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Autophagy-targeting modulation to promote peripheral nerve regeneration

Neural Regeneration Research 2025年第7期20卷 1864-1882页

作者： Yan Chen Hongxia Deng Nannan Zhang department of obstetrics and gynecology West China Second HospitalSichuan UniversityChengduSichuan ProvinceChina Key Laboratory of Birth Defects and Women and children’s Diseases Ministry of EducationSichuan UniversityChengduSichuan ProvinceChina Laboratory of Reproductive Endocrinology and Reproductive Regulation Sichuan UniversityChengduSichuan ProvinceChina National Center for Birth Defect Monitoring West China Second University HospitalSichuan UniversityChengduSichuan ProvinceChina

Nerve regeneration following traumatic peripheral nerve injuries and neuropathies is a complex process modulated by diverse factors and intricate molecular *** studies have focused on factors that stimulate axonal outgrowth and myelin ***,recent studies have highlighted the pivotal role of autophagy in peripheral nerve regeneration,particularly in the context of traumatic ***,autophagy-targeting modulation has emerged as a promising therapeutic approach to enhancing peripheral nerve *** current understanding suggests that activating autophagy facilitates the rapid clearance of damaged axons and myelin sheaths,thereby enhancing neuronal survival and mitigating injury-induced oxidative stress and *** actions collectively contribute to creating a favorable microenvironment for structural and functional nerve regeneration.A range of autophagyinducing drugs and interventions have demonstrated beneficial effects in alleviating peripheral neuropathy and promoting nerve regeneration in preclinical models of traumatic peripheral nerve *** review delves into the regulation of autophagy in cell types involved in peripheral nerve regeneration,summarizing the potential drugs and interventions that can be harnessed to promote this *** hope that our review will offer novel insights and perspectives on the exploitation of autophagy pathways in the treatment of peripheral nerve injuries and neuropathies.

关键词： autophagy autophagy related genes Charcot–Marie–Tooth diseases diabetic peripheral neuropathy metformin myelination peripheral nerve injury schwann cells sciatic nerve Wallerian degeneration

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Unlocking the future:Mitochondrial genes and neural networks in predicting ovarian cancer prognosis and immunotherapy response

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World Journal of Clinical Oncology 2025年第1期16卷 43-52页

作者： Zhi-Jian Tang Yuan-Ming Pan Wei Li Rui-Qiong Ma Jian-Liu Wang department of obstetrics and gynecology Peking University People’s HospitalBeijing 100044China Cancer Research Center Beijing Chest HospitalBeijing 101149China department of Thoracic surgery Sichuan Provincial People's HospitalChengdu 610072Sichuan ProvinceChina

BACKGROUND Mitochondrial genes are involved in tumor metabolism in ovarian cancer(OC)and affect immune cell infiltration and treatment *** To predict prognosis and immunotherapy response in patients diagnosed with OC using mitochondrial genes and neural *** Prognosis,immunotherapy efficacy,and next-generation sequencing data of patients with OC were downloaded from The Cancer Genome Atlas and Gene Expression *** genes were sourced from the MitoCarta3.0 *** discovery cohort for model construction was created from 70% of the patients,whereas the remaining 30% constituted the validation *** the expression of mitochondrial genes as the predictor variable and based on neural network algorithm,the overall survival time and immunotherapy efficacy(complete or partial response)of patients were *** In total,375 patients with OC were included to construct the prognostic model,and 26 patients were included to construct the immune efficacy *** average area under the receiver operating characteristic curve of the prognostic model was 0.7268[95% confidence interval(CI):0.7258-0.7278]in the discovery cohort and 0.6475(95%CI:0.6466-0.6484)in the validation *** average area under the receiver operating characteristic curve of the immunotherapy efficacy model was 0.9444(95%CI:0.8333-1.0000)in the discovery cohort and 0.9167(95%CI:0.6667-1.0000)in the validation *** The application of mitochondrial genes and neural networks has the potential to predict prognosis and immunotherapy response in patients with OC,providing valuable insights into personalized treatment strategies.

