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Effects of mesenchymal stem cell on dopaminergic neurons,motor and memory functions in animal models of Parkinson's disease:a systematic review and meta-analysis

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Neural Regeneration Research 2024年第7期19卷 1584-1592页

作者： Jong Mi Park Masoud Rahmati Sang Chul Lee Jae Il Shin Yong Wook Kim department and Research Institute of Rehabilitation Medicine Yonsei University College of MedicineSeoulSouth Korea department of Physical Education and Sport Sciences Faculty of Literature and Human SciencesLorestan UniversityKhoramabadIran department of Pediatrics Yonsei University College of MedicineSeoulSouth Korea

Parkinson’s disease is chara cterized by the loss of dopaminergic neurons in the substantia nigra pars com pacta,and although restoring striatal dopamine levels may improve symptoms,no treatment can cure or reve rse the disease *** cell therapy has a regenerative effect and is being actively studied as a candidate for the treatment of Parkinson’s *** stem cells are considered a promising option due to fewer ethical concerns,a lower risk of immune rejection,and a lower risk of *** performed a meta-analysis to evaluate the therapeutic effects of mesenchymal stem cells and their derivatives on motor function,memory,and preservation of dopamine rgic neurons in a Parkinson’s disease animal *** searched bibliographic databases(PubMed/MEDLINE,Embase,CENTRAL,Scopus,and Web of Science)to identify articles and included only pee r-reviewed in vivo interve ntional animal studies published in any language through J une 28,*** study utilized the random-effect model to estimate the 95%confidence intervals(CI)of the standard mean differences(SMD)between the treatment and control *** use the systematic review center for laboratory animal expe rimentation’s risk of bias tool and the collaborative approach to meta-analysis and review of animal studies checklist for study quality assessment.A total of 33studies with data from 840 Parkinson’s disease model animals were included in the *** with mesenchymal stem cells significantly improved motor function as assessed by the amphetamine-induced rotational *** the stem cell types,the bone marrow MSCs with neurotrophic factor group showed la rgest effect size(SMD[95%CI]=-6.21[-9.50 to-2.93],P=0.0001,I^(2)=0.0%).The stem cell treatment group had significantly more tyrosine hydroxylase positive dopamine rgic neurons in the striatum([95%CI]=1.04[0.59 to 1.49],P=0.0001,I^(2)=65.1%)and substantia nigra(SMD[95%CI]=1.38[0.89 to 1.87],P=0.0001,I^(2)=75.3%),indicating a

关键词： animal animal experimentation mesenchymal stem cells models Parkinson’s disease stem cell transplantation

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Consequences of early life stress on the structure and function of the adult mouse retina

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Neural Regeneration Research 2024年第1期19卷 150-151页

作者： Juan S.Calanni Ruth E.Rosenstein Laboratory of Retinal Neurochemistry and Experimental Ophthalmology Department of Human BiochemistrySchool of Medicine/CEFyBOUniversity of Buenos Aires/CONICETBuenos AiresArgentina

Early-life stress(ELS)refers to a period of environmental/social deprivation,physica l,sexual or emotional abuse,neglect,severe and/or chronic trauma in the prenatal/early postnatal stage,which is closely related to many adverse psychiatric disorders later in life,such as depressive disorder,substance abuse,dysthymia,panic,anxiety,and suicidal behavior in adulthood(Waters and Gould,2022).

关键词： stress life Gould

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Parametric study on contact sensors for MASW measurement-based interfacial debonding detection for SCCS

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Earthquake Engineering and Engineering Vibration 2024年第2期23卷 331-344页

作者： Chen Hongbing Pang Xin Gan Shiyu Li Yuanyuan Gokarna Chalise Nie Xin Research Institute of Urbanization and Urban Safety School of Civil and Resource EngineeringUniversity of Science and Technology BeijingBeijing 100083China department of Civil Engineering Tsinghua UniversityBeijing 100084China Faculty of Infrastructure Engineering Dalian University of TechnologyDalian 116081China

