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The role of a drug-loaded poly(lactic co-glycolic acid)(PLGA) copolymer stent in the treatment of ovarian cancer

Cancer Biology & Medicine 2020年第1期17卷 237-250页

作者： Yanqing Wang Xiaoyin Qiao Xiao Yang Mengqin Yuan Shu Xian Li Zhang Dongyong Yang Shiyi Liu Fangfang Dai Zhikai Tan Yanxiang Cheng department of obstetrics and Gynecology Renmin Hospital of Wuhan UniversityWuhan 430060China College of Biology Hunan UniversityChangsha 410082China department of obstetrics and Gynecology Renmin Hospital of Peking UniversityBeijing 100044China department of obstetrics and Gynecology Taihe HospitalHubei University of MedicineShiyan 442000China

Objectives:Cisplatin(CDDP)is a widely used and effective basic chemotherapeutic drug for the treatment of a variety of tumors,including ovarian ***,adverse side effects and acquired drug resistance are observed in the clinical application of *** a mode of administration that can alleviate side effects and reduce drug resistance has become a promising strategy to solve this ***:In this study,3 D printing technology was used to prepare a CDDP-poly(lactic-co-glycolic acid)(CDDP-PLGA)polymer compound stent,and its physicochemical properties and cytotoxicity were evaluated both in vitro and in ***:The CDDP-PLGA stent had a significant effect on cell proliferation and apoptosis and clearly decreased the size of subcutaneous tumors in nude mice,whereas the systemic side effects were mild compared with those of intraperitoneal CDDP *** with the control group,CDDP-PLGA significantly increased the mRNA and protein levels of p-glycoprotein(P<0.01;P<0.01)and decreased vascular endothelial growth factor mRNA(P<0.05)and protein levels(P<0.01),however,CDDP-PLGA significantly decreased the mR NA and protein levels of p-glycoprotein(P<0.01;P<0.01)and vascular endothelial growth factor(P<0.01;P<0.01),which are associated with chemoresistance,in subcutaneous tumor *** assay results revealed that,in the CDDP-PLGA group,the staining of the proliferation-related genes Ki67 and PCNA were lightly,and the apoptosis-related gene caspase-3 stained ***:PLGA biomaterials loaded with CDDP,as compared with the same amount of free CDDP,showed good efficacy in terms of cytotoxicity,as evidenced by changes in *** local CDDP release can decrease the systemic side effects of this drug and the occurrence of drug resistance and angiogenesis,and improve the therapeutic *** new approach may be an effective strategy for the local treatment of epithelial ovarian cancer.

关键词： 3D printing drug-loaded stent local treatment cisplatin ovarian cancer

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The role of TLRs in cervical cancer with HPV infection:a review

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Signal Transduction and Targeted Therapy 2017年第1期2卷 51-60页

作者： Xiao Yang Yanxiang Cheng Chunsheng Li department of obstetrics and Gynecology Renmin Hospital of Wuhan UniversityWuhanChina department of obstetrics and Gynecology University of Pennsylvania Perelman School of MedicinePhiladelphiaPAUSA

The main cause of cervical cancer is persistent infection with high-risk human papilloma virus(HR-HPV),but not all human papilloma virus(HPV)infections lead to cervical *** key factors that determine the outcome of HPV infection remain poorly understood,and how the host immune system protects against HPV infection is ***-like receptors(TLRs)are a group of pattern recognition receptors present in the cytoplasm and cell membrane,and can specifically recognize pathogen-associated molecular *** the key molecules of innate and acquired immunity,TLRs not only play important roles in the immune defense against infectious diseases,but also are involved in the occurrence and development of a variety of malignant *** cervical cancer caused by HR-HPV infection,TLRs have been found to regulate the local immune *** role of TLRs in HR-HPV infection and HPV-induced cervical cancer and its relationship with HPV vaccine are reviewed in this article.

