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Targetoid Polycyclic Concentric Hair Regrowth Pattern Is a Sign of immunological Recovery in Alopecia Areata

Journal of Cosmetics, Dermatological Sciences and Applications 2018年第3期8卷 151-157页

作者： Khalifa E. Sharquie Raheeq K. Ahmed Inas K. Sharquie department of Dermatology College of Medicine University of Baghdad Baghdad Iraq Iraqi and Arab Board for Dermatology & Venereology College of Medicine Baghdad Teaching Hospital Baghdad Iraq University of Guglielmo Marconi Roma Italy Baghdad Teaching Hospital Baghdad Iraq department of microbiology and immunology College of Medicine University of Bagdad Baghdad Iraq

Background: Alopecia areata is a common autoimmune disease, where there are many topical and systemic therapies, during which hair growth appears in a uniform pattern. In certain cases, hair regrowth takes a polycyclic pattern simulating a target, so called targetoid phenomena. Objective: To screen all cases of treated alopecia areata for hair targetoid regrowth pattern. ?Methods: This is an observational study, was conducted in Dermatology department of Baghdad Teaching Hospital in Iraq, during the period, August 2017 to October 2017. All cases treated for alopecia areata with im triamcinolone 20 - 40 mg injection every 2 weeks with topical clobetasone ointment and zinc sulfate 2 mg/kg/day for 2 months, were examined for the targetoid concentric hair regrowth pattern. Result: Among all cases of alopecia areata, seven patients were recorded to have the targetoid concentric hair pattern, which seen 2 - 4 weeks after therapy, their ages ranged from 4 to 25 years old with a mean 14.5, all of them were males. All these patients returned back with hair growth in a form of rings of hair growth alternating with rings of little or no hair growth forming a typical picture of target. Conclusion: Targetoid polycyclic concentric hair regrowth pattern is an important phenomenon seen in patients receiving treatment for alopecia areata, which is a good sign of recovery where its etiopathogenesis could not well be elucidated but alternating immunological reactions could explain this targetoid pattern.

关键词： Alopecia Areata Targetoid Phenomenon Zinc Sulfate

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Paediatric primary care in Germany during the early COVID-19 pandemic:the calm before the storm

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Family Medicine and Community Health 2021年第2期9卷 40-47页

作者： Malte Kohns Vasconcelos Katharina Weil Daniela Vesterling-Hörner Mehrsad Klemm Tarik el Scheich Hanna Renk Katharina Remke Hans Martin Bosse Institute for Medical microbiology and Hospital Hygiene Heinrich Heine University DüsseldorfDüsseldorfGermany department for General Paediatrics Neonatology and Paediatric CardiologyUniversity Hospital DüsseldorfDüsseldorfGermany Paediatric Practice Dr.med.Vesterling-Hörner DüsseldorfGermany Kinderärzte im Karree LeverkusenGermany Kinderärzte am Zoo DüsseldorfGermany department of Paediatric Cardiology Pulmonology and Intensive Care MedicineUniversity Children’s Hospital TübingenTübingenGermany

Objectives Globally,the COVID-19 pandemic has a major impact on healthcare *** effects in primary care are *** study aimed to explore changes in consultation numbers and patient management during the COVID-19 pandemic,and to identify challenges for patient *** Survey of paediatric primary care practices on consultation numbers and patient management changes,and semistructured interviews to identify challenges for patient *** and interviews were partially linked in an explanatory sequential design to identify patient groups perceived to be at higher risk for worse care during the *** In and around Düsseldorf,a densely populated area in Western *** primary care facilities are spread over an area with approximately 2 million *** Primary care in Germany is provided through practices run by self-employed specialist physicians that are contracted to offer services to patients under public health insurance which is compulsory to the majority of the *** sample contained 44 paediatric primary care practices in the area,the response rate was 50%.Results Numbers of consultations for scheduled developmental examinations remained unchanged compared with the previous year while emergency visits were strongly reduced(mean 87.3 less/week in March-May 2020 compared with 2019,median reduction 55.0%).Children dependent on developmental therapy and with chronic health conditions were identified as patient groups receiving deteriorated *** patient numbers,including of mildly symptomatic children presenting for health certificates,in combination with increased organisational demands and expected staff outages are priority concerns for the *** Primary care paediatricians offered stable service through the early pandemic but expected strained resources for the upcoming *** guidance on which children should present to primary care and who should be tested would h