Steel-concrete composite structures(SCCS)have been widely used as primary load-bearing components in large-scale civil *** the basis of the co-working ability of steel plate and concrete,the bonding status plays an essential role in guaranteeing the structural performance of ***,efficient non-destructive testing(NDT)on interfacial debondings in SCCS has become a prominent research ***-channel analysis of surface waves(MASW)has been validated as an effective NDT technique for interfacial debonding detection for ***,the feasibility of MASW must be validated using experimental *** study establishes a high-frequency data synchronous acquisition system with 32 channels to perform comparative verification experiments in ***,the current sensing approaches for high-frequency vibration and stress waves are ***,three types of contact sensors,namely,piezoelectric lead-zirconate-titanate(PZT)patches,accelerometers,and ultrasonic transducers,are selected for MASW ***,the selection and optimization of the force hammer head are *** experiments are carried out for the optimal selection of ultrasonic transducers,PZT patches,and accelerometers for MASW *** addition,the influence of different pasting methods on the output signal of the sensor array is *** results indicate that optimized PZT patches,acceleration sensors,and ultrasonic transducers can provide efficient data acquisition for MASW-based non-destructive *** research findings in this study lay a solid foundation for analyzing the recognition accuracy of contact MASW measurement using different sensor arrays.

关键词： steel-concrete composite structures(SCCS) interface debonding detection multi-channel analysis of surface waves(MASW) sensor selection comparative experimental study

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An efficient and safe strategy for germ cell-specific automatic excision of foreign DNA in F1 hybrid transgenic silkworms

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Insect Science 2024年第1期31卷 28-46页

作者： Dingpei Long Rongpeng Liu Yang Huang Anyao Fu Yuli Zhang Zhanzhang Hao Qiang Li Hanfu Xu Zhonghuai Xiang Aichun Zhao State Key Laboratory of resource Insects Institute of Sericulture and Systems BiologySouthwest UniversityChongqingChina department of Biology Georgia State UniversityAtlantaGeorgiaUSA Guangxi Institute of Sericulture Science NanningGuangxiChina department of Mathematics and Statistics Georgia State UniversityAtlantaGeorgiaUSA

The safety of transgenic technology is a major obstacle in the popularization and use of transgenic silkworms and their *** sericulture,only the first filial generation(F1)hybrid eggs produced by cross-breeding Japanese and Chinese original strains are usually used for the large-scale breeding of silkworms,but this may result in uncontrolled transgene dispersal during the popularization and application of the F1 hybrid transgenic *** address this issue,we developed a safe and efficient strategy using the GAL4/Upstream activating sequence(UAS)system,the FLP/flippase recognition target(FRT)system,and the gonad-specific expression gene promoters(RSHP1p and Nanosp)for the germ cell-specific automatic excision of foreign DNA in the F1 hybrid transgenic *** established 2 types of activator strains,R1p::GAL4-Gr and Nsp::GAL4-Gr,containing the testis-specific GAL4 gene expression cassettes driven by RSHP1p or Nanosp,respectively,and 1 type of effector strain,UAS::FLP-Rg,containing the UAS-linked FLP gene expression *** FLP recombinase-mediated sperm-specific complete excision of FRT-flanked target DNA in the F1 double-transgenic silkworms resulting from the hybridization of R1p::GAL4-Gr and UAS::FLP-Rg was 100%,whereas the complete excision efficiency resulting from the hybridization of Nsp::GAL4-Gr and UAS::FLP-Rg ranged from 13.73%to 80.3%.Additionally,we identified a gene,sw11114,that is expressed in both testis and ovary of Bombyx mori,and can be used to establish novel gonad-specific expression systems in transgenic *** strategy has the potential to fundamentally solve the safety issue in the production of F1 transgenic silkworm eggs and provides an important reference for the safety of transgenic technology in other insect species.

