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Journal of Materials Science & Technology 2021年第19期78卷 92-99页

作者： Peng Wan Weidan Wang lizhen Zheng ling Qin Ke Yang School of Materials Science and Engineering Dongguan University of TechnologyDongguan523808China li ka shing institute of health sciences Department of Orthopaedics and TraumatologyThe Chinese University of Hong KongHong KongChina department of orthopaedics Affiliated Zhongshan Hospital of Dalian UniversityDalian116001China institute of Metal Research Chinese Academy of SciencesShenyang110016China

Osteoporotic fracture with increase of aging population became an urgent orthopedic *** were widely recommended as effective clinical treatment *** of biodegradable Mg-based implants and merits of bisphosphonates was suggested for osteoporotic fracture *** the mild and sustained drug release,a novel one-step electrodeposition synthesis of drug loaded coating was proposed in this *** comparison to conventional soaking method,encapsulated zoledronate coating by one-step electrodeposition method could modulate drug release in first diffusion-controlled and later degradation-controlled *** in vitro cell response to zoledronate loaded coating showed enhanced proliferation and osteogenic differentiation of osteoblasts and no significant inhibition on osteoclasts,which could improve bone-forming and decrease bone resorption due to osteoporosis.

关键词： Bisphosphonate Magnesium Coating Electrodeposition Osteoporosis

High formability Mg-Zn-Gd wire facilitates ACL reconstruction via its swift degradation to accelerate intra-tunnel endochondral ossification

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Journal of Magnesium and Alloys 2024年第1期12卷 295-315页

作者： Xuan He Ye li Hongwei Miao Jiankun Xu Michael Tim-yun Ong Chenmin Wang lizhen Zheng Jiali Wang Le Huang Haiyue Zu Zhi Yao Jie Mi Bingyang Dai Xu li Patrick Shu-hang Yung Guangyin Yuan ling Qin Musculoskeletal Research Laboratory of department of orthopaedics&traumatology and Innovative Orthopaedic Biomaterial and Drug Translational Research Laboratory of li ka shing institute of health sciences The Chinese University of Hong KongHong KongChina National Engineering Research Center of light Alloy Net Forming School of Materials Science&EngineeringShanghai Jiao Tong UniversityShanghaiChina department of orthopaedics and traumatology Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina Orthopaedic department Peking University Third HospitalBeijingChina department of Rehabilitation sciences The Hong Kong Polytechnic UniversityHong KongChina

After reconstructing the anterior cruciate ligament(ACL),unsatisfactory bone tendon interface healing may often induce tunnel enlargement at the early healing *** good biological features and high formability,Magnesium-Zinc-Gadolinium(ZG21)wires are developed to bunch the tendon graft for matching the bone tunnel during ***,tensile strength,degradation,and cytotoxicity of ZG21 wire are *** rabbit model is used for assessing the biological effects of ZG21 wire by Micro-CT,histology,and mechanical *** SEM/EDS,immunochemistry,and in vitro assessments are performed to investigate the underlying *** tests demonstrate the high formability of ZG21 wire as surgical ***-CT shows ZG21 wire degradation accelerates tunnel bone formation,and histologically with earlier and more fibrocartilage regeneration at the healing *** mechanical test shows higher ultimate load in the ZG21 *** SEM/EDS presents ZG21 wire degradation triggered calcium phosphate(Ca-P)*** results demonstrate upregulation of Wnt3a,BMP2,and VEGF at the early phase and TGFβ3 and Type II collagen at the late phase of *** vitro tests also confirmed the Ca-P in the metal extract could elevate the expression of Wnt3a,βcatenin,ocn and opn to stimulate *** vivo tests of clinical samples indicated suturing with ZG21 wire did not weaken the ultimate loading of human tendon *** conclusion,the ZG21 wire is feasible for tendon graft *** degradation products accelerated intra-tunnel endochondral ossification at the early healing stage and therefore enhanced bone-tendon interface healing in ACL reconstruction.

