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Contrast-enhanced guided endoscopic ultrasound procedures

World Journal of Gastroenterology 2024年第17期30卷 2311-2320页

作者： Marcel Ioan Gheorghiu Andrada Seicean Cristina Pojoga Claudia Hagiu Radu Seicean Zeno Sparchez department of Gastroenterology “Prof.Dr.Octavian Fodor”Regional Institute of Gastroenterology and Hepatology"Iuliu Hatieganu"University of Medicine and PharmacyCluj-Napoca 400162ClujRomania department of Clinical Psychology and Psychotherapy International Institute for Advanced Study of Psychotherapy and Applied Mental HealthBabeș-Bolyai UniversityCluj-Napoca 400375ClujRomania The First Surgical Clinic "Iuliu Hatieganu"University of Medicine and PharmacyCluj Napoca 400006ClujRomania

Contrast-enhanced endoscopic ultrasound(CH-EUS)can overcome the limi-tations of endoscopic ultrasound-guided acquisition by identifying microvessels inside inhomogeneous tumours and improving the characterization of these *** the initial enthusiasm that oriented needle sampling under CH-EUS guidance could provide better diagnostic yield in pancreatic solid lesions,further studies did not confirm the supplementary values in cases of tissue acquisition guided by *** review details the knowledge based on the available data on contrast-guided *** indications for CH-EUS tissue acquisition include isoechoic EUS lesions with poor visible delineation where CH-EUS can differentiate the lesion vascularisation from the surrounding parenchyma and also the mural nodules within biliopancreatic cystic lesions,which occur in select ***,the roles of CH-EUS-guided therapy in patients whose pancreatic fluid collections or bile ducts that have an echogenic content have indications for drainage,and patients who have nonvisualized vessels that need to be highlighted via Doppler EUS are *** indication is represented if there is a need for an immediate assessment of the post-radiofrequency ablation of pancreatic neuroendocrine tumours,in which case CH-EUS can be used to reveal the incomplete tumour destruction.

关键词： Endosonography Contrast-enhanced endoscopic ultrasound Tissue acquisition Fine needle aspiration Fine needle biopsy Drainage Pancreatic fluid collections Biopsy Pancreas

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Role of knowledge economy in managing demand-based environmental Kuznets Curve

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Geoscience Frontiers 2024年第4期15卷 397-410页

作者： Rukhsana Kalim Shajara Ul-Durar Mubasher Iqbal Noman Arshed Muhammad Shahbaz department of Economics and Statistics Dr.Hassan Murad School of ManagementUniversity of Management and TechnologyLahorePakistan University of Sunderland The School of Business ManagementEdinburgh BuildingChester RoadSunderland SR13SDUnited Kingdom department of Economics Division of Management and Administrative SciencesUniversity of EducationLahorePakistan department of international Trade and Finance School of Management and EconomicsBeijing Institute of TechnologyBeijingChina Center for Sustainable Energy and Economic development Gulf University for Science and TechnologyHawallyKuwait

Aggregate demand or supply at equilibrium is commonly used as a representative of the macroeconomic activity of an economy whereby aggregate demand denotes the behaviour of individuals and ***,aggregate demand can also directly affect environmental deterioration via changes in aggregate *** study tried to explore this relationship,known as the demand-based Environmental Kuznets Curve(Demand EKC)and the role of different knowledge economy *** economy indicators are proposed to influence consumption patterns,altering the demand EKC that empirical studies have *** this purpose,secondary data for 147 countries were collected from 2008 to 2018,also classified as *** study found that aggregate demand significantly affects carbon *** long-run results are estimated using the Fully Modified Ordinary Least Square *** factors like renewable energy consumption,population density,and financial development significantly affect carbon emissions in sample *** study has incorporated four pillars of a knowledge-based economy and the results showed that these indicators helped reduce consumption-related CO_(2) emissions.