关键词： cervical infection TLRs

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Fundus changes in pregnancy induced hypertension

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International Journal of Ophthalmology(English edition) 2012年第6期5卷 694-697页

作者： Sagili Chandrasekhara Reddy Sivalingam Nalliah Sheila Rani a/pKovil George Tham Seng Who department of Ophthalmology Faculty of MedicineInternational Medical University department of obstetrics and Gynaecology Faculty of Medicine International Medical University department of obstetrics and Gynaecology Hospital Tuanku Jaafar

AIM: To determine the prevalence of retinal changes in pregnancy induced hypertension (PIH) and any association between the retinal changes and blood pressure, proteinuria, and severity of the disease. METHODS: All the patients admitted with diagnosis of PIH were included in this study. Age, race, gravida, gestation period, blood pressure, and proteinuria were noted from the case records. After taking history for any eye symptoms, fundus examination was done after dilating the pupils with direct ophthalmoscope in the ward itself. All the findings were noted on a data sheet, and were analyzed using SPSS programme. RESULTS: A total of 78 patients of PIH were examined. Majority (75.6%) were Malays. The mean age of patients was 30.2 years (range 21-45 years). The gestation period ranged from 25 weeks to 41 weeks; 34 (43.5%) were primi gravida. Thirty (38.4%) patients had mild preeclampsia, 46 (59%) had severe preeclampsia and 2(2.5%) had eclampsia. Retinal changes (hypertensive retinopathy) were noted in 46 (59%) patients --- grade I in 41 (52.6%) and grade II in 5 (6.4%). Haemorrhages or exudates or retinal detachment were not seen in any patient. There was statistically significant positive association of retinal changes and blood pressure (P =0.001), proteinuria (P =0.018) and severity of the PIH (P =0.024). CONCLUSION: Retinal changes (grade I and II hypertensive retinopathy) were seen in 59% of patients with PIH and they were significantly associated with blood pressure, proteinuria and severity of the disease. Fundus examination helps in assessing the severity of PIH.

关键词： pregnancy induced hypertension retinal changes preeclampsia eclampsia cortical blindness

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Measurement and significance of sperm morphology

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Asian Journal of Andrology 2011年第1期13卷 59-68页

作者： Roelof Menkveld Cas AG Holleboom Johann PT Rhemrev Andrology Laboratory Department of Obstetrics and Gynaecology Tygerberg Academic Hospital and University of Stellenbosch Tygerberg 7505 South Africa department of obstetrics and Gynecology Bronovo Hospital The Hague 2597AX The Netherlands

The measurement or evaluation and clinical significance of human sperm morphology has always been and still is a controversial aspect of the semen analysis for the determination of a male＇s fertility potential. In this review the background of the development of the evaluation criteria for sperm morphology will be discussed. Aspects of criticism on the strict criteria definition and use of the criteria for sperm morphology evaluation will be discussed as well as possible reasons for the decline in normal sperm morphology values and how we can compromise for this phenomenon resulting in the very low normal reference value as published in the 2010 WHO manual for the Examination and Processing of Human Semen. One of the possible solutions may be to give more attention to a limited number of abnormal sperm morphology categories and the inclusion of sperm morphology patterns. It is concluded in this review that if done correctly and with care and with strict application of existing guidelines as outlined in the 2010 WHO manual, sperm morphology measurement still has a very important role to play in the clinical evaluation of male fertility potential.

关键词： human sperm morphology male fertility potential strict criteria traditional or liberal criteria WHO manual for semen analysis

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Estrogen up-regulates MMP2/9 expression in endometrial epithelial cell via VEGF-ERK1/2 pathway

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Asian Pacific Journal of Tropical Medicine 2013年第10期6卷 826-830页

作者： Bao Shan Wang Li Shu-Ying Yang Zhuo-Ri Li department of Gynaecology and obstetrics of Hainan People's Hospital