关键词： Magnesium wire ACL reconstruction Magnesium alloy Biomaterials Endochondral ossification

Recent progress in functional metal-organic frameworks for bio-medical application

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Regenerative Biomaterials 2024年第2期3卷 37-54页

作者： Wenwen Chai Xiaochen Chen Jing liu liyan Zhang Chunyu liu li li John Robert Honiball Haobo Pan Xu Cui Deping Wang School of Materials Science and Engineering Tongji UniversityShanghai 201804China Shenzhen institute of Advanced Technology Chinese Academy of SciencesShenzhen 518055China department of orthopaedics&traumatology School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina

Metal-organic frameworks(MOFs)have a high specific surface area,adjustable pores and can be used to obtain functional porous materials with diverse and well-ordered structures through coordination and self-assembly,which has intrigued wide interest in a broad range of *** the arena of biomedical engineering,the functionalized modification of MOFs has produced drug carriers with excellent dispersion and functionalities such as target delivery and response release,with promising applications in bio-detection,disease therapy,tissue healing,and other *** review summa-rizes the present state of research on the functionalization of MOFs by physical binding or chemical cross-linking of small *** *** hvdrogels and evaluates the role and approach of MOFs functionalization in boosting the reactivity of *** this basis,research on the application of functionalized MOFs composites in biomedical engineering fields such as drug delivery,tissue repair,disease treatment,bio-detection and imaging is surveyed,and the development trend and application prospects of functionalized MOFs as an important new class of biomedical materials in the biomedical field are anticipated,which may provide some inspiration and reference for further development of MOF for bio-medical applications.

关键词： metal-organic frameworks porous functionalization tissue repair disease treatment

Augmenting osteoporotic bone regeneration through a hydrogel-based rejuvenating microenvironment

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Bioactive Materials 2024年第11期41卷 440-454页

作者： Xiaoting Zhang Boguang Yang Lu Feng Xiayi Xu Chenmin Wang Yuk-wai Lee Ming Wang Xuan Lu ling Qin Sien lin liming Bian Gang li Musculoskeletal Research Laboratory Department of Orthopaedics&TraumatologyThe Chinese University of Hong KongPrince of Wales HospitalHong KongChina Stem Cells and Regenerative Medicine Laboratory Li Ka Shing Institute of Health SciencesThe Chinese University of Hong KongPrince of Wales HospitalHong KongChina The CUHK-ACC Space Medicine Centre on health Maintenance of Musculoskeletal System The Chinese University of Hong Kong Shenzhen Research InstituteShenzhenPR China SH Ho Scoliosis Research Laboratory Department of Orthopaedics and TraumatologyThe Chinese University of Hong KongHong KongChina Joint Scoliosis Research Center of the Chinese University of Hong Kong and Nanjing University The Chinese University of Hong KongHong KongChina li ka shing institute of health sciences The Chinese University of Hong KongChina School of Biomedical sciences and Engineering Guangzhou International CampusSouth China University of TechnologyGuangzhou511442PR China department of orthopaedics and traumatology The University of Hong KongHong KongChina

Osteoporotic bone defects pose a significant challenge for bone regeneration as they exhibit impaired healing capacity and delayed healing *** address this issue,this study introduces a hydrogel that creates a rejuvenating microenvironment,thereby facilitating efficient bone repair during the initial two weeks following bone defect *** hydrogel,named GelHFS,was created through host-guest polymerization of gelatin and acrylatedβ-*** of the human fetal mesenchymal stem cell secretome(HFS)formed GelHFS hydrogel aimed at mimicking a rejuvenated stem cell *** results demonstrated that GelHFS hydrogel promotes cell stellate spreading and osteogenic differentiation via integrinβ1-induced focal adhesion *** of GelHFS hydrogel in an osteoporotic bone defect rat model recruited endogenous integrinβ1-expressing cells and enhanced new bone formation and bone *** findings reveal that GelHFS hydrogel provides a rejuvenating niche for endogenous MSCs and enhances bone regeneration in osteoporotic bone *** findings highlight the potential of GelHFS hydrogel as an effective therapeutic strategy for addressing challenging bone healing such as osteoporotic bone regeneration.

