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小灶性肝细胞癌皮下乙醇注射:基于20年观察的治疗效应

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世界核心医学期刊文摘（胃肠病学分册） 2006年第1期2卷 55-55页

作者： Ebara M. Okabe S. Kita K. 王志宇 department of Medicine and Clinical Oncology Graduate School of Medicine Chiba University 1-8-1 Inohana Chuo-ku Chiba-shi Chiba 260-8670 Japan

Background/Aims: To evaluate the therapeutic efficacy of percutaneous ethanol injection (PEI) for patients with ≤ 3 lesions of small (≤ 3 cm diameter) hepatocellular carcinoma (HCC). Methods: PEI was applied to 270 patients with small HCC as the first-line treatment option during a 20-year period. Results: (1) There was no treatment-related deaths, and only 2.2% of severe complications; (2) PEI induced a complete response of all HCCs according to CT evaluation performed within one month after the procedure, and the local recurrence rate at 3 years was 10% ; (3) the overall 3-and 5-year survival rates after treatment were 81.6 and 60.3% , respectively, but the rates were higher, 87.3 and 78.3% , in Child A patients with a solitary tumor ≤ 2 cm in diameter; (4) factors significantly influencing survival were liver function (P=0.0033) and serum alpha-fetoprotein level (P=0.0014), and (5) the recurrence rate at remote sites in the liver was lower in patients with HCC ≤ 2 cm(P=0.0395) and in those with a solitary HCC (Psmall HCC in terms of safety and efficacy.

关键词：肝细胞癌小灶性治疗效应局部复发率射频消融患者存活率

计算机辅助联合吲哚菁绿分子荧光影像技术在肝脏肿瘤诊断和手术导航中的应用指南（2019版）（英文）

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南方医科大学学报 2019年第10期39卷 1127-1140页

作者：无方驰华 LU Qiping LAU Wanyee 中华医学会数字医学分会中国研究型医院学会数字智能化专业委员会中国医师协会肝癌专业委员会中国医师协会临床精准医学专业委员会中国图学学会医学图像与设备专业委员会中国生物物理学会分子影像学专业委员会南方医科大学珠江医院肝胆一科广东省数字医学临床工程技术研究中心 department of General Surgery General Hospital of Central Theater Command Faculty of Medicine The Chinese University of Hong Kong

计算机辅助联合吲哚菁绿分子荧光影像技术可以从三维的形态解剖和细胞功能水平进行术前规划和术中侦测,从而导航肝癌解剖性、功能性、根治性的肝切除术,临床应用证明其有重要的诊疗价值,此项技术现已在全国得到了广泛推广和应用。为规... 详细信息

计算机辅助联合吲哚菁绿分子荧光影像技术可以从三维的形态解剖和细胞功能水平进行术前规划和术中侦测,从而导航肝癌解剖性、功能性、根治性的肝切除术,临床应用证明其有重要的诊疗价值,此项技术现已在全国得到了广泛推广和应用。为规范计算机辅助联合吲哚菁绿分子荧光影像技术在肝脏肿瘤精准诊疗中的应用,本指南在以下几个方面进行了研究:(1)三维可视化技术应用流程;(2)ICG分子荧光成像的机制及应用流程;(3)三维可视化和虚拟现实技术的临床应用;(4)ICG分子荧光影像技术的临床应用。ICG分子荧光成像技术能从分子、细胞水平层面实现肿瘤边界界定、肝段和肝叶切除切线的确定;微小病灶或转移灶的侦测;术中根据肝脏肿瘤的荧光信号特点,结合术中快速冰冻病理学检查,可初步判定肝脏占位性病变的分化程度;肝切除后对肝断面进行残留肿瘤病灶和胆漏的检测。计算机辅助联合ICG分子荧光影像技术在肝脏肿瘤诊断和手术导航中的应用,为肝脏肿瘤的外科治疗提供了一种新的数字智能化外科诊疗技术,该项技术亦将不断改进和完善,为肝脏肿瘤的精准诊疗展现出良好的应用前景。

关键词：吲哚菁绿荧光影像三维可视化肝脏肿瘤导航手术

Characterizing Poroelasticity of Biological Tissues by Spherical Indentation: An Improved Theory for Large Relaxation

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医用生物力学 2019年第A1期34卷 167-167页

