检索结果-南通市图书馆

Efficacy and Economic Evaluation of Nonbiological Artificial Liver Therapy in Acute-on-chronic Hepatitis B Liver Failure

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Clinical and Translational Hepatology 2023年第2期11卷 433-440页

作者： Cichun Wu Wenting Peng Da Cheng Huimin Gu Fei Liu Shifang Peng Lei Fu department of infectious diseases Xiangya Hospital Central South UniversityChangshaHunanChina National Clinical Research center for Geriatric Disorders Xiangya Hospital Central South UniversityChangshaHunanChina

Background and Aims:Nonbiological artificial liver(NBAL)is frequently used as a first-line treatment for hepatitis B virus-associated acute-on-chronic liver failure(HBV-ACLF).This study aimed to compare the therapeutic efficacy and cost-effectiveness ratio(CER)of comprehensive medical treatment,plasma exchange(PE),and double plasma molecular adsorption system(DPMAS)plus half-dose PE(DPMAS+PE)in patients with ***:A total of 186 patients with HBV-ACLF randomly received comprehensive medical treatment,PE,or DPMAS+PE and were prospectively *** were divided into four subgroups based on the pretreatment prothrombin activity(PTA):Group I(PTA>40%),group II(PTA 30–40%),group III(PTA 20–30%),and group IV(PTA<20%).The main outcome measures were 28 day effectiveness;90 day liver transplantation-free survival;change of biochemical parameters;and ***:DPMAS+PE treatment was associated with significantly higher 28 day effectiveness and 90 day liver transplantation-free survival compared with PE treatment in patients with group I liver *** of serum total bilirubin(TBIL),AST,and creatinine(Cr)were significantly higher in the DPMAS+PE group than in the PE *** subjects with group I liver failure,DPMAS+PE treatment had advantages of lower CER values and better ***:Compared with comprehensive medical treatment and PE alone,DPMAS with halfdose sequential PE treatment more effectively improved TBIL,AST,and Cr in HBV-ACLF patients,improved 28 day effectiveness and 90 day survival rates in patients with group I liver failure,and was more cost ***+PE is a viable NBAL approach for treatment of HBV-ACLF.

关键词： Nonbiological artificial liver Acute-on-chronic liver failure Double plasma molecular adsorption system Plasma exchange

Liver Stiffness Measurement Can Reflect the Active Liver Necroinflammation in Population with Chronic Liver Disease:A Real-world Evidence Study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Clinical and Translational Hepatology 2019年第4期7卷 313-321页

作者： Leijie Wang Mingyu Zhu Lihua Cao Mingjie Yao Yiwei Lu Xiajie Wen Ying Zhang Jing Ning Huiling Long Yueyong Zhu Guoxin Hu Shuangsuo Dang Qingchun Fu Liang Chen Xinxin Zhang Jingmin Zhao Zhiliang Gao Yuemin Nan Fengmin Lu department of Microbiology&infectious Disease center School of Basic Medical SciencesPeking University Health Science CenterBeijingChina department of infectious diseases Rui Jin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Liver Disease center Qinhuangdao Third HospitalQinhuangdaoHebeiChina department of Anatomy and Embryology School of Basic Medical SciencesPeking University Health Science CenterBeijingChina Eshelman School of Pharmacy University of North CarolinaChapel HillNCUSA department of Traditional and Western Medical Hepatology The Third Hospital of Hebei Medical UniversityShijiazhuangHebeiChina department of infectious diseases The Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouGuangdongChina Liver Research center First Affiliated Hospital of Fujian Medical UniversityFuzhouFujianChina department of infectious diseases Peking University Shenzhen HospitalShenzhenGuangdongChina department of infectious diseases Second Affiliated Hospital of Medical College of Xi'an Jiaotong UniversityXi'anShaanxiChina Shanghai Liver diseases Research center 85th HospitalNanjing Military CommandShanghaiChina department of Liver Disease Shanghai Public Health Clinical CenterFudan UniversityShanghaiChina department of Pathology and Hepatology The Fifth Medical Center of PLA General HospitalBeijingChina Intervention and Cell Therapy center Peking University Shenzhen HospitalShenzhenGuangdongChina

