad department of Electrical Electronic and SystemsFaculty of Engineering and Built EnvironmentUniversiti Kebangsaan MalaysiaBangi43600Malaysia department of Physiology Faculty of MedicineUniversiti Kebangsaan MalaysiaCheras56000Malaysia department of medicine Faculty of MedicineUniversiti Kebangsaan MalaysiaCheras56000Malaysia family medicine department Faculty of MedicineUniversiti Kebangsaan MalaysiaCheras56000Malaysia

Hyperuricemia is an alarming issue that contributes to cardiovascular *** acid(UA)level was proven to be related to pulse wave velocity,a marker of arterial stiffness.A hyperuricemia prediction method utilizing photoplethysmogram(PPG)and arteriograph by using machine learning(ML)is *** the literature search,there is no available papers found that relates PPG with UA level even though PPG is highly associated with vessel *** five phases in this research are data collection,signal preprocessing including denoising and signal quality indexes,features extraction for PPG and SDPPG waveform,statistical analysis for feature selection and classification of UA levels using *** PPG to the current arteriograph able to reduce cost and increase the prediction *** and arteriograph data were measured from 113 subjects,and 226 sets of data were collected from the left and right hands of the *** performance of four types of ML,namely,artificial neural network(ANN),linear discriminant analysis(LDA),k-nearest neighbor(kNN),and support vector machine(SVM)in predicting hyperuricemia was *** the total of 98 features extracted,16 features of which showed statistical significance for hyper and *** gives the best performance compared to the other three ML techniques with 91.67%,95.45%,and 94.12%for sensitivity,specificity,and accuracy,*** from PPG and arteriograph able to be used to predict hyperuricemia accurately and *** study is the first to find the relationship of PPG with *** shows a significant relation between PPG signals and arteriograph data toward the UA *** proposed method of UA prediction shows its potential for noninvasive preliminary assessment.

关键词： PPG arteriograph second derivative of PPG hyperuricemia ML

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Helicobacter pylori infection concomitant with metabolic syndrome further increase risk of colorectal adenomas

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World Journal of Gastroenterology 2010年第30期16卷 3841-3846页

作者： Ying-Lung Lin Jui-Kun Chiang Shih-Min Lin Chih-En Tseng department of family medicine Buddhist Tzu-Chi Dalin General Hospital department of Biological Sciences University of Waikato department of Anatomic Pathology Buddhist Dalin Tzu Chi General Hospital School of medicine Buddhist Tzu Chi University

AIM: To investigate the association of colorectal adenomas with both Helicobacter pylori (H. pylori) infection and metabolic syndrome. METHODS: Using a cross-sectional hospital-based study, we analyzed physical examination data from 9311 healthy subjects with overnight physical examinations performed between January 2004 and December 2006. Examined data included gender, age, life style, anthropometric measurements, blood pressure, biochemical and hematological studies, H. pylori infection detected by esophagogastroduodenoscopy and biopsy urease tests, and colorectal adenomas detected with a complete total colonoscopy. RESULTS: The prevalence values for H. pylori infection, metabolic syndrome, and colorectal adenoma were39.2%, 18.7%, and 20.7%, respectively. Colorectal adenoma risk factors included male gender [odd ratio (OR): 2.005, 95% conf idence interval (CI): 1.740-2.310, P < 0.001], advanced age (OR: 1.046, 95% CI: 1.040-1.052, P < 0.001), smoking (OR: 1.377, 95% CI: 1.146-1.654, P = 0.001), increased body fat (OR: 1.016, 95% CI: 1.007-1.026, P = 0.001), higher white blood cell count (OR: 1.038, 95% CI: 1.005-1.073, P = 0.025), H. pylori infection (OR: 1.366, 95% CI: 1.230-1.517, P < 0.001), and metabolic syndrome (OR: 1.408, 95% CI: 1.231-1.610, P < 0.001). In addition, concomitant H. pylori infection with metabolic syndrome further increased the probability of colorectal adenomas. CONCLUSION: Our study revealed H. pylori infection with concomitant metabolic syndrome might further increase the risk of colorectal adenomas.