作者： Ming Wang Shaobao Liu Zhimin Xu Kai Qu Moxiao Li Xin Chen Qing Xue Guy MGenin Tian Jianlu Feng Xu The Key Laboratory of Biomedical Information Engineering of Ministry of Education School of Life Science and TechnologyXi'an Jiaotong UniversityXi’an710049China Bioinspired Engineering&Biomechanics Center(BEBC) Xi'an Jiaotong UniversityXi'an710049China State Key Laboratory of Mechanics and Control of MechanicalStructures Nanjing University of Aeronautics and AstronauticsNanjing210016China State Key Laboratory forStrength and Vibration of Mechanical Structures School of AerospaceXi'an Jiaotong UniversityXi'an710049China department of Hepatobiliary Surgery The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an710061China National Science Foundation Science and Technology Center for Engineering Mechanobiology Washington UniversitySt.LouisMO63130USA

Flow of fluids within biological tissues often meets with resistance that causes a rate-and size-dependent material behavior known as *** poroelasticity can provide insight into a broad range of physiological functions,and is done qualitatively in the clinic by *** has been widely used for characterizing poroelasticity of soft materials,where quantitative interpretation of indentation requires a model of the underlying physics,and such existingmodels are well established for cases of small strain and modest force relaxationWe showed here that existing models are inadequate for large relaxation,where the force on the indenter at a prescribed depth at long-time scale drops to below half of the initially peak *** developed an indentation theory for such cases of large relaxation,based upon Biot theory and a generalized Hertz contact *** demonstrated that proposed theory is suitable for biological tissues(e.g.,spleen,kidney,skin and human cirrhosis liver)with both small and large *** proposed method would be a powerful tool to characterize poroelastic properties of biological materials for various applications such as pathological study and disease diagnosis.

关键词： mechanical characterization porous biomaterials shear modulus Poisson ratio diffusion coefficient

Face the Challenge of Organ Donation

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器官移植内科学杂志 2013年第4期8卷 117-123页

作者： Weiguo Sui Can Zheng Ming Yang Yong Dai Nephrology department of Guilin 181st Hospital Guangxi Key laboratory of Metabolic Diseases Research Guilin 541002 Guangxi China College of Life Science Guangxi Normal University Guilin 541004 Guangxi China Clinical Medical Research Center the Second Clinical Medical College of Jinan University (Shenzhen People's Hospital) Shenzhen 518020 Guangdong China.

Chinese experience in organ transplants began in late 1950s and today it is ranked second in the world in total organ transplantation after USA. In some key aspects such as liver transplantation, hmg transplantation and kidney transplantation, China has entered the ranks of international developed countries. The rapid development of medical science and facilities, the improvement of clinical skills and care to organ recipients significantly enhanced their survival time and chance. In China, the longest survival time of lung transplant recipients was 8 years, of liver transplant recipients was 13 years, and of kidney transplant recipients has reached 30 years,t31 60% or more patients after kidney transplantation will survive in the first 10 years, There is an increasing number of national and international academic exchanges about Chinese organ transplant work. However, at meantime, China has been one of the countries which are severely short of the organ donors.

关键词：器官移植肾移植生存时间存活时间学术交流肝移植中国 HMG

liver transplantation from Donation after Cardiac Death

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器官移植内科学杂志 2014年第1期9卷 85-96页

作者： Weiguo Sui Xianliang Hou Wenti Che Jiejing Chen Can Zheng Yong Dai Nephrology department of Guilin 181st Hospital Guangxi Key laboratory of Metabolic Diseases Research541002 Guilin Guangxi China College of Life Science Guangxi Normal University 541004 Guilin Guangxi China Clinical medical research center the Second Clinical Medical College of Jinan University (Shenzhen People'sHospital) Shenzhen Guangdong 518020 R.P. China

Because of ongoing advances in transplant immunology and surgical techniques, organ transplantation has become the preferred modality for the treatment of organ failure and has led to improved survival, decreased morbidity, significantly improvement to quality of life and reduced healthcare costs. This success has resulted in more patients being listed for transplantation out of proportion to the number of available organs. In the search to reduce the growing shortage of liver allografts, donation after cardiac death (DCD) livers are increasingly used as an alternative source to the standard donation after brain death (DBD) livers. The use of livers from DCD donors is not a new idea.

关键词：移植免疫学死亡心脏肝脏器官功能器官移植生活质量生存率

人免疫缺陷病毒感染孕妇奈韦拉平毒性的队列研究

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世界核心医学期刊文摘（妇产科学分册） 2006年第4期2卷 13-13页

作者： Joāo E.C. Calvet G.A. Menezes J.A. 李奎 Infectious Diseases department Hospital Dos Servidores Do Estado R. Sacadura Cabral 178-Saude 5 Andar DIP Rio de Janeiro RJ 20221903 Brazil Dr.

