Recent advancement of sonogenetics:A promising noninvasive cellular manipulation by ultrasound
作者机构：Pediatric Research InstituteChildren’s Hospital of Chongqing Medical UniversityNational Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChina International Science and Technology Cooperation Base of Child Development and Critical DisordersChongqing Engineering Research Center of Stem Cell TherapyChongqing 400014China Department of UltrasoundThe First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430074China
出 版 物：《Genes & Diseases》 (基因与疾病（英文）)
年 卷 期：2024年第11卷第5期
页 面：163-182页
核心收录：
学科分类：0710[理学-生物学] 07[理学] 071007[理学-遗传学]
基 金：the National Natural Science Foundation of China(No.81771845) the Chongqing Science and Technology Committee,Chongqing,China(No.CSTB2022NSCQ-MSX0812)
主 题：Mechanosensitive channel Neuromodulation Sonogenetics Ultrasound Ultrasound-sensitive protein
摘 要：Recent advancements in biomedical research have underscored the importance of noninvasive cellular manipulation ***,a method that uses genetic engineering to produce ultrasound-sensitive proteins in target cells,is gaining prominence along with optogenetics,electrogenetics,and *** stimulation with ultrasound,these proteins trigger a cascade of cellular activities and *** traditional ultrasound modalities,sonogenetics offers enhanced spatial selectivity,improving precision and safety in disease *** technology broadens the scope of non-surgical interventions across a wide range of clinical research and therapeutic applications,including neuromodulation,oncologic treatments,stem cell therapy,and *** current literature predominantly emphasizes ultrasonic neuromodulation,this review offers a comprehensive exploration of *** discuss ultrasound properties,the specific ultrasound-sensitive proteins employed in sonogenetics,and the technique’s potential in managing conditions such as neurological disorders,cancer,and ophthalmic diseases,and in stem cell *** objective is to stimulate fresh perspectives for further research in this promising field.
维普期刊数据库