关键词： winter storm unchanged

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Histamine activates HinK to promote the virulence of Pseudomonas aeruginosa

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Science Bulletin 2021年第11期66卷 1101-1118,M0004页

作者： Yaya Wang Qiao Cao Qin Cao Jianhua Gan Ning Sun Cai-Guang Yang Taeok Bae Min Wu Lefu Lan State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China College of Life Science Northwest UniversityXi'an 710069China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Genetic Engineering Shanghai Public Health Clinical CenterCollaborative Innovation Center of Genetics and DevelopmentSchool of Life SciencesFudan UniversityShanghai 201438China The State Key Laboratory of Chemical Biology and Drug Discovery Department of Applied Biology and Chemical TechnologyThe Hong Kong Polytechnic UniversityHong Kong 999077China School of Pharmaceutical Science and Technology Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China department of microbiology and immunology Indiana University School of Medicine-NorthwestGary IN 46408USA department of Biomedical Sciences University of North DakotaGrand Forks ND 58203-9037USA NMPA Key Laboratory for Testing Technology of Pharmaceutical microbiology Shanghai Institute for Food and Drug ControlShanghai 201203China

During infections,bacteria stimulate host cells to produce and release histamine,which is a key mediator of vital cellular processes in ***,the mechanisms underlying the bacterial cell’s ability to sense and respond to histamine are poorly ***,we show that HinK,a Lys R-type transcriptional regulator,is required to evoke responses to histamine in Pseudomonas aeruginosa,an important human *** directly binds to and activates the promoter of genes involved in histamine uptake and metabolism,iron acquisition,and Pseudomonas quinolone signal(PQS)*** transcriptional regulatory activity of HinK is induced when histamine is present,and it occurs when HinK binds with imidazole-4-acetic acid(im AA),a histamine metabolite whose production in *** depends on the HinK-activated histamine uptake and utilization operon hin ***,the inactivation of HinK inhibits diverse pathogenic phenotypes of *** results suggest that histamine acts as an interkingdom signal and provide insights into the mechanism used by pathogenic bacteria to exploit host regulatory signals to promote virulence.

关键词： Pseudomonas aeruginosa Histamine Metabolism Host-microbe interaction Virulence

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Journal of Plant Ecology 2021年第1期14卷 33-43页

作者： Xuefei Tang Chunqiang Wei Lunlun Gao Bingbing Jia Xinmin Lu School of Life Sciences Central China Normal UniversityHubei 430079China State Key Laboratory of Agricultural microbiology Huazhong Agricultural UniversityHubei 430070China Institute of Invasion Biology Agriculture&Ecological SafetyHuazhong Agricultural UniversityHubei 430070China department of Plant Protection College of Plant Sciences&TechnologyHuazhong Agricultural UniversityHubei 430070China

