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Immunohistochemical expression of matrix metalloproteinase-9 and 13 in oral squamous cell carcinoma and their role in predicting lymph node metastasis

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World Journal of Methodology 2025年第2期15卷 108-116页

作者： Bhari Sharanesha Manjunatha Keshav T Handge Vandana Sandeep Shah Yasser Eid Al-Thobaiti Deepak Gowda Sadashivappa Pateel department of Basic oral Medicine and Allied Dental sciences Taif UniversityAt`Taif 26571MakkahSaudi Arabia department of oral and maxillofacial Pathology Dr.Vasantrao Pawar Medical CollegeHospital and Research CentreNashik 423101MaharashtraIndia department of oral Pathology and Microbiology KM Shah Dental College and HospitalSumandeep VidyapeethVadodara 391760GujaratIndia department of oral and maxillofacial Surgery and Diagnostic sciences Faculty of DentistryTaif UniversityAl-Haweiah 26571 MakkahSaudi Arabia department of oral Pathology and Microbiology Faculty of DentistryMAHSA UniversitySelangor 42610Malaysia

BACKGROUND One of the main characteristics of oral squamous cell carcinoma(OSCC)is that it metastasizes to cervical lymph nodes frequently with a high degree of local invasiveness.A primary feature of malignant tumors is their penetration of neighboring tissues,such as lymphatic and blood arteries,due to the tumor cells'capacity to break down the extracellular matrix(ECM).Matrix metalloproteinases(MMPs)constitute a family of proteolytic enzymes that facilitate tissue remo-deling and the degradation of the ***-9 and MMP-13 belong to the group of extracellular matrix degrading enzymes and their expression has been studied in OSCC because of their specific ***-13,a collagenase family member,is thought to play an essential role in the MMP activation cascade by breaking down the fibrillar collagens,whereas MMP-9 is thought to accelerate the growth of *** MMP-13 expression has been associated with tumor behavior and patient prognosis in a number of malignant *** authors wish to thank Jadhav KB for his valuable opinion during the preparation of the manuscript.

关键词： Matrix metalloproteinases oral squamous cell carcinoma Tumor staging Immunohistochemistry Invasion Lymph node metastasis TNM stage

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Magnification:The game changer in dentistry

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World Journal of Methodology 2025年第2期15卷 74-82页

作者： Sachin Chauhan Radha Chauhan Prashant Bhasin Meenu Bhasin department of Conservative Dentistry and Endodontics Sudha Rustagi College of Dental Sciences and ResearchFaridabad 121002India department of Prosthodontics and Crown and Bridge and oral Implantology Mahatma Gandhi Dental College and HospitalJaipur 302022India department of Periodontics Sudha Rustagi College of Dental Sciences and ResearchFaridabad 121002India

During dental examinations and treatments,many dentists are using magni-fication to improve their *** dental operating microscope serves as the most effective tool for this purpose,enhancing the quality,longevity,and outcome of clinical *** review will explore the latest research and data on the importance of magnification devices in dentistry,including diagnostic methods,treatment options and ergonomics in specialities such as restorative dentistry,endodontics,pedodontics,periodontics,and *** review aims to provide insights into the optimal magnification for different clinical situations,the specific benefits of dental operating microscopes for each dental branch,and their limitations.

关键词： Magnification Vision Endodontics Dentistry Dental operating microscope

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Present status and future directions:Apexification

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World Journal of Methodology 2025年第1期15卷 26-32页

作者： Sachin Chauhan Radha Chauhan Prashant Bhasin Bhavna G Sharaf department of Conservative Dentistry and Endodontics Sudha Rustagi College of Dental Sciences and ResearchFaridabad 121002HaryanaIndia department of Prosthodontics and Crown and Bridge and oral Implantology Mahatma Gandhi Dental College&HospitalJaipur 302022RajasthanIndia department of Pedodontics and Preventive Dentistry Sudha Rustagi College of Dental Sciences and ResearchFaridabad 121002HaryanaIndia

The success rate of apexification is primarily determined by multiple factors,including the material used,the size of the open apex compared to the length of the root,and the technique used in each *** main objective of this review was to provide an update on the present management of open apex to identify factors and circumstances that may influence the success of apexification using different materials and *** research on apexification should focus on how to treat open apices with wide periapical lesions without ***,the predictability of these parameters with non-surgical procedures was uncertain,but now,with the use of a dental operating microscope,it has become more *** reason could be that extra visits are no longer required due to major advances in the armamentarium and materials used for apexification.

