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Matrix from urine stem cells boosts tissue-specific stem cell mediated functional cartilage reconstruction

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Bioactive Materials 2023年第5期23卷 353-367页

作者： Ming Pei Yixuan Amy Pei Sheng Zhou Elmira Mikaeiliagah Christopher Erickson Benjamin Giertych Halima Akhter Lei Wang Amanda Stewart Joshua Parenti Bin Wang Sijin Wen Sotcheadt Sim Eric Quenneville Kirk C.Hansen Steven Frisch Gangqing Hu Stem Cell and Tissue Engineering Laboratory Department of OrthopaedicsWest Virginia UniversityMorgantownWVUSA WVU Cancer Institute Robert C.Byrd Health Sciences CenterWest Virginia UniversityMorgantownWVUSA Perelman School of medicine University of PennsylvaniaPhiladelphiaPAUSA department of Biology Ardabil BranchIslamic Azad UniversityArdabilIran department of Biochemistry&Molecular Genetics University of Colorado DenverAuroraCOUSA department of Microbiology Immunologyand Cell BiologyWest Virginia UniversityMorgantownWVUSA department of Foot and Hand Surgery Clinical Medical College of Yangzhou UniversitySubei People’s Hospital of Jiangsu ProvinceYangzhouJiangsuChina department of Biostatistics School of Public HealthWest Virginia UniversityMorgantownWVUSA Biomomentum Inc. LavalQuebecCanada department of Biochemistry West Virginia UniversityMorgantownWVUSA Bioinformatics core West Virginia UniversityMorgantownWVUSA

Articular cartilage has a limited capacity to self-heal once ***-specific stem cells are a solution for cartilage regeneration;however,ex vivo expansion resulting in cell senescence remains a challenge as a large quantity of high-quality tissue-specific stem cells are needed for cartilage *** previous report demonstrated that decellularized extracellular matrix(dECM)deposited by human synovium-derived stem cells(SDSCs),adipose-derived stem cells(ADSCs),urine-derived stem cells(UDSCs),or dermal fibroblasts(DFs)provided an ex vivo solution to rejuvenate human SDSCs in proliferation and chondrogenic potential,particularly for dECM deposited by *** make the cell-derived dECM(C-dECM)approach applicable clinically,in this study,we evaluated ex vivo rejuvenation of rabbit infrapatellar fat pad-derived stem cells(IPFSCs),an easily accessible alternative for SDSCs,by the abovementioned C-dECMs,in vivo application for functional cartilage repair in a rabbit osteochondral defect model,and potential cellular and molecular mechanisms underlying this *** found that C-dECM rejuvenation promoted rabbit IPFSCs’cartilage engineering and functional regeneration in both ex vivo and in vivo models,particularly for the dECM deposited by UDSCs,which was further confirmed by proteomics ***-Seq analysis indicated that both mesenchymal-epithelial transition(MET)and inflammation-mediated macrophage activation and polarization are potentially involved in the C-dECM-mediated promotion of IPFSCs’chondrogenic capacity,which needs further investigation.

关键词： Decellularized extracellular matrix Tissue-specific stem cell Urine-derived stem cell Rejuvenation Functional cartilage repair

Confounders in Adenoma Detection at Initial Screening Colonoscopy: A Factor in the Assessment of Racial Disparities as a Risk for Colon Cancer

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Journal of Cancer Therapy 2019年第4期10卷 269-289页

作者： Yakira David Lorenzo Ottaviano Jihye Park Sadat Iqbal Michelle Likhtshteyn Samir Kumar Helen Lyo Ayanna E. Lewis Brandon E. Lung Jesse T. Frye Li Huang Ellen Li Jie Yang Laura Martello Shivakumar Vignesh Joshua D. Miller Michele Follen Evan B. Grossman department of medicine SUNY Downstate Medical Center Brooklyn NY USA department of Gastroenterology Icahn School of Medicine at Mount Sinai New York City NY USA department of medicine Stony Brook University Stony Brook NY USA department of Applied Mathematics and statistics Stony Brook University Stony Brook NY USA department of Family Population and Preventive Medicine Stony Brook University Stony Brook NY USA department of Obstetrics and Gynecology NYC HNC/Kings County Brooklyn NY USA department of medicine Division of Gastroenterology NYC Health and Hospitals/Kings County Brooklyn NY USA