Background and Aims: Non-invasive evaluation of liver nec-roinflammation in patients with chronic liver disease is an un-met need in clinical *** diagnostic accuracy of transient elastography-based liver stiffness measurement(LSM)for liver fibrosis could be affected by liver necroinflam-mation,the latter of which could intensify stiffness of the *** results have prompted us to explore the diagnosis potential of LSM for liver ***: Three cross-sectional cohorts of liver biopsy-proven chronic liver dis-ease patients were enrolled,including 1417 chronic hepatitis B(CHB)patients from 10 different medical centers,106 non-al-coholic steatohepatitis patients,and 143 patients with auto-immune-related liver *** longitudinal cohort of 14 entecavir treatment patients was also *** re-ceiver operating characteristic(ROC)curve was employed to explore the diagnostic value of ***: In CHB patients,LSM value ascended with the increased severity of liver nec-roinflammation in patients with the same fibrosis *** positive correlation between LSM and liver necroinflammation was also found in non-alcoholic steatohepatitis and autoim-mune-related liver diseases ***,the ROC curve exhibited that LSM could identify moderate and se-vere inflammation in CHB patients(area under the ROC curve as 0.779 and 0.838)and in non-alcoholic steatohepatitis pa-tients(area under the ROC curve as 0.826 and 0.871),*** moderate diagnostic value was also found in autoimmune-related liver diseases *** addition,in the longitudinal entecavir treated CHB cohort,a decline of LSM values was observed in parallel with the control of inflam-matory activity in ***: Our study implicates a diagnostic potential of LSM to evaluate the severity of liver necroinflammation in chronic liver disease patients.

关键词： Liver stiffness measurement Liver necroinflammatory grade Alanine aminotransferase Chronic liver disease

Focal adhesion kinase-related non-kinase ameliorates liver fibrosis by inhibiting aerobic glycolysis via the FAK/Ras/c-myc/ENO1 pathway

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2022年第1期28卷 123-139页

作者： Tao Huang Yuan-Qing-Xiao Li Ming-Yu Zhou Rui-Han Hu Gao-Liang Zou Jian-Chao Li Shu Feng Yong-Mei Liu Chang-Qin Xin Xue-Ke Zhao department of infectious diseases Affiliated Hospital of Guizhou Medical UniversityGuizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina Clinical Laboratory center Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina department of infectious diseases People’s Hospital of Weining YiHui and Miao Autonomous CountyWeining 553100Guizhou ProvinceChina

BACKGROUND Hepatic stellate cell(HSC)hyperactivation is a central link in liver fibrosis *** perform aerobic glycolysis to provide energy for their *** adhesion kinase(FAK)promotes aerobic glycolysis in cancer cells or fibroblasts,while FAK-related non-kinase(FRNK)inhibits FAK phosphorylation and biological *** To elucidate the effect of FRNK on liver fibrosis at the level of aerobic glycolytic metabolism in *** Mouse liver fibrosis models were established by administering CCl4,and the effect of FRNK on the degree of liver fibrosis in the model was *** growth factor-β1 was used to activate LX-2 *** phosphorylation at position 397(pY397-FAK)was detected to identify activated FAK,and the expression of the glycolysis-related proteins monocarboxylate transporter 1(MCT-1)and enolase1(ENO1)was *** analysis was performed to predict putative binding sites for c-myc in the ENO1 promoter region,which were validated with chromatin immunoprecipitation(ChIP)and dual luciferase reporter *** The pY397-FAK level was increased in human fibrotic liver *** knockout promoted liver fibrosis in mouse *** also increased the activation,migration,proliferation and aerobic glycolysis of primary hepatic stellate cells(pHSCs)but inhibited pHSC ***,opposite trends for these phenomena were observed after exogenous FRNK treatment in LX-2 ***,the FAK/Ras/c-myc/ENO1 pathway promoted aerobic glycolysis,which was inhibited by exogenous *** FRNK inhibits aerobic glycolysis in HSCs by inhibiting the FAK/Ras/c-myc/ENO1 pathway,thereby improving liver *** might be a potential target for liver fibrosis treatment.

