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Immunohistochemical expression of matrix metalloproteinase-9 and 13 in oral squamous cell carcinoma and their role in predicting lymph node metastasis

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World Journal of Methodology 2025年第2期15卷 108-116页

作者： Bhari Sharanesha Manjunatha Keshav T Handge Vandana Sandeep Shah Yasser Eid Al-Thobaiti Deepak Gowda Sadashivappa Pateel department of Basic oral Medicine and Allied Dental Sciences Taif UniversityAt`Taif 26571MakkahSaudi Arabia department of oral and maxillofacial pathology Dr.Vasantrao Pawar Medical CollegeHospital and Research CentreNashik 423101MaharashtraIndia department of oral pathology and Microbiology KM Shah Dental College and HospitalSumandeep VidyapeethVadodara 391760GujaratIndia department of oral and maxillofacial surgery and Diagnostic Sciences Faculty of DentistryTaif UniversityAl-Haweiah 26571 MakkahSaudi Arabia department of oral pathology and Microbiology Faculty of DentistryMAHSA UniversitySelangor 42610Malaysia

BACKGROUND One of the main characteristics of oral squamous cell carcinoma(OSCC)is that it metastasizes to cervical lymph nodes frequently with a high degree of local invasiveness.A primary feature of malignant tumors is their penetration of neighboring tissues,such as lymphatic and blood arteries,due to the tumor cells'capacity to break down the extracellular matrix(ECM).Matrix metalloproteinases(MMPs)constitute a family of proteolytic enzymes that facilitate tissue remo-deling and the degradation of the ***-9 and MMP-13 belong to the group of extracellular matrix degrading enzymes and their expression has been studied in OSCC because of their specific ***-13,a collagenase family member,is thought to play an essential role in the MMP activation cascade by breaking down the fibrillar collagens,whereas MMP-9 is thought to accelerate the growth of *** MMP-13 expression has been associated with tumor behavior and patient prognosis in a number of malignant *** authors wish to thank Jadhav KB for his valuable opinion during the preparation of the manuscript.

关键词： Matrix metalloproteinases oral squamous cell carcinoma Tumor staging Immunohistochemistry Invasion Lymph node metastasis TNM stage

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ERK phosphorylation functions in invadopodia formation in tongue cancer cells in a novel silicate fibre-based 3D cell culture system

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International Journal of oral Science 2018年第4期10卷 253-262页

作者： Masaharu Noi Ken-Ichi Mukaisho Saori Yoshida Shoko Murakami Shinya Koshinuma Takeshi Adachi Yoshisato Machida Masashi Yamori Takahisa Nakayama Gaku Yamamoto Hiroyuki Sugihara department of oral and maxillofacial surgery Shiga University of Medical Science department of pathology Division of Molecular Diagnostic PathologyShiga University of Medical Science Dental oral surgery Nagahama Red Cross Hospital

To screen for additional treatment targets against tongue cancer, we evaluated the contributions of extracellular signal-related kinase(ERK), AKT and ezrin in cancer development. Immunohistochemical staining showed that ERK and ezrin expressions were significantly higher in invasive squamous cell carcinoma than in carcinoma in situ. To investigate the roles of ERK and ezrin in cancer development, we used the non-woven silica fibre sheet Cellbedwith a structure resembling the loose connective tissue morphology in a novel 3 D culture system. We confirmed that the 3 D system using CellbedTMaccurately mimicked cancer cell morphology in vivo. Furthermore, cell projections were much more apparent in 3 D-cultured tongue cancer cell lines than in 2 D cultures. Typically, under conventional 2 D culture conditions, F-actin and cortactin are colocalized in the form of puncta within ***, in the 3 D-cultured cells, colocalization was mainly observed at the cell margins, including the projections. Projections containing F-actin and cortactin colocalization were predicted to be invadopodia. Although suppressing ezrin expression with small interfering RNA transfection caused no marked changes in morphology, cell projection formation was decreased, and the tumour thickness in vertical sections after 3 D culture was markedly decreased after suppressing ERK activity because both the invasion ability and proliferation were inhibited. An association between cortactin activation as well as ERK activity and invadopodia formation was detected. Our novel 3 D culture systems using Cellbed? are simple and useful for in vitro studies before conducting animal experiments. ERK contributes to tongue cancer development by increasing both cancer cell proliferation and migration via cortactin activation.