关键词： Osteoporotic bone defects Bone regeneration Rejuvenating microenvironment Secretome Focal adhesion pathway

Dual-response of multi-functional microsphere system to ultrasound and microenvironment for enhanced bone defect treatment

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Bioactive Materials 2024年第2期32卷 304-318页

作者： Qingxu Song Dianwei Wang Haoyu li Zongliang Wang Songjia Sun Zhenyu Wang Yi liu Sien lin Gang li Shaokun Zhang Peibiao Zhang department of Spine Surgery The First Hospital of Jilin UniversityChangchun130021China Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China department of Dermatology Second Hospital of Jilin UniversityChangchun130022China department of orthopaedics and traumatology and li ka shing institute of health sciences Prince of Wales HospitalThe Chinese University of Hong KongShatinHong Kong Special Administrative Region of China

Using bone tissue engineering strategies to achieve bone defect repair is a promising ***,the repair process outcomes are often *** we properly designed a multi-functional microsphere system,which could deliver bioactive proteins under the dual response of ultrasound and microenvironment,release microenvironment-responsive products on demand,reverse bone injury microenvironment,regulate the immune microenvironment,and achieve excellent bone defect treatment *** particular,the MnO_(2) introduced into the poly(lactic-co-glycolic acid)(PLGA)microspheres during synthesis could consume the acid produced by the degradation of PLGA to protect bone morphogenetic protein-2(BMP-2).More importantly,MnO_(2) could consume reactive oxygen species(ROS)and produce Mn^(2+)and oxygen(O_(2)),further promoting the repair of bone defects while reversing the ***,the reversal of the bone injury microenvironment and the depletion of ROS promoted the polarization of M1 macrophages to M2 macrophages,and the immune microenvironment was ***,the ultrasound(US)irradiation used during treatment also allowed the on-demand release of microenvironment-responsive *** multi-functional microsphere system combines the effects of on-demand delivery,reversal of bone injury microenvironment,and regulation of the immune microenvironment,providing new horizons for the clinical application of protein delivery and bone defect repair.

关键词： BMP-2 Multi-functional microsphere Bone defect repair Bone injury microenvironment Immune microenvironment

Low-molecular-weight estrogenic phytoprotein suppresses osteoporosis development through positive modulation of skeletal estrogen receptors

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Bioactive Materials 2024年第12期42卷 299-315页

作者： John Akrofi Kubi Augustine Suurinobah Brah Kenneth Man Chee Cheung Andy Chun Hang Chen Yin Lau Lee kai-Fai Lee Wei Qiao Yibin Feng Kelvin Wai Kwok Yeung department of orthopaedics and traumatology Li Ka Shing Faculty of MedicineThe University of Hong Kong(HKU)PR China Shenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma HKU-Shenzhen HospitalShenzhen518053PR China department of Obstetrics and Gynaecology Li Ka Shing Faculty of MedicineHKU21 Sassoon RoadPR China Shenzhen Key Laboratory of Fertility Regulation Reproductive Medicine CenterHKU-Shenzhen HospitalShenzhenPR China Applied Oral sciences and Community Dental Care Faculty of DentistryPR China School of Chinese Medicine Li Ka Shing Faculty of MedicineThe University of Hong Kong(HKU)PR China

Age-related osteoporosis is a metabolic skeletal disorder caused by estrogen deficiency in postmenopausal *** use of anti-osteoporotic drugs such as bisphosphonates and FDA-approved anti-resorptive selective estrogen receptor modulators(SERMs)has been associated with various clinical *** recently discovered a low-molecular-weight biocompatible and osteoanabolic phytoprotein,called HKUOT-S2 protein(32 kDa),from Dioscorea opposita Thunb that can accelerate bone defect ***,we demonstrated that the HKUOT-S2 protein treatment can enhance osteoblasts-induced ossification and suppress osteoporosis development by upregulating skeletal estrogen receptors(ERs)ERα,ERβ,and GPR30 expressions in ***,HKUOT-S2 protein estrogenic activities promoted hMSCs-osteoblasts differentiation and functions by increasing osteogenic markers,ALP,and RUNX2 expressions,ALP activity,and osteoblast biomineralization in *** treatment impaired the HKUOT-S2 protein-induced ERs expressions,osteoblasts differentiation,and ***,we demonstrated that the HKUOT-S2 protein could bind to ERs to exert osteogenic and osteoanabolic *** results showed that the biocompatible HKUOT-S2 protein can exert estrogenic and osteoanabolic properties by positively modulating skeletal estrogen receptor signaling to promote ossification and suppress ***,there is no or limited data if any,on osteoanabolic *** HKUOT-S2 protein can be applied as a new osteoanabolic SERM for osteoporosis treatment.

