Reservoir of human immunodeficiency virus in the brain:New insights into the role of T cells

作     者：YINGDONG ZHANG MING CHU HONGZHOU LU 

作者机构：Department of NeurosurgeryThe Second Affiliated HospitalSchool of MedicineSouthern University of Science and TechnologyShenzhen518055China School of MedicineThe Second Affiliated HospitalShenzhen518000China Department of Infectious DiseasesNational Clinical Research Center for Infectious DiseasesShenzhen Third People’s HospitalShenzhen518000China 

出 版 物：《BIOCELL》 (生物细胞（英文）)

年 卷 期：2023年第47卷第12期

页      面：2591-2595页

核心收录：

学科分类：0710[理学-生物学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：funded by the Shenzhen Science and Technology Innovation Program(Nos.JCYJ20210324131607019 KCXFZ20211020163544002). 

主　　题：Human immunodeficiency virus Central nervous system Reservoir Latent infection T cells 

摘      要：Human immunodeficiency virus(HIV)infection of the central nervous system(CNS)has attracted significant attention because it contributes to severe complications of acquired immunodeficiency syndrome(AIDS)and seriously impairs the life quality of infected patients.In this review,we briefly describe the latent infection of HIV in CNS and focus on the role of the important immune cells,such as T cells,in the formation and maintenance of the HIV reservoir in CNS.This review explores the mechanisms by which T cells enter CNS and establish latent infection of HIV in the CNS.In conclusion,we summarize the role of these cells in the interaction between HIV and CNS.With our better understanding of the underlying mechanisms,we propose future directions for the development of novel strategies to eliminate HIV reservoirs in the CNS based on cellular components.