检索结果-南通市图书馆

Molecular mechanisms and cellular process in signal transduction pathway related to air pollutants in obstructive lung diseases:A mini-review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

BIOCELL 2023年第8期47卷 1703-1708页

作者： AN-SOO JANG Division of allergy and Respiratory Medicine Department of Internal MedicineSoonchunhyang University Bucheon Hospital170 Jomaru-roBucheon-siGyeonggi-do14584Korea

Exposure to air pollutants such as PM_(10),PM_(2.5),PM_(0.1),O_(3),CO,NO2,and SO_(2),and biological pollutants are important factors causing the evolution and furtherance of obstructive lung diseases(OLD),including asthma and chronic obstructive pulmonary disease(COPD).Asthma is the most frequent chronic inflammatory airway disease,characterized by breathlessness,wheezing,chest tightness,and cough,together with the presence of exaggerated expiratory airflow fluctuation that varies over *** is a heterogeneous lung condition characterized by chronic respiratory symptoms such as dyspnea,cough,expectoration,and/or exacerbations due to abnormalities of the airways and/or alveoli that cause persistent,often progressive,airflow *** the molecular mechanisms and cellular processes based on the development of OLD on exposure to air pollutants will provide insights into the solution of pathogenesis,prevention,and treatment of these *** molecular mechanisms and cellular process involved in signal transduction pathway plays a role in the binding of extracellular signaling molecules and ligands to receptors placed on the cell surface or on the inner side cell that trigger inflammation that occurs,especially when something important enters the cell to bring into a cascade *** binding then alters the cell metabolism,shape,and gene expression in the *** review aimed to reveal the effect of air pollutants on the molecular mechanisms and cellular processes involved in the signal transduction pathways in OLD.

关键词： Air pollutants Obstructive lung diseases Signal pathway

Food allergy among Mexican infants and preschoolers:prevalence and associated factors

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2023年第4期19卷 401-405页

作者： Martín Bedolla-Barajas Jaime Morales-Romero Rafael Sánchez-Magallón Jorge Alejandro Valdez-Soto Tonatiuh Ramses Bedolla-Pulido Carlos Meza-López allergy and immunology department Nuevo Hospital Civil de Guadalajara Dr.Juan I.MenchacaSalvador Quevedo y Zubieta No.740Colonia La Perla44340GuadalajaraJaliscoMéxico Institute of Public Health Universidad VeracruzanaXalapaMexico Pediatrics department Nuevo Hospital Civil de Guadalajara Dr.Juan I.MenchacaGuadalajaraMexico

The number of people with food allergy(FA)has increased in recent decades,as has the number of foods to which they are *** of FA prevalence vary widely,likely because of different definitions,evaluated foods and geo-graphic *** developed countries,overall preva-lence estimates range from 1.9%to 7.2%[1,2].In Latin America,the prevalence of FA in children is between 1.4%and 5.3%[3-6],with important age-based variations(from 1.9%in infants to 0.4%in preschoolers)[7].FA is a complex trait in which the interplay of genetic and environmental fac-tors results in disease ***-known factors that increase atopic susceptibility include sex[8,9],age[10],and socioeconomic status[11-13].Furthermore,the asso-ciation between family history of allergies and childhood FA has been consistently reported in recent ***,a maternal history of allergic disease appears to be more strongly associated with FA than paternal history of atopy[14].

关键词： prevalence allergy allergic

New therapeutic perspectives in Type 1 Diabetes: dietary interventions prevent β cell-autoimmunity by modifying the gut metabolic environment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular immunology 2017年第12期14卷 951-953页

作者： Chiara Sorini Ilaria Cosorich Marika Falcone immunology and allergy Unit Department of MedicineKarolinska InstitutetStockholmSweden Experimental Diabetes Unit-DRI Division of ImmunologyTransplantation and Infectious DiseasesIRCCS San Raffaele Scientific InstituteMilanItaly

The gut microbiota plays a key role in the pathogenesis of autoimmune diseases such as Type 1 Diabetes(T1D),but the mechanism underlying this modulation is yet to be *** paper highlights the crucial role of the microbiota-induced gut metabolic profile,rather than the presence of single bacterial strains,in T1D *** importantly,it provides the first evidence that dietary interventions can modulate the autoimmune pathogenesis of T1D by altering the gut metabolic environment.