Aims Soil biota can affect plant-plant interactions and non-native plant invasions via plant-soil feedback(PSF).Understanding the drivers underlying interspecific variations in PSF is im portant for predicting the role of soil biota in non-native plant *** studies found that PSF could be predicted by plant *** success of plant invasions is also linked with plant traits,suggesting a potential linkage between PSF and plant invasion via plant traits,but has not yet been ***,we compared PSF between six phylogenetically paired co-occurring native and invasive plants,and explored the potential linkage between PSF with plant root *** We conducted a two-phase PSF *** collected soils were conditioned by the six plant species for 3 months firstly,then seedllings of these plants were grown in living or sterilized soils that had been conditioned by conspecific ***(the conge ner/confamilial species)*** estimated effects of biota in conspecific(conspecific PSF)or heterospecific(heterospecific PSF)soils relative to sterilized soils,and the relative effects of biota in conspecific *** soils(PSF-away)on plant *** Findings In general,soil biota suppressed plant growth,and there were no differences in conspecific PSF,heterospecific PSF and PSF-away between native and invasive *** increased with rising plant fineto-total root mass ratio in the presence of soil biota,and its value was comparable between native and invasive *** results indicate that similarity in plant fine-to-total root mass ratio that predicted PSF may have partially led to the comparable PSFs between these native and invasive *** exploring the linkages among plant traits,PSF and plant invasions with more plants,in particular phylogenetically distant plants,are needed to improve our understanding of the role of soil biota in plant invasions.

关键词： functional traits invasive plants plant invasions plant-soil feedback phylogenetic-paired species

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Relationship between acute kidney injury before thoracic endovascular aneurysm repair and in-hospital outcomes in patients with type B acute aortic dissection

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Journal of Geriatric Cardiology 2015年第3期12卷 232-238页

作者： Hong-Mei REN Xiao WANG Chun-Yan HU Bin QUE Hui AI Chun-Mei WANG Li-Zhong SUN Shao-Ping NIE Emergency & Critical Care Center Beijing Anzhen Hospital Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing China State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and Epidemiology Beijing China department of Cardiovascular Surgery Beo'ing Anzhen Hospital Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing China

Objective Acute kidney injury （AKI） frequently occurs after catheter-based interventional procedures and increases mortality. However, the implications of AKI before thoracic endovascular aneurysm repair （TEVAR） of type B acute aortic dissection （AAD） remain unclear. This study evaluated the incidence, predictors, and in-hospital outcomes of AKI before TEVAR in patients with type B AAD. Methods Between 2009 and 2013, 76 patients were retrospectively evaluated who received TEVAR for type B AAD within 36 h from symptom onset. The patients were classified into no-AKI vs. AKI groups, and the severity of AKI was further staged according to kidney disease： im- proving global outcomes criteria before TEVAR. Results The incidence of preoperative AKI was 36.8%. In-hospital complications was significantly higher in patients with preoperative AKI compared with no-AKI （50.0% vs. 4.2%, respectively; P 〈 0.001）, including acute renal failure （21.4% vs. O, respectively; P 〈 0.001）, and they increased with severity of AKI （P 〈 0.001）. The maximum levels of body tem- perature and white blood cell count were significantly related to maximum serum creatinine level before TEVAR. Multivariate analysis showed that systolic blood pressure on admission （OR： 1.023; 95% CI： 1.003-1.044; P ： 0.0238） and bilateral renal artery involvement （OR： 19.076; 95% CI： 1.914 190.164; P = 0.0120） were strong predictors of preoperative AKI. Conclusions Preoperative AKI frequently occurred in patients with type B AAD, and correlated with higher in-hospital complications and enhanced inflammatory reaction. Systolic blood pressure on admission and bilateral renal artery involvement were major risk factors for AKI before TEVAR.

关键词： Acute aortic dissection Kidney injury Renal failure Thoracic endovascular aneurysm repair

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Disrupted Ca^(2+) h homeostasis and immunodeficiency in patients with functional IP_(3) receptor subtype 3 defects

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Cellular & Molecular immunology 2023年第1期20卷 11-25页

