Pre-existing diabetes mellitus increases the risk of gastric cancer:A meta-analysis

作     者：Jae Moon Yoon Ki Young Son Chun Sick Eom Daniel Durrance Sang Min Park 

作者机构：Department of Family MedicineSeoul National University HospitalSeoul National University College of MedicineSeoul 110-744South Korea Center for Health PromotionSeoul National University HospitalSeoul 110-744South Korea Department of Family MedicineHallym UniversityChuncheon Sacred Heart HospitalChunCheon 200-704South Korea Family MedicineGraduate School of Korea University College of MedicineSeoul 110-799South Korea 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2013年第19卷第6期

页      面：936-945页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by Grant from the Seoul National University Hospital Research Fund No.04-2011-0540 

主　　题：Disease association Diabetes mellitus Gastric cancer Incidence Risk Meta-analysis 

摘      要：AIM:To systematically assess the association between diabetes and incidence of gastric ***:We searched MedLine (PubMed),EMBASE,and the Cochrane Library without any limitations with respect to publication date or language,we also searched the references of qualifying *** studies and cohort studies comparing the risk of gastric cancer between diabetic patients and control subjects were *** excluded studies reporting only standardized incidence ratios without control groups and those that investigated only mortality but not *** studies met our criteria,and the qualities of these studies were assessed using theNewcastle-Ottawa Quality Assessment *** performed a meta-analysis of pre-existing diabetes and gastric cancer incidence using the DerSimonian-Laird method for *** subgroup analyses,we separated the studies by study type,region,sex and method to determine confounding factors and *** also conducted subgroup analyses to examine the effects of smoking,Helicobacter pylori (***) infection,and cancer *** bias was evaluated using Begg s ***:A random-effects model meta-analysis showed an increased gastric cancer risk in diabetic patients [relative risk (RR)=1.19;95%CI:1.08-1.31].Subgroup analyses indicated that this result persisted in cohort studies (RR=1.20;95%CI:1.08-1.34),in studies on populations of both Western (RR=1.18;95%CI:1.03-1.36) and Eastern countries (RR=1.19;95%CI:1.02-1.38),in a female subgroup (RR=1.24;95%CI:1.01-1.52),and in highly qualified studies (RR=1.17;95%CI:1.05-1.31).Moreover,these results persisted when the analysis was confined to studies adjusted for well-known gastric cancer risk factors such as smoking (RR=1.17;95%CI:1.01-1.34) and *** infection (RR=2.35;95%CI:1.24-4.46).CONCLUSION:Pre-existing diabetes mellitus may increase the risk of gastric cancer by approximately 19%.This effect seems to be unrelated to geographical region.