关键词： Diabetes autoimmune pathogenesis

Possible therapeutic role of Ig E blockade in irritable bowel syndrome

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2016年第43期22卷 9451-9456页

作者： Eli Magen Tinatin Chikovani Medicine C department Allergy and Clinical Immunology Unit Barzilai Medical Center Ben Gurion University of Negev department of Microbiology and Im-munology Tbilisi State Medical University

Omalizumab is a humanized monoclonal antibody that binds to the high-affinity type-I Ig E Fc receptors on mast cells(MCs) and basophils, inhibiting the Ig E immune pathway. Irritable bowel syndrome(IBS) is the most common functional gastrointestinal disorder, and dysregulation of the immune system likely contributes to its etiology and/or symptomatology. Colonic biopsies from patients with IBS demonstrate considerable increase in the number of degranulating MCs releasing histamine in proximity to nerves, and this event may underlie the common IBS symptom of abdominal pain. Pharmacologic control of MC activation and mediator release is a current area of active interest in the field of IBS research. Recently, we and Pearson et al described 2 cases of patients with IBS with diarrhea(IBS-D) showing positive clinical response to omalizumab. In both cases, the female patients had severe, long-lasting IBS-D and achieved an almost complete resolution of IBS symptoms. Both patients were also able to discontinue all IBS medications after commencing the anti-Ig E therapy. For both patients, the omalizumab treatment showed a relatively rapid onset of action, resembling the efficacy observed in and previously reported for patients with chronic spontaneous urticaria. In this Editorial, we discuss the possible biological mechanisms that may underlie the clinical efficacy of omalizumab in IBS. We suggest that there is a need for a well-designed prospective study to investigate the therapeutic effects of anti-Ig E in IBS.

关键词： IgE Omalizumab 急躁的肠症候群反煽动性有腹泻的急躁的肠症候群

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Methodology 2022年第4期12卷 224-234页

作者： ÖnerÖzdemir Zeynep Arslan Division of Pediatric allergy and immunology Sakarya University Medical FacultySakarya 54100Turkey department of Pediatrics Sakarya University Research and Training HospitalSakarya 54100Turkey

The pandemic caused by severe acute respiratory syndrome coronavirus-2(SARSCoV-2)in 2019-2022 leads to a multisystem illness that results in damage to numerous organ *** this review,our goal was to assess current research on long-term respiratory,cardiac,neurological,digestive,rheumatological,urogenital,and dermatological system complications of coronavirus disease 2019(COVID-19).Bibliographic searches were conducted in December 2021 using PubMed and Google Scholar,retrospectively,covering all COVID-19 literature to determine the consequences of the *** review may help to determine the prospects for new studies and predict the upcoming aspects requiring assessment in post-COVID-19 syndrome.

关键词： Coronavirus COVID-19 Post-COVID-19 syndrome Pandemic SARS-CoV-2

Juvenile dermatomyositis:advances in clinical presentation,myositis-specific antibodies and treatment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2020年第1期16卷 31-43页

作者： Jian-Qiang Wu Mei-Ping Lu Ann M.Reed department of Rheumatology immunology and allergy Children's HospitalZhejiang University School of MedicineHangzhou 310052China department of Pediatrics Division of Pediatric RheumatologyDuke University School of MedicineDurham 27710USA

Background Juvenile dermatomyositis(JDM)is a chronic autoimmune disease characteristic by inflammation of small vessels within the skin,muscle and vital *** the clinical features and treatment of JDM have not been fully *** sources Databases underwent through PubMed for articles about the clinical features,myositis-specific antibodiesof JDM and its treatment,and we selected publications written in English which were relevant to the topic of this *** Clinical features and myositis-specific antibodies may predict the severity and prognosis of *** the mortality rate has been lower with traditional treatments,such as corticosteroid,intravenous immunoglobulin,and diseasemodifying anti-rheumatic drugs such as methotrexate,their usages are *** biological therapies seem to be effective for refractory JDM patients,but more clinical trials are *** JDM is a sever disease of *** need to better understand recent advances of JDM in the context of clinical features including skin manifestations,muscle weakness and organ damage,myositis-specific antibodies and their associated outcomes and the treatment of disease.

