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Immunohistochemical expression of matrix metalloproteinase-9 and 13 in oral squamous cell carcinoma and their role in predicting lymph node metastasis

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World Journal of Methodology 2025年第2期15卷 108-116页

作者： Bhari Sharanesha Manjunatha Keshav T Handge Vandana Sandeep Shah Yasser Eid Al-Thobaiti Deepak Gowda Sadashivappa Pateel department of Basic oral Medicine and Allied Dental sciences Taif UniversityAt`Taif 26571MakkahSaudi Arabia department of oral and maxillofacial Pathology Dr.Vasantrao Pawar Medical CollegeHospital and Research CentreNashik 423101MaharashtraIndia department of oral Pathology and Microbiology KM Shah Dental College and HospitalSumandeep VidyapeethVadodara 391760GujaratIndia department of oral and maxillofacial Surgery and Diagnostic sciences Faculty of DentistryTaif UniversityAl-Haweiah 26571 MakkahSaudi Arabia department of oral Pathology and Microbiology Faculty of DentistryMAHSA UniversitySelangor 42610Malaysia

BACKGROUND One of the main characteristics of oral squamous cell carcinoma(OSCC)is that it metastasizes to cervical lymph nodes frequently with a high degree of local invasiveness.A primary feature of malignant tumors is their penetration of neighboring tissues,such as lymphatic and blood arteries,due to the tumor cells'capacity to break down the extracellular matrix(ECM).Matrix metalloproteinases(MMPs)constitute a family of proteolytic enzymes that facilitate tissue remo-deling and the degradation of the ***-9 and MMP-13 belong to the group of extracellular matrix degrading enzymes and their expression has been studied in OSCC because of their specific ***-13,a collagenase family member,is thought to play an essential role in the MMP activation cascade by breaking down the fibrillar collagens,whereas MMP-9 is thought to accelerate the growth of *** MMP-13 expression has been associated with tumor behavior and patient prognosis in a number of malignant *** authors wish to thank Jadhav KB for his valuable opinion during the preparation of the manuscript.

关键词： Matrix metalloproteinases oral squamous cell carcinoma Tumor staging Immunohistochemistry Invasion Lymph node metastasis TNM stage

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Magnification:The game changer in dentistry

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World Journal of Methodology 2025年第2期15卷 74-82页

作者： Sachin Chauhan Radha Chauhan Prashant Bhasin Meenu Bhasin department of Conservative Dentistry and Endodontics Sudha Rustagi College of Dental Sciences and ResearchFaridabad 121002India department of Prosthodontics and Crown and Bridge and oral Implantology Mahatma Gandhi Dental College and HospitalJaipur 302022India department of Periodontics Sudha Rustagi College of Dental Sciences and ResearchFaridabad 121002India

During dental examinations and treatments,many dentists are using magni-fication to improve their *** dental operating microscope serves as the most effective tool for this purpose,enhancing the quality,longevity,and outcome of clinical *** review will explore the latest research and data on the importance of magnification devices in dentistry,including diagnostic methods,treatment options and ergonomics in specialities such as restorative dentistry,endodontics,pedodontics,periodontics,and *** review aims to provide insights into the optimal magnification for different clinical situations,the specific benefits of dental operating microscopes for each dental branch,and their limitations.

关键词： Magnification Vision Endodontics Dentistry Dental operating microscope

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Tetrahedral framework nucleic acid carrying angiogenic peptide prevents bisphosphonate-related osteonecrosis of the jaw by promoting angiogenesis

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International Journal of oral Science 2022年第2期14卷 201-211页

作者： Dan Zhao Dexuan Xiao Mengting Liu Jiajie Li Shuanglin Peng Qing He Yue Sun Jingang Xiao Yunfeng Lin State Key Laboratory of oral Diseases&National clinical Research Center for oral Diseases&department of oral and maxillofacial Surgery West China Hospital of StomatologySichuan UniversityChengduChina department of oral and maxillofacial Surgery The Affiliated Stomatology Hospital of Southwest Medical UniversityLuzhouChina