关键词： Kuznets Curve Knowledge economy Higher education Institutional quality Innovation Technology

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Investigation of HO_(2) uptake mechanisms onto multiple-component ambient aerosols collected in summer and winter time in Yokohama,Japan

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Journal of Environmental Sciences 2024年第3期137卷 18-29页

作者： Jun Zhou Yukiko Fukusaki Kentaro Murano Tania Gautam Yu Bai Yoshimi Inomata Hiroaki Komatsu Mayuko Takeda Bin Yuan Min Shao Yosuke Sakamoto Yoshizumi Kajii Institute for Environmental and Climate Research Jinan UniversityGuangzhou 511443China Guangdong-Hongkong-Macao Joint Laboratory of Collaborative Innovation forEnvironmental Quality Guangzhou 511443China Graduate School of Global Environmental studies Kyoto UniversityKyoto606-8501Japan Yokohama Environmental Science Research Institute Yokohama Kanagawa 221–0024Japan department of Chemistry University of AlbertaAlbertaEdmonton T6G 2G2Canada Graduate School of Human and Environmental studies Kyoto UniversityKyoto 606-8501Japan Kanagawa Environmental Research Center Kanagawa 254-0014Japan Center for regional Environmental Research National Institute for Environmental StudiesIbaraki305-8506Japan

The heterogeneous loss of HO_(2)radicals onto ambient aerosols plays an important role in tropospheric ***,sparse investigation of the dominating parameters controlling the HO_(2)uptake coefficients onto ambient aerosols(γHO_(2))has largely hindered the application of the measuredγHO_(2)to the global spatial *** we induced an offine method using LFP-LIF technique to measure the kinetics of HO_(2)uptake onto ambient aerosols collected in summertime and wintertime in Yokohama city,a regional urban site near Tokyo,*** controlling the dominating parameters which infuenceγHO_(2),we were able to investigate the detailed HO_(2)uptake *** characterized the chemical composition of the collected ambient aerosols,including organics,inorganics,transition metals ions,*** modeledγHO_(2)using different *** show thatγHO_(2)increased with the increase in RH,and the aerosol states(“dry”or wet/aqueous)have large effects onγHO_(2).With fixed RH and aerosol chemical composition,γHO_(2)was highly dependent on pH and inversely correlated with[HO_(2)]_*** combing the measuredγHO_(2)values with the modeled ones,we found that both the HO_(2)self-reaction and transition metal-catalyzed reactions should be accounted for to yield a single parameterization to predictγHO_(2),and different chemical compositions may have collective effects onγHO_(2).Results may serve for extending theγHO_(2)values measured at one observation site to different environmental conditions,which will help us to achieve more accurate modeling results concerning secondary pollutant formation(i.e.,ozone).

关键词： HO_(2)uptake kinetics Offine method Impacting factors Mechanism

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Recent advancement of sonogenetics:A promising noninvasive cellular manipulation by ultrasound

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Genes & Diseases 2024年第5期11卷 163-182页

作者： Jin Tang Mingxuan Feng Dong Wang Liang Zhang Ke Yang Pediatric Research Institute Children’s Hospital of Chongqing Medical UniversityNational Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChina International Science and Technology Cooperation Base of Child Development and Critical DisordersChongqing Engineering Research Center of Stem Cell TherapyChongqing 400014China department of Ultrasound The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Tongji Medical College Huazhong University of Science and TechnologyWuhanHubei 430074China

Recent advancements in biomedical research have underscored the importance of noninvasive cellular manipulation ***,a method that uses genetic engineering to produce ultrasound-sensitive proteins in target cells,is gaining prominence along with optogenetics,electrogenetics,and *** stimulation with ultrasound,these proteins trigger a cascade of cellular activities and *** traditional ultrasound modalities,sonogenetics offers enhanced spatial selectivity,improving precision and safety in disease *** technology broadens the scope of non-surgical interventions across a wide range of clinical research and therapeutic applications,including neuromodulation,oncologic treatments,stem cell therapy,and *** current literature predominantly emphasizes ultrasonic neuromodulation,this review offers a comprehensive exploration of *** discuss ultrasound properties,the specific ultrasound-sensitive proteins employed in sonogenetics,and the technique’s potential in managing conditions such as neurological disorders,cancer,and ophthalmic diseases,and in stem cell *** objective is to stimulate fresh perspectives for further research in this promising field.

