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Epidemiology of maxillofacial Trauma in Pediatric and Adolescent Population: An Institutional Experience of 6 Years

Open Journal of Orthopedics 2022年第6期12卷 277-287页

作者： Noaman Kazi Pallavi Ranadive Suday Rajurkar Ankit Sharma Mohan Deshpande Snehal Ingole department of oral and maxillofacial surgery M. A. Rangoonwala College of Dental Sciences & Research Centre Pune India department of oral and maxillofacial surgery Nair Hospital Dental College Mumbai India Consultant Oral and Maxillofacial Surgery Nagpur India department of oral and maxillofacial surgery Pacific Dental College Udaiur India

Introduction: Facial fractures are uncommon injuries in children. Pediatric maxillofacial fractures constitute 1% to 15% of all facial fractures, but show different clinical features when compared with adult patients. Worldwide, the major causes of fractures in children are accidents, falls, violence, and sports- related accidents. Facial trauma in children may result in injury to the facial growth centers, leading to subsequent developmental abnormalities in the injured area. Patients & Methods: Data of pediatric and adolescent patients (0 - 17 years), with a history of trauma, has been compiled over a period of 6 years. History, clinical and radiographic data records were analyzed. Compilation was done in the following categories;age and sex distribution, etiology, site of trauma and associated soft tissue injuries were recorded. The treatment rendered has also been mentioned. Results: A total of 340 patient records were assessed. Demographic data, etiology, type of fracture, associated injury and treatment rendered were recorded. It was found that males (54.7%) were more frequently affected than females (45.3%). Incidence of trauma was more in children belonging to the pre-school age group (38.5%) and the most common etiology was sports-related injuries (43.8%). Dentoalveolar fractures were the most common type (58.5%) of fractures seen in the patients. Most of the patients were managed by conservative treatment (35%) or closed reduction (48%), while a few required open reduction (7.9%). Conclusion: It is felt that this data will be useful in determining the pattern and etiology of maxillofacial trauma in pediatric patients in an Indian setting. Additionally, an outline of the treatment plan in different types of fractures is also summarized.

关键词： maxillofacial Trauma Pediatric Trauma Open Reduction Closed Reduction Mandibular Fractures

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Risk of interstitial lung disease with the use of programmed cell death 1 (PD-1) inhibitor compared with programmed cell death ligand 1 (PD-L1) inhibitor in patients with breast cancer: A systematic review and meta-analysis

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Cancer Pathogenesis and Therapy 2024年第2期2卷 91-102页

作者： Lijuan Guo Xiaoyi Lin Xin Lin Yulei Wang Jiali Lin Yi Zhang Xiangqing Chen Miao Chen Guochun Zhang Yifang Zhang department of Breast surgery Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong 510000China Schol of Medicine South China University of TechnologyGuangzhouGuangdong 510000China Medical College Shantou UniversityShantouGuangdong 515000China The Second School of Clinical Medicine Southerm Medical UniversityGuangzhouGuangdong 510000China department of Breast Cancer Guangdong Provincial People's Hospital's Nanhai HospitalFoshanGuangdong 528000China department of Emergency Medicine Guangdong Provincial People's Hospitals Nanhai HospitalFoshanGuangdong 528000China

Background:Programmed cell death 1(PD-1)and programmed cell death ligand 1(PD-L1)inhibitors have become integral elements within the current landscape of breast cancer treatment modalities;however,they are associ-ated with interstitial lung disease(ILD),which is rare but potentially ***,only a few studies have compared the difference in ILD incidence between PD-1 and PD-L1 ***,this study aimed to assess the discrepancies regarding ILD risk between the two immune checkpoint *** also reported three cases of ILD after PD-1 inhibitor ***:We comprehensively searched PubMed,EMBASE,and the Cochrane Library to identify clinical trials that investigated PD-1/PD-L1 inhibitor treatment for patients with breast *** overall estimates of incidence and risk ratio(RR)were calculated with a 95%confidence interval(CI),and a mirror group analysis was per-formed using eligible ***:This meta-analysis included 29 studies with 4639 patients who received PD-1/PD-L1 inhibitor treatment.A higher ILD incidence was observed among 2508 patients treated with PD-1 inhibitors than among 2131 patients treated with PD-L1 inhibitors(0.05 vs.0.02).The mirror group analysis further revealed a higher ILD event risk in patients treated with PD-1 inhibitors than in those treated with PD-L1 inhibitors(RR=2.34,95%CI,1.13-4.82,P=0.02).Conclusion:Our findings suggest a greater risk of ILD with PD-1 inhibitors than with PD-L1 *** findings are instrumental for clinicians in treatment deliberations,and the adoption of more structured diagnostic approaches and management protocols is necessary to mitigate the risk of ILD.

