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Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

Neural Regeneration research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui Zhang Sonata S Y Yau Kwok-Fai So Li Zhang Haining Ou department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina department of Rehabilitation sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina center for Exercise and Brain science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise

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Activation of adult endogenous neurogenesis by a hyaluronic acid collagen gel containing basic fibroblast growth factor promotes remodeling and functional recovery of the injured cerebral cortex

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Neural Regeneration research 2025年第10期20卷 2923-2937页

作者： Yan Li Peng Hao hongmei Duan Fei Hao Wen Zhao Yudan Gao Zhaoyang Yang Kwok-Fai So Xiaoguang Li department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina China Rehabilitation science Institute China Rehabilitation Research CenterBeijing Key Laboratory of Neural Injury and RehabilitationBeijingChina center of Neural Injury and Repair Beijing Institute for Brain DisordersBeijingChina Beijing Key Laboratory for Biomaterials and Neural Regeneration School of Engineering MedicineBeihang UniversityBeijingChina Guangdong-hongkong-macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) GuangzhouGuangdong ProvinceChina department of Ophthalmology and State Key Laboratory of Brain and Cognitive sciences The University of Hong KongHong Kong Special Administration RegionChina center for Brain science and Brain-Inspired Intelligence Guangdong-HongKong-Macao Greater Bay AreaGuangzhouGuangdong ProvinceChina Co-innovation center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina department of Biomedical Engineering School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina

The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after ***,whether it is possible to stimulate neurogenesis and reconstruct cortical layers II to VI in non-neurogenic regions,such as the cortex,remains *** this study,we implanted a hyaluronic acid collagen gel loaded with basic fibroblast growth factor into the motor cortex immediately following traumatic *** findings reveal that this gel effectively stimulated the proliferation and migration of endogenous neural stem/progenitor cells,as well as their differentiation into mature and functionally integrated ***,these new neurons reconstructed the architecture of cortical layers II to VI,integrated into the existing neural circuitry,and ultimately led to improved brain *** findings offer novel insight into potential clinical treatments for traumatic cerebral cortex injuries.

关键词： adult endogenous neurogenesis basic fibroblast growth factor-hyaluronic acid collagen gel cortical remodeling functional recovery migration motor cortex injury neural circuits neural stem cells newborn neurons proliferation

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Plant type effect overweighs seasonal variation in n-alkanoic acid biomarker on regional Loess Plateau of China

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science China Earth sciences 2024年第8期67卷 2547-2562页

作者： Jinzhao LIU S.Nemiah LADD Jiaju ZHAO Dongna YAN Ding HE Yunning CAO Zhisheng AN State Key Laboratory of Loess and Quaternary Geology Institute of Earth EnvironmentChinese Academy of SciencesXi’an 710061China CAS center for Excellence in Quaternary science and Global Change Xi’an 710061China department of Environmental sciences University of BaselBasel 4056Switzerland department of ocean science and center for ocean research in hong kong and macao The Hong Kong University of Science and TechnologyHong Kong 999077China

The effect of plant type on n-alkane biomarker has been widely studied,but the influence of plant type on n-alkanoic acids(n-FAs)has received less *** the effect of the distribution of n-FAs and their hydrogen isotope composition(δ^(2)H_(FA))is critical for interpreting sedimentaryδ^(2)H_(FA)values as proxies of hydroclimate and/or vegetation *** this study,we systematically investigated the distribution ofn-FAs andδ^(2)H_(FA)values across seasons on the Chinese Loess Plateau(CLP).Our results showed that there were no significant seasonal differences in n-FAs distribution andδ^(2)H_(FA)values,but there were significant differences inδ^(2)H_(FA)values across plant ***δ^(2)H_(FA)values ranged from-185‰to-125‰in dicots(-161‰±28‰),and from-215‰to-170‰in monocots(-196‰±22‰)on the *** fractionation betweenδ^(2)H_(FA)values and precipitationδ^(2)H(ε_(FA-P))was also^(2)H-enriched in dicots relative to *** the regional scale of the CLP,δ^(2)H_(FA)values were not correlated withδ^(2)H values of ***,δ^(2)H_(FA)values from the CLP were similar to expectations from a global comparison,both in terms of their mean values and high variability among plants growing in sites with similarδ^(2)H values of *** some of this variability inεFA-Pis due to the effect of plant type,a careful assessment of the likely sources of waxes in terrestrial sediments is critical when usingδ^(2)H_(FA)values for paleohydroclimate reconstruction.