Background and Aims: The incidence and mortality of colorectal cancer is persistently highest in Black/African-Americans in the United States. While access to care, barriers to screening, and poverty might explain these findings, there in increased interest in examining biological factors that impact the colonic environment. Our group is examining biologic factors that contribute to disparities in development of adenomas prospectively. In preparation for this and to characterize a potential patient population, we conducted a retrospective review of initial screening colonoscopies in a cohort of patients. Methods: A retrospective review was performed on initial average risk screening colonoscopies on patients (age 45 - 75 years) during 2012 at three institutions. Descriptive statistics and multivariable logistic regression models were used to examine the relationship between potential risk factors and the detection of adenomas. Results: Of the 2225 initial screening colonoscopies 1495 (67.2%) were performed on Black/African-Americans and 566 (25.4%) on Caucasians. Multivariable logistic regression revealed that older age, male sex, current smoking and teaching gastroenterologists were associated with higher detection of adenomas and these were less prevalent among Black/African-Americas except for age. Neither race, ethnicity, BMI, diabetes mellitus, HIV nor insurance was associated with adenoma detection. Conclusion: In this sample, there was no association between race and adenoma detection. While this may be due to a lower prevalence of risk factors for adenomas in this sample, our findings were confounded by a lower detection rate by consultant gastroenterologists at one institution. The study allowed us to rectify the problem and characterize patients for future trials.

关键词： Colorectal Cancer Screening Adenoma Quality

Arithmetic Operations of Generalized Trapezoidal Picture Fuzzy Numbers by Vertex Method

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American Journal of Computational Mathematics 2023年第1期13卷 99-121页

作者： Mohammad Kamrul Hasan Abeda Sultana Nirmal Kanti Mitra department of Mathematics Jahangirnagar University Savar Bangladesh department of Mathematics and statistics Bangladesh University of Business and Technology Dhaka Bangladesh

In this article, we define the arithmetic operations of generalized trapezoidal picture fuzzy numbers by vertex method which is assembled on a combination of the (α, γ, β)-cut concept and standard interval analysis. Various related properties are explored. Finally, some computations of picture fuzzy functions over generalized picture fuzzy variables are illustrated by using our proposed technique.

关键词： Picture Fuzzy Set Generalized Trapezoidal Picture Fuzzy Number (α γ β)-Cut Arithmetic Operations Vertex Method

Experimental study on performance of spring damping support structure system for large deformation tunnel in soft rock

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Underground Space 2024年第2期15卷 221-243页

作者： Jinfeng Xu Xiongyao Xie Zhou Shi Wuqiang Cai Dinglun Xu Chen Xu department of Geotechnical Engineering College of Civil EngineeringTongji UniversityShanghai 200092China Key Laboratory of Geotechnical and Underground Engineering Ministry of EducationTongji UniversityShanghai 200092China Zhaotong City Zhaolu Expressway Investment and Development Co. ZhaotongYunnan Province 657000China Institute of Rock Mechanics Ningbo UniversityNingboZhejiang 315211China

According to the convergence confinement theory,it is an effective measure to control the large deformation of high ground stress in fractured soft rock tunnels by using yielding *** yielding support can be classified as either radial or circumferential yielding *** yielding support is achieved by transforming radial displacement into circumferential tangential closure without compromising the support capacity of the primary lining support *** on this,and inspired by the design principle of dampers,a yielding support structure system with spring damping elements as its core was developed,based on the connection characteristics of steel arches in highway tunnel,which can provide increasing support resistance in the yielding deformation *** the mechanical properties of spring damping elements were obtained through indoor axial pressure and flexural *** addition,according to these results with numerical calculations,the yielding support structure system with embedded spring damping elements can reduce the internal force of the support structure by approximately 10%and increase the area of the plastic zone of the surrounding rock by 11.23%,which can fully utilize the self-bearing capacity of surrounding rock and verify the effectiveness of circumferential yielding ***,the spring damping support structure system was designed with reference to the construction process of the tunnel excavated by drilling and blasting method,and the transformation of the spring damping element to spring damping support structure was *** on field test results,surrounding ground pressure for the yielding support optimization scheme was reduced by 40%and more evenly distributed,resulting in the successful application and a reduction in the construction cost of large deformation tunnels in soft rock.