关键词： Ovariectomy(ovx) Osteoporosis Osteoblast functions Estrogen receptors(ERs) HKUOT-S2 protein

Synergistic effects of magnesium ions and simvastatin on attenuation of high-fat diet-induced bone loss

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Bioactive Materials 2021年第8期6卷 2511-2522页

作者： Bingyang Dai Xu li Jiankun Xu Yuwei Zhu Le Huang Wenxue Tong Hao Yao Dick Ho-kiu Chow ling Qin Musculoskeletal Research Laboratory of department of Orthopedics&traumatology and Innovative Orthopaedic Biomaterial&Drug Translational Research Laboratory Li Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong KongChina department of Chemistry The Chinese University of Hong KongNew TerritoriesHong KongChina

Introduction:Magnesium(Mg)has a prophylactic potential against the onset of *** to statin,Mg is recommended as lipid-lowering medication for hypercholesterolemia and concomitantly exhibits an association with increased bone *** combination of statin with Mg ions(Mg^(2+))may be able to alleviate the high-fat diet(HFD)-induced bone loss and reduce the side-effects of *** study aimed to explore the feasibility of combined Mg^(2+)with simvastatin(SIM)for treating HFD-induced bone loss in mice and the involving *** and methods:C57BL/6 male mice were fed with a HFD or a normal-fat diet(NFD).Mice were intraperitoneally injected SIM and/or orally received water with additional Mg^(2+)until ***-linked immunosorbent assay was performed to measure cytokines and cholesterol in serum and liver *** mineral density(BMD)and microarchitecture were assessed by micro-computed tomography(μCT)in different *** adipogenesis in palmitate pre-treated HepG2 cells was performed under various ***:μCT analysis showed that the trabecular bone mass was significantly lower in the HFD-fed group than that in NFD-fed group since week *** cortical thickness in HFD-fed group had a significant decrease at week 24,as compared with NFD-fed *** combination of Mg^(2+)and SIM significantly attenuated the trabecular bone loss in HFD-fed mice via arresting the osteoclast formation and bone ***,such combination also reduced the hepatocytic synthesis of cholesterol and inhibited matrix metallopeptidase 13(Mmp13)mRNA expression in ***:The combination of Mg^(2+)and SIM shows a synergistic effect on attenuating the HFD-induced bone *** current formulation may be a cost-effective alternative treatment to be indicated for obesity-related bone loss.

关键词： Obesity Bone loss Magnesium Simvastatin Trabecular bone Cholesterol

Biodegradable magnesium pins enhanced the healing of transverse patellar fracture in rabbits

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Bioactive Materials 2021年第11期6卷 4176-4185页

作者： Dick Ho Kiu Chow Jiali Wang Peng Wan lizhen Zheng Michael Tim Yun Ong Le Huang Wenxue Tong lili Tan Ke Yang ling Qin Musculoskeletal Research Laboratory Department of Orthopaedics&TraumatologyThe Chinese University of Hong KongHong Kong SARChina Innovative Orthopaedic Biomaterial and Drug Translational Research Laboratory Li Ka Shing Institute of Health SciencesThe Chinese University of Hong KongShatinHong Kong SARChina institute of Metal Research Chinese Academy of SciencesShenyangChina School of Materials Science and Engineering Dongguan University of TechnologyDongguanChina

Displaced fractures of patella often require open reduction surgery and internal fixation to restore the extensor continuity and articular *** fixation with biodegradable magnesium(Mg)pins enhanced fracture *** hypothesized that fixation with Mg pins and their degradation over time would enhance healing of patellar fracture radiologically,mechanically,and *** patellar fracture surgery was performed on thirty-two 18-weeks old female New Zealand White *** fracture was fixed with a pin made of stainless steel or pure Mg,and a figure-of-eight stainless steel band *** were harvested at week 8 or 12,and assessed with microCT,tensile testing,microindentation,and *** analysis showed that Mg group showed 12%higher in the ratio of bone volume to tissue volume at week 8,and 38.4%higher of bone volume at week *** testing showed that the failure load and stiffness of Mg group were 66.9%and 104%higher than the control group at week 8,*** week 12,Mg group was 60.8%higher in ultimate strength than the control *** showed that,compared to the Control group,Mg group showed 49.9%higher Vickers hardness and 31%higher elastic modulus at week 8 and 12,*** week 12,the new bone of Mg group remodelled to laminar bone,but those of the control group remained woven *** of transverse patellar fracture with Mg pins and its degradation enhanced new bone formation and mechanical properties of the repaired patella compared to the Control group.