关键词： n-Alkanoic acid Hydrogen isotope Plant type Paleohydroclimate Chinese Loess Plateau

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Surface settlements induced by twin tunneling in silty sand

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Underground Space 2022年第1期7卷 58-75页

作者： K.K.Pabodha M.Kannangara Zhi Ding Wan-Huan Zhou State Key Laboratory of Internet of Things for Smart City and department of Civil and Environmental Engineering University of MacaoMacaoChina department of Civil and Environmental Engineering School of EngineeringZhejiang University City CollegeHangzhouChina center for ocean research in hong kong and macao(CORE) Hong Kong Special Administrative Region

Surface settlements caused by twin tunneling are a major interest in underground space *** prevailing studies have investigated the surface settlements observed over twin tunnels constructed in ***,less attention is given to the twin tunnels exca-vated in silty sand,which is the focus of this study.A comprehensive field monitoring scheme was designed in the Hangzhou metro line six project to measure the surface settlements during twin tunneling by adopting earth pressure balance *** influence of four shield operational parameters,namely,face pressure,tail grouting pressure,penetration rate,and pitching angle on the surface settle-ments due to twin tunneling are *** general,the total settlement profiles observed over twin tunnels follow an inverted bimodal *** post-settlement observed over the 1^(st)tunnel due to the 2^(nd)tunnel excavation is non-trivial when the twin tunnels are spaced *** face pressure and tail grouting pressure can induce excessive peak surface settlements during twin tunneling in silty sand.

关键词： Surface settlement Earth pressure balance shield Filed measurement Shield operational parameters

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A “Seawater-in-Sludge” approach for capacitive biochar production via the alkaline and alkaline earth metals activation

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Frontiers of Environmental science & Engineering 2021年第1期15卷 63-76页

作者： Xiling Li Tianwei Hao Yuxin Tang Guanghao Chen department of Civil&Environmental Engineering The Hong Kong University of Science and TechnologyHong Kong 999077China department of Civil and Environmental Engineering Faculty of Science and TechnologyUniversity of MacaoMacao 999078China Institute of Applied Physics and Materials Engineering University of MacaoMacao 999078China Water Technology center The Hong Kong University of Science and TechnologyHong Kong 999077China hong kong Branch of Chinese National Engineering research center for Control&Treatment of Heavy Metal Pollution The Hong Kong University of Science and TechnologyHong Kong 999077China Wastewater Treatment Laboratory FYT Graduate SchoolThe Hong Kong University of Science and TechnologyGuangzhou 511458China

Sewage sludge is a potential precursor for biochar production,but its effective utilization involves costly activation *** modify biochar properties while ensuring cost-effectiveness,we examined the feasibility of using seawater as an agent to activate biochar produced from sewage *** our proof-of-concept study,seawater was proven to be an effective activation agent for biochar production,achieving a surface area of 480.3 m^(2)/g with hierarchical porosity *** from our design,the catalytic effect of seawater increased not only the surface area but also the graphitization degree of biochar when comparing the pyrolysis of sewage sludge without *** leads to seawater activated biochar electrodes with lower resistance,higher capacitance of 113.9 F/g comparing with control groups without *** the global increase in the salinity of groundwater,especially in coastal areas,these findings provide an opportunity for recovering a valuable carbon resource from sludge.

关键词： Sewage sludge Biochar Seawater Recourse recovery Capacitor

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Coastal Flood Risk and Smart Resilience Evaluation under a Changing Climate

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ocean-Land-Atmosphere research 2023年第1期2卷 334-350页

作者： Ping Shen Shilan Wei Huabin Shi Liang Gao Wan-Huan Zhou State Key Laboratory of Internet of Things for Smart City and department of Civil Environmental Engineering University of MacaoTaipaMacao center for ocean research in hong kong and macao(CORE) Hong Kong SARPeople’s Republic of China