关键词： Programmed cell death 1 inhibitor Programmed cell death ligand 1 inhibitor Interstitial lung disease Breast cancer Immune-related adverse events

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Beclin-1/LC3-II dependent macroautophagy was uninfluenced in ischemia-challenged vascular endothelial cells

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Genes & Diseases 2022年第2期9卷 549-561页

作者： Yaping Ma Chaofan Li Yan He Tiwei Fu Li Song Qingsong Ye Fugui Zhang Chongqing Key Laboratory of oral Diseases and Biomedical sciences Chongqing 401147PR China department of oral and maxillofacial surgery Stomatological Hospital of Chongqing Medical UniversityChongqing 401147PR China Tianyou Hospital Wuhan University of Science&TechnologyWuhanHubei 430064PR China department of oral and maxillofacial surgery Massachusetts General HospitalBostonMA 02114USA Chongqing Municipal Key Laboratory of oral Biomedical Engineering of Higher Education Chongqing 401147PR China Center for Regenerative Medicine Renmin Hospital of Wuhan UniversityWuhanHubei 430060PR China

Autophagy has been extensively studied and occurs in many biological ***,a question remains as to whether ischemia enhances Beclin-1/LC3-II-dependent macroautophagy in vascular endothelial cells,as has been previously ***,the effect of the level of autophagy on cell or skin flap survival still requires *** created a lethal ischemia model in human umbilical vascular endothelial cells(HUVECs),performed quantitative proteomics and bioinformatics analyses,and verified the autophagic status and effect both in vitro and in *** significantly upregulated proteins encoded by autophagy-related genes(ATGs)included ATG2A,ATG3,ATG4B,ATG5,ATG7,ATG9A,ATG12,ATG16,and *** significantly enhanced lysosomal proteins were cathepsin B,cathepsin D,lysosome-associated membrane protein 1(LAMP1),and ***,the differentially expressed proteins excluded Beclin-1,microtubule-associated protein light chain 3(LC3)-I,and *** blot analyses verified that the protein expression levels of Beclin-1,LC3-I,and LC3-II were neither upregulated nor downregulated in ischemia-challenged *** autophagic status was not enhanced by rapamycin in ischemic HUVECs but appeared to be inhibited by *** in vivo study on rats showed that a downregulation in autophagic status jeopardized skin flap *** conclusion,Ischemia neither enhanced nor inhibited Beclin-1/LC3-II-dependent canonical macroautophagy both in vitro and in vivo,in contradiction to previous *** appropriate autophagic homeostasis can minimize cell or skin flap damage.

关键词： Autophagy Bioinformatics analysis Human umbilical vein endothelial cell Quantitative proteomics study Skin flap

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NUPR1 promotes the proliferation and metastasis of oral squamous cell carcinoma cells by activating TFE3-dependent autophagy

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Signal Transduction and Targeted Therapy 2022年第5期7卷 1797-1807页