关键词： Patellar fracture Tension band wire Biodegradable implant Osteogenesis Microindentation

Advanced Hydrogel systems for mandibular reconstruction

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Bioactive Materials 2023年第3期21卷 175-193页

作者： Jiaxin Guo Hao Yao Xu li liang Chang Zixuan Wang Wangyong Zhu Yuxiong Su ling Qin Jiankun Xu Musculoskeletal Research Laboratory Department of Orthopaedics&TraumatologyThe Chinese University of Hong KongHong Kong SARChina Innovative Orthopaedic Biomaterial and Drug Translational Research Laboratory Li Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong Kong SARChina department of Mechanical Engineering Tsinghua UniversityBeijingChina Division of Oral and Maxillofacial Surgery Faculty of DentistryThe University of Hong KongHong Kong SARChina

Mandibular defect becomes a prevalent maxillofacial disease resulting in mandibular dysfunctions and huge psychological burdens to the *** the routine presence of oral contaminations and aesthetic restoration of facial structures,the current clinical treatments are however limited,incapable to reconstruct the structural integrity and regeneration,spurring the need for cost-effective mandibular tissue *** systems possess great merit for mandibular reconstruction with precise involvement of cells and bioactive *** this review,current clinical treatments and distinct mode(s)of mandible formation and pathological resorption are summarized,followed by a review of hydrogel-related mandibular tissue engineering,and an update on the advanced fabrication of hydrogels with improved mechanical property,antibacterial ability,injectable form,and 3D bioprinted hydrogel *** exploration of advanced hydrogel systems will lay down a solid foundation for a bright future with more biocompatible,effective,and personalized treatment in mandibular reconstruction.

关键词： Hydrogel Mandibular defect Tissue engineering Injectable materials Bone regeneration

Probiotic-based nanoparticles for targeted microbiota modulation and immune restoration in bacterial pneumonia

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National Science Review 2023年第2期10卷 183-198页

作者： Jieni Fu Xiangmei liu Zhenduo Cui Yufeng Zheng Hui Jiang Yu Zhang Zhaoyang li Yanqin liang Shengli Zhu Paul K Chu Kelvin Wai Kwok Yeung Shuilin Wu School of Materials Science & Engineering the Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China Tianjin University School of Materials Science & Engineering Peking University School of health Science & Biomedical Engineering Hebei University of Technology department of Orthopedics Guangdong Provincial People's HospitalGuangdong Academy of Medical Sciences department of Physics Department of Materials Science and Engineering and Department of Biomedical Engineering City University of Hong Kong department of orthopaedics & traumatology Li Ka Shing Faculty of Medicine The University of Hong Kong

While conventional bacterial pneumonia mainly centralizes avoidance of bacterial colonization,it remains unclear how to restore the host immunity for hyperactive immunocompetent primary and immunocompromised secondary bacterial ***,probiotic-based nanoparticles of OASCLR were formed by coating chitosan,hyaluronic acid and ononin on living Lactobacillus *** nanoparticles could effectively kill various clinic common pathogens and antibacterial efficiency was> 99.97%.Importantly,OASCLR could modulate lung microbiota,increasing the overall richness and diversity of microbiota by decreasing pathogens and increasing probiotic and commensal ***,OASCLR could target inflammatory macrophages by the interaction of OASCLR with the macrophage binding site of CD 44 and alleviate overactive immune responses for hyperactive immunocompetent ***,OASCLR could break the state of the macrophage' s poor phagocytic ability by upregulating the expression of the extracellular matrix assembly,immune activation and fibroblast activation in immunocompromised *** macrophage' s phagocytic ability was increased from 2.61% to 12.3 %.Our work provides a potential strategy for hyperactive immunocompetent primary and immunocompromised secondary bacterial pneumonia.

关键词： probiotic-based nanoparticles immunocompetent primary bacterial pneumonia immunocompromised secondary bacterial pneumonia restoring host immunity