关键词： Liver fibrosis Hepatic stellate cells Focal adhesion kinase Focal adhesion kinase-related non-kinase Aerobic glycolysis Enolase1

Reservoir of human immunodeficiency virus in the brain:New insights into the role of T cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

BIOCELL 2023年第12期47卷 2591-2595页

作者： YINGDONG ZHANG MING CHU HONGZHOU LU department of Neurosurgery The Second Affiliated HospitalSchool of MedicineSouthern University of Science and TechnologyShenzhen518055China School of Medicine The Second Affiliated HospitalShenzhen518000China department of infectious diseases National Clinical Research Center for Infectious DiseasesShenzhen Third People’s HospitalShenzhen518000China

Human immunodeficiency virus(HIV)infection of the central nervous system(CNS)has attracted significant attention because it contributes to severe complications of acquired immunodeficiency syndrome(AIDS)and seriously impairs the life quality of infected *** this review,we briefly describe the latent infection of HIV in CNS and focus on the role of the important immune cells,such as T cells,in the formation and maintenance of the HIV reservoir in *** review explores the mechanisms by which T cells enter CNS and establish latent infection of HIV in the *** conclusion,we summarize the role of these cells in the interaction between HIV and *** our better understanding of the underlying mechanisms,we propose future directions for the development of novel strategies to eliminate HIV reservoirs in the CNS based on cellular components.

关键词： Human immunodeficiency virus Central nervous system Reservoir Latent infection T cells

Gut microbiota shifts in hepatitis B-related portal hypertension after transjugular intrahepatic portosystemic shunt:Mechanistic and clinical implications

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2025年第3期31卷 134-137页

作者： Qi-Rong Jiang Da-Wu Zeng department of Hepatology Hepatology Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhou 350005Fujian ProvinceChina department of infectious diseases The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350004Fujian ProvinceChina

In this article,we provide commentary on the recent article by Zhao et *** focus on the shifts in the gut microbiota of patients with hepatitis B virus(HBV)-associated cirrhosis/portal hypertension(PH)following transjugular intrahepatic portosystemic shunt(TIPS)and the implications for understanding the mechanisms,diagnosis,and *** comparing the gut microbiota composition and dynamic changes before and after TIPS in patients with and without hepatic encephalopathy,the authors found an increase in non-probiotic bacteria in those who developed hepatic encephalopathy post-TIPS,with Morganella species present only in the hepatic encephalopathy *** gut microbiota changes post-TIPS among patients without the occurrence of hepatic encephalopathy suggest potential therapeutic benefits through prophylactic microbiome ***,the specific gut microbiota alterations may hold promise to predict the risk of hepatic encephalopathy in individuals undergoing TIPS for HBVrelated *** these promising findings,future studies are needed to address limitations,including a small sample size,a relatively short evaluation period for gut microbiota alterations,the absence of data on dynamic alterations in gut microbiota post-TIPS and their correlation with blood ammonia levels,and the lack of validation in animal *** conclusion,Zhao et al's study has shed new light on the link of gut microbiota with post-TIPS hepatic encephalopathy,potentially through the intricate gut-liver axis,and has important clinical implications for improving the management of patients with HBV-related PH.

关键词： Hepatitis B virus Cirrhosis Portal hypertension Hepatic encephalopathy Transjugular intrahepatic portosystemic shunt Gut microbiota

sTREM-1 as promising prognostic biomarker for acute-on-chronic liver failure and mortality in patients with acute decompensation of cirrhosis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第9期30卷 1177-1188页

作者： Song-Man Yu Hai Li Guo-Hong Deng Xian-Bo Wang Xin Zheng Jin-Jun Chen Zhong-Ji Meng Yu-Bao Zheng Yan-Hang Gao Zhi-Ping Qian Feng Liu Xiao-Bo Lu Yu Shi Jia Shang Ruo-Chan Chen Yan Huang department of infectious diseases Xiangya HospitalCentral South UniversityChangsha 410000Hunan ProvinceChina department of Gastroenterology Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China department of infectious diseases Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China center of Integrative Medicine Beijing Ditan HospitalCapital Medical UniversityBeijing 100020China department of infectious diseases Institute of Infection and ImmunologyUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430020Hubei ProvinceChina department of infectious diseases Nanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina department of infectious Disease Taihe HospitalHubei University of MedicineShiyan 442009Hubei ProvinceChina department of infectious diseases The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630Guangdong ProvinceChina department of Hepatology The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina department of Liver Intensive Care Unit Shanghai Public Health Clinical CentreFudan UniversityShanghai 200093China Tianjin Institute of Hepatology Nankai University Second People's HospitalTianjin 300192China infectious Disease center The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054Xinjiang Uygur Autonomous RegionChina The State Key Laboratory for Diagnosis and Treatment of infectious diseases The First Affiliated Hospital of School of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvineChina department of infectious diseases Henan Provincial People's HospitalZhengzhou 463599Henan ProvineChina department of infectious diseases Hunan Key Laboratory of Viral HepatitisXiangya HospitalCentral South UniversityChangsha 110051Hunan ProvineChina