作者： Julika Neumann Erika Van Nieuwenhove Lara E.Terry Frederik Staels Taylor R.Knebel Kirsten Welkenhuyzen Kourosh Ahmadzadeh Mariah R.Baker Margaux Gerbaux Mathijs Willemsen John S.Barber Irina I.Serysheva Liesbeth De Waele François Vermeulen Susan Schlenner Isabelle Meyts David IYule Geert Bultynck Rik Schrijvers Stephanie Humblet-Baron Adrian Liston VIB Center for Brain and Disease Research LeuvenBelgium department of microbiology and immunology KU LeuvenLeuvenBelgium UZ Leuven LeuvenBelgium department of Pharmacology and Physiology University of RochesterRochesterNY14526USA Laboratory of Molecular and Cellular Signaling Department of Cellular and Molecular MedicineLeuven KankerinstituutKU LeuvenLeuvenBelgium Laboratory of immunobiology Department Microbiology and ImmunologyRega InstituteKU LeuvenLeuvenBelgium department of Biochemistry and Molecular Biology Structural Biology Imaging CenterMcGovern Medical School at The University of Texas Health Science Center at HoustonHoustonTX77030USA Pediatric department Academic Children Hospital Queen FabiolaUniversitéLibre de BruxellesBrusselsBelgium department of Pediatric Neurology University Hospitals LeuvenLeuvenBelgium department of Pulmonology University Hospitals LeuvenLeuvenBelgium Laboratory for Inborn Errors of immunity Department of Immunology and MicrobiologyKU LeuvenLeuvenBelgium Laboratory for Allergy and Clinical immunology and immunogenetics Research Group Department of MicrobiologyImmunology and TransplantationKU LeuvenLeuvenBelgium immunology Programme The Babraham InstituteBabraham Research CampusCambridgeCB223ATUK

Calcium signaling is essential for lymphocyte activation, with genetic disruptions of store-operated calcium (Ca^(2+)) entry resulting in severe immunodeficiency. The inositol 1,4,5-trisphosphate receptor (IP_(3)R), a homo- or heterotetramer of the IP_(3)R1-3 isoforms, amplifies lymphocyte signaling by releasing Ca^(2+) from endoplasmic reticulum stores following antigen stimulation. Although knockout of all IP_(3)R isoforms in mice causes immunodeficiency, the seeming redundancy of the isoforms is thought to explain the absence of variants in human immunodeficiency. In this study, we identified compound heterozygous variants of ITPR3 (a gene encoding IP_(3)R subtype 3) in two unrelated Caucasian patients presenting with immunodeficiency. To determine whether ITPR3 variants act in a nonredundant manner and disrupt human immune responses, we characterized the Ca^(2+) signaling capacity, the lymphocyte response, and the clinical phenotype of these patients. We observed disrupted Ca^(2+) signaling in patient-derived fibroblasts and immune cells, with abnormal proliferation and activation responses following T-cell receptor stimulation. Reconstitution of IP_(3)R3 in IP_(3)R knockout cell lines led to the identification of variants as functional hypomorphs that showed reduced ability to discriminate between homeostatic and induced states, validating a genotype–phenotype link. These results demonstrate a functional link between defective endoplasmic reticulum Ca^(2+) channels and immunodeficiency and identify IP_(3)Rs as diagnostic targets for patients with specific inborn errors of immunity. These results also extend the known cause of Ca^(2+)-associated immunodeficiency from store-operated entry to impaired Ca^(2+) mobilization from the endoplasmic reticulum, revealing a broad sensitivity of lymphocytes to genetic defects in Ca^(2+) signaling.

关键词： Primary immunodeficiency Calcium signalling Whole exome sequencing

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肝脏移植术后糖尿病患者肠道微生物组的变化

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Engineering 2023年第12期31卷 98-111页

作者： Qi Ling Yuqiu Han Yue Ma Xiaosen Wang Zheng Zhu Jingyu Wang Jiaying Cao Lin Xiaohan Jun Wang Baohong Wang State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Jinan Microecological Biomedicine Shandong Laboratory Jinan 250117China department of Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Key Lab of Combined Multi-Organ Transplantation Ministry of Public HealthHangzhou 310003China CAS Key Laboratory for Pathogenic microbiology and immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100101China Shandong First Medical University&Shandong Academy of Medical Sciences Jinan 250117China Research Units of Infectious Disease and Microecology Chinese Academy of Medical SciencesHangzhou 310003China