关键词： Biologic agents Extramuscular manifestations Juvenile dermatomyositis Myositis autoantibodies

Surfactant protein D inhibits lipid-laden foamy macrophages and lung inflammation in chronic obstructive pulmonary disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular immunology 2023年第1期20卷 38-50页

作者： Miao-Hsi Hsieh Pei-Chi Chen Han-Yin Hsu Jui-Chang Liu Yu-Sheng Ho Yuh Jyh Lin Chin-Wei Kuo Wen-Shuo Kuo Hui-Fang Kao Shulhn-Der Wang Zhi-Gang Liu Lawrence Shih-Hsin Wu Jiu-Yao Wang Center for allergy Immunologyand Microbiome(A.I.M.)China Medical University HospitalTaichungTaiwanChina Graduate Institute of Basic Medical Sciences College of MedicineNational Cheng Kung UniversityTainanTaiwanChina department of Nursing National Tainan Junior College of NursingTainanTaiwanChina Graduate Institute of Biochemistry and Molecular Biology College of MedicineNational Cheng Kung UniversityTainanTaiwanChina department of Pediatrics National Cheng Kung University HospitalTainanTaiwanChina Division of Pulmonary Medicine Department of Internal MedicineNational Cheng Kung University HospitalCollege of MedicineNational Cheng Kung UniversityTainanTaiwanChina Institute of Clinical Medicine College of MedicineNational Cheng Kung UniversityTainanTaiwanChina School of Chemistry and Materials Science Nanjing University of Information Science and TechnologyNanjingChina School of Post-Baccalaureate Chinese Medicine China Medical UniversityTaichungTaiwanChina department of Respirology and allergy Third Affiliated Hospital of Shenzhen UniversityShenzhenChina Institute of Biomedical Sciences China Medical UniversityTaichungTaiwanChina department of allergy Immunologyand Rheumatology(AIR)China Medical University Children’s HospitalTaichungTaiwanChina

Increased levels of surfactant protein D (SP-D) and lipid-laden foamy macrophages (FMs) are frequently found under oxidative stress conditions and/or in patients with chronic obstructive pulmonary disease (COPD) who are also chronically exposed to cigarette smoke (CS). However, the roles and molecular mechanisms of SP-D and FMs in COPD have not yet been determined. In this study, increased levels of SP-D were found in the bronchoalveolar lavage fluid (BALF) and sera of ozone- and CS-exposed mice. Furthermore, SP-D-knockout mice showed increased lipid-laden FMs and airway inflammation caused by ozone and CS exposure, similar to that exhibited by our study cohort of chronic smokers and COPD patients. We also showed that an exogenous recombinant fragment of human SP-D (rfhSP-D) prevented the formation of oxidized low-density lipoprotein (oxLDL)-induced FMs in vitro and reversed the airway inflammation and emphysematous changes caused by oxidative stress and CS exposure in vivo. SP-D upregulated bone marrow-derived macrophage (BMDM) expression of genes involved in countering the oxidative stress and lipid metabolism perturbations induced by CS and oxLDL. Our study demonstrates the crucial roles of SP-D in the lipid homeostasis of dysfunctional alveolar macrophages caused by ozone and CS exposure in experimental mouse emphysema, which may provide a novel opportunity for the clinical application of SP-D in patients with COPD.

关键词： Alveolar macrophages Chronic obstructive pulmonary diseases Surfactant protein D Lipid metabolism Ozone Cigarettes

From infections to autoimmunity:Diagnostic challenges in common variable immunodeficiency

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2020年第18期8卷 3942-3955页

作者： Ewa Więsik-Szewczyk Karina Jahnz-Różyk department of Internal Medicine PulmonologyAllergy and Clinical ImmunologyCentral Clinical Hospital of the Ministry of National DefenseMilitary Institute of MedicineWarsaw 04-141Poland