关键词： Bombyx mori FLP/FRT system GAL4/UAS system germ cell-specific excision safety of transgenic technology transgenic silkworm

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Global Stability of a Viral Infection Model with Defectively Infected Cells and Latent Age

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Chinese Annals of Mathematics,Series B 2024年第4期45卷 555-572页

作者： Jianquan LI Yuming CHEN Peijun ZHANG Dian ZHANG School of Computer Science Xijing University department of Mathematics Wilfrid Laurier University Xi'an Key Laboratory of human-Machine Integration and Control Technology for Intelligent Rehabilitation Xijing University Equal contributor.department of Immunology Xi'an Medical University

The authors propose and analyze a viral infection model with defectively infected cells and age of the latently infected cells. The existence of steady states is determined by the basic reproduction number of virus. With the Lyapunov's direct method, they establish a threshold dynamics of the model with the basic reproduction number of virus as the threshold parameter. To achieve it, a novel procedure is proposed. Its novelties are two-folded. On one hand, the coefficients involved in the specific forms of the used Lyapunov functionals for the two feasible steady states are determined by the same set of inequalities. On the other hand, for the infection steady state, a new approach is proposed to check whether the derivative of the Lyapunov functional candidate along solutions is negative(semi-)definite or not. This procedure not only simplifies the analysis but also exhibits the relationship between the two Lyapunov functionals for the two feasible steady states. Moreover, the procedure is expected to be applicable for other similar models.

关键词： Age structure Basic reproduction number Equilibrium Global stability Lyapunov direct method Viral infection model

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Ensemble Wind Power Prediction Interval with Optimal Reserve Requirement

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Journal of Modern Power Systems and Clean Energy 2024年第1期12卷 65-76页

作者： Hamid Rezaie Cheuk Hei Chung Nima Safari the Saskatchewan Power Corporation(SaskPower) ReginaSaskatchewanCanada the department of Electrical and Computer Engineering and department of human Biology University of TorontoTorontoON M5S 3G4Canada the Alberta Electric System Operator(AESO) CalgaryAlbertaCanada

Wind power prediction interval(WPPI)models in the literature have predominantly been developed for and tested on specific case ***,wind behavior and characteristics can vary significantly across ***,a prediction model that performs well in one case might underperform in *** address this shortcoming,this paper proposes an ensemble WPPI framework that integrates multiple WPPI models with distinct characteristics to improve *** important and often overlooked factor is the role of probabilistic wind power prediction(WPP)in quantifying wind power uncertainty,which should be handled by operating *** reserve in WPPI frameworks enhances the efficacy of *** this regard,the proposed framework employs a novel bi-layer optimization approach that takes both WPPI quality and reserve requirements into *** analysis with different real-world datasets and various benchmark models validates the quality of the obtained WPPIs while resulting in more optimal reserve requirements.

关键词： Ensemble model linear programming operating reserve optimal reserve requirement prediction interval probabilistic prediction renewable integration uncertainty representation wind power prediction(WPP)

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Opportunities and challenges in studies of mammalian hybrid speciation

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Science China(Life Sciences) 2024年第3期67卷 614-617页

作者： Hong Wu Yuxing Zhang Li Yu State Key Laboratory for Conservation and Utilization of Bio-resource in Yunnan School of Life SciencesYunnan UniversityKunming 650091China

Revealing the mechanisms of speciation remains one of the most attractive and challenging issues in the field of evolutionary biology, and is also key to understanding the biodiversity present in nature.

关键词： biodiversity attractive evolutionary

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Efficient fidelity estimation: alternative derivation and related applications

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Communications in Theoretical Physics 2024年第9期76卷 18-22页

作者： Diego S Starke Marcos L W Basso Jonas Maziero Physics department Center for Natural and Exact Sciences Federal University of Santa Maria Center for Natural and human Sciences Federal University of ABC Avenue of the States

In[***.A 107 012427 (2023)],Baldwin and Jones prove that Uhlmann–Jozsa’s fidelity between two quantum statesρandσ,i.e.,■,can be written in a simplified form as ■.In this article,we give an alternative proof of this result,using a function power series expansion and the properties of the trace *** approach not only reinforces the validity of the simplified expression but also facilitates the exploration of novel dissimilarity functions for quantum states and more complex trace functions of density operators.

