Enhancing metformin efficacy with cholecalciferol and taurine in diabetes therapy:Potential and limitations
作者机构：Department of Basic Medical SciencesCollege of MedicineAjman UniversityAjman 346United Arab Emirates Department of AnatomyDivision of Human BiologySchool of MedicineIMU UniversityKuala Lumpur 57000Malaysia
出 版 物：《World Journal of Diabetes》 (世界糖尿病杂志（英文）)
年 卷 期：2025年第16卷第1期
页 面：22-26页
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：Diabetes Metformin Cholecalciferol Taurine Hyperglycemia Oxidative stress Triglycerides
摘 要：Diabetes mellitus,particularly type 2 diabetes mellitus(T2DM),poses a significant global health *** management strategies primarily focus on glycemic control;however,there is a growing need for comprehensive approaches addressing the complex pathophysiology of diabetes *** recent study by Attia et al explores the potential of a novel therapy combining metformin with cholecalciferol(vitamin D3)and taurine to mitigate T2DM-related complications in a rat *** findings indicate that this treatment combination improves glycemic control and reduces oxidative stress,inflammation,and lipid ***,the study is limited by a lack of safety profile data and in-depth molecular mechanism *** editorial critically highlights the study s strengths and weaknesses,compares it against other combination therapy research in T2DM,and underscores the need to explore further the mechanisms underpinning the observed therapeutic effects and investigate the safety profile of this novel approach.
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