Coastal areas are highly vulnerable to flood risks,which are exacerbated by the changing *** paper provides a comprehensive review of the literature on coastal flood risk assessment and resilience evaluation and proposes a smart-resilient city framework based on pre-disaster,mid-disaster,and post-disaster ***,this paper systematically reviews the origin of the resilience concept and the development of flood ***,it introduces the social-acceptable risk criteria and the flood resilience level for different flood ***,a coastal flood resilience management system for smart cities is proposed,covering 3 phases of flood disasters(before,during,and after).Risk assessment is essential in pre-disaster scenarios because it provides a comprehensive understanding of the potential hazards and vulnerabilities of an area or *** data monitoring during disasters is an essential component of effective emergency management and response that can allow for more informed decisions and thus quicker,more effective responses to disasters,ultimately saving lives and minimizing ***-informed loss assessments are crucial in providing a rapid,accurate understanding of post-disaster *** understanding,in turn,is instrumental in expediting recovery and reconstruction efforts by aiding decision-making processes and resource ***,the impacts of climate change on the 3 phases of flood disasters are *** development of more resilient coastal communities that are better equipped to withstand the impacts of climate change and adapt to changing environmental conditions is *** address coastal compound floods,researchers should focus on understanding trigging factor interactions,assessing economic and social risks,improving monitoring and emergency response systems,and promoting interdisciplinary research with data *** strategies will enable comprehensive and holistic management of coastal flood risks

关键词： flood disaster coastal

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Source apportionment of PM_(2.5)using PMF combined online bulk and single-particle measurements:Contribution of fireworks and biomass burning

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Journal of Environmental sciences 2024年第2期136卷 325-336页

作者： Yanjing Zhang Wenshuai Li Lei Li Mei Li Zhen Zhou Jianzhen Yu Yang Zhou Frontier science center for Deep ocean Multispheres and Earth System(FDOMES)and Physical oceanography Laboratory Ocean University of ChinaQingdaoShandong 266100China College of oceanic and Atmospheric sciences Ocean University of ChinaQingdaoShandong 266100China Institute of Atmospheric Environment Safety and Pollution Control Jinan UniversityGuangdong 510632China Institute of Environment Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina department of Chemistry Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Division of Environment The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina

Fireworks(FW)could significantly worsen air quality in short term during *** to similar tracers with biomass burning(BB),the fast and precise qualification of FW and BB is still *** this study,online bulk and single-particle measurements were combined to investigate the contributions of FW and BB to the overall mass concentrations of PM_(2.5)and specific chemical species by positive matrix factorization(PMF)during the Chinese New Year in hong kong in February *** combined information,fresh/aged FW(abundant ^(140)K_(2)NO_(3)^(+)and ^(213)K_(3)SO_(4)^(+)formed from ^(113)K_(2)Cl^(+)discharged by fresh FW)can be extracted from the fresh/aged BB sources,in addition to the Second Aerosol,Vehicles+Road Dust,and Sea Salt *** contributions of FW and BB were investigated during three high particle matter episodes influenced by the pollution transported from the Pearl River Delta *** fresh BB/FW contributed 39.2%and 19.6%to PM_(2.5)during the Lunar Chinese New Year ***,the contributions of aged FW/BB enhanced in the last two episodes due to the aging process,evidenced by high contributions from secondary ***,the fresh BB/FW showed more significant contributions to nitrate(35.1%and15.0%,respectively)compared with sulfate(25.1%and 5.9%,respectively)and OC(14.8%and11.1%,respectively)on *** comparison,the aged FW contributed more to sulfate(13.4%).Overall,combining online bulk and single-particle measurement data can combine both instruments’advantages and provide a new perspective for applying source apportionment of aerosols using PMF.

关键词： Source apportionment PMF Online bulk measurements Single particle analysis Fireworks Biomass burning

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High-order compact gas-kinetic schemes for three-dimensional flow simulations on tetrahedral mesh

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Advances in Aerodynamics 2023年第1期5卷 1-28页

作者： Fengxiang Zhao Xing Ji Wei Shyy Kun Xu department of Mechanical and Aerospace Engineering Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina department of Mathematics Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Shaanxi Provincial Key Laboratory of Environment and Control for Flight Vehicles Xi’an Jiaotong UniversityXi’anChina center for ocean research in hong kong and macao(CORE) Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Shenzhen research Institute Hong Kong University of Science and TechnologyShenzhenChina