关键词： Ovarian cancer Mitochondria Prognosis Immunotherapy Neural network

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Drosophila models used to simulate human ATP1A1 gene mutations that cause Charcot-Marie-Tooth type 2 disease and refractory seizures

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Neural Regeneration Research 2025年第1期20卷 265-276页

作者： Yao Yuan Lingqi Yu Xudong Zhuang Dongjing Wen Jin He Jingmei Hong Jiayu Xie shengan Ling Xiaoyue Du Wenfeng Chen Xinrui Wang Institute of Life sciences College of Biological Science and EngineeringFuzhou UniversityFuzhouFujian ProvinceChina NHC Key Laboratory of Technical Evaluation of Fertility Regulation for Non-human Primate(Fujian Maternity and Child Health hospital) FuzhouFujian ProvinceChina Medical Research Center Fujian Maternity and Child Health HospitalCollege of Clinical Medicine for Obstetrics&Gynecology and PediatricsFujian Medical UniversityFuzhouFujian ProvinceChina department of Neurology and Institute of Neurology of The First Affiliated hospital Institute of Neuroscienceand Fujian Key Laboratory of Molecular NeurologyFujian Medical UniversityFuzhouFujian ProvinceChina

Certain amino acids changes in the human Na^(+)/K^(+)-ATPase pump,ATPase Na^(+)/K^(+)transporting subunit alpha 1(ATP1A1),cause Charcot-Marie-Tooth disease type 2(CMT2)disease and refractory *** develop in vivo models to study the role of Na^(+)/K^(+)-ATPase in these diseases,we modified the Drosophila gene homolog,Atpα,to mimic the human ATP1A1 gene mutations that cause *** located within the helical linker region of human ATP1A1(I592T,A597T,P600T,and D601F)were simultaneously introduced into endogenous Drosophila Atpαby CRIsPR/Cas9-mediated genome editing,generating the Atpα^(TTTF)*** addition,the same strategy was used to generate the corresponding single point mutations in flies(Atpα^(I571T),Atpα^(A576T),Atpα^(P579T),and Atpα^(D580F)).Moreover,a deletion mutation(Atpα^(mut))that causes premature termination of translation was generated as a positive *** these alleles,we found two that could be maintained as homozygotes(Atpα^(I571T)and Atpα^(P579T)).Three alleles(Atpα^(A576T),Atpα^(P579)and Atpα^(D580F))can form heterozygotes with the Atpαmut *** found that the Atpαallele carrying these CMT2-associated mutations showed differential phenotypes in *** heterozygous for Atpα^(TTTF)mutations have motor performance defects,a reduced lifespan,seizures,and an abnormal neuronal *** Drosophila models will provide a new platform for studying the function and regulation of the sodium-potassium pump.

关键词： ATP1A1 Atpα bang-sensitive paralysis Charcot-Marie-Tooth disease type 2 CRIsPR/Cas9 homology-directed repair Na^(+)/K^(+)-ATPase point mutation seizures sodium pump

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Impact of different stereoisomers of inositol on insulin sensitivity of gestational diabetes mellitus patients

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World Journal of Clinical Cases 2021年第3期9卷 565-572页

作者： Jing He Yan-Li Zhang Li-Ping Wang Xiao-Chun Liu department of obstetrics and gynecology Shanxi Bethune HospitalShanxi Medical UniversityTaiyuan 030032Shanxi ProvinceChina

BACKGROUND Inositol is a hexa-carbon polyol,a naturally soluble vitamin,often found in various *** To discuss the impact of different stereoisomers of inositol on insulin sensitivity of gestational diabetes mellitus(GDM)*** Eighty GDM pregnant women were divided into four groups according to their treatment received:A group(placebo folic acid 400μg/d),B group[myo-inositol(MI)1500 mg,twice a day],C group[D-chiro-inositol(DCI)250 mg,twice a day],and D group(inositol MI and inositol DCI 1500 mg/250 mg,twice a day).Each patient routinely used dietary guidance adjustments and did some safe and effective aerobic exercise in addition to receiving placebo or inositol from GDM diagnosis to ***,total cholesterol,fasting plasma glucose,oral glucose tolerance test postprandial glucose(2 h postprandial blood glucose),fasting insulin,fasting plasma glucose,and glycosylated hemoglobin levels and Homeostasis Model Assessment-insulin resistance(HOMA-IR)and Homeostasis Model Assessment-insulin sensitivity index(HOMA-IsI)scores were determined before treatment and 8 wk after treatment *** maternal and infant outcomes,including hypoglycemia,excessive amniotic fluid,premature infants,macrosomia,fetal distress etc.,were also *** There was no statistical difference in the baseline data of each *** levels of 2 h blood glucose,glycosylated hemoglobin,fasting insulin,total cholesterol,and triglyceride in the B,C,and D groups were significantly lower than those in the control group(A group)after treatment(Ps in the C and D groups decreased more significantly,and the differences were statistically significant(Ps decreased significantly,and the HOMA-IsI increased significantly compared with the A group,and the differences were statistically significant(Pse of HOMA-IR and the increase of HOMA-IsI