Objective: The purpose of this study was to complete an evaluation of nevirapine (NVP) toxicity in a cohort of HIV+pregnant women. Study design: This was a retrospective study of 611 women followed from January 1996 to December 2003. All women who used NVP for > 7 days were included. Multivariate logistic regression was used to test independent association of CD4 and hepatitis C virus (HCV) infection related to the outcome of toxic effects of NVP. Results: One hundred ninety seven women were exposed to NVP for > 7 days, and toxicity occurred in 11 (5.6%), leading to drug discontinuation in 7 patients. One case of Stevens-Johnson syndrome occurred. No serious liver toxicity occurred except for 1 grade 4 cholestasis. Median CD4 was 344 in women without toxicities and 298 in women with toxicities. HCV was the only significant factor associated to toxicity by logistic regression (odds ratio [OR] 15.61, P = .001). Conclusion: NVP toxicities occurred in a very small fraction of patients and were not associated with fatalities.

关键词：人免疫缺陷病毒奈韦拉平感染孕妇队列研究肝炎病毒毒效 Stevens 胆汁淤积研究设计死

胆管闭锁:755例肝移植患儿的临床特点、危险因素以及预后情况

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世界核心医学期刊文摘（儿科学分册） 2006年第1期2卷 27-27页

作者： Utterson E.C. Shepherd R.W. Sokol R.J. 王一飞 department of Pediatrics Washington University School of Medicine St. Louis Children's Ho spital One Children's Place St. Louis MO 63110 United States Dr.

Objectives: To test the hypothesis that risk analysis from the time of listing for liver transplantation (LT) focuses attention on areas where outcomes can be improved. Study design: Competing outcomes and multivariate models were used to determine significant risk factors for pretransplantation and posttransplantati on mortality and graft failure in patients with biliary atresia (BA) listed for LT and enrolled in the Studies of Pediatric liver transplantation (SPLIT) regist ry. Results: Of 755 patients, most were infants (age liver disease (PELD) score ≥20, whose components were also continuous risk factors. S urvival posttransplantation (n = 567) was 88%at 3 years. Most deaths were from infection (37%). Posttransplantation mortality risk factors included infant rec ipients, height/weight transplantation. Graft failure risks included height/weight < -2 SD, cadaveric partial donors,donor age ≤5 months, use of cyclosporine vers us tacrolimus, and rejection. Conclusions: Referral for LT should be anticipator y for infants with BA with failed portoenterostomies. Failing nutrition should p rompt aggressive support. Post-LT risk factors are mainly nonsurgical, includin g nutrition, the relative risk of infection over rejection, and the choice of im munosuppression.

关键词：胆管闭锁肝移植捐赠器官肝门肠吻合术儿童肝脏移植晚期肝病再次移植环孢素婴儿期多变量模

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1例血友病甲原位肝移植者的凝血研究

Oncology and Translational Medicine 1994年第3期11卷 173-173页

作者： Th.Eller R.S.Ross L.Volbracht H.Herfahrt J.Erhard R.Scherer F.W.Eigler D.Paar 向直富 Division of Clinical Chemistry and Laboratory Diagnostics department of Internal Medicine University of Essen Hufelandstr.55 D-45122 Essen Germany 同济医科大学附属同济医院

1例39岁重型血友病甲(Ⅷ:C 1.0%)伴继发慢性进行性丙型肝炎的肝硬化,为治疗其肝硬化和先天性凝血病,进行原位肝移植术。移植前,发现血浆中肝脏合成的凝血因子减少、血小板数降低、血浆von Willebrand 因子(vWf)浓度和瑞斯托霉素辅因子... 详细信息

1例39岁重型血友病甲(Ⅷ:C 1.0%)伴继发慢性进行性丙型肝炎的肝硬化,为治疗其肝硬化和先天性凝血病,进行原位肝移植术。移植前,发现血浆中肝脏合成的凝血因子减少、血小板数降低、血浆von Willebrand 因子(vWf)浓度和瑞斯托霉素辅因子活性增高。血小板中测不出 vWf。血浆 vWf 多聚体结构异常。术前、术中和术后,患者共接受1.3×10～4UⅧ因

关键词：血友病甲肝脏血浆多聚体凝血凝血功能障碍