Post-transplant diabetes mellitus(PTDM)increases the risk of graft failure and death in liver transplant(LT)*** studies have indicated that enteric dysbiosis mediated by immunosuppressive tacrolimus(TAC)could contribute to glucose disorders,but no data on human recipients with PTDM have been ***,by combining high-throughput shotgun metagenomics sequencing and metabolomics profiling,we characterized the intestinal microbiome(im)in LT recipient cohort with or without PTDM and deciphered the potential relationship among im,TAC dosage,and *** comparing with both non-PTDM and classical type 2 diabetes mellitus(T2DM),we identified microbial signatures of PTDM,which was characterized by the enriched Proteobacteria and decreased ***,the altered microbes,as well as the microbial metabolomics,correlated with the dosage of ***,the levels of beneficial microbes associated with PTDM were lowered in recipients with the high TAC trough concentrations(>5 ng·mL^(-1))than those with low ones(im to PTDM.

关键词： Post-transplant diabetes mellitus Tacrolimus Metagenomics Metabolomics

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impact of satellite blood culture on early diagnosis of sepsis

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Journal of Intensive Medicine 2022年第1期2卷 56-60页

作者： Ziqi Guo Bo Guo Shanmei Wang Huifeng Zhang Wenxiao Zhang Bingyu Qin Huanzhang Shao department of Critical Care Medicine Henan University People’s HospitalZhengzhouHenan 455000China department of Critical Care Medicine Henan Provincial People’s HospitalZhengzhouHenan 455000China Henan Key Laboratory for Critical Care Medicine Henan Provincial People’s HospitalZhengzhouHenan 455000China department of Critical Care Medicine Zhengzhou University People’s HospitalZhengzhouHenan 455000China department of microbiology Laboratory Henan Provincial People’s HospitalZhengzhouHenan 455000China

Background:The aim of this study was to assess whether satellite blood culture(SBC)can improve turnaround times,antibiotic switching,and patient prognosis,relative to laboratory blood culture(LBC).Methods:Patients with sepsis treated in the intensive care units(ICUs)of Henan Provincial People’s Hospital from February 5,2018 to January 19,2019 who met the inclusion criteria were recruited to the study and divided into the SBC group and LBC group according to different blood culture *** demographics,blood culture,antibiotic adjustment,and prognosis data were collected and compared between the two ***:A total of 204 blood culture sets from 52 ICU patients,including 100 from the medical microbiology LBC group and 104 from the SBC group,were analyzed in this *** was no significant difference in the positive rates between the two *** from specimen collection to incubation was significantly shorter in the SBC group than that in the LBC group(1.65 h vs.3.51 h,z=−4.09,Pime from specimen collection to notification of blood culture positivity was 24.83 h in the SBC group and 27.83 h in the LBC *** times from adjustment of antibiotics according to the first report were 26.05 h and 51.71 h in the SBC and LBC groups,respectively,while those according to the final report were 97.17 h and 111.45 h,*** ICU lengths of stay were 15.00 days and 17.00 days in the SBC and LBC groups,respectively,and median ICU lengths of stay were 18.00 days and 23.50 days,*** hospitalization costs were 157.99 and 186.73 thousand yuan in the SBC and LBC groups,***:SBC can significantly reduce blood culture turnaround times;however,there were no significant differences between the two blood culture methods in initial reporting of positive cultures,time to adjustment of antibiotic therapy,or medical costs,despite a trend toward improvement.

