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Self-Healing,Self-Adhesive and Stable Organohydrogel-Based Stretchable Oxygen Sensor with High Performance at Room Temperature

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Nano-Micro Letters 2022年第3期14卷 257-275页

作者： Yuning Liang Zixuan Wu Yaoming Wei Qiongling Ding Meital Zilberman Kai Tao Xi Xie Jin Wu State Key Laboratory of Optoelectronic Materials and Technologies and the Guangdong Province Key Laboratory of Display Material and Technology School of Electronics and Information TechnologySun Yat-Sen UniversityGuangzhou 510275People’s Republic of China department of Biomedical engineering Faculty of EngineeringTel Aviv University69978 Tel AvivIsrael Ministry of Education Key Laboratory of Micro and Nano systems for Aerospace Northwestern Polytechnical UniversityXi’an 710072People’s Republic of China

With the advent of the 5G era and the rise of the Internet of Things,various sensors have received unprecedented attention,especially wearable and stretchable sensors in the healthcare ***,a stretchable,self-healable,self-adhesive,and room-temperature oxygen sensor with excellent repeatability,a full concentration detection range(0-100%),low theoretical limit of detection(5.7 ppm),high sensitivity(0.2%/ppm),good linearity,excellent temperature,and humidity tolerances is fabricated by using polyacrylamide-chitosan(PAM-CS)double network(DN)organohydrogel as a novel transducing *** PAM-CS DN organohydrogel is transformed from the PAM-CS composite hydrogel using a facile soaking and solvent replacement *** with the pristine hydrogel,the DN organohydrogel displays greatly enhanced mechanical strength,moisture retention,freezing resistance,and sensitivity to ***,applying the tensile strain improves both the sensitivity and response speed of the organohydrogel-based oxygen ***,the response to the same concentration of oxygen before and after self-healing is basically the ***,we propose an electrochemical reaction mechanism to explain the positive current shift of the oxygen sensor and corroborate this sensing mechanism through rationally designed *** organohydrogel oxygen sensor is used to monitor human respiration in real-time,verifying the feasibility of its practical *** work provides ideas for fabricating more stretchable,self-healable,self-adhesive,and high-performance gas sensors using ion-conducting organohydrogels.

关键词： Stretchable oxygen sensors Organohydrogel Self-healing Self-adhesive Electrochemical reaction

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Wearable Robots for human Underwater Movement Ability Enhancement:A Survey

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IEEE/CAA Journal of Automatica Sinica 2022年第6期9卷 967-977页

作者： Haisheng Xia Muhammad Alamgeer Khan Zhijun Li MengChu Zhou IEEE department of Automation University of Science and Technology of ChinaHefei 230026China Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefei 230026China Helen and John C.Hartmann department of Electrical and Computer engineering New Jersey Institute of TechnologyNewark NJ 07102 USA department of Cyber-Physical systems St.Petersburg State Marine Technical UniversitySt.Petersburg 198262Russia

Underwater robot technology has shown impressive results in applications such as underwater resource *** underwater applications that require extremely high flexibility,robots cannot replace skills that require human dexterity yet,and thus humans are often required to directly perform most underwater *** robots(exoskeletons)have shown outstanding results in enhancing human movement on *** are expected to have great potential to enhance human underwater *** purpose of this survey is to analyze the state-of-the-art of underwater exoskeletons for human enhancement,and the applications focused on movement assistance while excluding underwater robotic devices that help to keep the temperature and pressure in the range that people can *** work discusses the challenges of existing exoskeletons for human underwater movement assistance,which mainly includes human underwater motion intention perception,underwater exoskeleton modeling and human-cooperative *** research should focus on developing novel wearable robotic structures for underwater motion assistance,exploiting advanced sensors and fusion algorithms for human underwater motion intention perception,building up a dynamic model of underwater exoskeletons and exploring human-in-theloop control for them.