关键词： ERK phosphorylation functions in invadopodia formation in tongue cancer cells in a novel silicate fibre-based 3D cell culture sy HSC

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Surface-modified deproteinized human demineralized tooth matrix for bone regeneration:physicochemical characterization and osteoblast cell biocompatibility

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Regenerative Biomaterials 2024年第4期3卷 1-13页

作者： Natwara Chokwattananuwat Srisurang Suttapreyasri department of oral and maxillofacial surgery Faculty of DentistryPrince of Songkla UniversitySongkhlaThailand

Tooth presents an intriguing option as a bone graft due to its compositional similarity to ***,the deproteinized human demineralized tooth matrix(dpDTM),developed to overcome the limited availability of autologous tooth grafts,has suboptimal pore size and surface *** study aimed to fabricate a surface-modified dpDTM using acid etching and collagen coating,followed by in vitro evaluation of physicochemical and biological *** dpDTM was modified into two protocols:Acid-modified dpDTM(A-dpDTM)and collagen-modified dpDTM(C-dpDTM).Results demonstrated that A-dpDTM and C-dpDTM had increased pore sizes and rougher surfaces compared to *** immobilization was evidenced by nitrogen presence exclusively in *** groups had a Ca/P molar ratio of 1.67 and hydroxyapatite as the sole constituent,with 65-67%*** rates significantly increased to 30%and 20%for C-dpDTM and A-dpDTM,respectively,compared to 10%for dpDTM after 120 *** collagen release of C-dpDTM on Day 30 was 45.16 mg/*** attachment and proliferation were enhanced on all scaffolds,especially C-dpDTM,which displayed the highest proliferation and differentiation *** conclusion,surface modified of dpDTM,including A-dpDTM and C-dpDTM,significantly enhances bioactivity by altering surface properties and promoting osteoblast activity,thereby demonstrating promise for bone regeneration applications.

关键词： acid-modified dpDTM biocompatibility bone graft collagen-modified dpDTM deproteinized human tooth matrix tooth-derived bone graft

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The Craniofacial Morphology in Adult Patients with Unoperated Isolated Cleft Palate

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Bone Research 2013年第2期1卷 195-200页

作者： Zhongtai Ye Xue Xu Adalet Ahmatjian Bing Shi The First Teaching Hospital of Xinjiang Medical University Department of Oral and Maxillofacial Surgery West China College of Stomatology Sichuan UniversityDepartment of Oral and Maxillofacial Surgery

Objective： To address the effect of intrinsic factors on craniofacial growth by analyzing the craniofacial morphology of unoperated isolated cleft palate in Chinese adult. Materials and Methods： This study included 37 nonsyndromic isolated cleft palate and 39 age and gender matched non-clefts. Twenty-six cephalometric measurements were employed to evaluate the facial morphology. Independent samples T test and Mann- Whitney U were used for comparison. Significant difference was defined at 95% level. Results： Data from this study showed patients with unoperated isolated cleft palate have a reduced maxillary sagittal length （ANS-PMP, A-PMP, P〈0.05）, a smaller ANB angle （ANB, P〈0.05） and a retrusive ANS point （S-N-ANS, P〈0.05; Ba-N-ANS, P〈0.05）. Measurements descripted position of maxilla （S-Ptm, P〉0.05）, depth of bony pharynx （Ba-PMP, P〉0.05）, anterior and posterior maxillary height （N-ANS, P〉0.05; R-PMP, P〉0.05） and mandible morphology （including linear measurements and angle measurements） did not show any significant difference between case and control groups. Conclusions： Patients with isolated cleft palate were characterized by maxillary retrusion. Mandible morphology and cranial basal morphology in isolated cleft palate showed no significant difference with nonclefts. Patients with isolated cleft palate are more vulnerable to cross bite than nonclefts. Intrinsic deficiencies did detrimental effect on maxilla sagittal length, but did no detrimental effect on maxilla position, mandible size and position.