作者： Tengfei Fan Xiaoning Wang Sheng Zhang Ping Deng Yi Jiang Yidan Liang Sheng Jie Qing Wang Chuwen Li Guocai Tian Zhen Zhang Zhenhu Ren Bo Li Yanrong Chen Zhijing He Yan Luo Mingliang Chen Hanjiang Wu Zhengping Yu Huifeng Pi Zhou Zhou Zhiyuan Zhang department of oral and maxillofacial-Head Neck Oncology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of Stomatology Research Unit of oral and maxillofacial Regenerative Medicine Chinese Academy of Medical SciencesShanghaiChina department of oral and maxillofacial surgery Zhang Zhiyuan Academician WorkstationHainan Western Central HospitalShanghai Ninth People’s HospitalDanzhouHainanChina department of oral and maxillofacial surgery The Second Xiangya Hospital of Central South UniversityChangshaHunanChina department of oral Pathology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghaiChina department of Occupational Health Third Military Medical UniversityChongqingChina department of Pathology The Second Xiangya Hospital of Central South UniversityChangshaHunanChina School of Medicine Guangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina department of oral and maxillofacial surgery Affiliated Hospital of Guilin Medical UniversityGuilinGuangxi Zhuang Autonomous RegionChina Institute of Pathology and Southwest Cancer Centre Southwest HospitalThird Military Medical UniversityChongqingChina and 10Department of Emergency MedicineFirst Affiliated Hospital and Department of Environmental MedicineSchool of Public HealthSchool of MedicineZhejiang UniversityHangzhouZhejiangChina

oral squamous cell carcinoma(OSCC)is the most common type of oral malignancy,and metastasis accounts for the poor prognosis of *** is considered to facilitate OSCC development by mitigating various cellular stresses;nevertheless,the mechanisms of autophagy in OSCC cell proliferation and metastasis remain *** our study,high-sensitivity label-free quantitative proteomics analysis revealed nuclear protein 1(NUPR1)as the most significantly upregulated protein in formalin-fixed paraffin-embedded tumour samples derived from OSCC patients with or without lymphatic metastasis.

关键词： metastasis squamous prognosis

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ERK phosphorylation functions in invadopodia formation in tongue cancer cells in a novel silicate fibre-based 3D cell culture system

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International Journal of oral Science 2018年第4期10卷 253-262页

作者： Masaharu Noi Ken-Ichi Mukaisho Saori Yoshida Shoko Murakami Shinya Koshinuma Takeshi Adachi Yoshisato Machida Masashi Yamori Takahisa Nakayama Gaku Yamamoto Hiroyuki Sugihara department of oral and maxillofacial surgery Shiga University of Medical Science department of Pathology Division of Molecular Diagnostic PathologyShiga University of Medical Science Dental oral surgery Nagahama Red Cross Hospital

To screen for additional treatment targets against tongue cancer, we evaluated the contributions of extracellular signal-related kinase(ERK), AKT and ezrin in cancer development. Immunohistochemical staining showed that ERK and ezrin expressions were significantly higher in invasive squamous cell carcinoma than in carcinoma in situ. To investigate the roles of ERK and ezrin in cancer development, we used the non-woven silica fibre sheet Cellbedwith a structure resembling the loose connective tissue morphology in a novel 3 D culture system. We confirmed that the 3 D system using CellbedTMaccurately mimicked cancer cell morphology in vivo. Furthermore, cell projections were much more apparent in 3 D-cultured tongue cancer cell lines than in 2 D cultures. Typically, under conventional 2 D culture conditions, F-actin and cortactin are colocalized in the form of puncta within ***, in the 3 D-cultured cells, colocalization was mainly observed at the cell margins, including the projections. Projections containing F-actin and cortactin colocalization were predicted to be invadopodia. Although suppressing ezrin expression with small interfering RNA transfection caused no marked changes in morphology, cell projection formation was decreased, and the tumour thickness in vertical sections after 3 D culture was markedly decreased after suppressing ERK activity because both the invasion ability and proliferation were inhibited. An association between cortactin activation as well as ERK activity and invadopodia formation was detected. Our novel 3 D culture systems using Cellbed? are simple and useful for in vitro studies before conducting animal experiments. ERK contributes to tongue cancer development by increasing both cancer cell proliferation and migration via cortactin activation.