BACKGROUND Acute decompensation(AD)of cirrhosis is associated with high short-term mortality,mainly due to the development of acute-on-chronic liver failure(ACLF).Thus,there is a need for biomarkers for early and accurate identification of AD patients with high risk of development of ACLF and *** triggering receptor expressed on myeloid cells-1(sTREM-1)is released from activated innate immune cells and correlated with various inflammatory *** To explore the prognostic value of sTREM-1 in patients with AD of *** A multicenter prospective cohort of 442 patients with cirrhosis hospitalized for AD was divided into a study cohort(n=309)and validation cohort(n=133).Demographic and clinical data were collected,and serum sTREM-1 was measured at *** enrolled patients were followed-up for at least 1 *** In patients with AD and cirrhosis,serum sTREM-1 was an independent prognosis predictor for 1-year survival and correlated with liver,coagulation,cerebral and kidney failure.A new prognostic model of AD(P-AD)incorporating sTREM-1,blood urea nitrogen(BUN),total bilirubin(TBil),international normalized ratio(INR)and hepatic encephalopathy grades was established and performed better than the model for end-stage liver disease(MELD),MELD-sodium(MELD-Na),chronic liver failure-consortium(CLIF-C)ACLF and CLIF-C AD ***,sTREM-1 was increased in ACLF and predicted the development of ACLF during first 28-d *** ACLF risk score incorporating serum sTREM-1,BUN,INR,TBil and aspartate aminotransferase levels was established and significantly superior to MELD,MELD-Na,CLIF-C ACLF,CLIF-C AD and P-AD in predicting risk of ACLF *** Serum sTREM-1 is a promising prognostic biomarker for ACLF development and mortality in patients with AD of cirrhosis.

关键词： Soluble triggering receptor expressed on myeloid cell-1 Acute decompensation Cirrhosis Acute-on-chronic liver failure Prognostic biomarker

Real-world effectiveness and safety of direct-acting antivirals in hepatitis C virus patients with mental disorders

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2023年第25期29卷 4085-4098页

作者： Dorota Dybowska Dorota Zarebska-Michaluk Piotr Rzymski Hanna Berak Beata Lorenc Marek Sitko Michal Dybowski Wlodzimierz Mazur Magdalena Tudrujek-Zdunek Justyna Janocha-Litwin Ewa Janczewska Jakub Klapaczynski Anna Parfieniuk-Kowerda Anna Piekarska Barbara Sobala-Szczygiel Krystyna Dobrowolska Malgorzata Pawlowska Robert Flisiak department of infectious diseases and Hepatology Faculty of MedicineNicolaus Copernicus UniversityBydgoszcz 85-030Poland department of infectious diseases and Allergology Jan Kochanowski UniversityKielce 25-317Poland department of infectious diseases Provincial HospitalKielce 25-317Poland department of Environmental Medicine University of Medical SciencesPoznań60-806Poland Integrated Science Association Universal Scientific Education and Research NetworkPoznań60-806Poland Outpatient Clinic Hospital for Infectious Diseases in WarsawWarsaw 01-201Poland Pomeranian center of infectious diseases Medical UniversityGdańsk 80-214Poland department of infectious and Tropical diseases Jagiellonian UniversityKraków 31-088Poland Utrecht university School of Economics Utrecht UniversityUtrecht 3584 ECNetherlands Clinical department of infectious diseases Medical University of SilesiaChorzów 41-500Poland department of infectious diseases Medical University of LublinLublin 20-059Poland department of infectious diseases and Hepatology Medical University of WrocławWrocław 50-367Poland department of Basic Medical Sciences Faculty of Public Health in BytomMedical University of SilesiaKatowice 40-007Poland department of Internal Medicine and Hepatology Central Clinical Hospital of the Ministry of Internal Affairs and AdministrationWarsaw 00-241Poland department of infectious diseases and Hepatology Medical University of BiałystokBiałystok 15-089Poland department of infectious diseases and Hepatology Medical University ofŁódźŁódź91-347Poland department of infectious diseases and Hepatology Medical University of SilesiaBytom 41-902Poland Collegium Medicum Jan Kochanowski UniversityKielce 25-317Poland