The significant clinical feature of bisphosphonate-related osteonecrosis of the jaw(BRONJ)is the exposure of the necrotic *** clinical manifestations include jaw pain,swelling,abscess,and skin fistula,which seriously affect the patients’life,and there is no radical ***,new methods need to be found to prevent the occurrence of ***,a novel nanoparticle,t FNA-KLT,was successfully synthesized by us,in which the nanoparticle tetrahedral framework nucleic acid(tFNA)was used for carrying angiogenic peptide,KLT,and then further enhanced ***-KLT possessed the same characteristics as tFNA,such as simple synthesis,stable structure,and good ***,tFNA enhanced the stability of KLT and carried more KLT to interact with endothelial ***,it was confirmed that tFNA-KLT had the superior angiogenic ability to tFNA and KLT both in vitro and in *** we apply tFNA-KLT to the prevention of *** results showed that tFNA-KLT can effectively prevent the occurrence of BRONJ by accelerating *** summary,the prepared novel nanoparticle,tFNA-KLT,was firstly synthesized by *** was also firstly confirmed by us that tFNA-KLT significantly enhanced angiogenesis and can effectively prevent the occurrence of BRONJ by accelerating angiogenesis,thus providing a new avenue for the prevention of BRONJ and a new choice for therapeutic angiogenesis.

关键词： angiogenesis prevention swelling

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Computational technology for nasal cartilage-related clinical research and application

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International Journal of oral Science 2020年第3期12卷 183-198页

作者： Bing Shi Hanyao Huang State Key Laboratory of oral Diseases&National clinical Research Center for oral Diseases&department of oral maxillofacial Surgery West China Hospital of StomatologySichuan University610041 ChengduChina

Surgeons need to understand the effects of the nasal cartilage on facial morphology,the function of both soft tissues and hard tissues and nasal function when performing nasal *** nasal cartilage-related surgery,the main goals for clinical research should include clarification of surgical goals,rationalization of surgical methods,precision and personalization of surgical design and preparation and improved convenience of doctor–patient *** technology has become an effective way to achieve these *** in three-dimensional(3D)imaging technology will promote nasal cartilage-related applications,including research on computational modelling technology,computational simulation technology,virtual surgery planning and 3D printing *** technologies are destined to revolutionize nasal surgery *** this review,we summarize the advantages,latest findings and application progress of various computational technologies used in clinical nasal cartilage-related work and *** application prospects of each technique are also discussed.

关键词： nasal clinical application

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Delayed Management of Parotid Sialocele:Role for Two-week Intraoral Drainage

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Current Medical Science 2022年第4期42卷 902-904页

作者： Amin Rahpeyma Saeedeh Khajehahmadi oral&maxillofacial Diseases Research Center Mashhad University of Medical sciences MashhadIran department of oral and maxillofacial Surgery School of DentistryMashhad University of Medical SciencesMashhadIran Dental Research Center Mashhad University of Medical sciences MashhadIran department of oral and maxillofacial Pathology School of DentistryMashhad University of Medical SciencesMashhadIran

Iatrogenic injury or trauma to the salivary gland duct is one of the most common causes of parotid sialoceles,which are usually superficial,soft,and filled with *** enrolled 7 patients with parotid sialocele were divided into two groups:trauma group(4 cases)and iatrogenic group(3 cases).No evidence of recurrence or cranial nerve injuries were *** persisted parotid sialocele,intraoral drainage for two weeks as a safe and inexpensive method is recommended.