关键词： Gestational diabetes mellitus Myo-inositol Insulin resistance during pregnancy

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Protective Effect and Mechanism of Kuntai Capsule on Angiotensin II-Induced Hypertension in Ovariectomized Rats

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Chinese Journal of Integrative Medicine 2023年第6期29卷 526-533页

作者： GE Xiao-fen LI sha-sha LIU Yan-hua LU Mei-qiu sU Hui-na YANG Xin sUN Xiao-wan department of obstetrics and gynecology Peking University People's HospitalBeijing(100044)China department of obstetrics and gynecology Dongying People's HospitalDongyingShandong Province(257000)China

Objective To explore the protective effect and mechanism of Kuntai(KT)Capsule on angiotensin II(Ang II)-induced hypertension in ovariectomized(OVX)*** Fifty-four rats were randomly divided into 6 groups according to a random number table,9 in each group:control,OVX sham+Ang II,OVX,OVX+Ang II,OVX+Ang II+E2,and OVX+Ang II+*** rats model was constructed by retroperitoneal bilateral *** 4 weeks of pretreatment with KT Capsule[0.8 g/(kg·d)and 17-β-estradiol(E2,1.2 mg/(kg·d)]respectively,Ang II was injected into a micro-osmotic pump with a syringe to establish a hypertensive rat *** pressure of rat tail artery was measured in a wake state of rats using a non-invasive *** pressure changes were compared between the intervention groups(OVX+Ang II+KT,OVX+Ang II+E2)and the negative control group(OVX+Ang II).serum malondialdehyde(MDA)level and superoxide dismutase(sOD)activity were detected *** expressions of oxidative stress-related protein superoxide dismutase2(sOD2)and anti-thioredoxin(TRX),autophagy marker protein[beclin1,light chain(LC)3 II/I ratio and autophagy canonical pathway protein phosphatidylinositol 3-kinase(PI3K)/serine/threonine kinase(AKT)-mammalian target of rapamycin(mTOR)]were evaluated by Western *** Compared with the OVX+Ang II group,the systolic blood pressure of OVX+Ang II+KT group was significantly lowered(Pstolic blood ***,sOD2 and TRX protein levels in mycardial tissues were significantly reduced in the OVX+Ang II+KT group compared with the OVX+Ang II group(Pstress serum markers MDA and sOD were down-and up-regulated in the OVX+Ang II+KT group,respectively(Ps of cardiac proteins beclin-1 and LC3II/LC3 I in OVX+Ang II+KT group were also up-regulated(Pssion levels of p-PI3K,p-AKT and mTOR protein were down-regulated(Psion KT could protect blood pr

关键词： Kuntai Capsule Chinese medicine perimenopausal hypertension angiotensin II

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Healthy neonate born to a sARs-CoV-2 infected woman:A case report and review of literature

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World Journal of Clinical Cases 2020年第23期8卷 6016-6025页

作者： Rong-Yue Wang Ke-Qiong Zheng Bo-Zhong Xu Wei Zhang Jin-Ge si Chong-Yong Xu Hua Chen Zhang-Ye Xu Xin-Mei Wu department of obstetrics and gynecology The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina department of obstetrics and gynecology The Yueqing People’s HospitalWenzhou 325600Zhejiang ProvinceChina department of obstetrics and gynecology The Zhongshan Affiliated Hospital of Sun Yat-Sen UniversityZhongshan 528400Guangdong ProvinceChina department of Radiology The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina department of Clinical Laboratory The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

BACKGROUND severe acute respiratory syndrome coronavirus 2(sARs-CoV-2)is a newly discovered coronavirus that has generated a worldwide outbreak of *** people with coronavirus disease-2019(COVID-19)have developed severe illness,and a significant number have ***,little is known regarding infection by the novel virus in pregnant *** herein present a case of COVID-19 confirmed in a woman delivering a neonate who was negative for sARs-CoV-2 and related it to a review of the literature on pregnant women and human coronavirus *** sUMMARY The patient was a 36-year-old pregnant woman in her third trimester who had developed progressive clinical symptoms when she was confirmed as infected with *** the potential risks for both the pregnant woman and the fetus,an emergency cesarean section was performed,and the baby and his mother were separately quarantined and cared *** a result,the baby currently shows no signs of sARs-CoV-2 infection(his lower respiratory tract samples were negative for the virus),while the mother completely recovered from *** Although we presented a single case,the successful result is of great significance for pregnant women with sARs-CoV-2 infection and with respect to fully understanding novel coronavirus pneumonia.