关键词： Chebyshev polynomials efficient fidelity estimation Rényi entropy Ulhmann-Jozsa fidelity

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Tailoring crystallization zinc hydroxide sulfates growth towards stable zinc deposition chemistry

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Nano Research 2024年第6期17卷 5243-5250页

作者： Kaixin Huang Xianguang Zeng Dan Zhang Yujie Wang Mu Lan Chengyan Wen Yi Guo College of Materials Science and Engineering Sichuan University of Science and EngineeringZigong 643000China department of Chemistry College of Resource and EnvironmentBaoshan UniversityBaoshan 678000China College of Optoelectronic Engineering Chengdu University of Information TechnologyChengdu 610225China

The unstable zinc anode/electrolyte interface induced by corrosion,interfacial water splitting reaction,and dendrite growth seriously degrades the performances of metal Zn anode in aqueous ***,the nucleation and growth of zinc hydroxide sulfate(ZHS),an interfacial by-product,has been tailored by Tween 80 in the electrolyte,which thereby assists in in-situ forming a dense solid electrolyte interphase(SEI)with small-sized ZHS and evenly distributed Tween *** SEI has high corrosion resistance and uniform distribution of zinc ions,which not only contributes to blocking the interfacial side reactions but also induces stable and calm zinc plating/***,the modified electrolyte can confer the assembled Zn||Zn symmetric cell with a stable operation life over 1500 h at 1 mA·cm^(−2)and 1 mAh·cm^(−2)as well as the practical Zn||NH4V4O10 full battery with a high-rate capacity of 120 mAh·g^(−1)at the current density of 5 A·g^(−1).This work provides a way for regulating and reusing interfacial by-products,and a new sight on stabilization electrodes/electrolyte interfaces.

关键词： zinc hydroxide sulfides tailoring crystallization in-situ solid electrolyte interphase electrolyte engineering strategy aqueous zinc-ion battery

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Foam rolling and stretching do not provide superior acute flexibility and stiffness improvements compared to any other warm-up intervention: A systematic review with meta-analysis

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Journal of Sport and Health Science 2024年第4期13卷 509-520页

作者： Konstantin Warneke Gerit Plöschberger Lars H.Lohmann Eric Lichtenstein Daniel Jochum Stanislav D.Siegel Astrid Zech David G.Behm Institute of Sport Science University of KlagenfurtKlagenfurt am Wörthersee 9020Austria department of human Motion Science and Exercise Physiology Friedrich Schiller UniversityJena 07749Germany department Sport Exercise and HealthUniversity of BaselBasel 4052Switzerland department of Health Sciences and Technology ETH ZurichZurich 8092Switzerland School of human Kinetics and Recreation Memorial University of NewfoundlandSt.JohnsNL A1C 5S7Canada

Background:Acute improvement in range of motion(ROM)is a widely reported effect of stretching and foam rolling,which is commonly explained by changes in pain threshold and/or musculotendinous ***,these effects were also reported in response to various other active and passive interventions that induce responses such as enhanced muscle ***,we hypothesized that acute ROM enhancements could be induced by a wide variety of interventions other than stretching or foam rolling that promote an increase in muscle ***:After a systematic search in PubMed,Web of Science,and SPORTDiscus databases,38 studies comparing the effects of stretching and foam rolling with several other interventions on ROM and passive properties were *** studies had 1134 participants in total,and the data analysis resulted in 140 effect sizes(ESs).ES calculations were performed using robust variance estimation model with ***:Study quality of the included studies was classified as fair(PEDro score=4.58)with low to moderate certainty of *** showed no significant differences in ROM(ES=0.01,p=0.88),stiffness(ES=0.09,p=0.67),or passive peak torque(ES=-0.30,p=0.14)between stretching or foam rolling and the other identified *** plots revealed no publication ***:Based on current literature,our results challenge the established view on stretching and foam rolling as a recommended component of warm-up *** lack of significant difference between interventions suggests there is no need to emphasize stretching or foam rolling to induce acute ROM,passive peak torque increases,or stiffness reductions.

关键词： Range of motion Passive properties Muscletendon unit Muscle tissue

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