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Effects of sodium β-aescin on expression of adhesion molecules and migration of neutrophils after middle cerebral artery occlusion in rats

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Acta Pharmacologica Sinica 2004年第7期25卷 23-29页

作者： Xia-min HU, Yan ZHANG2,Fan-dian ZENG3 Instituteof Clinical Pharmacology 2department of anatomy, Tongjimedical college of Huazhong Universityof Science and Technology, Wuhan 430030, China Institute of Clinical Pharmacology department of anatomy Tongji Medical College of Huazhong University of Science and Technology

AIM: To investigate the effects of sodium β-aescin on neutrophil migration and expression of adhesion molecules (ICAM-1 and E-selectin) after middle cerebral artery occlusion (MCAO) in rats. METHODS: Rats were pretreated with sodium β-aescin for 7 d and then subjected to cerebral ischemia/reperfusion (I/R) injury induced by an MCAO. After a 2-h ischemia and a 24-h reperfusion, the infarct volume and neurological deficit were determined by the method of TTC staining and the Longa’s score. The effect of sodium β-aescin on the migration of neutro- phils was evaluated by measuring the activity of myeloperoxidase (MPO) enzyme. The expressions of adhesion molecules were determined by immunohistochemistry and Western blot. RESULTS: Sodium β-aescin significantly reduced the cerebral infarct volume and ameliorated the neurological deficit (P<0.05 or P<0.01). The MPO activity and the expressions of ICAM-1 and E-selectin in the vehicle-treated rats were increased significantly (P<0.01) after cerebral I/R. After treatment with sodium β-aescin, the enzymatic activity of MPO and the expressions of these adhesion molecules were significantly reduced compared with the vehicle-treated group (P<0.05 or P<0.01). CONCLUSION: Sodium β-aescin can attenuate brain injury, down-regulate the protein expressions of ICAM-1 and E-selectin, and reduce the migration of neutrophils after cerebral I/R.

关键词： brain ischemia aescin neutrophils peroxides intercellular adhesion molecule-1 E-selectin

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Constraint-induced movement therapy promotes brain functional reorganization in stroke patients with hemiplegia

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Neural Regeneration Research 2012年第32期7卷 2548-2553页

作者： Wenqing Wang Aihui Wang Limin Yu Xuesong Han Guiyun Jiang Changshui Weng Hongwei Zhang Zhiqiang Zhou department of Rehabilitation Medicine Affiliated Hospital of Chengde Medical College Chengde 067000 Hebei Province China department of Computer Tomography Affiliated Hospital of Chengde Medical College Chengde 067000 Hebei Province China department of anatomy Chengde Nursing Vocational College Chengde 067000 Hebei Province China department of Computer & Information Engineering Chengde Petroleum College Chengde 067000 Hebei Province China department of Rehabilitation Medicine General Hospital of Chinese PLA Beijing 100853 China

Stroke patients with hemiplegia exhibit flexor spasms in the upper limb and extensor spasms in the lower limb, and their movement patterns vary greatly. Constraint-induced movement therapy is an upper limb rehabilitation technique used in stroke patients with hemiplegia; however, studies of lower extremity rehabilitation are scarce. In this study, stroke patients with lower limb hemiplegia underwent conventional Bobath therapy for 4 weeks as baseline treatment, followed by constraint-induced movement therapy for an additional 4 weeks. The 10-m maximum walking speed and Berg balance scale scores significantly improved following treatment, and lower extremity motor function also improved. The results of functional MRI showed that constraint-induced movement therapy alleviates the reduction in cerebral functional activation in patients, which indicates activation of functional brain regions and a significant increase in cerebral blood perfusJon. These results demonstrate that constraint-induced movement therapy promotes brain functional reorganization in stroke patients with lower limb hemiplegia.