关键词： ERK phosphorylation functions in invadopodia formation in tongue cancer cells in a novel silicate fibre-based 3D cell culture sy HSC

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Massive low-grade myxoid liposarcoma of the floor of the mouth:A case report and review of literature

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World Journal of Clinical Cases 2022年第34期10卷 12742-12749页

作者： Takuma Kugimoto Yuko Yamagata Toshimitsu Ohsako Hideaki Hirai Naoto Nishii Kou Kayamori Tohru Ikeda Hiroyuki Harada department of oral and maxillofacial Surgical Oncology Division of Oral Health ScienceGraduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityBunkyo-ku 113-8549TokyoJapan department of oral Pathology Division of Oral Health ScienceGraduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityBunkyo-ku 113-8549TokyoJapan

BACKGROUND oral liposarcoma is an extremely rare lesion that is often clinically misdiagnosed as a benign tumor due to its asymptomatic and indolent clinical ***,we report a case of massive low-grade myxoid liposarcoma(MLS)of the floor of the *** SUMMARY A 71-year-old man presented with a huge mass in the left floor of the mouth.A biopsy was performed,and a diagnosis of a myxoid tumor suspicious for lowgrade MLS or myxoma was ***-enhanced T1-weighted magnetic resonance imaging showed an intensely enhanced tumor lesion that occupies the left sublingual space and extends to the submandibular *** dissection,tumor resection,and reconstruction with a radial forearm flap were *** surgical specimen exhibited histologically low-grade *** in sarcoma(FUS,also known as TLS)and DNA damage-inducible transcript 3(DDIT3,also known as CHOP)break-apart was not detected in the fluorescence in situ hybridization *** tumor was completely encapsulated and did not require additional ***,no recurrence was reported 40 mo after *** We experienced an extremely rare,massive,low-grade MLS emerging from the floor of the ***,an MLS of the floor of the mouth lacks significant clinical findings and is often *** no FUS-DDIT3 fusion gene was detected,a low-grade MLS was ultimately diagnosed based on the histological findings.

关键词： Myxoid liposarcoma Floor of mouth surgery Fluorescence in situ hybridization Sublingual space Case report

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Interleukin-13 promotes cellular senescence through inducing mitochondrial dysfunction in IgG4-related sialadenitis

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International Journal of oral Science 2022年第3期14卷 321-333页

作者： Mengqi Zhu Sainan Min Xiangdi Mao Yuan Zhou Yan Zhang Wei Li Li Li Liling Wu Xin Cong Guangyan Yu department of oral and maxillofacial surgery Peking University School and Hospital of Stomatology&National Center of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijingChina department of Physiology and Pathophysiology Peking University School of Basic Medical SciencesKey Laboratory of Molecular Cardiovascular SciencesMinistry of Educationand Beijing Key Laboratory of Cardiovascular Receptors ResearchBeijingChina department of Biomedical Informatics Peking University School of Basic Medical SciencesKey Laboratory of Molecular Cardiovascular SciencesMinistry of EducationBeijingChina

Immunoglobulin G4-related sialadenitis(IgG4-RS)is an immune-mediated fibro-inflammatory disease and the pathogenesis is still not fully *** aim of this study was to explore the role and mechanism of interleukin-13(IL-13)in the cellular senescence during the progress of *** found that the expression of IL-13 and IL-13 receptorα1(IL-13Rα1)as well as the number of senescent cells were significantly higher in the submandibular glands(SMGs)of IgG4-RS ***-13 directly induced senescence as shown by the elevated activity of senescence-associatedβ-galactosidase(SA-β-gal),the decreased cell proliferation,and the upregulation of senescence markers(p53 and p16)and senescence-associated secretory phenotype(SASP)factors(IL-1βand IL-6)in SMG-C6 ***,IL-13 increased the level of phosphorylated signal transducer and activator of transcription 6(p-STAT6)and mitochondrial-reactive oxygen species(mt ROS),while decreased the mitochondrial membrane potential,ATP level,and the expression and activity of superoxide dismutase 2(SOD2).Notably,the IL-13-induced cellular senescence and mitochondrial dysfunction could be inhibited by pretreatment with either STAT6 inhibitor AS1517499 or mitochondria-targeted ROS scavenger Mito ***,IL-13 increased the interaction between p-STAT6 and c AMP-response element binding protein(CREB)-binding protein(CBP)and decreased the transcriptional activity of CREB on *** together,our findings revealed a critical role of IL-13 in the induction of salivary gland epithelial cell senescence through the elevated mitochondrial oxidative stress in a STAT6–CREB–SOD2-dependent pathway in IgG4-RS.