Objective:To study the effect of estrogen on anovulatory dysfunctional uterine bleeding(ADUB).Methods:Primary endometrial epithelial cells of Hainan Lizu female was cultured and hydrolylic activity of gelalinase was determined by gelatin zymography *** mRNA and protein synthesis was blocked respectively to determine whether the increased expression of MMP-2/9 was induced by *** expression of VEGF was blocked by *** treatment with various ***-9,VEGF,total Erk and phosphorylated Erk expression in primary uterine epithelial cells was detected by Western blotting *** MMP-2/9mRNA levels was measured by real-time ***:The activity and expression of MMP2/9 was inereased in the endometrium of patients with *** could up-regulate the expression of VEGF and activate Erk 1/2-Elk1 signal *** interference by siRNA,ERK1/2 pathway was blocked in cells,and the expression of MMP-2/9 was ***1/2 specific blocker U0126 blocked ERK phosphorylation,and it could down-regulate the expression of MMP-2/***:The results showed that the estrogen can increase the expression of VEGF,and thus activate ERK1/2 pathway to induce MMP-2/9 expression.

关键词： Dysfunctional uterine bleeding Matrix metalloproteinase 2 and 9 Vascular endothelial growth factor ERK1/2 signal pathway Estrogen Primary uterine epithelial cells

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Synchronous quadruple primary malignancies of the cervix,endometrium, ovary, and stomach in a single patient: A case report and review of literature

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World Journal of Clinical Cases 2019年第20期7卷 3364-3371页

作者： Dan-Dan Wang Qing Yang department of obstetrics and Gynecology Shengjing Hospital of China Medical University

BACKGROUND The diagnosis of multiple primary malignancies(MPMs)has increased due to the improvements and development of diagnostic techniques,in conjunction with extended life *** however,reports of synchronous quadruple primary malignancies remain extremely *** SUMMARY Herein we describe the case of a 56-year-old woman who was diagnosed with synchronous quadruple multiple primary cancers,namely an endocervical adenocarcinoma admixed with neuroendocrine features,localized endometrial endometrioid adenocarcinoma,unilateral endometrioid ovarian carcinoma,and gastric *** four of these tumors were removed in one combined surgical *** To our knowledge the above-described combination of multiple synchronous primary malignancies has not been previously *** nature of the association between them is *** research should focus on the etiology and mechanisms involved in MPMs.

关键词： Quadruple primary malignancy Synchronous Surgery Case report

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Effects of menopausal hormone therapy-based on the role of estrogens,progestogens,and their metabolites in proliferation of breast cancer cells

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Cancer Biology & Medicine 2022年第4期19卷 432-449页

作者： Yu Deng Hongyan Jin department of obstetrics and Gynecology Peking University First HospitalBeijing 100034China

Menopausal hormone therapy(MHT)has been widely used for the clinical treatment of symptoms associated with menopause in ***,the exact nature of the relationship between MHT and the increased risk of breast cancer has not been fully *** results of the Women’s Health Initiative’s randomized controlled clinical studies showed that estrogen monotherapy was associated with a lower incidence of breast cancer as compared to estrogen-progesterone combined therapy,with an elevated risk of breast *** evidence currently available from randomized trials and observational studies is based on data from different populations,drug formulations,and routes of *** though the risks of MHT and breast cancer have received a great deal of attention,information regarding the unpredictable toxicological risks of estrogen and progestogen metabolism needs to be further ***,the diversity and complexity of the metabolic pathways of estrogen and different progestogens as well as the association of the different estrogen and progestogen metabolites with the increased risk of breast cancer need to be adequately ***,this review aimed to describe the biological effects of estrogen,progesterone,and their metabolites on the proliferation of breast cancer cells,based on relevant basic research and clinical trials,to improve our understanding of the biological functions of estrogen and progestogen as well as the safety of MHT.

关键词： Menopausal hormone therapy estrogen progestogens breast cancer

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Correlation of An Ultrasonic Scoring System and Intraoperative Blood Loss in Placenta Accreta Spectrum Disorders: A Retrospective Cohort Study

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Biomedical and Environmental Sciences 2021年第2期34卷 163-169页

作者： CHEN Lian SHI Hui Feng JIANG Hai SHI Xiao Ming WANG Yuan Yuan ZHANG Ai Qing CHONG Yi Wen ZHAO Yang Yu department of obstetrics and Gynecology Peking University Third HospitalBeijing 100191China

