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The concentration game: differential effects of bioactive signaling in 2D and3D culture

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Neural Regeneration Research 2016年第1期11卷 66-68页

作者： Laura A.Smith Callahan The Vivian L.Smith department of Neurosurgery & center for Stem Cell and Regenerative Medicine University of Texas Health Science Center at Houston

Traumatic injuries to the central nervous system,such as traumatic brain injury,spinal cord injury and stroke,have a high prevalence,enormous financial costs and lack clinical treatments that restore neurological function（Ma et al.,2014）These injuries trigger a series of secondary biochemical and cellular responses that ultimately lead to cellular death and themaintenance of an unsupportive extracellular matrix （ECM） for tissue regeneration （Silva et al., 2014）. Artificial ECM or scaf- folds represent a way to alter this unsupportive environment to improve the efficacy of stem cell therapies and enhance neural tissue regeneration （Figure 1）.

关键词： bioactive injuries restore biochemical neurological traumatic signaling scaffold ultimately likely

Retinoic acid receptor α promotes autophagy to alleviate liver ischemia and reperfusion injury

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World Journal of Gastroenterology 2015年第43期21卷 12381-12391页

作者： Chen Zhong Li-Yong Pu Ming-Ming Fang Zhen Gu Jian-Hua Rao Xue-Hao Wang Key Laboratory of Living Donor Liver Transplantation of Chinese Ministry of Health Liver Transplantation CenterFirst Affiliated Hospital of Nanjing Medical University department of neurology Jiangsu Province Hospital on Integration of Chinese and Western MedicineNanjing University of Chinese Medicine State Key Laboratory of Reproductive Medicine Research Center for Bone and Stem CellsDepartment of Human AnatomyNanjing Medical University

AIM: To study the role of autophagy and the relationship between retinoic acid receptor α(RARα) and autophagy in liver ischemia and reperfusion(IR) ***: All-trans retinoic acid(ATRA) was administered to mice for two weeks before operation. Reverse transcription-polymerase chain reaction and Western blot were used to detect the expression levels of related factors. To demonstrate the role of RARα,LE540,a RARα inhibitor,was used to treat hepatocytes injured by H2O2 in ***: ATRA pretreatment noticeably diminished levels of serum alanine aminotransferase and as-partate aminotransferase as well as the degree of histopathological changes. Apoptosis was also inhibited,whereas autophagy was promoted. In vitro,RARα was inhibited by LE540,which resulted in decreased autophagy and increased apoptosis. Similarly,the expression of Foxo3 a and p-Akt was downregulated,but Foxo1 expression was ***: This research provides evidence that ATRA can protect the liver from IR injury by promoting autophagy,which is dependent on Foxo3/p-Akt/Foxo1 signaling.

关键词： Ischemia/reperfusion Retinoic acid rece ptor α Fox

2-Methyl-5H-benzo[d]pyrazolo[5,1-b][1,3]oxazin-5-imine, an edaravone analog, exerts neuroprotective effects against acute ischemic injury via inhibiting oxidative stress

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The Journal of Biomedical Research 2018年第4期32卷 270-280页

作者： Huanyu Ni Yixuan Song Haiyin Wu Lei Chang Chunxia Luo Dongya Zhu Institution of Stem Cells and Neuroregeneration Nanjing Medical University department of Pharmacology School of Pharmacy Nanjing Medical University The Key Laboratory of Precision Medicine of Cardiovascular Disease Nanjing Medical University

Oxidative stress plays an indispensable role in the pathogenesis of cerebral *** oxidative stress has been considered as an effective approach for stroke ***,a free radical scavenger,has been shown to prevent cerebral ischemic ***,the clinical efficacy of edaravone is limited because it has a low scavenging activity for superoxide anions（O_2-（·-））.Here,we report that 2-methyl-5 H-benzo[d]pyrazolo[5,1-b][1,3]oxazin-5-imine,a novel small-molecule compound structurally related to edaravone,showed a stronger inhibitory effect on oxidative stress in *** vivo,2-methyl-5 H-benzo[d]pyrazolo[5,1-b][1,3]oxazin-5-imine reversed transient middle cerebral artery occlusion-induced dysfunctions of superoxide dismutases and malondialdehyde,two proteins crucial for oxidative stress,suggesting a strengthened antioxidant ***,2-methyl-5 H-benzo[d]pyrazolo[5,1-b][1,3]oxazin-5-imine decreased blood brain barrier ***,we found that 2-methyl-5 Hbenzo[d]pyrazolo[5,1-b][1,3]oxazin-5-imine had a stronger neuroprotective effect than *** importantly,2-methyl-5 H-benzo[d]pyrazolo[5,1-b][1,3]oxazin-5-imine decreased not only infarct size and neurological deficits in the acute phase but also modified neurological severity score and escape latency in Morris water maze task in the delayed period,indicating enhanced neuroprotection,sensorimotor function and spatial ***,these findings suggest that 2-methyl-5 H-benzo[d]pyrazolo[5,1-b][1,3]oxazin-5-imine could be a preferable option for stroke treatment.