关键词： Cyborg intelligence diving exoskeleton intention perception modeling and control swimming underwater exoskeletons underwater robots wearable robots

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On Synergy Deployment in engineering Design

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材料科学与工程（中英文B版） 2012年第6期2卷 408-413页

作者： Tiit Hindreus Frid Kaljas Rommi Kaillo Andres Martin Toivo Taihemaa Vello Reedik Faculty of mechanical engineering Department of Machinery Tallinn University of Technology Tallinn 19086 Estonia

An overview of the progress in the deployment of synergy effects in engineering design is presented. On the example of the development of fluidic sensors, the difficulties to discover qualitative synergy through experimental search of are evaluated. It is arrived at the truth that using the tools of computational intelligence may be the faster way to the solution. Further the paper is focussed on the latest research efforts in quantitative synergy area where engineering design quality is concerned. The success in development of adaptive tools for synergy-based design of interdisciplinary systems is analyzed. It is shown that using the synergy-based design approach in quality management context makes it possible to create an effective synergy-supported quality assurance environment.

关键词：工程设计质量协同效应部署协同作用设计工具计算智能设计方法质量管理

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基于虚拟开车环境的自闭症儿童脑电样本熵

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物理学报 2016年第10期65卷 330-341页

作者：雷敏孟光张文明 Nilanjan Sarkar 上海交通大学机械与动力工程学院机械系统与振动国家重点实验室振动所上海200240 Robotics and Autonomous systems Laboratory Department of Mechanical Engineering Vanderbilt University USA

自闭症谱系障碍是一种涉及感觉、情感、记忆、语言、智力、动作等认知功能和执行功能障碍的精神疾病.本文从神经工效学角度出发,用虚拟开车环境作为复杂多任务激励源将大脑系统与人体动作控制等有机地结合起来,通过对脑电信号的滑动平... 详细信息

自闭症谱系障碍是一种涉及感觉、情感、记忆、语言、智力、动作等认知功能和执行功能障碍的精神疾病.本文从神经工效学角度出发,用虚拟开车环境作为复杂多任务激励源将大脑系统与人体动作控制等有机地结合起来,通过对脑电信号的滑动平均样本熵分析来探索自闭症儿童在虚拟开车环境中的脑活动特征.研究发现不论是休息状态还是开车状态,自闭症患者的滑动平均样本熵总体上低于健康者,尤其在前额叶、颞叶、顶叶和枕叶功能区,表明自闭症儿童的行为适应性较低.不过,自闭症患者的开车状态与健康受试者的休息状态比较接近,表明虚拟开车环境或许有助于自闭症患者的干预治疗.此外,自闭症患者在颞叶区呈现显著性右半球优势性.本研究为进一步深入开展自闭症疾病的机理研究及其诊断、评估和干预等研究提供一种新的研究思路.

关键词：自闭症虚拟开车样本熵脑电信号

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Torque Sharing Function Control of Switched Reluctance Machines with Reduced Current Sensors

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CES Transactions on Electrical Machines and systems 2018年第4期2卷 355-362页

作者： Wei Peng Johan Gyselinck Jin-Woo Ahn Dong-Hee Lee Bio ElectroUniversitéLibre de Bruxelles(ULB)BrusselsBelgium mechanical systems(BEAMS)department UniversitéLibre de Bruxelles(ULB)BrusselsBelgium department of Mechatronics engineering Kyungsung UniversityBusanKorea

This paper presents a Torque Sharing Function(TSF)control of Switched Reluctance Machines(SRMs)with different current sensor placements to reconstruct the phase *** requires precise phase current information to ensure accurate torque *** proposed methods with different chopping transistors or a new PWM implementation require four or two current sensors to replace the current sensors on each phase regardless of the phase *** both approaches,the actual phase current can be easily extracted during the single phase conducting ***,how to separate the incoming and outgoing phase current values during the commutation region is the difficult issue to deal *** order to derive these two adjacent currents,the explanations and comparisons of two proposed methods are *** effectiveness is verified by experimental results on a four-phase 8/6 ***,the approach with a new PWM implementation is selected,which requires only two current sensors for reducing the number of *** control system can be more compact and cheaper.

关键词： Current sensor placement pulse width modulation(PWM) switched reluctance machines torque sharing function

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Distributed Vehicle Platoon Control with Leader Selection Strategy

Distributed Vehicle Platoon Control with Leader Selection St...