关键词： parotid gland sialocele saliva

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Icariin contributes to healing skull defects in rabbit models

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Journal of Traditional Chinese Medicine 2021年第3期41卷 470-477页

作者： HAO Fuliang MEI Shuang LIU Xiao LIU Yang ZHANG Xudog DONG Fusheng department of oral and maxillofacial surgery Hebei Key Laboratory of StomatologyHebei Clinical Research Center for Oral DiseasesSchool and Hospital of StomatologyHebei Medical UniversityShijiazhuang050017China

OBJECTIVE: To investigate the efficacy of icariin for healing skull defects in rabbit ***: Thirty-six 3-month-old female New Zealand white rabbits, weighing 1.8-2.0 kg each, were randomly divided into either the control or experimental group. Skull defect models were constructed in both groups, with the experimental group receiving oral icariin afterwards. At 4, 8 and 12 postoperative weeks, the rabbits were euthanized, and X-rays and samples were taken. Tissue sections were stained using hematoxylin and eosin, followed by additional processing using histological and bone metrological methods for observing the rate and quality of the bone ***: Histologically, additional mature lamellar bone formed in the defect area in the experimental group compared with that of the control *** metrological methods showed that the bone mass, trabecular bone width and number of osteoblasts in the experimental group were significantly higher than those of the control group(P 0.05).CONCLUSION: Icariin increased the bone mass and improved the condition of the defect area in the rabbit skulls.

关键词： osteogenesis icariin skull defect bone metrology

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Applications of single cell RNA sequencing to research of stem cells

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World Journal of Stem Cells 2019年第10期11卷 722-728页

作者： Xiao Zhang Lei Liu State Key Laboratory of oral Diseases and National clinical Research Center for oral Diseases and department of oral and maxillofacial Surgery West China Hospital of Stomatology Sichuan University

Stem cells(SCs)with their self-renewal and pluripotent differentiation potential,show great promise for therapeutic applications to some refractory diseases such as stroke,Parkinsonism,myocardial infarction,and ***,as seed cells in tissue engineering,SCs have been applied widely to tissue and organ ***,previous studies have shown that SCs are heterogeneous and consist of many cell *** to this heterogeneity of cell states,gene expression is highly diverse between cells even within a single tissue,making precise identification and analysis of biological properties difficult,which hinders their further research and ***,a defined understanding of the heterogeneity is a key to research of *** ensemble-based sequencing approaches,such as microarrays,reflect an average of expression levels across a large population,which overlook unique biological behaviors of individual cells,conceal cell-to-cell variations,and cannot understand the heterogeneity of SCs *** development of high throughput single cell RNA sequencing(scRNA-seq)has provided a new research tool in biology,ranging from identification of novel cell types and exploration of cell markers to the analysis of gene expression and predicating developmental ***-seq has profoundly changed our understanding of a series of biological ***,it has been used in research of SCs in many fields,particularly for the research of heterogeneity and cell subpopulations in early embryonic *** this review,we focus on the scRNA-seq technique and its applications to research of SCs.

关键词： Stem cells Heterogeneity Single cell RNA sequencing Developmental trajectories Cell subpopulations

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Concomitant paraganglioma and thyroid carcinoma:A case report

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World Journal of clinical Cases 2019年第5期7卷 656-662页

作者： Bo Lin Hong-Yu Yang Hui-Jun Yang Shi-Yue Shen department of oral and maxillofacial Surgery Peking University Shenzhen Hospital

BACKGROUND Paraganglioma/pheochromocytoma and medullary thyroid carcinoma can coexist and are often found in multiple endocrine neoplasia(MEN). However,very few cases highlight papillary thyroid carcinoma. We present herein a rare case of head and neck paraganglioma associated with papillary thyroid *** SUMMARY A 51-year-old man presented to our department with right-sided neck swelling and hypertension. Physical examination showed neck masses with obvious pulsation. Concentrations of serum calcium, phosphorus, parathormone, thyroid stimulating hormone, free thyroxine, and calcitonin were within normal *** computed tomography revealed an irregular solid nodule, located in the carotid artery bifurcation. A low-density nodule of the thyroid isthmus with a spot-like dense shadow was also detected. The diagnosis of carotid body tumor was raised and an ultrasound-guided fine needle aspiration biopsy of the thyroid nodule revealed papillary thyroid carcinoma. The patient underwent surgery for lesion excision, total thyroidectomy, and neck dissection, and the pathology was reported as paraganglioma and papillary carcinoma. Genetic studies showed negative results for germline mutation of succinate dehydrogenase subunit D on 11q23. He was treated with ^(131)I after surgery and remained disease-free so *** The presence of concomitant paraganglioma and thyroid papillary carcinoma could be either coincidental or a result of an unknown mutation.