关键词： stroke constraint-induced movement therapy functional MRI lower extremity maximum walking speed Berg balance scale central nervous injury neuroimaging regeneration neural regeneration

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The protective effect and underlying mechanism of Hainan papaya water extract against neuronal apoptosis induced by A β 40

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Asian Pacific Journal of Tropical Medicine 2016年第7期9卷 653-658页

作者： Jiu-Hong Zhao Hai-Ying Zhang Xian-Fang Zhang Xu Dong Qi-Bing Liu Yue-Li Liu Yi-Di Huang Quan-Peng Zhang Gang Luo Zhi-Jian Ma Xi-Nan Yi department of anatomy Hainan Medical College Neuroscience Research Institute Hainan Medical College School of Pharmacy Hainan Medical College

Objective:To investigate whether Hainan papayas has protective effects in an Aimary neuron injury model and elucidate the underlying molecular mecha β 40-induced ***:Cultured primary neurons from the dorsal root ganglia(DRG) of Sprague-Dawley(SD) rats were treated with 20 μM A culture medium β 40 peptide,100 μg/L Hainan papaya water extract,peptide plus extract,or for 24 *** viability was measured by MTT assay,and neuronal apoptosis was evaluated by DAPI *** signaling pathway-associated molecule activation and changes in Bax expression were analyzed by Western blotting and ***:A cell viability rate of(44.11±6.59)% in the Ading different concentrations of the extract β 40 group was rescued to(79.13±6.64)% by *** showed pyknotic nuclei in 39.5% of A β 40-treated cells;the fraction dropped to 17.4% in the 100 μg/L extract *** phosphorylation was observed in the Aent with 100 μg/L *** papaya water ex β 40 group but was ameliorated by pretreatmtract also prevented Ation of MEK,RSK1 and CREB associated with ERK signaling and d β 40-induced phosphorylaownregulated Bax expression in the ***:The resultss suggest that Hainan papaya water extract has protective effects on neurons;the mechanism may be related to suppression of ERK signaling activation.

关键词： A β peptide Neuron protection ERK signaling pathway

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Enhancing metformin efficacy with cholecalciferol and taurine in diabetes therapy:Potential and limitations

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World Journal of Diabetes 2025年第1期16卷 22-26页

作者： Gehan El-Akabawy Nabil Eid department of Basic medical Sciences College of MedicineAjman UniversityAjman 346United Arab Emirates department of anatomy Division of Human BiologySchool of MedicineIMU UniversityKuala Lumpur 57000Malaysia

Diabetes mellitus,particularly type 2 diabetes mellitus(T2DM),poses a significant global health *** management strategies primarily focus on glycemic control;however,there is a growing need for comprehensive approaches addressing the complex pathophysiology of diabetes *** recent study by Attia et al explores the potential of a novel therapy combining metformin with cholecalciferol(vitamin D3)and taurine to mitigate T2DM-related complications in a rat *** findings indicate that this treatment combination improves glycemic control and reduces oxidative stress,inflammation,and lipid ***,the study is limited by a lack of safety profile data and in-depth molecular mechanism *** editorial critically highlights the study's strengths and weaknesses,compares it against other combination therapy research in T2DM,and underscores the need to explore further the mechanisms underpinning the observed therapeutic effects and investigate the safety profile of this novel approach.

关键词： Diabetes Metformin Cholecalciferol Taurine Hyperglycemia Oxidative stress Triglycerides

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Monte Carlo Simulation on Growth of Antibody-Antigen Complexes： the Role of Unequal Reactivity

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Chinese Physics Letters 2010年第3期27卷 328-331页

作者：张平王海军 college of Chemistry and Environment Science Hebei University Baoding 071002 department of Biomedical Engineering Chengde Medical College Chengde 067000 International Centre for Materials Physics Chinese Academy of Sciences Shenyang 110016 Key Laboratory of medical Chemistry and Molecular Diagnosis (Ministry of Education) Hebei University Baoding 071002

Growth of Antibody-Antigen complexes in a multivalent Antibody-Antigen system is studied by the Monte Carlo simulation method. The validity of the algorithm is first demonstrated for the case of the equal reactivity, then the simulation is presented for the case of unequal reactivity. It is shown that the influence of the unequal reactivity on the critical point, size distribution and the weight-average binding degree is significant. Especially, the gelation regions for the cases of unequal reactivity are studied, which can provide some useful clues for the immunological experiments.