关键词： Mechanosensitive channel Neuromodulation Sonogenetics Ultrasound Ultrasound-sensitive protein

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Lift system optimization for hover-capable flapping wing micro air vehicle

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Frontiers of Mechanical Engineering 2024年第3期19卷 61-75页

作者： Shengjie XIAO Yongqi SHI Zemin WANG Zhe NI Yuhang ZHENG Huichao DENG Xilun DING department of Mechanical Engineering and Automation Beihang UniversityBeijing 100191China department of Mechanical Engineering Tsinghua UniversityBeijing 100084China Shenzhen international Graduate School Tsinghua UniversityShenzhen 518055China

A key challenge is using bionic mechanisms to enhance aerodynamic performance of hover-capable flapping wing micro air vehicle(FWMAV).This paper presented a new lift system with high lift and aerodynamic efficiency,which use a hummingbird as a bionic *** new lift system is able to effectively utilize the high lift mechanism of hummingbirds,and this study innovatively utilizes elastic energy storage elements and installs them at the wing root to help improve aerodynamic performance.A flapping angle of 154°is achieved through the optimization of the flapping mechanism *** optimized wing shape and parameters are obtained through experimental studies on the ***,the max net lift generated is 17.6%of the flapping wing vehicle’s ***,energy is stored and released periodically during the flapping cycle,by imitating the musculoskeletal system at the wing roots of hummingbirds,thereby improving the energy utilization rate of the FWMAV and reducing power consumption by 4.5%under the same ***,strength verification and modal analyses are conducted on the flapping mechanism,and the weight of the flapping mechanism is reduced through the analysis and testing of different *** results show that the lift system can generate a stable lift of 31.98 g with a wingspan of 175 mm,while the lift system weighs only 10.5 g,providing aerodynamic conditions suitable for high maneuverability flight of FWMAVs.

关键词： lift optimization flapping wing elastic energy hovering flapping mechanism

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Jianpi Decoction Combined with Medroxyprogesterone Acetate Alleviates Cancer Cachexia and Prevents Muscle Atrophy by Directly Inhibiting E3 Ubiquitin Ligase

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Chinese Journal of Integrative Medicine 2024年第6期30卷 499-506页

作者： LI Qi KONG Zhao-di WANG Huan GU Hong-hui CHEN Zhong Li Shi-guang CHEN Yi-qi CAI Yu YANG Zhen-jiang department of Oncology and Hematology Shenzhen Traditional Chinese Medicine HospitalShenzhenGuangdong Province518033China College of Pharmacy/international Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug development of Ministry of Education(MOE)of China Jinan UniversityGuangzhou510632China Guangdong Key Lab of Traditional Chinese Medicine Information Technology Jinan UniversityGuangzhou510632China

ObjectiveTo provide comprehensive evidence for the anti-cancer cachexia effect of Jianpi Decoction(JP)and to explore its mechanism of anti-cancer *** mouse model of colon cancer(CT26)-induced cancer cachexia(CC)was used to investigate the anti-CC effect of JP combined with medroxyprogesterone acetate(MPA).Thirty-six mice were equally divided into 6 groups:normal control,CC,MPA(100 mg·kg^(−1)·d^(−1)),MPA+low-dose(20 mg·kg^(−1)·d^(−1))JP(L-JP),MPA+medium-dose(30 mg·kg^(−1)·d^(−1))JP(M-JP),and MPA+high-dose(40 mg·kg^(−1)·d^(−1))JP(H-JP)*** successful modeling,the mice were administered by gavage for 11 *** body weight and tumor volume were measured and recorded every 2 d starting on the 8th day after *** liver,heart,spleen,lung,kidney,tumor and gastrocnemius muscle of mice were collected and *** pathological changes of the tumor was observed,and the cross-sectional area of the gastrocnemius muscle was *** protein expressions of STAT3 and E3 ubiquitinase in the gastrocnemius muscle were measured by Western *** addition,an in vitro C2C12 myotube formation model was established to investigate the role of JP in hindering dexamethasone-induced muscle *** vitro experiments were divided into control,model,and JP serum *** 2-d administration,microscopic photographs were taken and myotube diameters were *** blot was performed to measure the protein expressions of STAT3 and E3 *** combined with MPA restored tumor-induced weight loss(P<0.05,***)and muscle fiber size(P<0.01,***).Mechanistically,JP reduced the expression of atrophy-related proteins MuRF1 and MAFbx in tumor-induced muscle atrophy in vivo(P<0.05,***).In addition,JP reduced the expression of atrophy-related proteins MuRF1 and MAFbx and p-STAT3 phosphorylation(P<0.05 or P<0.01 *** group)in C2C12 myotubes treated with dexamethasone in *** of JP combined with MPA restores t