关键词： neuroprotection oxidative stress scavenging activity sensorimotor function spatial memory stroke

Nerve growth factor promotes in vitro proliferation of neural stem cells from tree shrews

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Neural Regeneration Research 2016年第4期11卷 591-596页

作者： Liu-lin Xiong Zhi-wei Chen Ting-hua Wang department of Anesthesiology Institute of Neurological DiseaseTranslational Neuroscience CenterWest China HospitalSichuan University Institute of Neuroscience Kunming Medical University Key Laboratory of National Physical Fitness and Altitude Training Adaptation in Yunnan Province Institute of Physical Education Yunnan Normal University

Neural stem cells promote neuronal regeneration and repair of brain tissue after injury,but have limited resources and proliferative ability in *** hypothesized that nerve growth factor would promote in vitro proliferation of neural stem cells derived from the tree shrews,a primate-like mammal that has been proposed as an alternative to primates in biomedical translational *** cultured neural stem cells from the hippocampus of tree shrews at embryonic day 38,and added nerve growth factor（100 μg/L） to the culture *** stem cells from the hippocampus of tree shrews cultured without nerve growth factor were used as *** 3 days,fluorescence microscopy after DAPI and nestin staining revealed that the number of neurospheres and DAPI/nestin-positive cells was markedly greater in the nerve growth factor-treated cells than in control *** findings demonstrate that nerve growth factor promotes the proliferation of neural stem cells derived from tree shrews.

关键词： nerve regeneration tree shrews hippocampus neural stem cells cell proliferation nerve growth factor neurosphere embryo cell number cell therapy in vitro neural regeneration

SAC-1 ensures epithelial endocytic recycling by restricting ARF-6 activity

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SAC-1 ensures epithelial endocytic recycling by restricting ...

Isolated cerebral mucormycosis that looks like stroke and brain abscess:A case report and review of the literature

第五届中国秀丽线虫大会

作者： Dan Chen Chao Yang Sha Liu Weijian Hang Xianghong Wang Juan Chen Anbing Shi department of Biochemistry and Molecular Biology School of Basic Medicine and the Collaborative Innovation Center for Brain ScienceTongji Medical CollegeHuazhong University of Science and Technology Institute for brain Research Huazhong University of Science and Technology Key Laboratory of Neurological Disease of National Education Ministry Tongji Medical CollegeHuazhong University of Science and Technology

Arf6/ARF-6 is a crucial regulator of the endosomal PI(4,5)P2 pool in endocytic *** further characterize ARF-6 regulation,we performed an ARF-6 interactor screen in *** and identified SAC-1,the homolog of the phosphoin...

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World Journal of Clinical Cases 2023年第7期11卷 1560-1568页

作者： Cai-Hong Chen Jing-Nan Chen Hang-Gen Du Dong-Liang Guo department of neurology Hangzhou Ninth People's HospitalHangzhou 311225Zhejiang ProvinceChina department of Neurosurgery The Second Affiliated Hospital of Zhejiang University of Traditional Chinese MedicineHangzhou 310005Zhejiang ProvinceChina

BACKGROUND Cerebral mucormycosis is an infectious disease of the brain caused by fungi of the order *** infections are rarely encountered in clinical practice and are often misdiagnosed as cerebral infarction or brain *** mortality due to cerebral mucormycosis is closely related to delayed diagnosis and treatment,both of which present unique challenges for *** SUMMARY Cerebral mucormycosis is generally secondary to sinus disease or other disseminated ***,in this retrospective study,we report and analyze a case of isolated cerebral *** The constellation of symptoms including headaches,fever,hemiplegia,and changes in mental status taken together with clinical findings of cerebral infarction and brain abscess should raise the possibility of a brain fungal *** diagnosis and prompt initiation of antifungal therapy along with surgery can improve patient survival.

