Tetrahedral framework nucleic acid carrying angiogenic peptide prevents bisphosphonate-related osteonecrosis of the jaw by promoting angiogenesis

作     者：Dan Zhao Dexuan Xiao Mengting Liu Jiajie Li Shuanglin Peng Qing He Yue Sun Jingang Xiao Yunfeng Lin Dan Zhao;Dexuan Xiao;Mengting Liu;Jiajie Li;Shuanglin Peng;Qing He;Yue Sun;Jingang Xiao;Yunfeng Lin

作者机构：State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Department of Oral and Maxillofacial SurgeryWest China Hospital of StomatologySichuan UniversityChengduChina Department of Oral and Maxillofacial SurgeryThe Affiliated Stomatology Hospital of Southwest Medical UniversityLuzhouChina 

出 版 物：《International Journal of Oral Science》 (国际口腔科学杂志（英文版）)

年 卷 期：2022年第14卷第2期

页      面：201-211页

核心收录：

学科分类：1003[医学-口腔医学] 100302[医学-口腔临床医学] 10[医学] 

基　　金：the National Key R&D Program of China(2019YFA0110600) the National Natural Science Foundation of China(81970916,81870746) the support of State Key Laboratory of Oral Diseases,National Clinical Research Center for Oral Diseases,Department of Oral&Maxillofacial Surgery,West China Hospital of Stomatology,Sichuan University 

主　　题：angiogenesis prevention swelling 

摘      要：The significant clinical feature of bisphosphonate-related osteonecrosis of the jaw(BRONJ)is the exposure of the necrotic *** clinical manifestations include jaw pain,swelling,abscess,and skin fistula,which seriously affect the patients’life,and there is no radical ***,new methods need to be found to prevent the occurrence of ***,a novel nanoparticle,t FNA-KLT,was successfully synthesized by us,in which the nanoparticle tetrahedral framework nucleic acid(tFNA)was used for carrying angiogenic peptide,KLT,and then further enhanced ***-KLT possessed the same characteristics as tFNA,such as simple synthesis,stable structure,and good ***,tFNA enhanced the stability of KLT and carried more KLT to interact with endothelial ***,it was confirmed that tFNA-KLT had the superior angiogenic ability to tFNA and KLT both in vitro and in *** we apply tFNA-KLT to the prevention of *** results showed that tFNA-KLT can effectively prevent the occurrence of BRONJ by accelerating *** summary,the prepared novel nanoparticle,tFNA-KLT,was firstly synthesized by *** was also firstly confirmed by us that tFNA-KLT significantly enhanced angiogenesis and can effectively prevent the occurrence of BRONJ by accelerating angiogenesis,thus providing a new avenue for the prevention of BRONJ and a new choice for therapeutic angiogenesis.