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第40届中国控制会议

作者： Zikai Ouyang Zhicheng Li Shibo Chen Zaiyue Yang Shenzhen Key Laboratory of Biomimetic Robotics and Intelligent systems Department of Mechanical and Energy Engineering and the Guangdong Provincial Key Laboratory of Human-Augmentation and Rehabilitation Robotics in Universities Southern University of Science and Technology Academy for Advanced Interdisciplinary Studies Southern University of Science and Technology

This paper investigates the control problem of vehicle platoon with leader selection strategy. The current research on vehicle platoon control is based on the leader-follower communication structure. Under such structure, each follower tracks the state of its front vehicle to maintain a proper distance and form a platoon. However, the disadvantage of this fixed communication structure is that followers are short of capacity of resisting disturbance when the first vehicle（FV） of platoon is disturbed. To solve this problem, a vehicle platoon model where each follower is able to take any front vehicle as its leader is proposed. Based on this model, the corresponding controller and leader selection strategy are designed. That is, first, a controller considering the string stability of vehicle platoon with various communication topologies is designed;then, each follower changes its connecting vehicle in the communication link to reduce the impact of disturbance on FV when FV suddenly slows down or speeds up. The simulation results show the effectiveness of the control method and the strategy.

关键词： Vehicle platoon leader selection strategy distributed control

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An openable artificial intestinal tract system for the in vitro evaluation of medicines

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Microsystems & Nanoengineering 2015年第1期1卷 106-111页

作者： Satoshi Konishi Takuya Fujita Koji Hattori Yusuke Kono Yoshifumi Matsushita department of mechanical engineering Ritsumeikan University1-1-1 Noji-higashiKusatsuShiga 525-8577Japan department of Pharmaceutical Sciences Ritsumeikan University1-1-1 Noji-higashiKusatsuShiga 525-8577Japan Ritsumeikan-Global Innovation Research Organization Ritsumeikan University1-1-1 Noji-higashiKusatsuShiga 525-8577Japan Graduate School of Science and engineering Ritsumeikan University1-1-1 Noji-higashiKusatsuShiga 525-8577Japan

In vitro drug screening systems for pharmacological targets have been studied as substitutes for whole-animal *** cells or tissues provide promising substitution models when coupled with technological innovations in micro total analysis *** this study,we focus on an intestinal drug absorption assay,as the oral route is most frequently used for drug *** studies have reported the development of artificial vessels that include tubular ***,it is difficult to observe the insides of these tubes in *** address this problem,we developed a micro-device that uses a pneumatic balloon actuator(PBA)to open and close an artificial intestinal tract.A human colon carcinoma cell line(Caco-2)was cultivated on the flat surface of the micro-device for 7 days to form the inner cellular layer of an artificial intestinal tract with which to evaluate drug *** artificial intestinal tract was completely actuated from a flat plate to a circular tube via a PBA with a pressure of 65 kPa,and drugs were perfused at a flow rate of 0.05 mL min^(−1) into the tubular artificial intestinal tract for 1 *** the openable artificial intestinal tract,the in vitro absorption of calcein and Texas Red were successfully estimated as models of hydrophilic and hydrophobic drugs,*** artificial intestinal tract enables the effective evaluation of the in vitro intestinal absorption of drug candidates and contributes to the reduction of costs incurred during the initial stage of drug development.

关键词： Caco-2 cells drug absorption intestinal tract microfluidic device pneumatic balloon actuator

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mechanical stimulation devices formechanobiology studies:a market,literature,and patents review

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Bio-Design and Manufacturing 2023年第3期6卷 340-371页

作者： F.Melo-Fonseca O.Carvalho M.Gasik G.Miranda F.S.Silva Center for MicroElectromechanical systems University of Minho(CMEMS-UMinho)Campus de Azurém4800-058 GuimarãesPortugal LABBELS–Associate Laboratory BragaGuimarãesPortugal International Iberian Nanotechnology Laboratory(INL) 4715-330 BragaPortugal School of Chemical engineering Aalto University Foundation00076 EspooFinland Seqvera Ltd. HelsinkiFinland department of Materials and Ceramic engineering CICECOAveiro Institute of MaterialsUniversity of Aveiro3810-193 AveiroPortugal