关键词： cancer cachexia muscle atrophy Jianpi Decoction Chinese medicine E3 ubiquitin ligases

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Dilemma of total allowable catch(TACs)allocated as shareable quotas:Applying a bio-economic game-theoretical approach to euro-mauritanian fisheries agreements

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Aquaculture and Fisheries 2024年第4期9卷 674-681页

作者： Elimane Abou Kane Abou Cire Ball Patrice Brehmer IMROP Laboratory of Social and Economic Studies-Mauritanian Institute of Oceanographic Research and FisheriesNouadhibouBP 22Mauritania UREMCD MacroeconomicsGrowth and Development Research UnitFaculty of Legal and Economic SciencesUniversity of Nouakchott Al AasriyaNouakchottBP 880Mauritania IRD Univ BrestCNRSIfremerLemarISRACRODTDakar1386Senegal CSRP SRFCSub Regional Fisheries CommissionDakar25485Senegal

The recent fisheries management approach by Mauritania recommends that Total Allowable Catch(TAC)quotas,identified as essential for maintaining fish stocks,be shared(allocated)among fishing fleets operating in Mauritanian ***,the efficiency of such management regulations is *** issue can be identified as the typical dilemma between distant-fishing countries and coastal *** developed a theoretical model to determine how to allocate TAC quotas between the fishing fleets of Mauritania(RIM)and the European Union(EU).We discuss the various procedures and conditions for optimizing the allocation of fishing quotas(by country)in context of the Nash *** found that both equilibria are characterized by strategic interactions of the exploitation that influence both the supply of TAC quotas available on the market and the cost of externalities due to RIM’s dependence on financial compensation by the EU and available TAC quotas.

关键词： Fish war Quotas Nash equilibrium Game theory TAC Fisheries management

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Effect of ambient pressures on laser-induced breakdown spectroscopy signals

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Frontiers of physics 2024年第4期19卷 243-256页

作者： Kaifan Zhang Weiran Song Zongyu Hou Zhe Wang State Key Laboratory of Power System Operation and Control Tsinghua-Rio Tinto Joint Research Centre for ResourcesEnergy and Sustainable DevelopmentInternational Joint Laboratory on Low Carbon Clean Energy InnovationInstitute for Carbon NeutralityDepartment of Energy and Power EngineeringTsinghua UniversityBeijing 100084China Shanxi Research Institute for Clean Energy Tsinghua UniversityTaiyuan 030032China

Laser-induced breakdown spectroscopy(LIBS)is regarded as the future superstar for analytical chemistry and widely applied in various *** the quality of LIBS signal is fundamental to achieving accurate quantification and large-scale commercialization of *** propose control methods that improve LIBS signal quality,it is essential to have a comprehensive understanding of the influence of key parameters,such as ambient gas pressure,temperature,and sample temperature on LIBS *** date,extensive research has been carried ***,different researchers often yield significantly different experimental results for LIBS,preventing the formation of consistent *** greatly prevents the understanding of influencing laws of key parameters and the improvement of LIBS quantitative *** ambient gas pressure as an example,this paper compares the effects of ambient gas pressure under different optimization conditions,reveals the influence of spatiotemporal window caused by inherent characteristics of LIBS signal sources,i.e.,intense temporal changes and spatial non-uniformity of laser-induced plasmas,on the impact patterns of key *** the perspective of plasma spatiotemporal evolution,the paper elucidates the influence patterns of ambient gas pressure on LIBS signals,clarifying seemingly contradictory research results in the literature.

关键词： laser-induced breakdown spectroscopy spatiotemporal window pressure condition signal uncertainty plasma modulation

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Improvement of the nutritional support management system for patients in intensive care units

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World Journal of Psychiatry 2024年第1期14卷 44-52页

作者： Yuan-Yuan Zhang Chun-Yi Wang Dong-Xian Guo Hai-Nu Gao Xian-Shan Jin Yan-Li Wu Lu-Han Chen Zhi-Xian Feng department of Critical Care Medicine Shulan(Hangzhou)HospitalZhejiang Shuren University Shulan International Medical CollegeHangzhou 310022Zhejiang ProvinceChina department of Information Shulan(Hangzhou)HospitalZhejiang Shuren University Shulan International Medical CollegeHangzhou 310022Zhejiang ProvinceChina department of Pharmacy Shulan(Hangzhou)HospitalZhejiang Shuren University Shulan International Medical CollegeHangzhou 310022Zhejiang ProvinceChina department of Nutrition Shulan(Hangzhou)HospitalZhejiang Shuren University Shulan International Medical CollegeHangzhou 310022Zhejiang ProvinceChina Administrative Office Shulan(Hangzhou)HospitalZhejiang Shuren University Shulan International Medical CollegeHangzhou 310022Zhejiang ProvinceChina