关键词： Novel coronavirus pneumonia sARs-CoV-2 Pregnant woman Neonate Case report

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Investigation of the status of interhospital transport of critically ill pediatric patients

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World Journal of Pediatrics 2015年第1期11卷 67-73页

作者： Jun Qiu Xiao-Li Wu Zheng-Hui Xiao Xian Hu Xue-Li Quan Yi-Min Zhu department of children's Intensive Research Center Hunan Children's HospitalChangsha 410007China department of obstetrics and gynecology Maternal And Child Health Hospital Of Hunan ProvinceChangsha 410007China

Background:With the unequal distribution of medical resources in developing countries,critially ill children need to be transferred to tertiary hospitals from primary hospitals with limited *** a large number of critically ill children are transferred each day in China,the standard process of inter-hospital transport is not ***:We retrospectively analyzed the data collected during transport.A total number of 9231 patients(≤14 years)who had been transferred to the Hunan children's hospital by a specialized team from primary hospitals from January 1,2009 to June 30,2012 were included in the ***:Nearly half of the critically ill children were neonates(48.72%)and two thirds of the children were suffering from respiratory,neurological and cardiac *** adjusted odds ratios(OR)and 95%confidence intervals(CI)were calculated using unconditional logistic *** time in non-working hours was longer than the working hours(OR=1.186,95%CI=1.059-1.329).Our study showed that mobilization time for neonates was shorter than that for older children(OR=0.801,95%CI=0.692-0.928).The mobilization time of referral cases was shorter in areas within a radius of 50 km than in those within a radius of over 250 km(OR=0.427,95%CI=0.350-0.521).Referred patients in summer needed a significantly shorter mobilization time than in winter(OR=0.705,95%CI=0.616-0.806).Conclusion:standardized processes and guidelines for inter-hospital transport would be essential to ensure effective transport of patients and reduce the mobilization activation time.

关键词： critically ill pediatric patients inter-hospital transport specialist retrieval teams

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Effects of insulin aspart and metformin on gestational diabetes mellitus and inflammatory markers

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World Journal of Diabetes 2023年第10期14卷 1532-1540页

作者： Yan Wang Min song Bang-Ruo Qi department of obstetrics and gynecology Sanya Women and Children’s Hospital Managed by Shanghai Children’s Medical CenterSanya 572099Hainan ProvinceChina

BACKGROUND Gestational diabetes mellitus(GDM)refers to hyperglycemia caused by insulin resistance or insufficient insulin secretion during *** with GDM have a high risk of pregnancy complications,which can adversely affect both maternal and fetal ***,early diagnosis,treatment and monitoring of GDM are *** recent years,a new treatment scheme represented by insulin aspart combined with metformin has received increasing *** To explore the effects of insulin aspart combined with metformin on patients with GDM and inflammatory *** From April 2020 to september 2022,124 patients with GDM in sanya Women and children’s hospital Managed by shanghai children’s Medical Center were collected and analyzed *** control group(CG)comprised 62 patients treated with insulin aspart alone,and 62 patients treated with insulin aspart and metformin formed the observation group(OG).Before and after treatment,improvement of blood-glucose-related indexes[fasting blood glucose(FBG),2-h postprandial glucose(2h PG)and hemoglobin A1c(HbA1c)],serum related factor[serum homocysteine(Hcy)],serum inflammatory cytokines[tumor necrosis factor(TNF)-α,interleukin(IL)-6 and C-reactive protein(CRP)]were compared between the two *** clinical efficacy,adverse pregnancy outcomes and incidence of pregnancy complications were compared between the two *** After treatment,the levels of FBG,2h PG,HbA1c,Hcy,TNF-α,IL-6 and CRP in both groups were significantly decreased(Ps of FBG,2h PG,HbA1c,Hcy,TNF-α,IL-6 and CRP in the OG were lower than in the CG(Pss in the OG was higher than that in the CG(Pse pregnancy outcomes and complications in the OG was significantly lower than in the CG(PsION Insulin aspart combined with metformin are effective for treatment of GDM,which can reduce blood-glucoserelated indexes,Hcy and serum inf