Significant advancements in various research and technological fields have contributed to remarkable findings on the physiological dynamics of the human *** closely mimic the complex physiological environment,research has moved from two-dimensional(2D)culture systems to more sophisticated three-dimensional(3D)dynamic *** bioreactors or microfluidic-based culture models,cells are typically seeded on polymeric substrates or incorporated into 3D constructs which are mechanically stimulated to investigate cell response to mechanical stresses,such as tensile or *** review focuses on the working principles of mechanical stimulation devices currently available on the market or custom-built by research groups or protected by patents and highlights the main features still open to *** are the features which could be focused on to perform,in the future,more reliable and accurate mechanobiology studies.

关键词： Biomaterials Polymers Actuators mechanical stress Mechanotransduction

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Accurate Parameter Estimation of Time-varying Nuclear Radiation Field with Mobile Sensors

Accurate Parameter Estimation of Time-varying Nuclear Radiat...

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第40届中国控制会议

作者： Bo Chen Zhicheng Li Zaiyue Yang Shenzhen Key Laboratory of Biomimetic Robotics and Intelligent systems Department of Mechanical and Energy Engineering and the Guangdong Provincial Key Laboratory of Human-Augmentation and Rehabilitation Robotics in Universities Southern University of Science and Technology Academy for Advanced Interdisciplinary Studies Southern University of Science and Technology

In this paper, the optimization strategy of mobile sensors and the parameter estimation of time-varying nuclear radiation field are investigated. Based on the measurement model with white Gaussian noise, Fisher information matrix is derived as an information metric. At each time step, finding the best mobile sensor coordinates that contain the amount of maximal information in the 4-Dimension space is formulated as a constrained nonlinear optimization problem, which is able to minimize the trace of Cramer-Rao Lower Bound. Further, an efficient heuristic algorithm called Augmented Lagrangian Genetic Algorithm is adopted to solve the above optimization problem. Then, the parameters of nuclear radiation field are estimated by a maximum likelihood estimator. The proposed sensor coordinates moving strategy has better estimation performance than random coordinates strategy, which is demonstrated via simulation results.

关键词： Optimal sensor coordinates Fisher information matrix(FIM) Cramer-Rao Lower Bound(CRLB) Augmented Lagrangian Genetic Algorithm(ALGA) Maximum likelihood estimate(MLE)

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Dendritic cells derived from pluripotent stem cells:Potential of large scale production

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World Journal of Stem Cells 2014年第1期6卷 1-10页

作者： Yan Li Meimei Liu Shang-Tian Yang department of Chemical and Biomedical engineering Florida Agricultural and Mechanical University-Florida State University College of EngineeringFlorida State University William G. Lowrie department of Chemical and Biomolecular engineering The Ohio State University

human pluripotent stem cells(hPSCs), including human embryonic stem cells and human induced pluripotent stem cells, are promising sources for hematopoietic cells due to their unlimited growth capacity and the pluripotency. Dendritic cells(DCs), the unique immune cells in the hematopoietic system, can be loaded with tumor specific antigen and used as vaccine for cancer immunotherapy. While autologous DCs from peripheral blood are limited in cell number, hPSC-derived DCs provide a novel alternative cell source which has the potential for large scale production. This review summarizes recent advances in differentiating hPSCs to DCs through the intermediate stage of hematopoietic stem cells. Step-wise growth factor induction has been used to derive DCs from hPSCs either in suspension cultureof embryoid bodies(EBs) or in co-culture with stromal cells. To fulfill the clinical potential of the DCs derived from hPSCs, the bioprocess needs to be scaled up to produce a large number of cells economically under tight quality control. This requires the development of novel bioreactor systems combining guided EB-based differentiation with engineered culture environment. Hence, recent progress in using bioreactors for hPSC lineage-specific differentiation is reviewed. In particular, the potential scale up strategies for the multistage DC differentiation and the effect of shear stress on hPSC differentiation in bioreactors are discussed in detail.

关键词： Pluripotent stem cells Dendritic cells Bioreactor Hematopoietic differentiation Large scale production

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