BACKGROUND Nutritional support for patients hospitalized in the intensive care unit(ICU)is an important part of clinical treatment and care,but there are significant implementation *** To introduce a modified nutritional support management system for ICU patients based on closed-loop information management and psychological *** The division of functions,personnel training,system construction,development of an intelligent decision-making software system,quality control,and improvement of the whole process were carried out to systematically manage nutritional support for ICU *** Following the implementation of the whole process management system,the scores of ICU medical staff’s knowledge,attitudes/beliefs,and practices regarding nutritional support were comprehensively *** proportion of hospital bed-days of total enteral nutrition(EN)in ICU patients increased from 5.58%to 11.46%,and the proportion of EN plus parenteral nutrition increased from 42.71%to 47.07%.The rate of EN initiation within 48 h of ICU admission increased from 37.50%to 48.28%,and the EN compliance rate within 72 h elevated from 20.59%to 31.72%.After the implementation of the project,the Self-rating Anxiety Scale score decreased from 61.07±9.91 points to 52.03±9.02 points,the Self-rating Depression Scale score reduced from 62.47±10.50 points to 56.34±9.83 points,and the ICU stay decreased from 5.76±2.77 d to 5.10±2.12 *** The nutritional support management system based on closed-loop information management and psychological counseling achieved remarkable results in clinical applications in ICU patients.

关键词： Closed-loop information Psychological counseling Intensive care unit patients Nutritional support Management system

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Federated Machine Learning Based Fetal Health Prediction Empowered with Bio-Signal Cardiotocography

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Computers, Materials & Continua 2024年第3期78卷 3303-3321页

作者： Muhammad Umar Nasir Omar Kassem Khalil Karamath Ateeq Bassam SaleemAllah Almogadwy Muhammad Adnan Khan Muhammad Hasnain Azam Khan Muhammad Adnan department of Computer Sciences Bahria University Lahore CampusLahore54000Pakistan Faculty of Information Technology Liwa CollegeAbu Dhabi00000United Arab Emirates department of Computing Skyline University CollegeSharjah1797United Arab Emirates department of Computer Science Taibah UniversityMedina42353Saudi Arabia Riphah School of Computing and Innovation Faculty of ComputingRiphah International UniversityLahore CampusLahore54000Pakistan department of Engineering and development Dubizzle LabsLahore54000Pakistan department of Software Faculty of Artificial Intelligence and SoftwareGachon UniversitySeongnam-si13120Korea

Cardiotocography measures the fetal heart rate in the fetus during pregnancy to ensure physical health because cardiotocography gives data about fetal heart rate and uterine shrinkages which is very beneficial to detect whether the fetus is normal or suspect or *** cardiotocography measures infer wrongly and give wrong predictions because of human *** traditional way of reading the cardiotocography measures is the time taken and belongs to numerous human errors as *** condition is very important to measure at numerous stages and give proper medications to the fetus for its *** the current period Machine learning(ML)is a well-known classification strategy used in the biomedical field on various issues because ML is very fast and gives appropriate results that are better than traditional *** techniques play a pivotal role in detecting fetal disease in its early *** research article uses Federated machine learning(FML)and ML techniques to classify the condition of the *** study proposed a model for the detection of bio-signal cardiotocography that uses FML and ML techniques to train and test the ***,the proposed model of FML used numerous data preprocessing techniques to overcome data deficiency and achieves 99.06%and 0.94%of prediction accuracy and misprediction rate,respectively,and parallel the proposed model applying K-nearest neighbor(KNN)and achieves 82.93%and 17.07%of prediction accuracy and misprediction accuracy,***,by comparing both models FML outperformed the KNN technique and achieved the best and most appropriate prediction results as compared with previous studies the proposed study achieves the best and most accurate results.

关键词： Cardiotocography ML FML fetal disease bio-signal

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