关键词： Soft rock Highway tunnel Convergence confinement method Circumferential yielding support with spring damping element Numerical calculations Field test

Helicobacter pylori plays a key role in gastric adenocarcinoma induced by spasmolytic polypeptide-expressing metaplasia

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World Journal of Clinical Cases 2023年第16期11卷 3714-3724页

作者： Mian-Li Li Xin-Xin Hong Wei-Jian Zhang Yi-Zhong Liang Tian-Tian Cai Yi-Fei Xu Hua-Feng Pan Jian-Yuan Kang Shao-Ju Guo Hai-Wen Li department of Gastroenterology Shenzhen Hospital of IntegratedTraditional Chinese and Western MedicineShenzhen 518033Guangdong ProvinceChina department of Gastroenterology Shenzhen Traditional Chinese Medicine HospitalShenzhen 518033Guangdong ProvinceChina Science and Technology Innovation Center Guangzhou University of Traditional Chinese MedicineGuangzhou 510405Guangdong ProvinceChina

Heliobacter pylori(H. pylori), a group 1 human gastric carcinogen, is significantly associated with chronic gastritis, gastric mucosal atrophy, and gastric *** 20% of patients infected with H. pylori develop precancerous lesions, among which metaplasia is the most critical. Except for intestinal metaplasia(IM), which is characterized by goblet cells appearing in the stomach glands, one type of mucous cell metaplasia, spasmolytic polypeptide-expressing metaplasia(SPEM), has attracted much attention. Epidemiological and clinicopathological studies suggest that SPEM may be more strongly linked to gastric adenocarcinoma than IM. SPEM, characterized by abnormal expression of trefoil factor 2, mucin 6, and Griffonia simplicifolia lectin II in the deep glands of the stomach, is caused by acute injury or inflammation. Although it is generally believed that the loss of parietal cells alone is a sufficient and direct cause of SPEM, further in-depth studies have revealed the critical role of *** is controversy regarding whether SPEM cells originate from the transdifferentiation of mature chief cells or professional progenitors. SPEM plays a functional role in the repair of gastric epithelial injury. However, chronic inflammation and immune responses caused by H. pylori infection can induce further progression of SPEM to IM, dysplasia, and adenocarcinoma. SPEM cells upregulate the expression of whey acidic protein 4-disulfide core domain protein 2 and CD44 variant 9, which recruit M2 macrophages to the wound. Studies have revealed that interleukin-33, the most significantly upregulated cytokine in macrophages, promotes SPEM toward more advanced metaplasia. Overall, more effort is needed to reveal the specific mechanism of SPEM malignant progression driven by *** infection.

关键词： Gastric cancers Helicobacter pylori Intestinal metaplasia Macrophages Spasmolytic polypeptide-expressing metaplasia

Improvements of Traditional Laser Fraunhofer Diffraction Experiment Using Digital Image Processing Method

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Journal of Donghua University(English Edition) 2020年第5期37卷 406-410页

作者： JIN Yuanwei WANG Yabing ZHAO Bin YI Zhaoguang XU Shenghui department of Mathematics and Physics Nanjing Institute of TechnologyNanjing 211167China School of Mathematics and statistics Institute of Space WeatherNanjing University of Information Science and TechnologyNanjing 210044China

We present an improved digital image processing(DIP)method to calculate the widths of single *** from the traditional laser Fraunhofer diffraction experiment in college physical experiments,by performing fast Fourier transform,inverse fast Fourier transform and the nonlinear leastsquare fitting on the diffraction pattern taken by a camera,the DIP method can quickly return an analytic expression,whose period is used to calculate widths of single *** comparing the measured results by the DIP method and the successional difference(SD)method,we find that for a single slit whose width is 60372μm,the DIP method is more *** results show that for single slits with widths between 40μm and 160μm,the relative error of the DIP method is less than 2.78%.Also,the DIP method can be used to measure the diameter of filament and fibres online in real time.