关键词： Computational physics Biological physics

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Use of FK506 and bone marrow mesenchymal stem cells for rat hind limb allografts

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Neural Regeneration Research 2012年第34期7卷 2681-2688页

作者： Youxin Song Zhujun Wang Zhixue Wang Hong Zhang Xiaohui Li Bin Chen department of Orthopedics Affiliated Hospital of Chengde Medical College Chengde 067000 Hebei Province China department of Research Affiliated Hospital of Chengde Medical College Chengde 067000 Hebei Province China department of Anesthesia Affiliated Hospital of Chengde Medical College Chengde 067000 Hebei Province China department of Surgery Affiliated Hospital of Chengde Medical College Chengde 067000 Hebei Province China

Dark Agouti rat donor hind limbs were orthotopically transplanted into Lewis rat recipients to verify the effects of bone marrow mesenchymal stem cells on neural regeneration and functional recovery of allotransplanted limbs in the microenvironment of immunotolerance, bone marrow mesenchymal stem cells were intramuscularly （gluteus maximus） injected with FK506 （tacrolimus） daily, and were transplanted to the injured nerves. Results indicated that the allograft group not receiving therapy showed severe rejection, with transplanted limbs detaching at 10 days after transplantation with complete necrosis. The number of myelinated axons and Schwann cells in the FK506 and FK506 ＋ bone marrow mesenchymal stem cells groups were significantly increased. We observed a lesser degree of gastrocnemius muscle degeneration, and increased polymorphic fibers along with other pathological changes in the FK506 ＋ bone marrow mesenchymal stem cells group. The FK506 ＋ bone marrow mesenchymal stem cells group showed significantly better recovery than the autograft and FK506 groups. The results demonstrated that FK506 improved the immune microenvironment. FK506 combined with bone marrow mesenchymal stem cells significantly promoted sciatic nerve regeneration, and improved sensory recovery and motor function in hind limb allotransplant.

关键词： FK506 (tacrolimus) bone marrow mesenchymal stem cells allotransplant hind limb transplant function recovery sensory function motor function peripheral nerve injury regeneration neuralregeneration

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Synthesis and Characteristics of Electrodeposited CoxZn1-x Nanorods

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Chinese Physics Letters 2010年第6期27卷 203-205页

作者： LIU Li-Hu GU Jian-Jun LI Hai-Tao CAI Ning SUN Hui-Yuan college of Physics Science and Information Engineering Hebei Normal University Shijiazhuang 050016 Key Laboratory of Advanced Films of Hebei Province Shijiazhuang 050016 department of Physics Hebei Chengde Teachers College Chengde 067000

CoxZn1-x nanorod arrays were fabricated by electrodeposition in porous anodic aluminum oxide templates at different electric potentials. X-ray diffraction and transmission electron microscopy indicate that highly-ordered and uniform nanorods have been fabricated. The amounts of Co and Zn contents are investigated using energy dispersive spectroscopy, which demonstrates that the atom ratio of the alloy nanorods changes with the deposition potential. In addition, magnetic measurements show that the magnetic isotropy Co-rich CoZn nanorods will change to magnetic anisotropy nanorods with the easy axis parallel to the rod long axis with decreasing Co content.

关键词： ELECTROFORMING MICROFABRICATION COBALT compounds POROUS materials ALUMINUM oxide X-ray diffraction MAGNETIC measurements ANISOTROPY

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IGF-1 promotes the growth and metastasis of hepatocellular carcinoma via the inhibition of proteasome-mediated cathepsin B degradation

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World Journal of Gastroenterology 2015年第35期21卷 10137-10149页

作者： Tian Lei Xie Ling department of Gastroenterology the First Affiliated Hospital of Liaoning Medical University department of anatomy Liaoning Medical College