Common variable immunodeficiency(CVID)is the most common clinically significant primary antibody deficiency diagnosed in *** early symptoms are not *** include common infections,mainly of the respiratory tract,caused by typical microorganisms,so cases can be missed in primary *** the majority of patients increased susceptibility to infections coexists with signs or symptoms of autoimmunity,inflammation or polyclonal lymphoproliferation,which can divert diagnosis from immune *** overall incidence of malignancy is increased in CVID and certain cancers are significantly more *** and gastric carcinoma are the most frequently reported malignancies in CVID,so a high index of suspicion is *** delay in CVID is seen *** main goal of this paper is to increase the awareness about CVID among health care *** aim to present features which can be helpful in CVID diagnosis in order to shorten the“latency”of proper management of CVID *** review clinical symptoms,complications and laboratory abnormalities of *** replacement therapy is regarded as the cornerstone of pharmacological *** modes of Ig application,mainly subcutaneously and via the hyaluronidase-facilitated subcutaneous route,help to adjust therapy to patients’needs and *** there remain unmet *** remains to be seen whether CVID complications can be avoided by earlier diagnosis,treatment and thorough monitoring in the context of increased risk of *** of patient tailored protocols depending on the clinical phenotype and risk factors might be more *** most important consideration is to diagnose suspected cases and stratify patients in a precise and timely *** is needed to define features predictive of unfavorable prognosis.

关键词： Primary antibody deficiency Recurrent respiratory tract infections Complications Immunoglobulin replacement Adults Early diagnosis

Discovery of highly immunogenic spleen-resident FCGR3^(+)CD103^(+)cDC1s differentiated by IL-33-primed ST2^(+)basophils

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular immunology 2023年第7期20卷 820-834页

作者： Myeong-Ho Kang JungHyub Hong Jinjoo Lee Min-Suk Cha Sangho Lee Hye-Young Kim Sang-Jun Ha Yong Taik Lim Yong-Soo Bae department of Biological Sciences Sungkyunkwan University2066 Seobu-roJangan-guSuwon-siGyeonggi-do 16419Republic of Korea Center for Immune Research on Non-Lymphoid Organs Sungkyunkwan University2066 Seobu-roJangan-guSuwon-siGyounggi-do 16419Republic of Korea Laboratory of Mucosal immunology Department of Biomedical SciencesSeoul National University College of Medicine103 Daehak-roJongno-guSeoul 03080Republic of Korea Institute of allergy and Clinical immunology Seoul National University Medical Research CenterSeoulRepublic of Korea department of Biochemistry College of Life Science and BiotechnologyYonsei UniversitySeoul 03722Republic of Korea department of Nano Engineering and School of Chemical Engineering Sungkyunkwan University2066 Seobu-roJangan-guSuwon-siGyeonggi-do 16419Republic of Korea.

Recombinant interleukin-33(IL-33)inhibits tumor growth,but the detailed immunological mechanism is still ***-33-mediated tumor suppression did not occur in Batf3^(−/−)mice,indicating that conventional type 1 dendritic cells(cDC1s)play a key role in IL-33-mediated antitumor immunity.A population of CD103^(+)cDC1s,which were barely detectable in the spleens of normal mice,increased significantly in the spleens of IL-33-treated *** newly emerged splenic CD103^(+)cDC1s were distinct from conventional splenic cDC1s based on their spleen residency,robust effector T-cell priming ability,and surface expression of *** and DC precursors did not express Suppressor of Tumorigenicity 2(ST2).However,recombinant IL-33 induced spleen-resident FCGR3^(+)CD103^(+)cDC1s,which were found to be differentiated from DC precursors by bystander ST2+immune *** immune cell fractionation and depletion assays,we found that IL-33-primed ST2^(+)basophils play a crucial role in the development of FCGR3^(+)CD103^(+)cDC1s by secreting IL-33-driven extrinsic *** GM-CSF also induced the population of CD103^(+)cDC1s,but the population neither expressed FCGR3 nor induced any discernable antitumor *** population of FCGR3^(+)CD103^(+)cDC1s was also generated in vitro culture of Flt3L-mediated bone marrow-derived DCs(FL-BMDCs)when IL-33 was added in a pre-DC stage of ***-BMDCs generated in the presence of IL-33(FL-33-DCs)offered more potent tumor immunotherapy than control Flt3L-BMDCs(FL-DCs).Human monocyte-derived DCs were also more immunogenic when exposed to IL-33-induced *** findings suggest that recombinant IL-33 or an IL-33-mediated DC vaccine could be an attractive protocol for better tumor immunotherapy.

关键词： Recombinant interleukin-33(IL-33) Highly immunogenic Spleen residency FCGR3^(+)CD103^(+)cDC1s ST2^(+)basophils Antitumor immunity