关键词： isolated cleft palate unoperated craniofacial morphology maxillary growth cephalometry

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Concomitant paraganglioma and thyroid carcinoma:A case report

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World Journal of Clinical Cases 2019年第5期7卷 656-662页

作者： Bo Lin Hong-Yu Yang Hui-Jun Yang Shi-Yue Shen department of oral and maxillofacial surgery Peking University Shenzhen Hospital

BACKGROUND Paraganglioma/pheochromocytoma and medullary thyroid carcinoma can coexist and are often found in multiple endocrine neoplasia(MEN). However,very few cases highlight papillary thyroid carcinoma. We present herein a rare case of head and neck paraganglioma associated with papillary thyroid *** SUMMARY A 51-year-old man presented to our department with right-sided neck swelling and hypertension. Physical examination showed neck masses with obvious pulsation. Concentrations of serum calcium, phosphorus, parathormone, thyroid stimulating hormone, free thyroxine, and calcitonin were within normal *** computed tomography revealed an irregular solid nodule, located in the carotid artery bifurcation. A low-density nodule of the thyroid isthmus with a spot-like dense shadow was also detected. The diagnosis of carotid body tumor was raised and an ultrasound-guided fine needle aspiration biopsy of the thyroid nodule revealed papillary thyroid carcinoma. The patient underwent surgery for lesion excision, total thyroidectomy, and neck dissection, and the pathology was reported as paraganglioma and papillary carcinoma. Genetic studies showed negative results for germline mutation of succinate dehydrogenase subunit D on 11q23. He was treated with ^(131)I after surgery and remained disease-free so *** The presence of concomitant paraganglioma and thyroid papillary carcinoma could be either coincidental or a result of an unknown mutation.

关键词： Paraganglioma Thyroid carcinoma Multiple endocrine tumors Case report

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Conservative and functional surgery in the treatment of salivary gland tumours

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International Journal of oral Science 2019年第3期11卷 176-179页

作者： Guangyan Yu Xin Peng department of oral & maxillofacial surgery Peking University School and Hospital of Stomatology

The principle of modern oncological surgery is to conserve the functional organs or tissues as much as possible based on eradication of the *** salivary gland tumours,conservative and functional salivary surgery,including partial sialoadenectomy as well as anatomical and functional preservation of the facial nerve,great auricular nerve,superficial musculoaponeurotic system (SMAS),and Stensen’s duct,has become increasingly *** the present review,we discuss the following aspects of conservative and functional surgery in the treatment of salivary gland tumours:(i) partial superficial parotidectomy (PP) to treat benign parotid gland tumours,(ii) modification of surgical incisions to improve cosmetic results,(iii) modification of the surgical approach to decrease complications,(iv) extracardial dissection to treat benign superficial parotid tumours,(v) partial sialoadenectomy to treat benign submandibular gland tumours,and (vi) 125I brachytherapy to preserve facial *** majority of the operated parotid or submandibular glands are preserved,and surgical complications are also *** and functional surgery plays a significant role in maintaining normal salivary gland function and in improving patients’ quality of life during the treatment of salivary gland tumours and thus should be further promoted.

关键词： salivary gland great auricular nerve parotid gland

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Lower lip recurrent keratoacanthoma:A case report

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World Journal of Clinical Cases 2022年第20期10卷 6960-6965页

作者： Xian-Guang Liu Xing-Guang Liu Cai-Jiao Wang Han-Xi Wang Xu-Xia Wang department of oral and maxillofacial surgery Shandong UniversityJinan 250100Shandong ProvinceChina department of oral pathology Shandong UniversityJinan 250100Shandong ProvinceChina

BACKGROUND This paper introduces a case of recurrent keratoacanthoma(KA).KA is a selfhealing *** after surgical resection is *** this case,the local application of retinoic acid ointment after the second operation achieved a good prognosis after 2 years of *** SUMMARY A 76-year-old male patient was admitted to the hospital for"lower lip rupture and scab for 3 mo".Treatment:A rectangular incision was made in the healthy tissue about 3 mm outside the periphery of the lower lip mass,and a modified Bernard sliding flap was designed to completely remove the *** showed(lower lip)*** the patient returned 6 mo after surgery,the middle mucosa of the lower lip had a bulge with a diameter of about 0.5 *** boundary was still clear,the surface was ulcerated.A recurrence of lower lip KA was suspected and a fan-shaped incision was performed in the healthy tissue about 5 mm outside the lesion to completely *** showed lower lip KA had *** application of tretinoin cream was applied once a day for 3 *** lower lip wounds were clean at the 2-year postoperative follow-up and the mucosa was *** Adjuvant retinoic acid treatment after KA surgical resection can achieve good results.