关键词： Blood culture Sepsis Intensive care unit Antibiotic switching Turnaround time Gram stain

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The sero-epidemiology of infectious mononucleosis in Neyshabur,Northeast Iran during 2010-2014

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Journal of Coastal Life Medicine 2016年第10期4卷 809-812页

作者： Mohammahd Salehi Mahtab Vafaei Abdolmajid Ghasemian Seyyed Khalil Shokouhi Mostafavi Research Center for HIV/AIDS HTLV and Viral HepatitisIranian Academic Center for EducationCulture and ResearchKhorasan Razavi BranchMashhadIran Medical Diagnostic Laboratory of Neyshabur Center of MedicalPathological and Genetic Diagnostic ServicesIranian Academic Center for EducationCulture and ResearchMashhad BranchMashhadIran department of Virology Laboratory Sciences Keyvan Virology LaboratoryTehranIran department of microbiology Tehran Medical Sciences BranchIslamic Azad UniversityTehranIran

Objective:To detect infectious mononucleosis(im)prevalence in Neyshabur,Northeast Iran during ***:This cross-sectional descriptive epidemiological survey was performed to reveal the prevalence of im in Neyshabur between 2010 and 2014.A total of 114 individuals were ***,individuals with positive test for specific immunoglobulin G and immunoglobulin M in the agglutination test were determined as positive ***:The overall prevalence of im was 14%.Mean±SD of age for im test was 18.96±*** age groups of 0-10 and 21-30 were the most positive cases in this *** addition,31-40 and over 50 years were not positive *** individuals were significantly more positive and likewise,it was observed that there were significantly higher positive cases of im in spring and ***:Among the five years of this study,it was a decreasing status from 2010(23.1%)to 2014(9.1%),though a slight fluctuation had *** prevalence of im was low in Neyshabur ***,children and male individuals had relatively higher prevalence of the ***,it was observed a higher rate of im in spring and summer.

关键词： Epstein-Barr virus Infectious mononucleosis Neyshabur City Iran

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Qinghai-tibetan plateau peatland sustainable utilization under anthropogenic disturbances and climate change

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Ecosystem Health and Sustainability 2017年第3期3卷 28-38页

作者： Gang Yang Changhui Peng Huai Chen Faqin Dong Ning Wu Yanzheng Yang Yao Zhang Dan Zhu Yixin He Shengwei Shi Xiaoyang Zeng Tingting Xi Qingxiang Meng Qiuan Zhu State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau Northwest A&F UniversityYangling712100 China School of Life Science and Engineering Southwest University of Science and TechnologyMianyang621010 China department of Biological Sciences Institute of Environmental SciencesUniversity of Quebec at MontrealMontrealQuebec C3H 3P8 Canada CAS Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization&Ecological Restoration Biodiversity Conservation Key Laboratory of Sichuan ProvinceChengdu Institute of BiologyChinese Academy of SciencesChengdu610041 China Zoige Peatland and Global Change Research Station Chengdu Institute of BiologyChinese Academy of SciencesHong yuan624400 China Key Laboratory of Solid Waste Treatment and Resource Recycle Ministry of EducationSouthwest University of Science and TechnologyMianyang621010 China department of microbiology and Plant Biology Center for Spatial AnalysisUniversity of OklahomaNormanOklahoma 73019 USA department of Landscape Architecture Sichuan College of Architectural TechnologyDeyang61800 China College of Economics Heilongjiang Institute of TechnologyHarbinHeilongjiang 150050 China College of Resources and Environmental Science Henan Agricultural UniversityZhengzhouHenan 450002 China

Often referred to as the“Third Pole,”China’s Qinghai-Tibetan Plateau developed large amounts of peatland owing to its unique alpine *** a renewable resource,peat helps to regulate the climate as well as performing other important ***,in recent years,intensifying climate change and anthropogenic disturbances have resulted in peatland degradation and consequently made sustainable development of peatland more *** review summarizes peatland ecological and economic functions,including carbon sequestration,biodiversity conservation,energy supplies,and *** identifies climate change and anthropogenic disturbances as the two key factors attributing to peatland degradation and ecosystem carbon *** problems in environmental degradation and future challenges in peatland management under the effects of global warming are also discussed and highlighted.

关键词： climate change mitigation peatland management renewable resource sustainable development

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