关键词： Bioceramics Magnification Biodentine Mineral trioxide aggregate Apexification Open apex

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Delayed Management of Parotid Sialocele:Role for Two-week Intraoral Drainage

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Current Medical Science 2022年第4期42卷 902-904页

作者： Amin Rahpeyma Saeedeh Khajehahmadi oral&maxillofacial Diseases Research Center Mashhad University of Medical sciences MashhadIran department of oral and maxillofacial Surgery School of DentistryMashhad University of Medical SciencesMashhadIran Dental Research Center Mashhad University of Medical sciences MashhadIran department of oral and maxillofacial Pathology School of DentistryMashhad University of Medical SciencesMashhadIran

Iatrogenic injury or trauma to the salivary gland duct is one of the most common causes of parotid sialoceles,which are usually superficial,soft,and filled with *** enrolled 7 patients with parotid sialocele were divided into two groups:trauma group(4 cases)and iatrogenic group(3 cases).No evidence of recurrence or cranial nerve injuries were *** persisted parotid sialocele,intraoral drainage for two weeks as a safe and inexpensive method is recommended.

关键词： parotid gland sialocele saliva

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Surface-modified deproteinized human demineralized tooth matrix for bone regeneration:physicochemical characterization and osteoblast cell biocompatibility

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Regenerative Biomaterials 2024年第4期3卷 1-13页

作者： Natwara Chokwattananuwat Srisurang Suttapreyasri department of oral and maxillofacial Surgery Faculty of DentistryPrince of Songkla UniversitySongkhlaThailand

Tooth presents an intriguing option as a bone graft due to its compositional similarity to ***,the deproteinized human demineralized tooth matrix(dpDTM),developed to overcome the limited availability of autologous tooth grafts,has suboptimal pore size and surface *** study aimed to fabricate a surface-modified dpDTM using acid etching and collagen coating,followed by in vitro evaluation of physicochemical and biological *** dpDTM was modified into two protocols:Acid-modified dpDTM(A-dpDTM)and collagen-modified dpDTM(C-dpDTM).Results demonstrated that A-dpDTM and C-dpDTM had increased pore sizes and rougher surfaces compared to *** immobilization was evidenced by nitrogen presence exclusively in *** groups had a Ca/P molar ratio of 1.67 and hydroxyapatite as the sole constituent,with 65-67%*** rates significantly increased to 30%and 20%for C-dpDTM and A-dpDTM,respectively,compared to 10%for dpDTM after 120 *** collagen release of C-dpDTM on Day 30 was 45.16 mg/*** attachment and proliferation were enhanced on all scaffolds,especially C-dpDTM,which displayed the highest proliferation and differentiation *** conclusion,surface modified of dpDTM,including A-dpDTM and C-dpDTM,significantly enhances bioactivity by altering surface properties and promoting osteoblast activity,thereby demonstrating promise for bone regeneration applications.

关键词： acid-modified dpDTM biocompatibility bone graft collagen-modified dpDTM deproteinized human tooth matrix tooth-derived bone graft

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The Craniofacial Morphology in Adult Patients with Unoperated Isolated Cleft Palate

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Bone Research 2013年第2期1卷 195-200页

作者： Zhongtai Ye Xue Xu Adalet Ahmatjian Bing Shi The First Teaching Hospital of Xinjiang Medical University Department of Oral and Maxillofacial Surgery West China College of Stomatology Sichuan UniversityDepartment of Oral and Maxillofacial Surgery

Objective： To address the effect of intrinsic factors on craniofacial growth by analyzing the craniofacial morphology of unoperated isolated cleft palate in Chinese adult. Materials and Methods： This study included 37 nonsyndromic isolated cleft palate and 39 age and gender matched non-clefts. Twenty-six cephalometric measurements were employed to evaluate the facial morphology. Independent samples T test and Mann- Whitney U were used for comparison. Significant difference was defined at 95% level. Results： Data from this study showed patients with unoperated isolated cleft palate have a reduced maxillary sagittal length （ANS-PMP, A-PMP, P〈0.05）, a smaller ANB angle （ANB, P〈0.05） and a retrusive ANS point （S-N-ANS, P〈0.05; Ba-N-ANS, P〈0.05）. Measurements descripted position of maxilla （S-Ptm, P〉0.05）, depth of bony pharynx （Ba-PMP, P〉0.05）, anterior and posterior maxillary height （N-ANS, P〉0.05; R-PMP, P〉0.05） and mandible morphology （including linear measurements and angle measurements） did not show any significant difference between case and control groups. Conclusions： Patients with isolated cleft palate were characterized by maxillary retrusion. Mandible morphology and cranial basal morphology in isolated cleft palate showed no significant difference with nonclefts. Patients with isolated cleft palate are more vulnerable to cross bite than nonclefts. Intrinsic deficiencies did detrimental effect on maxilla sagittal length, but did no detrimental effect on maxilla position, mandible size and position.