关键词： Insulin aspart Metformin Gestational diabetes mellitus Efficacy Homocysteine Tumor necrosis factor-α Interleukin-6 C-reactive protein

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Chinese Medicine Plaster as A New Treatment for surgical site Infection in Patients with Cesarean Delivery:A Randomized,Double-Blind,Controlled Trial

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Chinese Journal of Integrative Medicine 2023年第6期29卷 483-489页

作者： HAN Guan-ya WU Xiao-li LI Dong-mei CAI Hai-rui ZHOU Jun-jun HE Xiao-bo department of obstetrics Ningbo Women and Children's HospitalNingboZhejiang Province(315012)China department of Medical Intensive Care Unit Ningbo Women and Children's HospitalNingboZhejiang Province(315012)China

Objective To evaluate the efficacy of Chinese plaster containing rhubarb and mirabilite on surgical site infection(ssI)in patients with cesarean delivery(CD)by performing a randomized controlled *** This randomized controlled trial included 560 patients with CD due to fetal head descent enrolled at a tertiary teaching center between December 31,2018 and October 31,*** patients were randomly assigned to a Chinese medicine(CM)group(280 cases)or a placebo group(280 cases)by a random number table,and were treated with CM plaster(made by rhubarb and mirabilite)or a placebo plaster,*** courses of treatment lasted from the day 1 of CD,followed day 2 until *** primary outcome was the total number of patients with superficial,deep and organ/space *** secondary outcome was duration of postoperative hospital stay,antibiotic intake,and unplanned readmission or reoperation due to *** reported efficacy and safety outcomes were confirmed by a central adjudication committee that was unaware of the study-group *** During the recovery process after CD,the rates of localized swelling,redness and heat were significantly lower in the CM group than in the placebo group[7.55%(20/265)vs.17.21%(47/274),Pstoperative antibiotic intake was shorter in the CM group than in the placebo group(Pstoperative hospital stay was significantly shorter in the CM group than in the placebo group(5.49±2.68 days vs.8.96±2.35 days,Pstoperative C-reactive protein elevation(≽100 mg/L)was lower in the CM group than in the placebo group[27.6%(73/265)vs.43.8%(120/274),Ps no difference in purulent drainage rate from incision and superficial opening of incision between the two *** intestinal reactions and skin allergies were found in the CM *** CM plaster containing rhubarb and mirabilite had an effect on *** is safe for mothers and im

关键词： Chinese medicine plaster rhubarb and mirabilite surgical site infection cesarean delivery randomizedcontrolledtrial

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Management of Cesarean scar Pregnancy: A Case series

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Chinese Medical sciences Journal 2015年第4期30卷 226-230页

作者： Min-hui Guo Mei-fen Wang Man-man Liu Feng Qi Fan Qu Jian-hong Zhou department of gynecology and obstetrics Women’s Hospital School of Medicine Zhejiang University department of gynecology and obstetrics Taizhou Hospital of Zhejiang Province

Objective To survey effective treatment strategies for cesarean scar pregnancy(CsP). Methods The clinical data of 78 patients diagnosed with CsP from January 2010 to December 2013 were reviewed. Results Among these patients, 17 patients were first treated at our hospital; of them, 2 were misdiagnosed. The other 61 patients were referred from other hospitals; of them, 21 were initially misdiagnosed. There were 9 patients who were treated with laparotomy, 50 patients with curettage after uterine artery embolization(UAE) with or without local methotrexate(MTX) infusion, 10 patients with dilatation and curettage, 6 patients with transvaginal sonographic guided local intragestational MTX injection, and 3 patients with systemic MTX injection. All patients finally recovered. Patients with excessive vaginal hemorrhage underwent either emergency UAE treatment or laparotomy. These two treatments had similar success rates(81.82% vs. 100%, χ2 =0.289, P>0.05). Conclusions The accurate diagnosis of CsP is important. Curettage after UAE with or without local MTX infusion is a safe and effective method.

关键词： cesarean scar pregnancy transvaginal ultrasound curettage uterine artery embolization laparotomy

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