关键词： digital image processing method traditional laser Fraunhofer diffraction experiment width of single slit

Influenza Viral Membrane Deformation Due to Refolding of HA-Protein:Two-dimensional Model and Analysis

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Advances in Applied Mathematics and Mechanics 2010年第2期2卷 160-182页

作者： Naveen K.Vaidya Huaxiong Huang Theoretical Biology and Biophysics Group MS K710Los Alamos National LaboratoryLos AlamosNM 87545USA department of Mathematics and statistics York UniversityTorontoM3J 1P3Canada

In this paper we study influenza viral membrane deformation related to the refolding of Hemagglutinin(HA)*** focus of the paper is to understand membrane deformation and budding due to experimentally observed linear HA-protein clusters,which have not been mathematically studied *** viral membrane is modeled as a two dimensional incompressible lipid bilayer with bending *** tensionless membranes,we derive an analytical solution while for membrane under tension we solve the problem *** solution for tensionless membranes shows that the height of membrane deformation increases monotonically with the bending moment exerted by HA-proteins and attains its maximum when the size of the protein cluster reaches a critical *** results also show that the hypothesis of dimple formation proposed in the literature is valid in the two dimensional *** comparative study of axisymmetric HA-clusters and linear HA-clusters reveals that the linear HA-clusters are not favorable to provide a sufficient energy required to overcome an energy barrier for a successful fusion,despite their capability to cause membrane deformation and budding.

关键词： Hemagglutinin protein Influenza virus Membrane deformation Membrane fusion

Homotopic mapping solitary traveling wave solutions for the disturbed BKK mechanism physical model

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Chinese Physics B 2014年第9期23卷 54-59页

作者：周先春石兰芳韩祥临莫嘉琪 College of Electronic and Information Engineering Nanjing University of Information Science and Technology Jiangsu Technology and Engineering Center for Meteorological Sensor Network Nanjing University of Information Science and Technology Jiangsu Key Laboratory of Meteorological Observation and Information Processing Nanjing University of Information Science and Technology College of Mathematics and statistics Nanjing University of information Science and Technology department of Mathematics Huzhou Teachers College department of Mathematics Anhui Normal University

Using the trial equation method, a Broer-Kau-Kupershmidt （BKK） mechanism physical model is obtained, and the exact and approximate solitary traveling wave solutions are found. As an example, it is pointed out that t... 详细信息

关键词： nonlinear solitary traveling wave

Slowing down critical transitions via Gaussian white noise and periodic force

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Science China(Technological Sciences) 2019年第12期62卷 2144-2152页

作者： MA JinZhong XU Yong XU Wei LI YongGe KURTHS Jirge department of Applied Mathematics Northwestern Polytechnical UniversityXi'an 710072China MIIT Key Laboratory of Dynamics and Control of Complex Systems Northwestern Polytechnical UniversiyXi'an 710072China Center for Mathematical Sciences&School of Mathematics and statistics Huazhong University of Science and TechmologyWuhan 430074China Potsdam Institute for Climate Impact Research Potsdam 14412Germany department of Physics Humboldt UniversityBerlin 12489Germany

Stochastic perturbations and periodic excitations are generally regarded as sources to induce critical transitions in complex systems. However, we find that they are also able to slow down an imminent critical transition. To illustrate this phenomenon, a periodically driven bistable eutrophication model with Gaussian white noise is introduced as a prototype class of real *** residence probability(RP) is presented to measure the possibility that the given system stays in the oligotrophic state versus Gaussian white noise and periodic force. Variations in the mean first passage time(MFPT) and the mean velocity(MV) of the first right-crossing process are also calculated respectively. We show that the frequency of the periodic force can increase the MFPT while reduce the MV under different control parameters. Nevertheless, the noise intensity or the amplitude may result in an increase of the RP only in the case of control parameters approaching the critical values. Furthermore, for an impending critical transition, an increase of the RP appears with the interaction between the amplitude and noise intensity or the combination of the noise intensity and frequency, while the interaction of the frequency and amplitude leads to an extension of the MFPT or a decrease of the MV. As a result, an increase of the RP and MFPT, and a decrease of the MVobtained from our results claim that it is possible to slow down an imminent critical transition via Gaussian white noise and periodic force.

关键词： critical transition slowing down bistable eutrophication model Gaussian white noise periodic force residence probability mean first passage time mean velocity