关键词： Biopsy urease test Colorectal adenoma Colorectal cancer Helicobacter pylori Metabolic syndrome

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Peficitinib suppresses diffuse-type tenosynovial giant cell tumor by targeting TYK2 and JAK/STAT signaling

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Science China Life Sciences 2025年

作者： Shan Lu Chenxi Cao Wenjia Zhang Jiayi Li Jingli Yang Zisheng Huang Zhijun Wu Baitao Liu Hongjie Huang Haijun Wang Yongjian Wang Dingge Liu Zhihua Zhang Kaiping Liu Gang Yang Xi Gong Hui Dai Yingjia Li Erdan Dong Xin Zhang Yan Zhang Haihe Laboratory of Cell Ecosystem Institute of Cardiovascular Diseases The First Affiliated Hospital of Dalian Medical University Institute of Cardiovascular Sciences School of Basic Medical Sciences Peking University Health Science Center Department of Cardiology and Institute of Vascular Medicine Peking University Third HospitalState Key Laboratory of Vascular Homeostasis and Remodeling Peking University department of Sports medicine Peking University Third Hospital Institute of Sports Medicine of Peking University Beijing Key Laboratory of Sports Injuries Engineering Research Center of Sports Trauma Treatment Technology and Devices Ministry of Education State Key Laboratory of Membrane Biology Institute of Molecular Medicine College of Future Technology Peking University Peking University Health Science Centre Peking University department of Immunology School of Basic Medical Sciences NHC Key Laboratory of Medical Immunology Peking University Research Center for Cardiopulmonary Rehabilitation University of Health and Rehabilitation Sciences Qingdao Hospital (Qingdao Municipal Hospital) School of Health and Life Sciences University of Health and Rehabilitation Sciences Research Unit of Medical Science Research Management/Basic and Clinical Research of Metabolic Cardiovascular Diseases Chinese Academy of Medical Sciences

Diffuse-type tenosynovial giant cell tumor(dTGCT) is a destructive but rare benign proliferative synovial neoplasm. Although surgery is currently the main treatment modality for dTGCT, the recurrence risk is up to 50%. Therefore, there is a great need for effective drugs against dTGCT with minor side effects. The Janus kinase(JAK)/signal transducer and activator of transcription(STAT) signaling plays a central role in rheumatoid arthritis(RA), a disease with similar characteristics as dTGCT, but its function in dTGCT remains *** fibroblast-like synoviocytes(FLS) and macrophages were isolated from 10 synovial tissue samples from dTGCT patients for the screening and validation of the five clinically approved JAK inhibitors to treat RA against dTGCT. Cell viability, cell death, inflammation and the activity of the JAK family members of cultured dTGCT FLS(both 2-D and 3-D) and macrophages were investigated for the efficacy of the JAK inhibitors. Here, we found that similar to RA, JAK/STAT signaling was markedly activated in the dTGCT synovium. Of the 5 JAK inhibitors, peficitinib was shown to have the most potency in addressing some of the pathological responses of dTGCT FLS and *** potency of peficitinib was much higher than pexidartinib, which is the only FDA-approved drug for dTGCT. Mechanistically, peficitinib inhibited tyrosine kinase 2(TYK2), a JAK family member necessary for the pathological progression of dTGCT FLS and macrophages. In summary, we not only revealed JAK/STAT(especially TYK2) signaling as the major mechanism underlying dTGCT, but also identified peficitinib as a promising drug against dTGCT.

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Case Report:Malignant peritoneal mesothelioma presenting with persistent high fever

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第5期12卷 381-384页

作者： Li-ying CHEN Ling-xiu HUANG Jin WANG Yi QIAN Li-zheng FANG department of family medicine Sir Run Run Shaw Hospital School of Medicine Zhejiang University Hangzhou 310016 China department of Pathology Sir Run Run Shaw Hospital School of Medicine Zhejiang University Hangzhou 310016 China

Malignant peritoneal mesothelioma(MPM) is a rare tumor that develops in the *** this paper,we describe an extremely rare case of MPM metastasizing to the appendix in a 48-year-old female who initially presented with a persistent high *** woman reported a slight lower abdominal discomfort which had been relieved by urination for four *** had lost 5 kg of *** was no nausea,vomiting,diarrhea,ab-dominal pain,or abdominal *** broad spectrum antibiotics were given without relief of *** tomography(CT) scans revealed a thickened omentum majus and diffused multiple omental *** omentec-tomy,appendectomy,and adnexectomy were carried out.A gross pathologic specimen of omentum tissue revealed a firm gray-white *** and immunohistochemical examinations confirmed the diagnosis of appendiceal and bilateral adnexal metastases of an *** results suggest that MPM should be considered in the differential diagnosis of unexplained persistent high *** of such atypical presentations of mesothelioma may help to make a correct diagnosis.

关键词： Malignant peritoneal mesothelioma High fever Metastasis

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