AIM: To investigate the molecular mechanisms of the high IGF-1 level linking diabetes and cancers, which is a risk ***: We used cell growth, wound healing and transwell assay to evaluate the proliferation and metastasis ability of the hepatocellular carcinoma(HCC) cells. Western blot and reverse transcription polymerase chain reaction were used to assess a previously identified lysosomal protease, cathepsin B(CTSB) expression in the HCC cell lines. C57 BL/6J and KK-Ay diabetic mice are used to detect the growth and metastasis of HCC cells that were depleted with or without CTSB sh RNA in vivo. Statistical significance was determined by Student's ***: IGF-1 promoted the growth and metastasis of the HCC cell lines via its ability to enhance CTSB expression in both a time-dependent and concentration-dependent manner. HCC cells grew much faster in diabetic KK-Ay mice than in C57 BL/6J mice. Additionally, more metastatic nodules were found in the lungs of KK-Ay mice than the lungs of C57 BL/6J mice. CTSB depletion protects against the tumorpromoting actions of IGF-1 in HCC cells, as well tumor growth and metastasis both in vitro and in ***-1 did not change the m RNA levels of CTSB but prolonged the half-life of cathepsin B in Hepa 1-6 and H22 cells. Our results showed that IGF-1 promotes the growth and metastasis of the HCC cells most likely by hindering CTSB degradation mediated by the ubiquitinproteasome system(UPS), but not autophagy. Overexpression of proteasome activator 28, a family of activators of the 20 S proteasome, could not only restore IGF-1-inhibited UPS activity but also decrease IGF-1-induced CTSB ***: Our study demonstrates that IGF-1 promotes the growth and metastasis of hepatocellular carcinoma by inhibition of proteasome-mediated CTSB degradation.

关键词： IGF-1 Cathepsin B Ubiquitin-proteasome system Hepa

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Biocompatibility and biosafety of butterfly wings for the clinical use of tissue-engineered nerve grafts

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Neural Regeneration Research 2021年第8期16卷 1606-1612页

作者： Shu Wang Miao Gu Cheng-Cheng Luan Yu Wang Xiaosong Gu Jiang-Hong He Key Laboratory for Neuroregeneration of Jiangsu Province and Ministry of Education Co-innovation Center of NeuroregenerationNantong UniversityNantongJiangsu ProvinceChina department of Basic Medicine Chengde Medical CollegeChengdeHebei ProvinceChina

In a previous study, we used natural butterfly wings as a cell growth matrix for tissue engineering materials and found that the surface of different butterfly wings had different ultramicrostructures, which can affect the qualitative growth of cells and regulate cell growth, metabolism, and gene expression. However, the biocompatibility and biosafety of butterfly wings must be studied. In this study, we found that Sprague-Dawley rat dorsal root ganglion neurons could grow along the structural stripes of butterfly wings, and Schwann cells could normally attach to and proliferate on different species of butterfly wings. The biocompatibility and biosafety of butterfly wings were further examined through subcutaneous implantation in Sprague-Dawley rats, intraperitoneal injection in Institute of Cancer Research mice, intradermal injection in rabbits, and external application to guinea pigs. Our results showed that butterfly wings did not induce toxicity, and all examined animals exhibited normal behaviors and no symptoms, such as erythema or edema. These findings suggested that butterfly wings possess excellent biocompatibility and biosafety and can be used as a type of tissue engineering material. This study was approved by the Experimental Animal Ethics Committee of Jiangsu Province of China(approval No. 20190303-18) on March 3, 2019.

关键词： biocompatibility biomaterials biosafety butterfly wings dorsal root ganglion neurons Schwann cells tissue engineering

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DIRECT CONNECTIONS BETWEEN HYPOTHALAMUS AND LUMBAR SPINAL CORD IN RABBITS

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Science China Chemistry 1984年第8期27卷 789-799页

作者：鞠躬 The Fourth Military medical college Shaanxi Province Xi’an department of anatomy

Horseradish peroxidase (HRP) was injected into the L6 spinal cord in seven rabbits andthe labeling in the hypothalamus traced. The distribution of the retrogradely labeled cellswas studied and the anterogradely labeled fibers and terminal branches were unequivocallyidentified. Hypothalamo-spinal projection cells were found predominantly on the ipsilateral side,mainly distributed in the posterior, dorsal, and lateral hypothalamic areas, and the paraven-tricular nucleus. Some were found in the perifornical nuelcus and a few could be seen in thetuber area, supranmmnfillary nucleus and tho region doisal to the supraoptic nucleus. Spino-hypothalamic projections were found to terminate mainly on the contralateral sidevia two. routes: (i) The dorsal longitudinal fascieulus, distributed to the posterior hypotha-lamie area. Some might end in the supramammillary nucleus; (ii) Fibers running latero-medially ventral to the mammillothalamic tract to terminate in the dorsal parts of the medialand lateral hypothalanms

关键词： DIRECT CONNECTIONS BETWEEN HYPOTHALAMUS AND LUMBAR SPINAL CORD IN RABBITS

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