关键词： Cerebral mucormycosis Stroke brain abscess Diagnosis Treatment Case report

Targeting TM4SF1 exhibits therapeutic potential via inhibition of cancer stem cells

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Signal Transduction and Targeted Therapy 2022年第11期7卷 4018-4021页

作者： Guang Chen Xiaofei She Yanxin Yin Junxian Ma Yaqun Gao Hua Gao Huanlong Qin Jianmin Fang Cancer center and Research Institute of Intestinal Diseases Shanghai Tenth People’s HospitalSchool of Life Sciences and Technology and School of MedicineTongji UniversityShanghaiPR China Shanghai Key Laboratory of Signaling and Disease Research School of Life Sciences and TechnologyTongji UniversityShanghaiPR China Biomedical Research center Tongji University Suzhou Institute and Department of NeurologyTongji HospitalTongji UniversityShanghaiPR China

Dear Editor,Cancer stem cells(CSCs)are thought to be responsible for cancer initiation,growth,recurrence,metastasis,and drug resistance.1 Therefore,targeting CSCs is an effective therapeutic approach for cancer.2 However,there are few CSC-specific targets with functional extracellular domains for the development of antibody drugs.3 Our published paper demonstrated that transmembrane 4 L six family member 1(TM4SF1)coupled discoidin domain receptor tyrosine kinase 1(DDR1)under collagen I stimulation activated JAK2-STAT3 *** noncanonical DDR1 signaling sustained the manifestation of CSC traits by inducing SOX2 and NANOG expression and drove multiorgan metastases.

关键词： drugs STAT3 metastasis

A case of hereditary multi-infarct dementia Mutation in exon 11 of the Notch3 gene on chromosome 19

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Neural Regeneration Research 2011年第35期6卷 2779-2783页

作者： Jie Huang Liru Li Bin Zhang Ting Zhang department of neurology Branch Hospital in Fengxian of Sixth People＇s Hospital Shanghai Neurological Research Institute of Anhui University of Science ＆ Technology the Affiliated Hospital of Anhui University of Science ＆ Technology Shanghai 201499 China department of Emergency Branch Hospital in Fengxian of Sixth People＇s Hospital Shanghai Neurological Research Institute of Anhui University of Science ＆ Technology the Affiliated Hospital of Anhui University of Science ＆ Technology Shanghai 201499 China department of neurology Sixth People＇s Hospital of Shanghai Jiao Tong University Shanghai 200233 China

This study is a report on one 59-year-old male patient with hereditary multi-infarct dementia who came from a family with a positive family history of this disease. The patient primarily presented with dizziness accompanied by vertigo and a positive Romberg＇s sign. Skull magnetic resonance images showed lacunar infarction in bilateral temporal lobes, bilateral basal ganglias, periventricular white matter and semioval center, and ischemic focus accompanied by white matter degeneration, exhibiting senile morphological brain changes. No abnormalities were observed by skull magnetic resonance angiography. Gene detection further confirmed that there was Arg607Cys heterozygous mutation in exon 11 of the Notch3gene. No other mutations in exons were detected.

关键词： cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy clinical manifestation magnetic resonance imaging molecular genetics Notch3 gene neural regeneration

A novel near-infrared light responsive 4D printed nanoarchitecture with dynamically and remotely controllable transformation

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Nano Research 2019年第6期12卷 1381-1388页

作者： Haitao Cui Shida Miao Timothy Esworthy Se-jun Lee Xuan Zhou Sung Yun Hann Thomas J.Webster Brent T.Harris Lijie Grace Zhang department of Mechanical and Aerospace Engineering The George Washington UniversityWashingtonDC 20052USA department of Chemical Engineering Northeastern UniversityBostonMA 02115USA department of neurology and Pathology Georgetown UniversityWashingtonDC 20007USA departments of Electrical and Computer Engineering The George Washington UniversityWashingtonDC 20052USA department of Biomedical Engineering The George Washington UniversityWashingtonDC 20052USA department of Medicine The George Washington UniversityWashingtonDC 20052USA

Four-dimensional (4D) printing is an emerging and highly innovative additive manufacturing process by which to fabricate pre-designed,self-assembly structures with the ability to transform over ***,one of the critical challenges of 4D printing is the lack of advanced 4D printing systems that not only meet all the essential requirements of shape change but also possess smart,dynamic capabilities to spatiotemporally and instantly control the shape-transformation ***,we present a facile 4D printing platform which incorporates nanomaterials into the conventional stimuli-responsive polymer,allowing the 4D printed object to achieve a dynamic and remote controlled,on-time and position shape transformation.A proof-of-concept 4D printed brain model was created using near-infrared light (NIR) responsive nanocomposite to evaluate the capacity for controllable 4D transformation,and the feasibility of photothermal stimulation for modulating neural stem cell *** novel 4D printing strategy can not only be used to create dynamic 3D patterned biological structures that can spatiotemporally control their shapes or behaviors of transformation under a human benign stimulus (NIR),but can also provide a potential method for building complex self-morphing objects for widespread applications.

关键词： near-infrared light responsive four-dimensional (4D) printing dynamically and remotely controllable graphene brain neural stem cell