关键词： Interleukin-13 promotes cellular senescence through inducing mitochondrial dysfunction in IgG4-related sialadenitis IgG

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Peripheral Facial Paralysis in People Living with Human Immunodeficiency Virus (HIV)

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International Journal of Otolaryngology and Head & Neck surgery 2024年第3期13卷 168-177页

作者： Lekassa Pierrette Andjock Nkouo Yves Christian Mouinga Abayi Alex Davy Assoumou Ada Prudence BiyeNgoghe Prudence Ngoma Manfoumbi Albert Brice Manfoumbi Manfoumbi Kévin Dimitri Miloundja Jerome Nzouba Léon ENT and CFS department Omar Bongo Ondimba Army Instruction Hospital Libreville Gabon department of surgery and Surgical Specialties University of Health Sciences Owendo Gabon ENT and CFS department Yaound&#233 General Hospital Yaound&#233 Cameroon Ophthalmology department Omar Bongo Ondimba Army Instruction Hospital Libreville Gabon Ophthalmology department Owendo University Hospital Center Libreville Gabon Internal Medicine department Omar Bongo Ondimba Army Instruction Hospital Libreville Gabon

Introduction: Peripheral facial palsy (PFP) is a frequent reason for ENT consultations. It is a common complication of human immunodeficiency virus (HIV) infection. The aim of this study was to describe the diagnostic and therapeutic aspects and to establish the correlation between PFP and HIV in our context. Patients and Method: This was a retrospective descriptive study conducted in the ENT and CFS department of the HIAOBO, covering the medical records of patients hospitalized for taking a PFP on HIV terrain from January 1, 2016 to December 31, 2020. Results: The study involved 17 patients, 10 men (59%) and 7 women (41%), a sex ratio of 1.4. The average age was 39 years with the extremes of 11 and 69 years. Shopkeepers reported 9 cases (53%). The reason for consultation was facial asymmetry in 11 cases (100%). The delay in consultation during the first week was 82.4%. Clinical signs were unilateral facial asymmetry, the opening of the palpebral fissure and lacrimation. All patients received medical treatment for PFP and HIV. Evolution was favorable, with complete recovery and no sequelae in 82.4% of cases. surgery was performed in one case. Conclusion: PFPs are common in HIV infection. Diagnosis is clinical and management is multidisciplinary. Progression depends on the length of time taken to treat the disease.

关键词： Peripheral Facial Paralysis HIV HIAOBO

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Hybrid intercalated duct lesion of the parotid:A case report

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World Journal of Clinical Cases 2022年第33期10卷 12358-12364页

作者： Dominykas Stankevicius Donatas Petroska Linas Zaleckas Otilija Kutanovaite Centre of oral and maxillofacial surgery Institute of DentistryFaculty of MedicineVilnius UniversityVilnius LT-08217Lithuania department of Pathology Forensic Medicine and PharmacologyInstitute of Biomedical SciencesFaculty of MedicineVilnius UniversityVilnius LT-03101Lithuania department of Head and Neck surgery and Oncology National Cancer InstituteVilnius LT-08660Lithuania