Objective This study aims to investigate the correlation of an ultrasonic scoring system with intraoperative blood loss(IBL) in placenta accreta spectrum(PAS) *** A retrospective cohort study was conducted between January 2015 and November *** data for patients with PAS have been obtained from medical records. Generalized additive models were used to explore the nonlinear relationships between ultrasonic scores and IBL. Logistic regressions were used to determine the differences in the risk of IBL ≥ 1,500 m L among groups with different ultrasonic *** A total of 332 patients participated in the analysis. Generalized additive models showed a significant positive correlation between score and blood loss. The amount of IBL was increased due to the rise in the ultrasonic score. All cases were divided into three groups according to the scores(low score group: ≤ 6 points, n = 147;median score group: 7-9 points, n = 126;and high score group: ≥ 10 points, n = 59). Compared with the low score group, the high score group showed a higher risk of IBL≥ 1,500 m L [odds ratio, 15.09;95% confidence interval(3.85, 59.19);P ≤ 0.001] after a multivariable *** The risk of blood loss equal to or greater than 1,500 m L increases further when ultrasonic score greater than or equal to 10 points, the preparation for transfusion and referral mechanism should be considered.

关键词： Ultrasonic scoring system Intraoperative blood loss Placenta accreta spectrum disorders

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Synthesis of 11β-ether-17α-ethinyl-3,17β-estradiols with strong ER antagonist activities

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Chinese Chemical Letters 2014年第4期25卷 567-570页

作者： Jing-Xin Zhang David C.Labaree Richard B.Hochberg department of obstetrics Gynecology & Reproductive SciencesYale University School of Medicine

We have previously found that several families of nonpolar short chain 11β-ethers and esters ofestradiol are selective estrogen receptor modulators （SERMs）. Surprisingly, the transformation from potent estrogen to anti-estrogen occurs when the 11β-side chain is increased slightly in length from four to five non-hydrogen atoms. To generate strong antagonists for preclinical development, we have synthesized other similar ER ligands with 11β-ethers and with an additional ethinyl group at the 17β-position in order to slow metabolism of the steroidal moiety. Here we report the synthesis and biological activity of two such compounds （11β-i-PrO-propyl and 11β-t-BuO-propyl ethers） with extremely strong antagonist activities.

关键词： Estrogen receptor SERM Antagonist Estradiol

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Oncogenic role of Tc17 cells in cervical cancer development

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World Journal of Clinical Cases 2020年第1期8卷 11-19页

作者： Zun-Sheng Zhang Ying Gu Bing-Gang Liu Hong Tang Yu Hua Jun Wang department of obstetrics and Gynecology Shanghai Seventh People’s Hospital

BACKGROUND As one of the subsets of CD8+T cells,Tc17 cells have recently been identified and are characterized by the secretion of interleukin(IL)-17,which is related to inflammatory *** To assess the status of Tc17 cells in cervical cancer and investigate the biological function of Tc17 cells in cervical cancer *** Flow cytometry assay,immunohistochemistry,and immunofluorescence were performed to detect the levels and phenotype of Tc17 cells in blood and tumor samples from patients with cervical *** to cell suspension culture,ELISA was carried out to measure the production of IL-6,IL-1β,IL-23,CXCL12,and IL-17 in tumor tissue supernatant and co-cultured supernatant of patients with cervical *** addition,multivariate analysis was performed to identify factors associated with overall survival using the Cox proportional hazards *** Compared with normal tissues,Tc17 cells specifically accumulated in tumor tissues of cervical cancer *** cells produced a greater amount of IL-6,IL-1β,and IL-23,which in turn promoted Tc17 cell *** the traditional cytotoxic CD8^+T cells,Tc17 cells secreted IL-17,which subsequently promoted CXCL12 expression in tumor cells,eventually enhancing the proliferation and migration of tumor ***,the ratio of tumor-infiltrating Tc17 cells was highly correlated with poor clinical outcome in patients with cervical *** Our data identified the oncogenic role of Tc17 cells in the development of cervical *** propose that the ratio of Tc17 cells may be a useful index in the prognosis of patients with cervical cancer.

关键词： Cervical cancer Tc17 cells Interleukin-17 Cancer development Biological function Oncogenic role

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