A general framework for the development of high-order compact schemes has been proposed *** core steps of the schemes are composed of the following.1).Based on a kinetic model equation,from a generalized initial distribution of flow variables construct a time-accurate evolution solution of gas distribution function at a cell interface and obtain the corresponding flux function;2).Introduce the WENO-type weighting functions into the high-order time-derivative of the cell interface flux function in the multistage multi-derivative(MSMD)time stepping scheme to cope with the possible impingement of a shock wave on a cell interface within a time step,and update the cell-averaged conservative flow variables inside each control volume;3).Model the time evolution of the gas distribution function on both sides of a cell interface separately,take moments of the inner cell interface gas distribution function to get flow variables,and update the cell-averaged gradients of flow variables inside each control volume;4).Based on the cell-averaged flow variables and their gradients,develop compact initial data reconstruction to get initial condition of flow distributions at the beginning of next time step.A compact gas-kinetic scheme(GKS)up to sixth-order accuracy in space and fourth-order in time has been constructed on 2D unstructured *** this paper,the compact GKS up to fourth-order accuracy on three-dimensional tetrahedral mesh will be further constructed with the focus on the WENO-type initial compact data *** weights are designed to achieve high-order accuracy for the smooth Navier-Stokes solution and keep super robustness in 3D computation with strong shock *** fourth-order compact GKS uses a large time step with a CFL number 0.6 in the simulations from subsonic to hypersonic flow.A series of test cases are used to validate the *** high-order compact GKS can be used in 3D applications with complex geometry.

关键词： Compact scheme High-order GKS WENO reconstruction Tetrahedral mesh

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Microbial carbon pump shapes chemical signatures of refractory dissolved organic carbon in ocean water column

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science China Earth sciences 2024年第7期67卷 2408-2410页

作者： Ruanhong CAI Nianzhi JIAO Fujian Key Laboratory of Marine Carbon Sequestration Xiamen UniversityXiamen 361102China department of ocean science The Hong Kong Universityof Science and TechnologyHong Kong SAR 999077China Carbon Neutral Innovation research center Xiamen UniversityXiamen 361102China

The global ocean sequesters a great amount of dissolved organic carbon(DOC),which is mainly originated from indigenous microbial activities(such as photosynthesis and chemoautotrophy)in the water column,as well as various exogenous sources such as riverine input,sediment mobilization,aerosol dissolution,hydrothermal vent effusion,and others(Cai and Jiao,2023).

关键词： ocean originated aerosol

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Dissecting the contributions of organic nitrogen aerosols to global atmospheric nitrogen deposition and implications for ecosystems

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National science Review 2023年第12期10卷 124-136页

作者： Yumin Li Tzung-May Fu Jian Zhen Yu Xu Yu Qi Chen Ruqian Miao Yang Zhou Aoxing Zhang Jianhuai Ye Xin Yang Shu Tao hongbin Liu Weiqi Yao Shenzhen Key Laboratory of Precision Measurement and Early Warning Technology for Urban Environmental Health Risks School of Environmental Science and Engineering Southern University of Science and Technology Guangdong Provincial Observation and research Station for Coastal Atmosphere and Climate of the Greater Bay Area Southern University of Science and Technology Division of Environment and Sustainability Hong Kong University of Science and Technology National center for Applied Mathematics Shenzhen department of Chemistry Hong Kong University of Science and Technology State Key Joint Laboratory of Environmental Simulation and Pollution Control International Joint Laboratory for Regional Pollution Control College of Environmental Sciences and Engineering Peking University Frontier science center for Deep ocean Multispheres and Earth System and Physical oceanography Laboratory Ocean University of China College of oceanic and Atmospheric sciences Ocean University of China department of ocean science Hong Kong University of Science and Technology department of ocean science and Engineering Southern University of Science and Technology

Atmospheric deposition of particulate organic nitrogen(ONp) is a significant process in the global nitrogen cycle and may be pivotally important for N-limited ***,past models largely overlo oked the spatial and chemical inhomogeneity of atmospheric ONpand were thus deficient in assessing global *** constructed a comprehensive global model of atmospheric gaseous and particulate organic nitrogen(ON),including the latest knowledge on emissions and secondary *** this model,we simulated global atmospheric ONpabundances consistent with *** estimated global atmospheric ON deposition was 26 Tg N yr-1,predominantly in the form of ONp(23 Tg N yr-1)and mostly from wildfires(37%),oceans(22%) and aqueous productions(17%).Globally,ONpcontributed as much as 40% to 80% of the total N deposition downwind of biomass-burning *** ONpdeposition thus constituted the dominant external N supply to the N-limited boreal forests,tundras and the Arctic ocean,and its importance maybe amplified in a future warming climate.

关键词： organic nitrogen aerosol secondary organic nitrogen biomass burning

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