BACKGROUND It is estimated that 58 million people worldwide are infected with the hepatitis C virus(HCV).Patients with severe psychiatric disorders could not be treated with previously available interferon-based therapies due to their unfavorable side effect *** has changed with the introduction of direct-acting antivirals(DAA),although their real-life tolerance and effectiveness in patients with different psychiatric disorders remain to be *** To evaluate the effectiveness and safety of DAA in patients with various mental *** This was a retrospective observational study encompassing 14272 patients treated with DAA for chronic hepatitis C in 22 Polish hepatology centers,including 942 individuals diagnosed with a mental disorder(anxiety disorder,bipolar affective disorder,depression,anxiety-depressive disorder,personality disorder,schizophrenia,sleep disorder,substance abuse disorder,and mental illness without a specific diagnosis).The safety and effectiveness of DAA in this group were compared to those in a group without psychiatric illness(n=13330).Antiviral therapy was considered successful if serum ribonucleic acid(RNA)of HCV was undetectable 12 wk after its completion[sustained virologic response(SVR)].Safety data,including the incidence of adverse events(AEs),serious AEs(SAEs),and deaths,and the frequency of treatment modification and discontinuation,were collected during therapy and up to 12 wk after treatment *** entire study population was included in the intent-to-treat(ITT)***-protocol(PP)analysis concerned patients who underwent HCV RNA evaluation 12 wk after completing *** Among patients with mental illness,there was a significantly higher percentage of men,treatmentnaive patients,obese,human immunodeficiency virus and hepatitis B virus-coinfected,patients with cirrhosis,and those infected with genotype 3(GT3)while infection with GT1b was more frequent in the population without psychia

关键词： Hepatitis C Mental disorders Direct-acting antivirals

Human microbiome is a diagnostic biomarker in hepatocellular carcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic diseases International 2020年第2期19卷 109-115页

作者： Ben-Chen Rao Jia-Min Lou Wei-Jie Wang Ang Li Guang-Ying Cui Zu-Jiang Yu Zhi-Gang Ren department of infectious diseases the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Gene hospital of Henan Province Precision Medicine Centerthe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China department of Hepatobiliary and Pancreatic Surgery the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China

Background:Hepatocellular carcinoma(HCC)is the third leading cause of cancer mortality *** evidence indicates a close relationship between HCC and the human ***,we reviewed the important potential of the human microbiota as a diagnostic biomarker of *** sources:Several innovative studies have investigated the characteristics of the gut and oral micro-biomes in patients with HCC and proposed that the human microbiome has the potential to be a diag-nostic biomarker of *** from February 1999 to February 2019 was searched in the PubMed database using the keywords"microbiota"or"microbiome"or"microbe"and"liver cancer"or"hepato-cellular carcinoma",and the results of clinical and experimental studies were ***:Specific changes occur in the human microbiome of patients with ***,the gut mi-crobiome and oral microbiome can be used as non-invasive diagnostic biomarkers for ***,they also have certain diagnostic potential for precancerous diseases of *** diagnostic potential of the blood microbiota and ascites microbiota in HCC will be gradually discovered in the ***:The human microbiome is valuable to the diagnosis of HCC and provides a novel strategy for targeted therapy of *** human microbiome may be widely used in the diagnosis,treatment and prognosis for multiple system diseases or cancers in the future.

关键词： Human microbiome Gut microbiome Oral microbiome Hepatocellular carcinoma Diagnostic biomarker

Extracellular HIV Tat and Tat cysteine rich peptide increase CCR5 expression in monocytes

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang university-Science B(Biomedicine & Biotechnology) 2005年第7期6卷 668-672页

作者：郑临杨益大吕国才 SALVATO Maria S. department of infectious diseases First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China Institute of Human Virology University of Maryland Biotechnology Center Baltimore MD 21201 USA

In our previous work we reported that HIV Tat and 6 cysteine rich peptides of Tat induce tumor necrosis factor-related apoptosis-induced ligand (TRAIL) in human monocytes (Yang et al., 2003). Here our results showed that HIV Tat and Tat cysteine rich peptide increase CCR5 expression in human monocytes, and this activity is inhibited by rabbit anti-Tat. Boiled Tat does not increase CCR5 expression in monocytes. These results provide insight into a new mechanism by which HIV Tat plays a key role in the pathogenesis of HIV-1 infection.

关键词： HIV Tat Tat cysteine rich peptide CCR5 Monocytes