关键词： Paraganglioma Thyroid carcinoma Multiple endocrine tumors Case report

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Loss of oral mucosal stem cell markers in oral submucous fibrosis and their reactivation in malignant transformation

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International Journal of oral Science 2020年第3期12卷 199-208页

作者： Mohit Sharma Felipe Paiva Fonseca Keith D.Hunter Raghu Radhakrishnan department of oral Pathology Sudha Rustagi College of Dental Sciences and ResearchFaridabadHaryanaIndia department of oral Surgery and Pathology School of DentistryFederal University of Minas GeraisBelo HorizonteMGBrazil Academic Unit of oral and maxillofacial Medicine and Pathology School of Clinical DentistryUniversity of SheffieldClaremont CrescentSheffieldUK department of oral Pathology Manipal College of Dental SciencesManipal Academy of Higher EducationManipalKarnatakaIndia

The integrity of the basal stem cell layer is critical for epithelial *** this paper,we review the expression of oral mucosal stem cell markers(OM-SCMs)in oral submucous fibrosis(OSF),oral potentially malignant disorders(OPMDs)and oral squamous cell carcinoma(OSCC)to understand the role of basal cells in potentiating cancer stem cell behaviour in *** the loss of basal cell clonogenicity triggers epithelial atrophy in OSF,the transition of the epithelium from atrophic to hyperplastic and eventually neoplastic involves the reactivation of basal *** vacillating expression patterns of OM-SCMs confirm the role of keratins 5,14,19,CD44,β1-integrin,p63,sex-determining region Y box(SOX2),octamer-binding transcription factor 4(Oct-4),c-MYC,B-cell-specific Moloney murine leukaemia virus integration site 1(Bmi-1)and aldehyde dehydrogenase 1(ALDH1)in OSF,OPMDs and *** downregulation of OM-SCMs in the atrophic epithelium of OSF and their upregulation during malignant transformation are illustrated with relevant literature in this review.

关键词： epithelium malignant mucosal

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Extracellular vesicles:Emerged as a promising strategy for regenerative medicine

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World Journal of Stem Cells 2023年第4期15卷 165-181页

作者： Dian-Ri Wang Jian Pan State Key Laboratory of oral Diseases and National clinical Research Center for oral Diseases and department of oral and maxillofacial Surgery West China Hospital of StomatologySichuan UniversityChengdu 610041Sichuan ProvinceChina

Cell transplantation therapy has certain limitations including immune rejection and limited cell viability,which seriously hinder the transformation of stem cellbased tissue regeneration into clinical *** vesicles(EVs)not only possess the advantages of its derived cells,but also can avoid the risks of cell *** are intelligent and controllable biomaterials that can participate in a variety of physiological and pathological activities,tissue repair and regeneration by transmitting a variety of biological signals,showing great potential in cell-free tissue *** this review,we summarized the origins and characteristics of EVs,introduced the pivotal role of EVs in diverse tissues regeneration,discussed the underlying mechanisms,prospects,and challenges of *** also pointed out the problems that need to be solved,application directions,and prospects of EVs in the future and shed new light on the novel cell-free strategy for using EVs in the field of regenerative medicine.

关键词： Mesenchymal stem cells Extracellular vesicles Regenerative medicine Cellfree strategy

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