关键词： Keratoacanthoma Lower lip Squamous cell carcinoma Clinical features Recurrence Case report

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Pingyangmycin-regulated Expressions of Adhesion Molecules in Human Venous Malformation Endothelial Cells

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2012年第5期32卷 760-766页

作者：贾玉林贾俊赵怡芳 department of oral and maxillofacial surgery Union HospitalTongji Medical CollegeHuazhong University of Science and Technology department of oral and maxillofacial surgery College & Hospital of StomatologyWuhan University

Pingyangmycin (bleomycin A5 hydrochloride,PYM) is one of the anti-neoplastic agents which have been commonly used to treat venous ***,the underlying mechanism by which PYM treats venous malformations remains poorly *** was reported that venous endothelial cells could recruit neutrophils via adhesion molecules (E-selectin,ICAM-1,ICAM-3,VCAM-1) during the acute/chronic inflammation and subsequent histological fibrosis after sclerotherapy with *** study explored if the expression of E-selectin,ICAM-1,ICAM-3 and VCAM-1 in human venous malformation endothelial cells could be affected by *** were cultured from human venous malformation *** of E-selectin,ICAM-1,ICAM-3 and VCAM-1 on HVMECs in response to PYM were analyzed by cell *** relative levels of mRNA expression in the cells were *** results showed that PYM up-regulated the expressions of E-selectin,ICAM-3,VCAM-1 and ICAM-1 in both time-and concentration-dependent *** findings suggested that PYM could induce the expression of adhesion molecules in HVMECs,which might be a possible mechanism by which sclerotherapy by intralesional injection of PYM treats venous malformations.

关键词： E-selectin intercellular adhesion molecule-1 intercellular adhesion molecule-3 vascular cell adhesion molecule-1 cell culture

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Subciliary incision and lateral cantholysis in rigid internal fixation of zygomatic complex fractures

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Chinese Journal of Traumatology 2004年第3期7卷 170-174页

作者：钟来平陈关福 department of oral and maxillofacial surgery

Objective: To introduce the technique of subciliary incision and lateral cantholysis with tri-dimension reduction and rigid internal fixation to treat zygomatic complex fractures. Methods: The subciliary incision and lateral cantholysis combined with tri-dimension reduction and rigid internal fixation of zygomatic complex fractures with titanium microplates were applied in 56 patients with zygomatic complex fractures. Another lateral eyebrow incision or sublabial incision was used to simplify the operation. Results: The postoperative follow-up period ranged from 6 months to 5 years. During the follow-up period, all the patients had satisfying postoperative results. All clinical symptoms disappeared except the numbness in the infraorbital region in 2 patients. In 94.6% patients no complications such as obvious scar, ectropion, entropion or blepharoedema were found, only 5.4% of the patients had slight ectropion 6 months after operation. Conclusions: The subciliary incision and lateral cantholysis have many advantages such as invisible scar, sufficient exposure, minimal injury, and few complications and combined with rigid internal fixation with titanium microplates this technique could be used as one of the routine operation methods to treat zygomatic complex fractures.

关键词： Zygomatic fractures Fracture fixation, internal Lateral cantholysis

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Expression of AT_(1a) mRNA in rat hepatic stellate cells and its effects on cell growth collagen production

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Chinese Medical Journal 2004年第5期117卷 772-774页

作者：张艺军杨希山吴平生廖贵清杨国平张晓峰陈晓清 department of Gernotology PLA Institute of Digestive Diseases department of Cardiology department of oral and maxillofacial surgery

Activated hepatic stellate cells (HSCs) play important roles in hepatic fibrosis. Studies on HSCs activation in vitro have shown that this process is regulated by a wide variety of growth factors and cytokines.1 Recent data indicate that AngⅡ is responsible for the mechanisms of myocardial fibrosis and kidney fibrosis; but there are only few reports on hepatic fibrosis.2-8

关键词： AT 1a mRNA·angiotensinⅡ· losartan ·hepatic stellate cell

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