BACKGROUND Intercalated duct lesions(IDLs)are considered relatively benign and rare tumors of salivary glands,that were only described *** histopathological appearance may range from ductal hyperplasia to encapsulated adenoma with hybrid patterns of both *** is thought that IDLs may be the precursor for malignant proliferations,therefore their correct diagnosis remains crucial for proper lesion *** is the first reported IDL case arising from the accessory parotid gland(APG),which stands for less frequent but higher malignancy rate tumor developmental *** SUMMARY A 24-years-old male with no accompanying diseases was referred to the hospital with a painless nodule on the right *** physical examination,the stiff,immobile,and painless mass was palpable in the anterior portion of the right parotideomasseteric region,just superior to the parotid *** examination demonstrated 1.5 cm×1.0 cm hypoechogenic mass on the anterior part of the right parotid ***-guided fine needle aspiration cytology,followed by liquid-based fine needle aspiration biopsy were ***,the results were uninformative.A contrast-enhanced magnetic res-onance imaging(MRI)of the parotid was obtained,demonstrating a 1.5 cm×1.0 cm×0.5 cm tumor with high intensity capsule together with low intensity core in the very anterior part of right superficial lobe,situated in the *** MRI features were uncharacteristic to common parotid tumors,therefore surgical resection followed *** histopathological examination,the final diagnosis of hybrid IDL was *** Fine needle aspiration biopsy might not always be diagnostic,and given the malignant potential,the surgical resection of such lesion remains the treatment of choice.

关键词： Intercalated duct lesion Accessory parotid gland Intercalated duct adenoma Intercalated duct hyperplasia Salivary gland Case report

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GPCR/endocytosis/ERK signaling/S2R is involved in the regulation of the internalization,mitochondria-targeting and-activating properties of human salivary histatin 1

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International Journal of oral Science 2022年第3期14卷 334-348页

作者： Dandan Ma Wei Sun Cuicui Fu Kamran Nazmi Enno C.I.Veerman Richard T.Jaspers Jan G.M.Bolscher Floris J.Bikker Gang Wu department of oral Biochemistry Academic Centre for Dentistry Amsterdam(ACTA)University of Amsterdam and Vrije Universiteit AmsterdamAmsterdamNetherlands School of Stomatology Zhejiang Chinese Medical UniversityHangzhouChina Laboratory for Myology Department of Human Movement SciencesFaculty of Behavioral and Movement SciencesAmsterdam Movement SciencesVrije Universiteit AmsterdamAmsterdamNetherlands department of oral Cell Biology Academic Centre for Dentistry Amsterdam(ACTA)University of Amsterdam and Vrije Universiteit AmsterdamAmsterdamNetherlands department of oral and maxillofacial surgery/Pathology Amsterdam UMC and Academic Center for Dentistry Amsterdam(ACTA)Vrije Universiteit AmsterdamAmsterdam Movement ScienceAmsterdamNetherlands

Human salivary histatin 1(Hst1)exhibits a series of cell-activating properties,such as promoting cell spreading,migration,and metabolic *** recently have shown that fluorescently labeled Hst1(F-Hst1)targets and activates mitochondria,presenting an important molecular ***,its regulating signaling pathways remain to be *** investigated the influence of specific inhibitors of G protein-coupled receptors(GPCR),endocytosis pathways,extracellular signal-regulated kinases1/2(ERK1/2)signaling,p38 signaling,mitochondrial respiration and Na+/K+-ATPase activity on the uptake,mitochondria-targeting and-activating properties of *** performed a si RNA knockdown(KD)to assess the effect of Sigma-2 receptor(S2R)/Transmembrane Protein 97(TMEM97)—a recently identified target protein of *** also adopted live cell imaging to monitor the whole intracellular trafficking process of *** results showed that the inhibition of cellular respiration hindered the internalization of *** inhibitors of GPCR,ERK1/2,phagocytosis,and clathrin-mediated endocytosis(CME)as well as siRNA KD of S2R/TMEM97 significantly reduced the uptake,which was accompanied by the nullification of the promoting effect of F-Hst1 on cell metabolic *** the inhibitor of CME and KD of S2R/TMEM97 significantly compromised the mitochondria-targeting of *** further showed the intracellular trafficking and targeting process of F-Hst1,in which early endosome plays an important ***,phagocytosis,CME,GPCR,ERK signaling,and S2R/TMEM97 are involved in the internalization of Hst1,while only CME and S2R/TMEM97 are critical for its subcellular *** inhibition of either internalization or mitochondria-targeting of Hst1 could significantly compromise its mitochondria-activating property.

关键词： GPCR/endocytosis/ERK signaling/S2R is involved in the regulation of the internalization mitochondria-targeting and activating properties of human salivary histatin 1 ERK

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