关键词： isolated cleft palate unoperated craniofacial morphology maxillary growth cephalometry

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Concomitant paraganglioma and thyroid carcinoma:A case report

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World Journal of Clinical Cases 2019年第5期7卷 656-662页

作者： Bo Lin Hong-Yu Yang Hui-Jun Yang Shi-Yue Shen department of oral and maxillofacial Surgery Peking University Shenzhen Hospital

BACKGROUND Paraganglioma/pheochromocytoma and medullary thyroid carcinoma can coexist and are often found in multiple endocrine neoplasia(MEN). However,very few cases highlight papillary thyroid carcinoma. We present herein a rare case of head and neck paraganglioma associated with papillary thyroid *** SUMMARY A 51-year-old man presented to our department with right-sided neck swelling and hypertension. Physical examination showed neck masses with obvious pulsation. Concentrations of serum calcium, phosphorus, parathormone, thyroid stimulating hormone, free thyroxine, and calcitonin were within normal *** computed tomography revealed an irregular solid nodule, located in the carotid artery bifurcation. A low-density nodule of the thyroid isthmus with a spot-like dense shadow was also detected. The diagnosis of carotid body tumor was raised and an ultrasound-guided fine needle aspiration biopsy of the thyroid nodule revealed papillary thyroid carcinoma. The patient underwent surgery for lesion excision, total thyroidectomy, and neck dissection, and the pathology was reported as paraganglioma and papillary carcinoma. Genetic studies showed negative results for germline mutation of succinate dehydrogenase subunit D on 11q23. He was treated with ^(131)I after surgery and remained disease-free so *** The presence of concomitant paraganglioma and thyroid papillary carcinoma could be either coincidental or a result of an unknown mutation.

关键词： Paraganglioma Thyroid carcinoma Multiple endocrine tumors Case report

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Conservative and functional surgery in the treatment of salivary gland tumours

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International Journal of oral Science 2019年第3期11卷 176-179页

作者： Guangyan Yu Xin Peng department of oral & maxillofacial Surgery Peking University School and Hospital of Stomatology

The principle of modern oncological surgery is to conserve the functional organs or tissues as much as possible based on eradication of the *** salivary gland tumours,conservative and functional salivary surgery,including partial sialoadenectomy as well as anatomical and functional preservation of the facial nerve,great auricular nerve,superficial musculoaponeurotic system (SMAS),and Stensen’s duct,has become increasingly *** the present review,we discuss the following aspects of conservative and functional surgery in the treatment of salivary gland tumours:(i) partial superficial parotidectomy (PP) to treat benign parotid gland tumours,(ii) modification of surgical incisions to improve cosmetic results,(iii) modification of the surgical approach to decrease complications,(iv) extracardial dissection to treat benign superficial parotid tumours,(v) partial sialoadenectomy to treat benign submandibular gland tumours,and (vi) 125I brachytherapy to preserve facial *** majority of the operated parotid or submandibular glands are preserved,and surgical complications are also *** and functional surgery plays a significant role in maintaining normal salivary gland function and in improving patients’ quality of life during the treatment of salivary gland tumours and thus should be further promoted.

关键词： salivary gland great auricular nerve parotid gland

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Expression of AT_(1a) mRNA in rat hepatic stellate cells and its effects on cell growth collagen production

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Chinese Medical Journal 2004年第5期117卷 772-774页

作者：张艺军杨希山吴平生廖贵清杨国平张晓峰陈晓清 department of Gernotology PLA Institute of Digestive Diseases department of Cardiology department of oral and maxillofacial Surgery

Activated hepatic stellate cells (HSCs) play important roles in hepatic fibrosis. Studies on HSCs activation in vitro have shown that this process is regulated by a wide variety of growth factors and cytokines.1 Recent data indicate that AngⅡ is responsible for the mechanisms of myocardial fibrosis and kidney fibrosis; but there are only few reports on hepatic fibrosis.2-8

关键词： AT 1a mRNA·angiotensinⅡ· losartan ·hepatic stellate cell

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Electrochemical flow aziridination of unactivated alkenes

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National Science Review 2023年第10期10卷 86-95页

作者：王盛淳王鹏杰李树劲陈宜鸿孙志军雷爱文 Institute for Advanced Studies (IAS) College of Chemistry and Molecular SciencesWuhan University State Key Laboratory of oral & maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of Education Hubei Key Laboratory of Stomatology School & Hospital of Stomatology Wuhan University department of oral maxillofacial-Head Neck Oncology School and Hospital of Stomatology Wuhan University

Aziridines derived from bioactive molecules may have unique pharmacological activities,making them useful in pharmacology(*** C).Furthermore,the substitution of the epoxide moiety in epothilone B with aziridine,an analog of epoxides,yielded a pronounced enhancement in its anticancer ***,there is interest in developing novel synthetic technologies to produce aziridines from bioactive ***,known methods usually require metal catalysts,stoichiometric oxidants and/or pre-functionalized amination reagents,causing difficulty in application.A practical approach without a metal catalyst and extra-oxidant for the aziridination of bioactive molecules is in demand,yet ***,we report an ele ctro-oxidative flow protocol that accomplishes an oxidant-free aziridination of natural *** process is achieved by an oxidative sulfonamide/alkene cross-coupling,in which sulfonamide and alkene undergo simultaneous oxidation or alkene is oxidized *** anticancer treatments in cell lines have demonstrated the pharmacological activities of these aziridines,supporting the potential of this method for drug discovery.

关键词： alkene aziridination electro-oxidative cross-coupling flow chemistry N -centered radical alkene radical cation

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